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Table 1 Overview of inclusion and exclusion criteria

From: Glucocorticoid Receptor (GR) antagonism as disease-modifying treatment for MDD with childhood trauma: protocol of the RESET-medication randomized controlled trial

Inclusion criteria

Exclusion criteria

1. Age of ≥ 18 years

1. Primary PTSD or ASD

2. Moderate/severe MDD

2. Lifetime BPD, bipolar disorder, schizophrenia or current substance abuse

3. Moderate/severe CT

3. Start of depression treatment in the week before or after the start of the intervention

4. For WOCBP, use of a non-hormonal contraceptive method (e.g. condom) during the intervention period and up to 1 month after the intervention

4. Chronic adrenal insufficiency

5. A history of unexplained vaginal bleeding or endometrial changes.

6. Pregnancy or breastfeeding

7. Current drug use of CYP3A4 inhibitors/inductors/substrates, CYP2C8/9 substrates, glucocorticoid antagonists and systemic corticosteroids