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Mood disorders

Section edited by Florian Seemüller

This section is dedicated to covering all aspects of a wide range of mood disorders. Topics of interest include, but are not limited to, biological psychiatry, depression, psychoneuroendocrinology, bipolar disorders, antidepressants, psychopharmacology, neuroimaging, transcranial/cortical stimulation, electroencephalography and co-morbid conditions associated with mood disorders.


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  1. Content type: Study protocol

    Depressive symptoms are quite prevalent in Primary Care (PC) settings. The treatment as usual (TAU) in PC is pharmacotherapy, despite the high relapse rates it produces. Many patients would prefer psychotherap...

    Authors: Alba Lopez-Montoyo, Soledad Quero, Jesus Montero-Marin, Alberto Barcelo-Soler, Maria Beltran, Daniel Campos and Javier Garcia-Campayo

    Citation: BMC Psychiatry 2019 19:301

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  2. Content type: Research article

    Research can inform culturally-appropriate care to strengthen social and emotional wellbeing (SEWB) among Aboriginal and Torres Strait Islander (hereafter, the term ‘Indigenous Peoples’ is respectfully used an...

    Authors: Sara Farnbach, Graham Gee, Anne-Marie Eades, John Robert Evans, Jamie Fernando, Belinda Hammond, Matty Simms, Karrina DeMasi and Maree L. Hackett

    Citation: BMC Psychiatry 2019 19:294

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  3. Content type: Research article

    Women with bipolar disorder (BD) have a high risk of illness relapse postpartum. The risk coincides with the period when mother-infant interactions are evolving. We compared mother-infant interactions in dyads...

    Authors: Teija M. S. Anke, Kari Slinning, Vibeke Moe, Cathrine Brunborg, Torill S. Siqveland and Dag Vegard Skjelstad

    Citation: BMC Psychiatry 2019 19:292

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  4. Content type: Research article

    The Patient Health Questionnaire-9 (PHQ-9) is a brief tool to assess the presence and severity of depressive symptoms. This study aimed to validate and calibrate the PHQ-9 to determine appropriate cut-off poin...

    Authors: María Urtasun, Federico Manuel Daray, Germán Leandro Teti, Fernando Coppolillo, Gabriela Herlax, Guillermo Saba, Adolfo Rubinstein, Ricardo Araya and Vilma Irazola

    Citation: BMC Psychiatry 2019 19:291

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  5. Content type: Study protocol

    While postpartum depression is a well-researched disorder in mothers, there is growing evidence indicating that some fathers also develop depressive symptoms (paternal postpartum depression, PPD). A recent met...

    Authors: Julia Albicker, Lars P. Hölzel, Jürgen Bengel, Katharina Domschke, Levente Kriston, Miriam A. Schiele and Fabian Frank

    Citation: BMC Psychiatry 2019 19:289

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  6. Content type: Study protocol

    Major depressive disorder is one of the most prevalent and disabling forms of mental illness in the general population. One public health strategy that may reduce the disease burden is early identification and...

    Authors: JianLi Wang, Glenda MacQueen, Scott Patten, Douglas Manuel, Bonnie Lashewicz and Norbert Schmitz

    Citation: BMC Psychiatry 2019 19:285

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  7. Content type: Research article

    Among patients suffering from coronary heart disease (CHD) and comorbid depression, women experience a higher burden compared to men. Little is known on the characteristics that differentiate men and women wit...

    Authors: Hala Allabadi, Nicole Probst-Hensch, Abdulsalam Alkaiyat, Saleem Haj-Yahia, Christian Schindler, Marek Kwiatkowski and Elisabeth Zemp

    Citation: BMC Psychiatry 2019 19:284

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  8. Content type: Research article

    Prepulse inhibition (PPI) is a measurement method for the sensory gating process, which helps the brain adapt to complex environments. PPI may be reduced in patients with bipolar disorder (BD). This study inve...

    Authors: Zhen Mao, Qijing Bo, Weidi Li, Zhimin Wang, Xin Ma and Chuanyue Wang

    Citation: BMC Psychiatry 2019 19:282

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  9. Content type: Study protocol

    People in green professions are exposed to a variety of risk factors, which could possibly enhance the development of depression. Amongst possible prevention approaches, internet- and mobile-based intervention...

    Authors: Lina Braun, Ingrid Titzler, David Daniel Ebert, Claudia Buntrock, Yannik Terhorst, Johanna Freund, Janika Thielecke and Harald Baumeister

    Citation: BMC Psychiatry 2019 19:278

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  10. Content type: Research article

    Although massive studies have explored the risk factors of suicidal ideation (SI), the prevalence of SI and its associated factors in the hypertensive individuals are largely unknown. This study aims to invest...

    Authors: Dandan Ge, Xinyi Zhang, Xiaolei Guo, Jie Chu, Long Sun and Chengchao Zhou

    Citation: BMC Psychiatry 2019 19:266

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  11. Content type: Debate

    Several international guidelines for the acute treatment of moderate to severe unipolar depression recommend a first-line treatment with antidepressants (AD). This is based on the assumption that AD obviously ...

    Authors: Martin Plöderl and Michael P. Hengartner

    Citation: BMC Psychiatry 2019 19:265

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  12. Content type: Research article

    Clear guidance for successive antidepressant pharmacological treatments for non-responders in major depression is not well established.

    Authors: D. Bennabi, T. Charpeaud, A. Yrondi, J.-B. Genty, S. Destouches, S. Lancrenon, N. Alaïli, F. Bellivier, T. Bougerol, V. Camus, J.-M. Dorey, O. Doumy, F. Haesebaert, J. Holtzmann, C. Lançon, M. Lefebvre…

    Citation: BMC Psychiatry 2019 19:262

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  13. Content type: Research article

    Functional somatic symptoms in depression disorder may cause inappropriate illness behavior hindering the treatment process. Health anxiety may play a role in this relationship, but few studies have examined i...

    Authors: Yue-Jiao Ma, Dong-Fang Wang, Ming Yuan, Jiang Long, Shu-Bao Chen, Qiu-Xia Wu, Xu-Yi Wang and Tie-Qiao Liu

    Citation: BMC Psychiatry 2019 19:260

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  14. Content type: Research article

    Antenatal depression is a prevalent mental disorder in women who have undergone caesarean section, and it often presages adverse postoperative outcomes. Because of the lack of a laboratory-based diagnostic str...

    Authors: Zhuoxi Wu, Peng Zhao, Zhonghong Long, Jie Li, Guiying Yang, Qingling Zhang, Guangyou Duan and Hong Li

    Citation: BMC Psychiatry 2019 19:259

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  15. Content type: Study protocol

    With the advent of the recovery movement in mental health, a humanistic paradigm shift has occurred, placing the focus on personal recovery (i.e., hope, identity, and life meaning) instead of functional or clinic...

    Authors: Sunny H. W. Chan, Samson Tse, K. F. Chung, C. H. Yu, Raymond C. K. Chung and Herman H. M. Lo

    Citation: BMC Psychiatry 2019 19:255

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  16. Content type: Research article

    Mental illnesses among children and adolescents are under-recognized and under-treated problems. Depression is one of today’s all-too-silent health crises in caregivers. Although primary caregivers of children...

    Authors: Woredaw Minichil, Wondale Getinet, Habtamu Derajew and Sofia Seid

    Citation: BMC Psychiatry 2019 19:249

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  17. Content type: Research article

    Postpartum depression was associated with maternal suffering and diminished functioning, increased risk of marital conflict as well as adverse child outcomes. Perceived social support during pregnancy was asso...

    Authors: Yuexin Gan, Ran Xiong, Junjiao Song, Xinli Xiong, Fei Yu, Weiming Gao, Hui Hu, Jinsong Zhang, Ying Tian, Xiaobo Gu, Jun Zhang and Dan Chen

    Citation: BMC Psychiatry 2019 19:232

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  18. Content type: Research article

    Research suggests that young people with major depressive disorder (MDD) experience neurocognitive deficits and that these are associated with poorer functional and clinical outcomes. However, we are yet to un...

    Authors: Catherine Morey-Nase, Lisa J. Phillips, Shayden Bryce, Sarah Hetrick, Andrea L. Wright, Emma Caruana and Kelly Allott

    Citation: BMC Psychiatry 2019 19:209

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  19. Content type: Study protocol

    Both depressive disorder and subclinical depressive symptoms during adolescence are a major public health concern. Therefore, it is important that depression is detected at an early stage and is treated preven...

    Authors: Marieke W. H. van den Heuvel, Denise H. M. Bodden, Mirjam Moerbeek, Filip Smit and Rutger C. M. E. Engels

    Citation: BMC Psychiatry 2019 19:200

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  20. Content type: Research article

    Traumatic events can trigger postpartum depression. Pregnant women in Brazil today are facing an extremely stressful experience. Thus, the objective here was to analyze the prevalence of symptoms of depression...

    Authors: Eleomar Vilela Moraes, Olegário Rosa Toledo, Flávia Lúcia David, Bruna Nascimento Godoi, Keila Araujo Monteiro, Thaisa Cimardi Deluqui, Thais Wérica Teixeira, Andiara Luiza Carvalho and Mariza Martins Avelino

    Citation: BMC Psychiatry 2019 19:199

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  21. Content type: Research article

    In an 8-week, randomized, placebo-controlled, double-blind study, an extended-release formulation of quetiapine, quetiapine XR, demonstrated efficacy and safety in Japanese patients with bipolar depression. Bi...

    Authors: Shigenobu Kanba, Mitsukuni Murasaki, Tsukasa Koyama, Masahiro Takeuchi, Yuriko Shimizu, Eri Arita, Kentaro Kuroishi, Masahiro Takeuchi and Shinya Kamei

    Citation: BMC Psychiatry 2019 19:198

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  22. Content type: Research article

    Safety monitoring of medicines is essential during therapy for bipolar disorder (BD). We determined the extent of safety monitoring performed according to the International Society for Bipolar Disorders (ISBD)...

    Authors: Uthpali Mannapperuma, Priyadarshani Galappatthy, Raveendra Laal Jayakody, Jayan Mendis, Varuni Asanka de Silva and Raveen Hanwella

    Citation: BMC Psychiatry 2019 19:194

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  23. Content type: Research article

    Postpartum depression (PPD) is a major depressive disorder that occurs after childbirth. Objective diagnostic and predictive methods for PPD are important for early detection and appropriate intervention. DNA ...

    Authors: Yukako Nakamura, Masahiro Nakatochi, Shohko Kunimoto, Takashi Okada, Branko Aleksic, Miho Toyama, Tomoko Shiino, Mako Morikawa, Aya Yamauchi, Akira Yoshimi, Yoko Furukawa-Hibi, Taku Nagai, Masako Ohara, Chika Kubota, Kiyofumi Yamada, Masahiko Ando…

    Citation: BMC Psychiatry 2019 19:190

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  24. Content type: Research article

    Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, which has yielded promising results in treating major depressive disorder. However, its effect on treatment-resista...

    Authors: Min-Shan Li, Xiang-Dong Du, Hsiao-Chi Chu, Yen-Ying Liao, Wen Pan, Zhe Li and Galen Chin-Lun Hung

    Citation: BMC Psychiatry 2019 19:180

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  25. Content type: Research article

    Selection of the optimal initial treatment in patients with major depressive disorder (MDD) in need of highly specialized care has the potential to benefit treatment outcomes and cost-effectiveness of treatmen...

    Authors: Frédérique C. W. van Krugten, Maartje Goorden, Anton J. L. M. van Balkom, Patricia van Oppen, Henricus G. Ruhé, Digna J. F. van Schaik, Werner B. F. Brouwer and Leona Hakkaart-van Roijen

    Citation: BMC Psychiatry 2019 19:179

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  26. Content type: Research article

    Abnormalities in heart rate during sleep linked to impaired neuro-cardiac modulation may provide new information about physiological sleep signatures of depression. This study assessed the validity of an algor...

    Authors: Mysa Saad, Laura B. Ray, Brad Bujaki, Amir Parvaresh, Iryna Palamarchuk, Joseph De Koninck, Alan Douglass, Elliott K. Lee, Louis J. Soucy, Stuart Fogel, Charles M. Morin, Célyne Bastien, Zul Merali and Rébecca Robillard

    Citation: BMC Psychiatry 2019 19:168

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  27. Content type: Study protocol

    Besides classical approaches for treating depression, physical activity has been demonstrated to be an effective option. Bouldering psychotherapy (BPT) combines psychotherapeutic interventions with action-orie...

    Authors: Lisa Dorscht, Nina Karg, Stephanie Book, Elmar Graessel, Johannes Kornhuber and Katharina Luttenberger

    Citation: BMC Psychiatry 2019 19:154

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  28. Content type: Research article

    Following treatment, many depressed patients have significant residual symptoms. However, large randomised controlled trials (RCT) in this population are lacking. When Attention bias modification training (ABM...

    Authors: Rune Jonassen, Catherine J. Harmer, Eva Hilland, Luigi A. Maglanoc, Brage Kraft, Michael Browning, Tore C. Stiles, Vegard Ø. Haaland, Torkil Berge and Nils Inge Landrø

    Citation: BMC Psychiatry 2019 19:141

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  29. Content type: Research article

    The current study aims to systematically assess and compare the antidepressant outcomes of repetitive transcranial magnetic stimulation (rTMS) with the figure-of-eight (F8)-coil and deep transcranial magnetic ...

    Authors: Helena M. Gellersen and Karina Karolina Kedzior

    Citation: BMC Psychiatry 2019 19:139

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  30. Content type: Research article

    Stigmatization of people with mental illness is still a significant problem even in Western society. Media is an important vector for public messaging that may lead to stigma (and potentially counteract it). T...

    Authors: Nele Cornelia Goepfert, Steffen Conrad von Heydendorff, Harald Dreßing and Josef Bailer

    Citation: BMC Psychiatry 2019 19:138

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  31. Content type: Study protocol

    Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive inte...

    Authors: Muriel Vicent-Gil, Beatriz Raventós, Eduardo D. Marín-Martínez, Sara González-Simarro, Anabel Martínez-Arán, Caterina del Mar Bonnin, Joan Trujols, Josefina Pérez-Blanco, Javier de Diego-Adeliño, Dolors Puigdemont, Maria Serra-Blasco, Narcís Cardoner and Maria J. Portella

    Citation: BMC Psychiatry 2019 19:135

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  32. Content type: Study protocol

    There are evidence-based interventions for depression that include different components. However, the efficacy of their therapeutic components is unknown. Another important issue related to depression interven...

    Authors: Adriana Mira, Amanda Díaz-García, Diana Castilla, Daniel Campos, Sonia Romero, Juana Bretón-López, Azucena García-Palacios, Rosa Baños and Cristina Botella

    Citation: BMC Psychiatry 2019 19:133

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  33. Content type: Study protocol

    Despite multiple pharmacological interventions, many people with bipolar disorder (BD) experience substantial residual mood symptoms, even in the absence of severe mood episodes, which have a negative impact o...

    Authors: I. Hanssen, M. J. Huijbers, M. W. H. Lochmann-van Bennekom, E. J. Regeer, A. W. M. M. Stevens, S. M. A. A. Evers, M. Wensing, R. W. Kupka and A. E. M. Speckens

    Citation: BMC Psychiatry 2019 19:130

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  34. Content type: Study protocol

    The transition phase from inpatient to outpatient care for patients suffering from Major Depressive Disorder represents a vulnerable period associated with a risk of depression worsening and suicide. Our group...

    Authors: Signe Dunker Svendsen, Anne Sofie Aggestrup, Lasse Benn Nørregaard, Philip Løventoft, Anne Præstegaard, Konstantin V. Danilenko, Mads Frost, Ulla Knorr, Ida Hageman, Lars Vedel Kessing and Klaus Martiny

    Citation: BMC Psychiatry 2019 19:124

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  35. Content type: Research article

    Depression has been associated with a higher risk of cardiovascular events and a higher mortality in patients with one or more comorbidities. This study investigated whether continuative use of antidepressants...

    Authors: Silvia Cocchio, Tatjana Baldovin, Patrizia Furlan, Alessandra Buja, Patrizia Casale, Marco Fonzo, Vincenzo Baldo and Chiara Bertoncello

    Citation: BMC Psychiatry 2019 19:122

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  36. Content type: Research article

    Clinical outcomes for patients with heterogeneous somatoform disorder (bodily distress disorder, including medically unexplained symptoms) are suboptimal, new treatments are required to improve acceptance. Bod...

    Authors: Frank Röhricht, Heribert Sattel, Christian Kuhn and Claas Lahmann

    Citation: BMC Psychiatry 2019 19:120

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  37. Content type: Research article

    About one in five patients with depression experiences a chronic course. Despite the great burden associated with this disease, there is no current screening instrument for Persistent Depressive Disorder (PDD)...

    Authors: Elisa Brinkmann, Sarah Glanert, Michael Hüppe, Ana Sofia Moncada Garay, Sophie Tschepe, Ulrich Schweiger and Jan Philipp Klein

    Citation: BMC Psychiatry 2019 19:119

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  38. Content type: Research article

    Controversial findings regarding the association between pro-inflammatory cytokines and depression have been reported in pregnant subjects. Scarce data about anxiety and its relationships with cytokines are av...

    Authors: P. Leff Gelman, I. Mancilla-Herrera, M. Flores-Ramos, M. F. Saravia Takashima, F. M. Cruz Coronel, C. Cruz Fuentes, A. Pérez Molina, J. Hernández-Ruiz, F. S. Silva-Aguilera, B. Farfan-Labonne, D. Chinchilla-Ochoa, S. Garza Morales and I. Camacho-Arroyo

    Citation: BMC Psychiatry 2019 19:104

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  39. Content type: Study protocol

    The treatment of major depressive disorder, a highly prevalent disorder associated with pronounced burden, is a large challenge to healthcare systems worldwide. Internet based self-management interventions see...

    Authors: Caroline Oehler, Frauke Görges, Daniel Böttger, Juliane Hug, Nicole Koburger, Elisabeth Kohls and Christine Rummel-Kluge

    Citation: BMC Psychiatry 2019 19:90

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  40. Content type: Research article

    Depression and anxiety are prevalent and associated with a worse prognosis in coronary heart disease (CHD) patients. However, the influence of disease severity on mood symptoms is unknown. The specific associa...

    Authors: Han Yin, Yuting Liu, Huan Ma, Guihao Liu, Lan Guo and Qingshan Geng

    Citation: BMC Psychiatry 2019 19:85

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  41. Content type: Research article

    Depression among tuberculosis patients, especially in settings with low economic status is common. Screening for depression in all levels of health facilities can identify patients who need support and treatme...

    Authors: Tamirat Tesfaye Dasa, Aklilu Abrham Roba, Fitsum Weldegebreal, Frehiwot Mesfin, Abiyot Asfaw, Habtamu Mitiku, Zelalem Teklemariam, Bahubali Jinnappa Geddugol, Mahantash Naganuri, Hilina Befikadu and Eden Tesfaye

    Citation: BMC Psychiatry 2019 19:82

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  42. Content type: Research article

    Depression is a global problem, affecting populations worldwide, but is too often under-diagnosed. The identification of depression among patients with diabetes is important because depression is prevalent in ...

    Authors: Michael Udedi, Adamson S. Muula, Robert C. Stewart and Brian W. Pence

    Citation: BMC Psychiatry 2019 19:81

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  43. Content type: Research article

    Clinical Practice Guidelines (CPGs) should follow an adequate methodology using an evidence-based approach in order to provide reliable recommendations. However, little is known regarding the quality of CPGs f...

    Authors: Jessica Hanae Zafra-Tanaka, Sergio Goicochea-Lugo, David Villarreal-Zegarra and Alvaro Taype-Rondan

    Citation: BMC Psychiatry 2019 19:76

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