Inclusion criteria | Exclusion criteria |
---|---|
1. Age of ≥ 18 years | 1. Primary PTSD or ASD |
2. Moderate/severe MDD | 2. Lifetime BPD, bipolar disorder, schizophrenia or current substance abuse |
3. Moderate/severe CT | 3. Start of depression treatment in the week before or after the start of the intervention |
4. For WOCBP, use of a non-hormonal contraceptive method (e.g. condom) during the intervention period and up to 1 month after the intervention | 4. Chronic adrenal insufficiency |
5. A history of unexplained vaginal bleeding or endometrial changes. | |
6. Pregnancy or breastfeeding | |
7. Current drug use of CYP3A4 inhibitors/inductors/substrates, CYP2C8/9 substrates, glucocorticoid antagonists and systemic corticosteroids |