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Mood disorders

This section is dedicated to covering all aspects of a wide range of mood disorders. Topics of interest include, but are not limited to, biological psychiatry, depression, psychoneuroendocrinology, bipolar disorders, antidepressants, psychopharmacology, neuroimaging, transcranial/cortical stimulation, electroencephalography and co-morbid conditions associated with mood disorders.


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  1. Depression and chronic diseases are frequently comorbid public health problems. However, clinical guidelines often fail to consider comorbidities. This study protocol describes a cluster randomized trial (CRT)...

    Authors: Graciela Rojas, Pablo Martínez, Viviana Guajardo, Solange Campos, Pablo Herrera, Paul A. Vöhringer, Víctor Gómez, Wilsa Szabo and Ricardo Araya

    Citation: BMC Psychiatry 2021 21:418

    Content type: Study protocol

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  2. Non-suicidal self-injury is a serious health problem among patients with depression or bipolar disorder. However, few studies within the Chinese context have investigated the prevalence of NSSI and its risk fa...

    Authors: Lu Wang, Jun Liu, Yuan Yang and Haiou Zou

    Citation: BMC Psychiatry 2021 21:389

    Content type: Research article

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  3. The Patient Health Questionnaire-8 (PHQ-8) is a screening questionnaire of depressive symptoms. However, it is unknown whether it is equivalent across time and between groups of individuals. The aim of our pap...

    Authors: Anne Moehring, Diana Guertler, Kristian Krause, Gallus Bischof, Hans-Juergen Rumpf, Anil Batra, Susanne Wurm, Ulrich John and Christian Meyer

    Citation: BMC Psychiatry 2021 21:386

    Content type: Research article

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  4. A motivation dimension of the core psychiatric symptom anhedonia additional has been suggested. The Temporal Experience of Pleasure Scale (TEPS) has been reported to assess anticipatory and consummatory pleasu...

    Authors: Shulin Fang, Xiaodan Huang, Panwen Zhang, Jiayue He, Xingwei Luo, Jianghua Zhang, Yan Xiong, Fusheng Luo, Xiaosheng Wang, Shuqiao Yao and Xiang Wang

    Citation: BMC Psychiatry 2021 21:378

    Content type: Research article

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  6. Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to ...

    Authors: Lumbini Azim, Paul Hindmarch, Georgiana Browne, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, John R. Geddes, Nicola Goudie, Sandy Harvey, Timea Helter, Eva-Maria Holstein, Garry Martin, Phil Mawson…

    Citation: BMC Psychiatry 2021 21:334

    Content type: Study protocol

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  7. Perception of entrapment can emerge when someone feels trapped in an aversive situation and incapable of escape. Depression is closely related to the construct of entrapment. In China, men who have sex with me...

    Authors: Chen Xu, Xiaoyue Yu, Lhakpa Tsamlag, Shuxian Zhang, Ruijie Chang, Huwen Wang, Shangbin Liu, Ying Wang and Yong Cai

    Citation: BMC Psychiatry 2021 21:328

    Content type: Research article

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  9. Caregiving in depression imposes a complex health and economic burden. Moreover, there is a paucity of studies examining the impact of caregiving for adult relatives with unipolar depression (CG-UD). This stud...

    Authors: B. L. Balkaran, D. H. Jaffe, D. Umuhire, B. Rive and R. U. Milz

    Citation: BMC Psychiatry 2021 21:312

    Content type: Research article

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  10. Internet-delivered cognitive behavioural therapy (ICBT) is a promising treatment for refugee and immigrant populations suffering from common mental disorders. The aim of the present study was to investigate ex...

    Authors: Tomas Lindegaard, Fatima Kashoush, Sara Holm, Asala Halaj, Matilda Berg and Gerhard Andersson

    Citation: BMC Psychiatry 2021 21:288

    Content type: Research article

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  11. Psychosomatic symptoms, characterized by physical-bodily complaints not fully explained by organic reasons, are highly prevalent. The present study aimed to culturally adapt and evaluate the psychometric prope...

    Authors: Zahra Heidari, Awat Feizi, Sara Rezaei, Hamidreza Roohafza and Peyman Adibi

    Citation: BMC Psychiatry 2021 21:269

    Content type: Research article

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    The Publisher Correction to this article has been published in BMC Psychiatry 2021 21:343

  12. Depressive disorders and problematic drinking often co-occur, also among young adults. These co-occurring conditions are associated with various negative health outcomes compared to both conditions alone. Earl...

    Authors: Maria J. E. Schouten, Jack J. M. Dekker, Tamara Q. de Bruijn, David D. Ebert, Lisanne M. Koomen, Sjoerd L. A. Kosterman, Heleen Riper, Michael P. Schaub, Anna E. Goudriaan and Matthijs Blankers

    Citation: BMC Psychiatry 2021 21:265

    Content type: Study protocol

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  13. Despite the availability of pharmacologic and nonpharmacologic treatment options, depression continues to be one of the leading causes of disability worldwide. This study evaluated whether depression symptom s...

    Authors: Jennifer Voelker, Kun Wang, Wenze Tang, Jinghua He, Ella Daly, Christopher D. Pericone and John J. Sheehan

    Citation: BMC Psychiatry 2021 21:257

    Content type: Research article

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  14. Exercise is now recommended as a primary treatment for mild-moderate depression in Canada. The ‘Exercise and Depression Toolkit’ was developed to help health care providers (HCP) integrate these treatment guid...

    Authors: Krista Glowacki, Daniah Zumrawi, Erin Michalak and Guy Faulkner

    Citation: BMC Psychiatry 2021 21:243

    Content type: Research article

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  15. Several evidence-based psychotherapeutic treatment options are available for depression, but the treatment results could be improved. The D*Phase study directly compares short-term psychodynamic supportive psy...

    Authors: M. F. Miggiels, P. M. ten Klooster, S. Bremer-Hoeve, J. J. M. Dekker, M. J. H. Huibers, E. Reefhuis, H. L. Van and M. K. van Dijk

    Citation: BMC Psychiatry 2021 21:233

    Content type: Study protocol

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  16. Functional near-infrared spectroscopy (fNIRS) is an emerging neuroimaging modality that provides a direct and quantitative assessment of cortical haemodynamic response during a cognitive task. It may be used t...

    Authors: Syeda Fabeha Husain, Tong-Boon Tang, Wilson W. Tam, Bach X. Tran, Cyrus S. Ho and Roger C. Ho

    Citation: BMC Psychiatry 2021 21:201

    Content type: Research article

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  17. Sleep disturbance and executive function impairment are common in patients with major depressive disorder (MDD), though the relationship between the two remains unclear. We investigated this association in fir...

    Authors: Feihuan Cui, Qi Liu, Xiaozhen Lv, Rainer Leonhart, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Tianmei Si and Xin Yu

    Citation: BMC Psychiatry 2021 21:198

    Content type: Research article

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  18. Confinement due to COVID-19 has increased mental ill-health. Few studies unpack the risk and protective factors associated with mental ill-health and addictions that might inform future preparedness.

    Authors: Eva Jané-Llopis, Peter Anderson, Lidia Segura, Edurne Zabaleta, Regina Muñoz, Gemma Ruiz, Jürgen Rehm, Carmen Cabezas and Joan Colom

    Citation: BMC Psychiatry 2021 21:194

    Content type: Research article

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  19. Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show p...

    Authors: Mustafa Abdul Karim, Nadeen Al-Baz, Sami Ouanes, Majid Alabdulla and Peter M. Haddad

    Citation: BMC Psychiatry 2021 21:180

    Content type: Case report

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  20. Negative coping strategies and behavioral problems are common among Chinese left-behind children, which are relate to a variety of negative consequences. At this stage of development, the relevant factors of c...

    Authors: Shu Cui, Fangshuo Cheng, Ling Zhang, Chao Zhang, Qiuyu Yuan, Cui Huang, Kai Zhang and Xiaoqin Zhou

    Citation: BMC Psychiatry 2021 21:158

    Content type: Research article

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  22. Major depressive disorder (MDD) is a highly prevalent mental disorder with large disease burden, high levels of relapse or persistence, and overall suboptimal outcomes of protocolized pharmacological and psych...

    Authors: H. Riese, L. von Klipstein, R. A. Schoevers, D. C. van der Veen and M. N. Servaas

    Citation: BMC Psychiatry 2021 21:143

    Content type: Study protocol

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  23. After decades of anti-stigma initiatives, the Advancing Research To Eliminate Mental Illness Stigma (ARTEMIS) intervention study is one of the first in Singapore to evaluate the effects of an anti-stigma inter...

    Authors: Chong Min Janrius GOH, Shazana SHAHWAN, Jue Hua LAU, Wei Jie ONG, Gregory Tee Hng TAN, Ellaisha SAMARI, Kian Woon KWOK, Mythily SUBRAMANIAM and Siow Ann CHONG

    Citation: BMC Psychiatry 2021 21:108

    Content type: Research article

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  24. Little is known about the influence on outcome of exploration of the patient-therapist relationship (that is, transference work) in psychoanalytic psychotherapy. We hypothesized that depressed adolescents woul...

    Authors: Randi Ulberg, Benjamin Hummelen, Anne Grete Hersoug, Nick Midgley, Per Andreas Høglend and Hanne-Sofie Johnsen Dahl

    Citation: BMC Psychiatry 2021 21:106

    Content type: Research article

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  26. Bipolar disorder is a common psychiatric disorder with a massive psychological and social burden. Research indicates that treatment adherence is not good in these patients. The families’ knowledge about the di...

    Authors: Nasim Mousavi, Marzieh Norozpour, Zahra Taherifar, Morteza Naserbakht and Amir Shabani

    Citation: BMC Psychiatry 2021 21:83

    Content type: Research article

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  27. Existing therapies for depression are effective, but many patients fail to recover or relapse. To improve care for patients, more research into the effectiveness and working mechanisms of treatments is needed....

    Authors: Jacqueline G. L. A-Tjak, Nexhmedin Morina, Maurice Topper and Paul M. G. Emmelkamp

    Citation: BMC Psychiatry 2021 21:41

    Content type: Research article

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  28. Although repetitive transcranial magnetic stimulation (‘TMS’) is becoming a gold standard treatment for pharmacoresistant depression, we lack neural target biomarkers for identifying who is most likely to resp...

    Authors: Leanne M. Williams, John T. Coman, Patrick C. Stetz, Nicole C. Walker, F. Andrew Kozel, Mark S. George, Jong Yoon, Laura M. Hack, Michelle R. Madore, Kelvin O. Lim, Noah S. Philip and Paul E. Holtzheimer

    Citation: BMC Psychiatry 2021 21:35

    Content type: Study protocol

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  29. Bipolar disorder is the fourth most common mental health condition, affecting ~ 1% of UK adults. Lithium is an effective treatment for prevention of relapse and hospital admission, and is widely recommended as...

    Authors: Ceri Parfitt, Christopher J. Duff, Jonathan Scargill, Lewis Green, David Holland, Adrian H. Heald and Anthony A. Fryer

    Citation: BMC Psychiatry 2021 21:32

    Content type: Research article

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  30. It has been proposed that adverse childhood experiences (ACEs) can put women at risk for mental illness in the pregnancy and postpartum periods. While some studies have found strong support for this propositio...

    Authors: Nicole Racine, Chloe Devereaux, Jessica E. Cooke, Rachel Eirich, Jenney Zhu and Sheri Madigan

    Citation: BMC Psychiatry 2021 21:28

    Content type: Research article

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  31. High serum uric acid (SUA) levels may provide protection against depression and anxiety through its defensive role in oxidative damage. The aim of this study was to test the hypothesis of the independent assoc...

    Authors: Rui Zhong, Qingling Chen, Mengmeng Li, Nan Li, Chaojia Chu, Jing Li, Xinyue Zhang and Weihong Lin

    Citation: BMC Psychiatry 2021 21:17

    Content type: Research article

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  32. Societies strive for fast-delivered, evidence-based and need-oriented depression treatment within budget constraints. To explore potential improvements, selective contracts can be implemented. Here, we evaluat...

    Authors: Alexander Engels, Hans-Helmut König, Julia Luise Magaard, Martin Härter, Sabine Hawighorst-Knapstein, Ariane Chaudhuri and Christian Brettschneider

    Citation: BMC Psychiatry 2020 20:591

    Content type: Research article

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  33. The goal of this study was to investigate treatment outcome and related intervention processes of mindfulness-based cognitive therapy versus health qigong-based cognitive therapy versus waitlist control among ...

    Authors: Sunny H. W. Chan, Wendy W. K. Chan, June Y. W. Chao and Phyllis K. L. Chan

    Citation: BMC Psychiatry 2020 20:590

    Content type: Research article

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  34. Major depressive disorder (MDD) is a considerable public health concern. In spite of evidence-based treatments for MDD, many patients do not improve and relapse is common. Therefore, improving treatment outcom...

    Authors: Michèle Schmitter, Jan Spijker, Filip Smit, Indira Tendolkar, Anne-Marie Derksen, Peter Oostelbos, Ben F. M. Wijnen, Tessa J. van Doesum, Jasper A. J. Smits and Janna N. Vrijsen

    Citation: BMC Psychiatry 2020 20:585

    Content type: Study protocol

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  35. A diagnosis of bipolar II disorder requires that the symptoms cannot be better explained by a medical condition. Epilepsy is in some cases associated with an affective syndrome mimicking an unstable bipolar II...

    Authors: O. K. Drange, S. G. Sæther, P. I. Finseth, G. Morken, A. E. Vaaler, V. Arntsen, O. Henning, O. A. Andreassen, T. Elvsåshagen, U. F. Malt and E. Bøen

    Citation: BMC Psychiatry 2020 20:582

    Content type: Research article

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  36. Low levels of the soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) and depression are linked to cardiovascular disease. Galectin-3, inadequate glycemic control and low high-density lipopr...

    Authors: Eva O. Melin, Jonatan Dereke and Magnus Hillman

    Citation: BMC Psychiatry 2020 20:574

    Content type: Research article

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  38. The pre-melancholic model described by Tellenbach may provide a common model for understanding the psychological implications of the lockdown. In this case report, we describe a rare catatonic status as a psyc...

    Authors: Giuseppe Sarli, Lorenzo Polidori, David Lester and Maurizio Pompili

    Citation: BMC Psychiatry 2020 20:558

    Content type: Case report

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  39. Several evidence-based practice guidelines have been developed to better treat bipolar disorder. However, the articles cited in these guidelines were not sufficiently based on real-world clinical practice.

    Authors: Keita Tokumitsu, Norio Yasui-Furukori, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi…

    Citation: BMC Psychiatry 2020 20:555

    Content type: Research article

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  40. To investigate the risk of treatment-resistant depression (TRD) in patients with depression by examining their clinical features, early prescription patterns, and early and lifetime comorbidities.

    Authors: Shiau-Shian Huang, Hsi-Han Chen, Jui Wang, Wei J. Chen, Hsi-Chung Chen and Po-Hsiu Kuo

    Citation: BMC Psychiatry 2020 20:541

    Content type: Research article

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  41. Little is known about the burden of common mental disorders in Russia despite high levels of suicide and alcohol-related mortality. Here we investigated levels of symptoms, self-reports of ever having received...

    Authors: Sarah Cook, Alexander V. Kudryavtsev, Natalia Bobrova, Lyudmila Saburova, Diana Denisova, Sofia Malyutina, Glyn Lewis and David A. Leon

    Citation: BMC Psychiatry 2020 20:537

    Content type: Research article

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  42. Limitations of current therapy of depression highlight the need for an immediately available, easily implementable add-on treatment option with high acceptance from patients. Hyperthermic baths (HTB) are a for...

    Authors: Johannes Naumann, Iris Kruza, Luisa Denkel, Gunver Kienle and Roman Huber

    Citation: BMC Psychiatry 2020 20:536

    Content type: Research article

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  43. Anxiety and depression are in both cross-sectional and longitudinal studies associated with urinary incontinence (UI) in women, strongest for the urgency component of UI. The role of psychotropic drugs in this...

    Authors: Gunhild Felde, Anders Engeland and Steinar Hunskaar

    Citation: BMC Psychiatry 2020 20:521

    Content type: Research article

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  44. Pharmacogenetic testing (PGx) has the potential to improve the quality of psychiatric prescribing by considering patients’ genetic profile. However, there is limited scientific evidence supporting its efficacy...

    Authors: Bonnie M. Vest, Laura O. Wray, Laura A. Brady, Michael E. Thase, Gregory P. Beehler, Sara R. Chapman, Leland E. Hull and David W. Oslin

    Citation: BMC Psychiatry 2020 20:518

    Content type: Research article

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  45. Major depressive disorder represents (MDD) a major cause of disability and disease burden. Beside antidepressant medication, psychotherapy is a key approach of treatment. Schema therapy has been shown to be ef...

    Authors: Johannes Kopf-Beck, Petra Zimmermann, Samy Egli, Martin Rein, Nils Kappelmann, Julia Fietz, Jeanette Tamm, Katharina Rek, Susanne Lucae, Anna-Katharine Brem, Philipp Sämann, Leonhard Schilbach and Martin E. Keck

    Citation: BMC Psychiatry 2020 20:506

    Content type: Study protocol

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  46. This study aimed to screen cardiovascular patients for depressive symptoms at a tertiary centre in Trinidad and Tobago; and to determine any significant associations amongst patients’ demographics, comorbiditi...

    Authors: Naveen Seecheran, Cathy-Lee Jagdeo, Rajeev Seecheran, Valmiki Seecheran, Sangeeta Persad, Lakshmipatty Peram, Matthew Evans, Justine Edwards, Sheri Thackoorcharan, Britney Davis, Shari Davis, Barbrianna Dawkins, Anisha Dayaram, Michelle De Freitas, Tsarina Deonarinesingh, Jiovanna Dhanai…

    Citation: BMC Psychiatry 2020 20:498

    Content type: Research article

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  47. A number of studies have explored the association between depression and ghrelin, leptin, and cortisol; further, postprandial C-peptide levels have a therapeutic effect on type 2 diabetes mellitus (T2DM). Howe...

    Authors: Yu Ming Sang, Li Jun Wang, Hong Xian Mao, Xue Yong Lou, Yi Jun Zhu and Yue Hua Zhu

    Citation: BMC Psychiatry 2020 20:490

    Content type: Research article

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  48. Bipolar disorder (BPD) is a common mood disorder that is often goes misdiagnosed or undiagnosed. Recently, machine learning techniques have been combined with neuroimaging methods to aid in the diagnosis of BP...

    Authors: Hao Li, Liqian Cui, Liping Cao, Yizhi Zhang, Yueheng Liu, Wenhao Deng and Wenjin Zhou

    Citation: BMC Psychiatry 2020 20:488

    Content type: Research article

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  49. Depression affects approximately 7.1% of the United States population every year and has an annual economic burden of over $210 billion dollars. Several recent studies have sought to investigate the pathophysi...

    Authors: Avery D. Franzen, Tukiet T. Lam, Kenneth R. Williams, Angus C. Nairn, Ronald S. Duman, Monica Sathyanesan, Vikas Kumar, Linda L. Carpenter and Samuel S. Newton

    Citation: BMC Psychiatry 2020 20:481

    Content type: Research article

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  50. The Patient Health Questionnaire (PHQ) is one of the most commonly used instruments to assess mental disorders. However, research on its cross-cultural measurement invariance is not yet sufficient. This study ...

    Authors: Yan Zhou, Jing Xu and Winfried Rief

    Citation: BMC Psychiatry 2020 20:480

    Content type: Research article

    Published on:

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