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Mood disorders

Section edited by Florian Seem ü ller

This section is dedicated to covering all aspects of a wide range of mood disorders. Topics of interest include, but are not limited to, biological psychiatry, depression, psychoneuroendocrinology, bipolar disorders, antidepressants, psychopharmacology, neuroimaging, transcranial/cortical stimulation, electroencephalography and co-morbid conditions associated with mood disorders.

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  1. Content type: Study protocol

    The transition phase from inpatient to outpatient care for patients suffering from Major Depressive Disorder represents a vulnerable period associated with a risk of depression worsening and suicide. Our group...

    Authors: Signe Dunker Svendsen, Anne Sofie Aggestrup, Lasse Benn Nørregaard, Philip Løventoft, Anne Præstegaard, Konstantin V. Danilenko, Mads Frost, Ulla Knorr, Ida Hageman, Lars Vedel Kessing and Klaus Martiny

    Citation: BMC Psychiatry 2019 19:124

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  2. Content type: Research article

    Depression has been associated with a higher risk of cardiovascular events and a higher mortality in patients with one or more comorbidities. This study investigated whether continuative use of antidepressants...

    Authors: Silvia Cocchio, Tatjana Baldovin, Patrizia Furlan, Alessandra Buja, Patrizia Casale, Marco Fonzo, Vincenzo Baldo and Chiara Bertoncello

    Citation: BMC Psychiatry 2019 19:122

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  3. Content type: Research article

    Clinical outcomes for patients with heterogeneous somatoform disorder (bodily distress disorder, including medically unexplained symptoms) are suboptimal, new treatments are required to improve acceptance. Bod...

    Authors: Frank Röhricht, Heribert Sattel, Christian Kuhn and Claas Lahmann

    Citation: BMC Psychiatry 2019 19:120

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  4. Content type: Research article

    About one in five patients with depression experiences a chronic course. Despite the great burden associated with this disease, there is no current screening instrument for Persistent Depressive Disorder (PDD)...

    Authors: Elisa Brinkmann, Sarah Glanert, Michael Hüppe, Ana Sofia Moncada Garay, Sophie Tschepe, Ulrich Schweiger and Jan Philipp Klein

    Citation: BMC Psychiatry 2019 19:119

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  5. Content type: Research article

    Controversial findings regarding the association between pro-inflammatory cytokines and depression have been reported in pregnant subjects. Scarce data about anxiety and its relationships with cytokines are av...

    Authors: P. Leff Gelman, I. Mancilla-Herrera, M. Flores-Ramos, M. F. Saravia Takashima, F. M. Cruz Coronel, C. Cruz Fuentes, A. Pérez Molina, J. Hernández-Ruiz, F. S. Silva-Aguilera, B. Farfan-Labonne, D. Chinchilla-Ochoa, S. Garza Morales and I. Camacho-Arroyo

    Citation: BMC Psychiatry 2019 19:104

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  7. Content type: Study protocol

    The treatment of major depressive disorder, a highly prevalent disorder associated with pronounced burden, is a large challenge to healthcare systems worldwide. Internet based self-management interventions see...

    Authors: Caroline Oehler, Frauke Görges, Daniel Böttger, Juliane Hug, Nicole Koburger, Elisabeth Kohls and Christine Rummel-Kluge

    Citation: BMC Psychiatry 2019 19:90

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  8. Content type: Research article

    Depression and anxiety are prevalent and associated with a worse prognosis in coronary heart disease (CHD) patients. However, the influence of disease severity on mood symptoms is unknown. The specific associa...

    Authors: Han Yin, Yuting Liu, Huan Ma, Guihao Liu, Lan Guo and Qingshan Geng

    Citation: BMC Psychiatry 2019 19:85

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  9. Content type: Research article

    Depression among tuberculosis patients, especially in settings with low economic status is common. Screening for depression in all levels of health facilities can identify patients who need support and treatme...

    Authors: Tamirat Tesfaye Dasa, Aklilu Abrham Roba, Fitsum Weldegebreal, Frehiwot Mesfin, Abiyot Asfaw, Habtamu Mitiku, Zelalem Teklemariam, Bahubali Jinnappa Geddugol, Mahantash Naganuri, Hilina Befikadu and Eden Tesfaye

    Citation: BMC Psychiatry 2019 19:82

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  10. Content type: Research article

    Depression is a global problem, affecting populations worldwide, but is too often under-diagnosed. The identification of depression among patients with diabetes is important because depression is prevalent in ...

    Authors: Michael Udedi, Adamson S. Muula, Robert C. Stewart and Brian W. Pence

    Citation: BMC Psychiatry 2019 19:81

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  11. Content type: Research article

    Clinical Practice Guidelines (CPGs) should follow an adequate methodology using an evidence-based approach in order to provide reliable recommendations. However, little is known regarding the quality of CPGs f...

    Authors: Jessica Hanae Zafra-Tanaka, Sergio Goicochea-Lugo, David Villarreal-Zegarra and Alvaro Taype-Rondan

    Citation: BMC Psychiatry 2019 19:76

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  12. Content type: Case report

    Rebound cholinergic syndrome is a rare, but well known unwanted phenomenon occurring after abrupt clozapine discontinuation. There have been previous reported cases of cholinergic rebound in the literature; ho...

    Authors: Andrea Galova, Patricia Berney, Jules Desmeules, Ioannis Sergentanis and Marie Besson

    Citation: BMC Psychiatry 2019 19:73

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  13. Content type: Study protocol

    There is a growing body of literature highlighting the role that wearable and mobile remote measurement technology (RMT) can play in measuring symptoms of major depressive disorder (MDD). Outcomes assessment t...

    Authors: F. Matcham, C. Barattieri di San Pietro, V. Bulgari, G. de Girolamo, R. Dobson, H. Eriksson, A. A. Folarin, J. M. Haro, M. Kerz, F. Lamers, Q. Li, N. V. Manyakov, D. C. Mohr, I. Myin-Germeys, V. Narayan, Penninx BWJH…

    Citation: BMC Psychiatry 2019 19:72

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  14. Content type: Study protocol

    The World Health Organization (WHO) has included comorbidity between depression and a chronic disease among the 10 leading global health priorities. Although there is a high prevalence of multimorbidity, healt...

    Authors: Alicia Monreal-Bartolomé, Alberto Barceló-Soler, Adoración Castro, Mª. Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, Maria Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M. Baños, Yolanda López-Del-Hoyo and Javier García-Campayo

    Citation: BMC Psychiatry 2019 19:66

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  15. Content type: Study protocol

    The role of dietary patterns in the prevention of unipolar depression has been analyzed in several epidemiological studies. The primary aims of this study are to determine the effectiveness of an extra-olive o...

    Authors: A. Sánchez-Villegas, B. Cabrera-Suárez, P. Molero, A. González-Pinto, C. Chiclana-Actis, C. Cabrera, F. Lahortiga-Ramos, M. Florido-Rodríguez, P. Vega-Pérez, R. Vega-Pérez, J. Pla, M. J. Calviño-Cabada, F. Ortuño, S. Navarro, Y. Almeida and J. L. Hernández-Fleta

    Citation: BMC Psychiatry 2019 19:63

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  16. Content type: Research article

    Major Depressive Disorder (MDD) is the leading cause of disability worldwide. The cardinal features of MDD are depressed mood and anhedonia. Anhedonia is defined as a “markedly diminished interest or pleasure ...

    Authors: Vera E. Heininga, Egon Dejonckheere, Marlies Houben, Jasmien Obbels, Pascal Sienaert, Bart Leroy, Joris van Roy and Peter Kuppens

    Citation: BMC Psychiatry 2019 19:59

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  17. Content type: Research article

    Depressive symptoms are common in patients with coronary artery disease (CAD) and are associated with an unfavourable outcome. Establishing prognostic patient profiles prior to the beginning of mental health care...

    Authors: Frank Vitinius, Steffen Escherich, Hans-Christian Deter, Martin Hellmich, Jana Jünger, Katja Petrowski, Karl-Heinz Ladwig, Frank Lambertus, Matthias Michal, Cora Weber, Martina de Zwaan, Christoph Herrmann-Lingen, Joram Ronel and Christian Albus

    Citation: BMC Psychiatry 2019 19:57

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  18. Content type: Study protocol

    Inpatients with depression have a poor long term outcome with high rates of suicide, high levels of morbidity and frequent re-admission. Current treatment often relies on pharmacological intervention and focus...

    Authors: Ian R. E. Averill, Ben Beaglehole, Katie M. Douglas, Jennifer Jordan, Marie T. Crowe, Maree Inder, Cameron J. Lacey, Christopher M. Frampton, Christopher R. Bowie and Richard J. Porter

    Citation: BMC Psychiatry 2019 19:52

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  19. Content type: Research article

    Recommendations for pharmacological treatments of major depression with specific comorbid psychiatric conditions are lacking.

    Authors: D. Bennabi, A. Yrondi, T. Charpeaud, J.-B. Genty, S. Destouches, S. Lancrenon, N. Allaili, F. Bellivier, T. Bougerol, V. Camus, O. Doumy, J.-M. Dorey, F. Haesebaert, J. Holtzmann, C. Lançon, M. Lefebvre…

    Citation: BMC Psychiatry 2019 19:50

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  20. Content type: Research article

    Parents are vulnerable to psychological distress symptoms in the postpartum period. It is routine to screen for depressive symptoms, but anxiety, stress, fatigue, irritability and insomnia symptoms are less of...

    Authors: Nathan Wilson, Karen Wynter, Clare Anderson, Shanthakumar M. W. Rajaratnam, Jane Fisher and Bei Bei

    Citation: BMC Psychiatry 2019 19:48

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  21. Content type: Research article

    Anxiety and depressive disorders are common mental disorders. A substantial part of patients does not achieve symptomatic remission after treatment in specialized services. Current care as usual (CAU) for thes...

    Authors: Maringa H. H. Zoun, Bauke Koekkoek, Henny Sinnema, Christina M. van der Feltz-Cornelis, Anton J. L. M. van Balkom, Aart H. Schene, Filip Smit and Jan Spijker

    Citation: BMC Psychiatry 2019 19:46

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  22. Content type: Research article

    Self-harm and depression are strong risk factors for repeat self-harm and suicide. We aimed to investigate the feasibility of a randomised controlled trial (RCT) of remotely delivered problem-solving cognitive...

    Authors: Kapil Sayal, James Roe, Harriet Ball, Christopher Atha, Catherine Kaylor-Hughes, Boliang Guo, Ellen Townsend and Richard Morriss

    Citation: BMC Psychiatry 2019 19:42

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  23. Content type: Research article

    Depression and anxiety are prevalent mental disorders among the working population with potentially high personal and financial cost. The overall aim of this study was to test the applicability of an outreach ...

    Authors: Helle Østermark Sørensen, Jan B. Valentin, Malene Krogsgaard Bording, Jens Ivar Larsen, Anelia Larsen and Øyvind Omland

    Citation: BMC Psychiatry 2019 19:40

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  24. Content type: Research article

    People with a family history of major depressive disorder (MDD) or bipolar disorder (BD) report specific psychoeducational needs that are unmet by existing online interventions. This trial aimed to test whethe...

    Authors: Llewellyn Mills, Bettina Meiser, Raghib Ahmad, Peter R. Schofield, Michelle Peate, Charlene Levitan, Lyndal Trevena, Kristine Barlow-Stewart, Timothy Dobbins, Helen Christensen, Kerry A. Sherman, Kate Dunlop and Philip B. Mitchell

    Citation: BMC Psychiatry 2019 19:29

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  25. Content type: Research article

    Patients with Major Depressive Disorder (MDD) who are non-improvers after two weeks of antidepressant treatment have a high risk of treatment failure. Recently, we did not find differences in outcomes in non-i...

    Authors: Nadine Dreimüller, Stefanie Wagner, Alice Engel, Dieter F. Braus, Sibylle C. Roll, Stefan Elsner, André Tadić and Klaus Lieb

    Citation: BMC Psychiatry 2019 19:24

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  26. Content type: Study protocol

    Although currently available evidence suggests that physical exercise can be beneficial for depressed patients and might be comparable to antidepressant treatment, the best way of implementing this recommendat...

    Authors: Jesús López-Torres Hidalgo

    Citation: BMC Psychiatry 2019 19:21

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  27. Content type: Research article

    The clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in treatment resistant patients (at least 4 medication trials) appears to be well accepted and forms the coverage policies and rTMS’...

    Authors: Jeffrey Voigt, Linda Carpenter and Andrew Leuchter

    Citation: BMC Psychiatry 2019 19:13

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  28. Content type: Research article

    Although depression is associated with changes in the hypothalamic-pituitary-thyroid axis, its relationship with subclinical hypothyroidism (SCH) is controversial. To date, there is a lack of data on the impro...

    Authors: Huai Heng Loh, Lee Ling Lim, Anne Yee and Huai Seng Loh

    Citation: BMC Psychiatry 2019 19:12

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  29. Content type: Research article

    Because the collection of mental health information through interviews is expensive and time consuming, interest in using population-based administrative health data to conduct research on depression has incre...

    Authors: Chelsea Doktorchik, Scott Patten, Cathy Eastwood, Mingkai Peng, Guanmin Chen, Cynthia A. Beck, Nathalie Jetté, Tyler Williamson and Hude Quan

    Citation: BMC Psychiatry 2019 19:9

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  33. Content type: Research article

    Although an “epidemic” of depression is frequently claimed, empirical evidence is inconsistent, depending on country, study design and depression assessment. Little is known about changes in depression over ti...

    Authors: Julia Bretschneider, Silke Janitza, Frank Jacobi, Julia Thom, Ulfert Hapke, Tobias Kurth and Ulrike E. Maske

    Citation: BMC Psychiatry 2018 18:394

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  34. Content type: Research article

    The Edinburgh Postnatal Depression Scale (EPDS) is widely used in many countries to screen women for depression in the perinatal period. However, across studies the psychometric properties and cutoff scores of...

    Authors: Johanne Smith-Nielsen, Stephen Matthey, Theis Lange and Mette Skovgaard Væver

    Citation: BMC Psychiatry 2018 18:393

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  35. Content type: Research article

    Research has shown that a history of childhood adversities is common in patients with psychiatric disorders but few studies have investigated links between specific types of adversity and specific psychiatric ...

    Authors: Antonella Bruni, Elvira Anna Carbone, Valentina Pugliese, Matteo Aloi, Giuseppina Calabrò, Gregorio Cerminara, Cristina Segura-García and Pasquale De Fazio

    Citation: BMC Psychiatry 2018 18:391

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  36. Content type: Research article

    Clinical studies have shown that bipolar patients have increased serum uric acid levels. High serum uric acid levels could play a role contributing to high prevalence of metabolic syndrome. Metabolic syndrome ...

    Authors: Jingxu Chen, Hongmei Chen, Junhui Feng, Ligang Zhang, Juyan Li, Ran Li, Shaoli Wang, Ian Wilson, Alison Jones, Yunlong Tan, Fude Yang and Xu-Feng Huang

    Citation: BMC Psychiatry 2018 18:390

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  37. Content type: Research article

    Seasonal affective disorder (SAD) is a seasonally recurrent type of major depression that has detrimental effects on patients’ lives during winter. Little is known about how it affects patients during summer a...

    Authors: Barbara Nussbaumer-Streit, Edda Pjrek, Christina Kien, Gerald Gartlehner, Lucie Bartova, Michaela-Elena Friedrich, Siegfried Kasper and Dietmar Winkler

    Citation: BMC Psychiatry 2018 18:372

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  38. Content type: Research article

    Treatment of depression in cardiac patients is difficult. Patients’ illness beliefs regarding depression are associated with outcomes. The aim of the mixed-methods study was to test whether patients in routine...

    Authors: Julia Luise Magaard, Bernd Löwe, Anna Levke Brütt and Sebastian Kohlmann

    Citation: BMC Psychiatry 2018 18:366

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  39. Content type: Study protocol

    In the absence of one intervention that can cure all patients with major depressive disorder (MDD), the leading cause of disability worldwide, increased attention has been focused on selecting the best treatme...

    Authors: Sigal Zilcha-Mano, Tohar Dolev, Liat Leibovich and Jacques P. Barber

    Citation: BMC Psychiatry 2018 18:362

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  41. Content type: Research article

    Diabetes and depression are both chronic debilitating conditions, and their coexistence has been associated with adverse outcomes. In this study, we investigated the association between glycaemic control and d...

    Authors: Josephine Akpalu, Ernest Yorke, Joana Ainuson-Quampah, Williams Balogun and Kwame Yeboah

    Citation: BMC Psychiatry 2018 18:357

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  42. Content type: Research article

    In the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, a third of patients did not achieve remission or adequate response after two treatment trials, fulfilling requirements for treatmen...

    Authors: Allitia DiBernardo, Xiwu Lin, Qiaoyi Zhang, Jim Xiang, Lang Lu, Carol Jamieson, Carmela Benson, Kwan Lee, Robert Bodén, Lena Brandt, Philip Brenner, Johan Reutfors and Gang Li

    Citation: BMC Psychiatry 2018 18:352

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  44. Content type: Study protocol

    The detection of early warning signs is essential in the long-term treatment of bipolar disorders. However, in bipolar patients’ daily life and outpatient treatment the assessment of upcoming state changes fac...

    Authors: Esther Mühlbauer, Michael Bauer, Ulrich Ebner-Priemer, Philipp Ritter, Holger Hill, Fabrice Beier, Nikolaus Kleindienst and Emanuel Severus

    Citation: BMC Psychiatry 2018 18:349

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  45. Content type: Research article

    Studies have confirmed that the thalamus and the primary somatosensory cortex (SI) are associated with cognitive function. These two brain regions are closely related in structure and function. The interaction...

    Authors: Lijun Kang, Aixia Zhang, Ning Sun, Penghong Liu, Chunxia Yang, Gaizhi Li, Zhifen Liu, Yanfang Wang and Kerang Zhang

    Citation: BMC Psychiatry 2018 18:339

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  46. Content type: Research article

    Several studies have suggested that depression is associated with an increased risk for fracture; however, the results are conflicting. This study aimed to conduct a meta-analysis of cohort studies assessing t...

    Authors: Lei Qiu, Qin Yang, Na Sun, Dandan Li, Yuxin Zhao, Xiaotong Li, Yanhong Gong, Chuanzhu Lv and Xiaoxv Yin

    Citation: BMC Psychiatry 2018 18:336

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  47. Content type: Study protocol

    Bipolar disorder (BD) is characterized by recurrent (hypo)manic and depressive episodes, alternating with euthymic states in which patients are relatively symptom free. Besides clinical recovery, it is importa...

    Authors: Jannis T. Kraiss, Peter M. ten Klooster, Melissa Chrispijn, Hester R. Trompetter, Anja W.M.M. Stevens, Erica Neutel, Ralph W. Kupka and Ernst T. Bohlmeijer

    Citation: BMC Psychiatry 2018 18:335

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  48. Content type: Research article

    Globally, depressive disorders are one of the most common forms of mental illness. Using data from the most recent Global Burden of Disease, Injury, and Risk Factor Study 2016 (GBD 2016), we aimed to describe ...

    Authors: Felix Akpojene Ogbo, Sruthi Mathsyaraja, Rajeendra Kashyap Koti, Janette Perz and Andrew Page

    Citation: BMC Psychiatry 2018 18:333

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  49. Content type: Research article

    A series of studies indicate that a fast onset of a depressive episode (within 7 days) is a clinical variable useful for indicating bipolarity even when no manic episode has occurred to date. The role of acute...

    Authors: Maria Strauss, Roland Mergl, Nora Gürke, Kerstin Kleinert, Christian Sander and Ulrich Hegerl

    Citation: BMC Psychiatry 2018 18:332

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  50. Content type: Research article

    Major depressive disorder (MDD) is related to human’s immune status, and immunological indicators such as mitogen stimulated cell proliferation and cytokines may become candidate biomarkers for disease diagnosis.

    Authors: Ping Lin, Bingyu Ding, Yunqiang Wu, Ke Dong and Qingtian Li

    Citation: BMC Psychiatry 2018 18:330

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