Eating disorders

Anorexia nervosa-associated pancytopenia mimicking idiopathic aplastic anemia: a case report

Patients with anorexia nervosa (AN) often present with pancytopenia. In most cases described in the literature, AN with pancytopenia demonstrates gelatinous marrow transformation (GMT), which is a typical bone...

Authors: Masahiro Takeshima, Hiroyasu Ishikawa, Akihiro Kitadate, Ryo Sasaki, Takahiro Kobayashi, Hiroshi Nanjyo, Takashi Kanbayashi and Tetsuo Shimizu

Cost-effectiveness of the mobile application TCApp combined with face-to-face CBT treatment compared to face-to-face CBT treatment alone for patients with an eating disorder: study protocol of a multi-centre randomised controlled trial

The clinical utility of the existing apps for people with eating disorders (EDs) is not clear. The TCApp has been specifically developed for people with EDs, is based on the principles of Cognitive Behavioural...

Authors: Dimitra Anastasiadou, Francisco Lupiañez-Villanueva, Clara Faulí, Jordina Arcal Cunillera and Eduardo Serrano-Troncoso

Prospective, randomized, double-blind, placebo-controlled phase IIa clinical trial on the effects of an estrogen-progestin combination as add-on to inpatient psychotherapy in adult female patients suffering from anorexia nervosa

There is a need for novel treatment approaches in anorexia nervosa (AN). While there is broad knowledge with regard to altered appetite regulation and neuropsychological deficits in AN patients on the one hand...

Authors: Georgios Paslakis, Stefanie Maas, Bernd Gebhardt, Andreas Mayr, Manfred Rauh and Yesim Erim

Family-based intervention in adolescent restrictive eating disorders: early treatment response and low weight suppression is associated with favourable one-year outcome

Family-based treatments are first-line treatments for adolescents with restrictive eating disorders (ED) but have to be improved since outcome is poor for some. We have investigated the one-year outcome of a f...

Authors: Ingemar Swenne, Thomas Parling and Helena Salonen Ros

Efficacy of a prevention program for eating disorders in schools: a cluster-randomized controlled trial

Previous prevention programs in the school context have not addressed both genders, have been time-consuming, or have had deficits in the evaluation method. The aim of the present study was to evaluate the imp...

Authors: Antje Gumz, Angelika Weigel, Anne Daubmann, Karl Wegscheider, Georg Romer and Bernd Löwe

Clinicians’ views on working with anorexia nervosa and autism spectrum disorder comorbidity: a qualitative study

Anorexia nervosa (AN) and autism spectrum disorder (ASD) form a relatively common comorbidity, with poorer illness outcomes and poorer responses to treatments for AN compared to individuals without ASD. Howeve...

Authors: Emma Kinnaird, Caroline Norton and Kate Tchanturia

Assessment of eating disorders with the diabetes eating problems survey – revised (DEPS-R) in a representative sample of insulin-treated diabetic patients: a validation study in Italy

The purpose of the study was to evaluate in a sample of insulin-treated diabetic patients, with type 1 or type 2 diabetes, the psychometric characteristics of the Italian version of the DEPS-R scale, a diabete...

Authors: Federica Pinna, Enrica Diana, Lucia Sanna, Valeria Deiana, Mirko Manchia, Eraldo Nicotra, Andrea Fiorillo, Umberto Albert, Alessandra Nivoli, Umberto Volpe, Anna Rita Atti, Silvia Ferrari, Federica Medda, Maria Gloria Atzeni, Daniela Manca, Elisa Mascia…

Confirmatory factor analysis and examination of the psychometric properties of the eating beliefs questionnaire

The Eating Beliefs Questionnaire (EBQ) is a 27-item self-report measure that assesses positive and negative beliefs about binge eating. It has been validated and its factor structure explored in a non-clinical...

Authors: Amy L. Burton, Phillipa Hay, Sabina Kleitman, Evelyn Smith, Jayanthi Raman, Jessica Swinbourne, Stephen W. Touyz and Maree J. Abbott

The PED-t trial protocol: The effect of physical exercise –and dietary therapy compared with cognitive behavior therapy in treatment of bulimia nervosa and binge eating disorder

Sufferers from bulimia nervosa (BN) and binge eating disorder (BED) underestimate the severity risk of their illness and, therefore, postpone seeking professional help for years. Moreover, less than one in fiv...

Authors: Therese Fostervold Mathisen, Jan H. Rosenvinge, Gunn Pettersen, Oddgeir Friborg, KariAnne Vrabel, Solfrid Bratland-Sanda, Mette Svendsen, Trine Stensrud, Maria Bakland, Rolf Wynn and Jorunn Sundgot-Borgen

A vicious cycle among cognitions and behaviors enhancing risk for eating disorders

Establishing the sequence in which risk factors for eating disorders (ED) emerge would enable more effective ED prevention. Thus, in our study we investigated reciprocal and indirect associations between three...

Authors: Karolina Zarychta, Barbara Mullan, Magdalena Kruk and Aleksandra Luszczynska

Comparison of associated features and drug treatment between co-occurring unipolar and bipolar disorders in depressed eating disorder patients

To examine the differences of associated characteristics and prescription drug use between co-occurring unipolar and bipolar disorders in patients with eating disorders (EDs).

Authors: Mei-Chih Meg Tseng, Chin-Hao Chang, Shih-Cheng Liao and Hsi-Chung Chen

Orthorexia and anorexia nervosa: two distinct phenomena? A cross-cultural comparison of orthorexic behaviours in clinical and non-clinical samples

Orthorexia nervosa (ON) is defined as pathological healthful eating. The aim of this study was to investigate whether there is any difference in orthorexic behaviours between clinical and non-clinical groups, ...

Authors: C. Gramaglia, A. Brytek-Matera, R. Rogoza and P. Zeppegno

Symptoms of Attention Deficit Hyperactivity Disorder (ADHD) among adult eating disorder patients

Very little is known about the prevalence of ADHD symptoms in Bulimia Nervosa and Binge Eating Disorder and even less in other eating disorders. This knowledge gap is of clinical importance since stimulant tre...

Authors: Nils Erik Svedlund, Claes Norring, Ylva Ginsberg and Yvonne von Hausswolff-Juhlin

A pragmatic randomised multi-centre trial of multifamily and single family therapy for adolescent anorexia nervosa

Considerable progress has been made in recent years in developing effective treatments for child and adolescent anorexia nervosa, with a general consensus in the field that eating disorders focussed family the...

Authors: Ivan Eisler, Mima Simic, John Hodsoll, Eia Asen, Mark Berelowitz, Frances Connan, Gladys Ellis, Pippa Hugo, Ulrike Schmidt, Janet Treasure, Irene Yi and Sabine Landau

Brain volumes and regional cortical thickness in young females with anorexia nervosa

Anorexia nervosa (AN) is a severe mental illness, with an unknown etiology. Magnetic resonance imaging studies show reduced brain volumes and cortical thickness in patients compared to healthy controls. Howeve...

Authors: Tone Seim Fuglset, Tor Endestad, Eva Hilland, Lasse Bang, Christian Krog Tamnes, Nils Inge Landrø and Øyvind Rø

Quality of life as a vulnerability and recovery factor in eating disorders: a community-based study

Emerging evidence suggests that changes in quality of life (QoL) predicts later changes in eating disorder (ED) symptoms. The objective of this study was to explore individual sufferers’ perspectives on the in...

Authors: Deborah Mitchison, Lisa Dawson, Lucy Hand, Jonathan Mond and Phillipa Hay

Effectiveness of enhanced cognitive behavioral therapy (CBT-E) in the treatment of anorexia nervosa: a prospective multidisciplinary study

Anorexia nervosa (AN) is a debilitating psychiatric disorder associated with a wide array of negative health complications and psychiatric comorbidity. Existing evidence for AN treatment in adults is weak, and...

Authors: Yngvild S. Danielsen, Guro Årdal Rekkedal, Stein Frostad and Ute Kessler

Predictive factors of dropout from inpatient treatment for anorexia nervosa

Patients with severe Anorexia Nervosa (AN) whose condition is life-threatening or who are not receiving adequate ambulatory care are hospitalized. However, 40 % of these patients leave the hospital prematurely...

Authors: H. Roux, A. Ali, S. Lambert, L. Radon, C. Huas, F. Curt, S. Berthoz and Nathalie Godart

How anorexia nervosa patients with high and low autistic traits respond to group Cognitive Remediation Therapy

The current study aimed to evaluate group Cognitive remediation therapy (CRT) inpatients with Anorexia Nervosa (AN). We aimed to examine the treatment response of group CRT in AN patients with high or low leve...

Authors: Kate Tchanturia, Emma Larsson and James Adamson

Rate, timing and predictors of relapse in patients with anorexia nervosa following a relapse prevention program: a cohort study

Relapse is common among recovered anorexia nervosa (AN) patients. Studies on relapse prevention with an average follow-up period of 18 months found relapse rates between 35 and 41 %. In leading guidelines ther...

Authors: Tamara Berends, Berno van Meijel, Willem Nugteren, Mathijs Deen, Unna N. Danner, Hans W. Hoek and Annemarie A. van Elburg

A randomised trial of Acceptance and Commitment Therapy for Anorexia Nervosa after daycare treatment, including five-year follow-up

No specific psychotherapy for adult anorexia nervosa (AN) has shown superior effect. Maintenance factors in AN (over-evaluation of control over eating, weight and shape) were addressed via Acceptance and Commi...

Authors: Thomas Parling, Martin Cernvall, Mia Ramklint, Sven Holmgren and Ata Ghaderi

A factor analysis of the meanings of anorexia nervosa: intrapsychic, relational, and avoidant dimensions and their clinical correlates

Anorexia nervosa (AN) is a difficult to treat disorder characterized by ambivalence towards recovery and high mortality. Eating symptomatology has a sort of adaptive function for those who suffer from AN but n...

Authors: Enrica Marzola, Corine Panepinto, Nadia Delsedime, Federico Amianto, Secondo Fassino and Giovanni Abbate-Daga

Treatment-seeking patients with binge-eating disorder in the Swedish national registers: clinical course and psychiatric comorbidity

We linked extensive longitudinal data from the Swedish national eating disorders quality registers and patient registers to explore clinical characteristics at diagnosis, diagnostic flux, psychiatric comorbidi...

Authors: Elisabeth Welch, Andreas Jangmo, Laura M. Thornton, Claes Norring, Yvonne von Hausswolff-Juhlin, Barry K. Herman, Manjiri Pawaskar, Henrik Larsson and Cynthia M. Bulik

Normal gray matter volumes in women recovered from anorexia nervosa: a voxel-based morphometry study

Anorexia nervosa (AN) has consistently been associated with reduced gray (GM) and white matter (WM) brain volumes. It is unclear whether GM alterations are present following recovery from AN, as previous findi...

Authors: Lasse Bang, Øyvind Rø and Tor Endestad

Aversive tension in female adolescents with Anorexia Nervosa: a controlled ecological momentary assessment using smartphones

Current models of Anorexia Nervosa (AN) emphasize the role of emotion regulation. Aversive tension, described as a state of intense arousal and negative valence, is considered to be a link between emotional ev...

Authors: David R. Kolar, Florian Hammerle, Ekkehart Jenetzky, Michael Huss and Arne Bürger

Influence of premorbid BMI on clinical characteristics at presentation of adolescent girls with eating disorders

Considering the prevalence of obesity in society it can be expected that some adolescents with an eating disorder (ED) start weight loss from an overweight and present at a near-normal weight. Presently, the i...

Authors: Ingemar Swenne

Binge-eating disorder diagnosis and treatment: a recap in front of DSM-5

Binge Eating Disorders is a clinical syndrome recently coded as an autonomous diagnosis in DSM-5. Individuals affected by Binge Eating Disorder (BED) show significantly lower quality of life and perceived heal...

Authors: Federico Amianto, Luisa Ottone, Giovanni Abbate Daga and Secondo Fassino

First results of a refeeding program in a psychiatric intensive care unit for patients with extreme anorexia nervosa

Anorexia nervosa (AN) is associated with a high mortality rate. This study describes a compulsory re-feeding program established in Munich for extremely underweight patients.

Authors: Christoph Born, Larissa de la Fontaine, Bettina Winter, Norbert Müller, Annette Schaub, Clemens Früstück, Cornelius Schüle, Ulrich Voderholzer, Ulrich Cuntz, Peter Falkai and Eva Meisenzahl

Cognitive Remediation and Emotion Skills Training (CREST) for anorexia nervosa in individual format: self-reported outcomes

To evaluate self-reported outcomes after a brief course of skills-based individual therapy for inpatients with anorexia nervosa (AN).

Authors: Kate Tchanturia, Eli Doris, Vicki Mountford and Caroline Fleming

A comparison of clinical characteristics between adolescent males and females with eating disorders

Eating disorders (ED) are serious disorders that have a negative impact on both the psychological and the physiological well-being of the afflicted. Despite the fact that ED affect both genders, males are ofte...

Authors: Elisabeth Welch, Ata Ghaderi and Ingemar Swenne

Preventing eating disorders with an interactive gender-adapted intervention program in schools: Study protocol of a randomized controlled trial

There are a high number of adolescents who are at risk of developing an eating disorder. There is, therefore, a strong need to implement prevention programs aimed at reducing the incidence of eating disorders ...

Authors: Angelika Weigel, Antje Gumz, Natalie Uhlenbusch, Karl Wegscheider, Georg Romer and Bernd Löwe

Decision making, central coherence and set-shifting: a comparison between Binge Eating Disorder, Anorexia Nervosa and Healthy Controls

Several studies have investigated the cognitive profile in patients with Anorexia Nervosa (AN) and Bulimia Nervosa (BN); on the contrary few studies have evaluated it in patients with Binge Eating Disorder (BE...

Authors: Matteo Aloi, Marianna Rania, Mariarita Caroleo, Antonella Bruni, Antonella Palmieri, Maria Antonella Cauteruccio, Pasquale De Fazio and Cristina Segura-García

Lack of efficacy of psychological and pharmacological treatments of disorders of eating behavior: neurobiological background

Treatments of eating disorders result too often in partial psychological and physical remission, chronicization, dropout, relapse and death, with no fully known explanations for this failure. In order to clari...

Authors: Francesca Brambilla, Federico Amianto, Riccardo Dalle Grave and Secondo Fassino

The household economic burden of eating disorders and adherence to treatment in Australia

This study investigated the household economic burden of eating disorders and cost-related non-adherence to treatment in Australia.

Authors: Lauren Gatt, Stephen Jan, Naresh Mondraty, Sarah Horsfield, Susan Hart, Janice Russell, Tracey Lea Laba and Beverley Essue

Decreasing the duration of untreated illness for individuals with anorexia nervosa: study protocol of the evaluation of a systemic public health intervention at community level

Anorexia nervosa (AN) is a mental disorder with grave burdens for affected individuals as well as for the healthcare system. One of the strongest predictors of a poor outcome is a long Duration of Untreated Il...

Authors: Antje Gumz, Natalie Uhlenbusch, Angelika Weigel, Karl Wegscheider, Georg Romer and Bernd Löwe

Specialized inpatient treatment of adult anorexia nervosa: effectiveness and clinical significance of changes

Previous studies have predominantly evaluated the effectiveness of inpatient treatment for anorexia nervosa at the group level. The aim of this study was to evaluate treatment outcomes at an individual level b...

Authors: Sandra Schlegl, Norbert Quadflieg, Bernd Löwe, Ulrich Cuntz and Ulrich Voderholzer

Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study

Functional neuroimaging techniques are widely used to elucidate changes in brain activity, and various questionnaires are used to investigate psychopathological features in patients with eating disorders (ED)....

Authors: Hiroto Katayama, Kunihiro Kohmura, Satoshi Tanaka, Miho Imaeda, Naoko Kawano, Yukihiro Noda, Kazuo Nishioka, Masahiko Ando, Branko Aleksic, Tetsuya Iidaka and Norio Ozaki

Eating disorders among patients incarcerated only for repeated shoplifting: a retrospective quasi-case-control study in a medical prison in Japan

Shoplifting is a serious problem among patients with eating disorders. For more than a decade, we have treated many patients with eating disorders incarcerated in Hachioji Medical Prison only for repeated shop...

Authors: Tomokuni Asami, Yoshiro Okubo, Mizuho Sekine and Toshiaki Nomura

Exploring health-related quality of life in eating disorders by a cross-sectional study and a comprehensive review

People with eating disorders (ED) often report poor health-related quality of life (HRQoL), which is explicitly correlated to illness’ severity and its effects on cognitive performance. We aimed to analyze hea...

Authors: Monica Baiano, Pierandrea Salvo, Pierluigi Righetti, Lucia Cereser, Erika Baldissera, Ilenia Camponogara and Matteo Balestrieri

Treatment outcome of patients with comorbid type 1 diabetes and eating disorders

Co-morbidity between Type 1 Diabetes Mellitus (T1DM) and eating disorders (ED) has been previously described; however the effect of this illness on the outcomes for conventional ED treatments has not been prev...

Authors: Nuria Custal, Jon Arcelus, Zaida Agüera, Francesca I Bove, Jackie Wales, Roser Granero, Susana Jiménez-Murcia, Isabel Sánchez, Nadine Riesco, Pino Alonso, José M Crespo, Nuria Virgili, Jose M Menchón and Fernando Fernandez-Aranda

Parent-focused treatment for adolescent anorexia nervosa: a study protocol of a randomised controlled trial

Family-based treatment is an efficacious outpatient intervention for medically stable adolescents with anorexia nervosa. Previous research suggests family-based treatment may be more effective for some familie...

Authors: Elizabeth K Hughes, Daniel Le Grange, Andrew Court, Michele SM Yeo, Stephanie Campbell, Erica Allan, Ross D Crosby, Katharine L Loeb and Susan M Sawyer

Pre-treatment predictors of attrition in a randomised controlled trial of psychological therapy for severe and enduring anorexia nervosa

Attrition is common in the treatment of anorexia nervosa and its causes are complex and incompletely understood. In particular, its relationship with adaptive function and motivational stage of change has been...

Authors: Ghada B Abd Elbaky, Phillipa J Hay, Daniel le Grange, Hubert Lacey, Ross D Crosby and Stephen Touyz

Erratum to: Resistance to treatment and change in anorexia nervosa: a clinical overview

Authors: Giovanni Abbate-Daga, Federico Amianto, Nadia Delsedime, Carlotta De-Bacco and Secondo Fassino

When eating healthy is not healthy: orthorexia nervosa and its measurement with the ORTO-15 in Hungary

For a better differential diagnosis of eating disorders, it is necessary to investigate their subtypes and develop specific assessment tools to measure their specific symptoms. Orthorexia nervosa is an alleged...

Authors: Márta Varga, Barna Konkolÿ Thege, Szilvia Dukay-Szabó, Ferenc Túry and Eric F van Furth

Study Protocol for a randomized controlled trial of mentalization based therapy against specialist supportive clinical management in patients with both eating disorders and symptoms of borderline personality disorder

The NOURISHED study: Nice OUtcomes for Referrals with Impulsivity, Self Harm and Eating Disorders.

Authors: Paul Robinson, Barbara Barrett, Anthony Bateman, Az Hakeem, Jennifer Hellier, Fenella Lemonsky, Clare Rutterford, Ulrike Schmidt and Peter Fonagy

Effectiveness of a web-based treatment program using intensive therapeutic support for female patients with bulimia nervosa, binge eating disorder and eating disorders not otherwise specified: study protocol of a randomized controlled trial

Disordered eating behavior and body dissatisfaction affect a large proportion of the Dutch population and account for severe psychological, physical and social morbidity. Yet, the threshold for seeking profess...

Authors: Elke D ter Huurne, Marloes G Postel, Hein A de Haan and Cor AJ DeJong

Predictors of the resumption of menses in adolescent anorexia nervosa

The resumption of menses is an important indicator of recovery in anorexia nervosa (AN). Patients with early-onset AN are at particularly great risk of suffering from the long-term physical and psychological c...

Authors: Astrid Dempfle, Beate Herpertz-Dahlmann, Nina Timmesfeld, Reinhild Schwarte, Karin M Egberts, Ernst Pfeiffer, Christian Fleischhaker, Christoph Wewetzer and Katharina Bühren

Brain responses to body image stimuli but not food are altered in women with bulimia nervosa

Research into the neural correlates of bulimia nervosa (BN) psychopathology remains limited.

Authors: Frederique Van den Eynde, Vincent Giampietro, Andrew Simmons, Rudolf Uher, Chris M Andrew, Philippe-Olivier Harvey, Iain C Campbell and Ulrike Schmidt

Resistance to treatment in eating disorders: a critical challenge

The Special Issue “Treatment resistance in Eating Disorders” gathers together the contributions provided by several experienced groups of researchers in the field of Eating Disorders (EDs). The main topic is a...

Authors: Secondo Fassino and Giovanni Abbate-Daga

Axis-I comorbidity is linked to prospective instability of diagnoses within eating disorders

Eating disorders (ED) are classified into Anorexia Nervosa, Bulimia Nervosa, and eating disorder not otherwise specified. Prospectively, the diagnostic instability within ED is high, but it is not clear which ...

Authors: Gabriella F Milos, Volker Baur, Sabina Muehlebach and Anja Spindler