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Mood disorders

Section edited by Florian Seemüller

This section is dedicated to covering all aspects of a wide range of mood disorders. Topics of interest include, but are not limited to, biological psychiatry, depression, psychoneuroendocrinology, bipolar disorders, antidepressants, psychopharmacology, neuroimaging, transcranial/cortical stimulation, electroencephalography and co-morbid conditions associated with mood disorders.


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  1. Bipolar disorder has been associated with several personality traits, cognitive styles and affective temperaments. Women who have bipolar disorder are at increased risk of experiencing postpartum psychosis, ho...

    Authors: A. Perry, K. Gordon-Smith, I. Webb, E. Fone, A. Di Florio, N. Craddock, I. Jones and L. Jones

    Citation: BMC Psychiatry 2019 19:395

    Content type: Research article

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  2. Although depression has a high rate of recurrence, no prior studies have established a method that could identify the warning signs of its recurrence.

    Authors: Narimasa Kumagai, Aran Tajika, Akio Hasegawa, Nao Kawanishi, Masaru Horikoshi, Shinji Shimodera, Ken’ichi Kurata, Bun Chino and Toshi A. Furukawa

    Citation: BMC Psychiatry 2019 19:391

    Content type: Research article

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  3. In China, young migrants are at elevated risk of mental health problems, such as depression. The influence of self-esteem on depression is well acknowledged. We examined correlates of depression and their medi...

    Authors: Qiuming Shen, Yue Shi, Shuxian Zhang, Lhakpa Tsamlag, Huwen Wang, Ruijie Chang, Zihe Peng, Ying Wang, Meili Shang and Yong Cai

    Citation: BMC Psychiatry 2019 19:390

    Content type: Research article

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  4. Due to long waiting periods for outpatient psychotherapy and the high resource requirements of inpatient treatment, there is a need for alternative treatment programs for patients with depressive disorders. Th...

    Authors: Martin Driessen, Philipp Schulz, Silvia Jander, Hedda Ribbert, Stefanie Gerhards, Frank Neuner and Steffi Koch-Stoecker

    Citation: BMC Psychiatry 2019 19:380

    Content type: Research article

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  5. Conclusions regarding the association between antithyroid antibodies or thyroid dysfunction and rapid cycling bipolar disorder (RCBD) have been conflicting. Previous studies suggest that the impact of antithyr...

    Authors: Zhaoyu Gan, Xiuhua Wu, Zhongcheng Chen, Yingtao Liao, Yingdong Wu, Zimeng He, Zhihua Yang and Qi Zhang

    Citation: BMC Psychiatry 2019 19:378

    Content type: Research article

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  6. Clinical depression is characterized by high levels of negative affect (NA) and attenuated positive affect (PA). Psychological and pharmacological treatments have been shown to reduce NA and to enhance PA in d...

    Authors: Thomas Suslow, Charlott Maria Bodenschatz, Anette Kersting, Markus Quirin and Vivien Günther

    Citation: BMC Psychiatry 2019 19:376

    Content type: Research article

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  7. There is an urgent need to develop additional treatment strategies for patients with treatment-resistant depression (TRD). The rapid but short-lived antidepressant effects of intravenous (IV) ketamine as a rac...

    Authors: Sanne Y. Smith-Apeldoorn, Jolien K. E. Veraart, Jeanine Kamphuis, Antoinette D. I. van Asselt, Daan J. Touw, Marije aan het Rot and Robert A. Schoevers

    Citation: BMC Psychiatry 2019 19:375

    Content type: Study protocol

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  8. Only a minority of dialysis patients with depressive symptoms are diagnosed and receive treatment. Depressive symptoms are highly prevalent in this population and are associated with adverse clinical outcomes....

    Authors: Els Nadort, Robbert W. Schouten, Friedo W. Dekker, Adriaan Honig, Patricia van Oppen and Carl E. H. Siegert

    Citation: BMC Psychiatry 2019 19:372

    Content type: Study protocol

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  9. Involuntary subordination is a mechanism that switches off fighting behaviors when a losing organism is unable to continue in a struggle. The study aim was to investigate the association between involuntary su...

    Authors: Shuxian Zhang, Suping Wang, Zezhou Wang, Ying Wang, Xueqin Jiang, Gang Xu and Yong Cai

    Citation: BMC Psychiatry 2019 19:369

    Content type: Research article

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  10. Knowledge construction is a form of communication in which people can work individually or collaboratively. Peer support services have been adopted by the public psychiatric and social welfare service as a reg...

    Authors: Samson Tse, Winnie W. Y. Yuen, Greg Murray, Larry Davidson, Queenie Lai and Alice Kan

    Citation: BMC Psychiatry 2019 19:368

    Content type: Research article

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  11. Stigma against mental illness cuts across all age, religion, ethnic origin or socio-economic status. Similarly, self-stigma among psychiatric patients is also prevalent worldwide. The consequences of self-stig...

    Authors: Shanta Maharjan and Bimala Panthee

    Citation: BMC Psychiatry 2019 19:347

    Content type: Research article

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  12. Although the cross-sectional association between mental disorders and suicide ideation is well studied, less is known about the prospective association. In this paper, we estimated among those without 12-month...

    Authors: Derek de Beurs, Margreet ten Have, Pim Cuijpers and Ron de Graaf

    Citation: BMC Psychiatry 2019 19:345

    Content type: Research article

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  13. Electroconvulsive therapy (ECT) is the most rapid and effective treatment for patients with depression, ECT can achieve remarkable antidepressant effects in the initial 3–4 sessions, but significant side effec...

    Authors: Han Rong, Shu-xian Xu, Jing Zeng, Ying-jia Yang, Jie Zhao, Wen-tao Lai, Li-chang Chen, Wen-feng Deng, Xiangyang Zhang, Ying-li Zhang, Min-zhi Li, Li Xiao and Xin-hui Xie

    Citation: BMC Psychiatry 2019 19:344

    Content type: Study protocol

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  14. Little is known about depression in middle-aged and older Canadians and how it is affected by health determinants, particularly immigrant status. This study examined depression and socio-economic, health, immi...

    Authors: Karen M. Davison, Yu Lung, Shen (Lamson) Lin, Hongmei Tong, Karen M. Kobayashi and Esme Fuller-Thomson

    Citation: BMC Psychiatry 2019 19:329

    Content type: Research article

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  15. Published research on depression among people living with HIV/AIDS (PLWHA) from Africa is increasing, but data from Kenya remains scarce. This cross-sectional study measured the prevalence and correlates of de...

    Authors: Moses K. Nyongesa, Paul Mwangi, Stanley W. Wanjala, Agnes M. Mutua, Charles R. J. C. Newton and Amina Abubakar

    Citation: BMC Psychiatry 2019 19:333

    Content type: Research article

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  16. Perinatal depression is a common problem that affects about 18% of women worldwide, though the heterogeneity between countries is great. The aims of this study were to assess the prevalence of perinatal depres...

    Authors: Limor Adler, Judith Tsamir, Rachel Katz, Gideon Koren and Ilan Yehoshua

    Citation: BMC Psychiatry 2019 19:331

    Content type: Research article

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  17. In a recent issue of the BMC Psychiatry, the evidence of effectiveness of treatments for psychiatric conditions in end-stage cancer patients was reviewed (Johnson, 2018). The review was comprehensive, and incl...

    Authors: Rafael Guimarães dos Santos, José Carlos Bouso and Jaime E. C. Hallak

    Citation: BMC Psychiatry 2019 19:321

    Content type: Commentary

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  18. People with bipolar disorder are highly vulnerable to risky sexual behaviors (RSBs). The magnitude of RSBs among bipolar disorders was not studied in our population. The present study aimed to explore the prev...

    Authors: Chalachew Shambel Obo, Lamesa Melese Sori, Tadesse Melaku Abegaz and Bizuneh Tesfaye Molla

    Citation: BMC Psychiatry 2019 19:313

    Content type: Research article

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  19. Bipolar disorder (BD) is a major psychiatric illness, however its physiopathology is unclear. The role of folate in the physiopathology of BD is controversial. We conducted this systematic review and meta-anal...

    Authors: Yung-Chi Hsieh, Li-Shiu Chou, Ching-Hua Lin, Hung-Chi Wu, Dian-Jeng Li and Ping-Tao Tseng

    Citation: BMC Psychiatry 2019 19:305

    Content type: Research article

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  20. Depressive symptoms are quite prevalent in Primary Care (PC) settings. The treatment as usual (TAU) in PC is pharmacotherapy, despite the high relapse rates it produces. Many patients would prefer psychotherap...

    Authors: Alba Lopez-Montoyo, Soledad Quero, Jesus Montero-Marin, Alberto Barcelo-Soler, Maria Beltran, Daniel Campos and Javier Garcia-Campayo

    Citation: BMC Psychiatry 2019 19:301

    Content type: Study protocol

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  21. Research can inform culturally-appropriate care to strengthen social and emotional wellbeing (SEWB) among Aboriginal and Torres Strait Islander (hereafter, the term ‘Indigenous Peoples’ is respectfully used an...

    Authors: Sara Farnbach, Graham Gee, Anne-Marie Eades, John Robert Evans, Jamie Fernando, Belinda Hammond, Matty Simms, Karrina DeMasi and Maree L. Hackett

    Citation: BMC Psychiatry 2019 19:294

    Content type: Research article

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  22. Women with bipolar disorder (BD) have a high risk of illness relapse postpartum. The risk coincides with the period when mother-infant interactions are evolving. We compared mother-infant interactions in dyads...

    Authors: Teija M. S. Anke, Kari Slinning, Vibeke Moe, Cathrine Brunborg, Torill S. Siqveland and Dag Vegard Skjelstad

    Citation: BMC Psychiatry 2019 19:292

    Content type: Research article

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  23. The Patient Health Questionnaire-9 (PHQ-9) is a brief tool to assess the presence and severity of depressive symptoms. This study aimed to validate and calibrate the PHQ-9 to determine appropriate cut-off poin...

    Authors: María Urtasun, Federico Manuel Daray, Germán Leandro Teti, Fernando Coppolillo, Gabriela Herlax, Guillermo Saba, Adolfo Rubinstein, Ricardo Araya and Vilma Irazola

    Citation: BMC Psychiatry 2019 19:291

    Content type: Research article

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  24. While postpartum depression is a well-researched disorder in mothers, there is growing evidence indicating that some fathers also develop depressive symptoms (paternal postpartum depression, PPD). A recent met...

    Authors: Julia Albicker, Lars P. Hölzel, Jürgen Bengel, Katharina Domschke, Levente Kriston, Miriam A. Schiele and Fabian Frank

    Citation: BMC Psychiatry 2019 19:289

    Content type: Study protocol

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  25. Major depressive disorder is one of the most prevalent and disabling forms of mental illness in the general population. One public health strategy that may reduce the disease burden is early identification and...

    Authors: JianLi Wang, Glenda MacQueen, Scott Patten, Douglas Manuel, Bonnie Lashewicz and Norbert Schmitz

    Citation: BMC Psychiatry 2019 19:285

    Content type: Study protocol

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  26. Among patients suffering from coronary heart disease (CHD) and comorbid depression, women experience a higher burden compared to men. Little is known on the characteristics that differentiate men and women wit...

    Authors: Hala Allabadi, Nicole Probst-Hensch, Abdulsalam Alkaiyat, Saleem Haj-Yahia, Christian Schindler, Marek Kwiatkowski and Elisabeth Zemp

    Citation: BMC Psychiatry 2019 19:284

    Content type: Research article

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  27. Prepulse inhibition (PPI) is a measurement method for the sensory gating process, which helps the brain adapt to complex environments. PPI may be reduced in patients with bipolar disorder (BD). This study inve...

    Authors: Zhen Mao, Qijing Bo, Weidi Li, Zhimin Wang, Xin Ma and Chuanyue Wang

    Citation: BMC Psychiatry 2019 19:282

    Content type: Research article

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  28. People in green professions are exposed to a variety of risk factors, which could possibly enhance the development of depression. Amongst possible prevention approaches, internet- and mobile-based intervention...

    Authors: Lina Braun, Ingrid Titzler, David Daniel Ebert, Claudia Buntrock, Yannik Terhorst, Johanna Freund, Janika Thielecke and Harald Baumeister

    Citation: BMC Psychiatry 2019 19:278

    Content type: Study protocol

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  29. Although massive studies have explored the risk factors of suicidal ideation (SI), the prevalence of SI and its associated factors in the hypertensive individuals are largely unknown. This study aims to invest...

    Authors: Dandan Ge, Xinyi Zhang, Xiaolei Guo, Jie Chu, Long Sun and Chengchao Zhou

    Citation: BMC Psychiatry 2019 19:266

    Content type: Research article

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  30. Several international guidelines for the acute treatment of moderate to severe unipolar depression recommend a first-line treatment with antidepressants (AD). This is based on the assumption that AD obviously ...

    Authors: Martin Plöderl and Michael P. Hengartner

    Citation: BMC Psychiatry 2019 19:265

    Content type: Debate

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  31. Clear guidance for successive antidepressant pharmacological treatments for non-responders in major depression is not well established.

    Authors: D. Bennabi, T. Charpeaud, A. Yrondi, J.-B. Genty, S. Destouches, S. Lancrenon, N. Alaïli, F. Bellivier, T. Bougerol, V. Camus, J.-M. Dorey, O. Doumy, F. Haesebaert, J. Holtzmann, C. Lançon, M. Lefebvre…

    Citation: BMC Psychiatry 2019 19:262

    Content type: Research article

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  32. Functional somatic symptoms in depression disorder may cause inappropriate illness behavior hindering the treatment process. Health anxiety may play a role in this relationship, but few studies have examined i...

    Authors: Yue-Jiao Ma, Dong-Fang Wang, Ming Yuan, Jiang Long, Shu-Bao Chen, Qiu-Xia Wu, Xu-Yi Wang and Tie-Qiao Liu

    Citation: BMC Psychiatry 2019 19:260

    Content type: Research article

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  33. Antenatal depression is a prevalent mental disorder in women who have undergone caesarean section, and it often presages adverse postoperative outcomes. Because of the lack of a laboratory-based diagnostic str...

    Authors: Zhuoxi Wu, Peng Zhao, Zhonghong Long, Jie Li, Guiying Yang, Qingling Zhang, Guangyou Duan and Hong Li

    Citation: BMC Psychiatry 2019 19:259

    Content type: Research article

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  34. With the advent of the recovery movement in mental health, a humanistic paradigm shift has occurred, placing the focus on personal recovery (i.e., hope, identity, and life meaning) instead of functional or clinic...

    Authors: Sunny H. W. Chan, Samson Tse, K. F. Chung, C. H. Yu, Raymond C. K. Chung and Herman H. M. Lo

    Citation: BMC Psychiatry 2019 19:255

    Content type: Study protocol

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  35. Mental illnesses among children and adolescents are under-recognized and under-treated problems. Depression is one of today’s all-too-silent health crises in caregivers. Although primary caregivers of children...

    Authors: Woredaw Minichil, Wondale Getinet, Habtamu Derajew and Sofia Seid

    Citation: BMC Psychiatry 2019 19:249

    Content type: Research article

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  36. Postpartum depression was associated with maternal suffering and diminished functioning, increased risk of marital conflict as well as adverse child outcomes. Perceived social support during pregnancy was asso...

    Authors: Yuexin Gan, Ran Xiong, Junjiao Song, Xinli Xiong, Fei Yu, Weiming Gao, Hui Hu, Jinsong Zhang, Ying Tian, Xiaobo Gu, Jun Zhang and Dan Chen

    Citation: BMC Psychiatry 2019 19:232

    Content type: Research article

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  37. Research suggests that young people with major depressive disorder (MDD) experience neurocognitive deficits and that these are associated with poorer functional and clinical outcomes. However, we are yet to un...

    Authors: Catherine Morey-Nase, Lisa J. Phillips, Shayden Bryce, Sarah Hetrick, Andrea L. Wright, Emma Caruana and Kelly Allott

    Citation: BMC Psychiatry 2019 19:209

    Content type: Research article

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  38. Both depressive disorder and subclinical depressive symptoms during adolescence are a major public health concern. Therefore, it is important that depression is detected at an early stage and is treated preven...

    Authors: Marieke W. H. van den Heuvel, Denise H. M. Bodden, Mirjam Moerbeek, Filip Smit and Rutger C. M. E. Engels

    Citation: BMC Psychiatry 2019 19:200

    Content type: Study protocol

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  39. Traumatic events can trigger postpartum depression. Pregnant women in Brazil today are facing an extremely stressful experience. Thus, the objective here was to analyze the prevalence of symptoms of depression...

    Authors: Eleomar Vilela Moraes, Olegário Rosa Toledo, Flávia Lúcia David, Bruna Nascimento Godoi, Keila Araujo Monteiro, Thaisa Cimardi Deluqui, Thais Wérica Teixeira, Andiara Luiza Carvalho and Mariza Martins Avelino

    Citation: BMC Psychiatry 2019 19:199

    Content type: Research article

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  40. In an 8-week, randomized, placebo-controlled, double-blind study, an extended-release formulation of quetiapine, quetiapine XR, demonstrated efficacy and safety in Japanese patients with bipolar depression. Bi...

    Authors: Shigenobu Kanba, Mitsukuni Murasaki, Tsukasa Koyama, Masahiro Takeuchi, Yuriko Shimizu, Eri Arita, Kentaro Kuroishi, Masahiro Takeuchi and Shinya Kamei

    Citation: BMC Psychiatry 2019 19:198

    Content type: Research article

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  41. Safety monitoring of medicines is essential during therapy for bipolar disorder (BD). We determined the extent of safety monitoring performed according to the International Society for Bipolar Disorders (ISBD)...

    Authors: Uthpali Mannapperuma, Priyadarshani Galappatthy, Raveendra Laal Jayakody, Jayan Mendis, Varuni Asanka de Silva and Raveen Hanwella

    Citation: BMC Psychiatry 2019 19:194

    Content type: Research article

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  42. Postpartum depression (PPD) is a major depressive disorder that occurs after childbirth. Objective diagnostic and predictive methods for PPD are important for early detection and appropriate intervention. DNA ...

    Authors: Yukako Nakamura, Masahiro Nakatochi, Shohko Kunimoto, Takashi Okada, Branko Aleksic, Miho Toyama, Tomoko Shiino, Mako Morikawa, Aya Yamauchi, Akira Yoshimi, Yoko Furukawa-Hibi, Taku Nagai, Masako Ohara, Chika Kubota, Kiyofumi Yamada, Masahiko Ando…

    Citation: BMC Psychiatry 2019 19:190

    Content type: Research article

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  43. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, which has yielded promising results in treating major depressive disorder. However, its effect on treatment-resista...

    Authors: Min-Shan Li, Xiang-Dong Du, Hsiao-Chi Chu, Yen-Ying Liao, Wen Pan, Zhe Li and Galen Chin-Lun Hung

    Citation: BMC Psychiatry 2019 19:180

    Content type: Research article

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  44. Selection of the optimal initial treatment in patients with major depressive disorder (MDD) in need of highly specialized care has the potential to benefit treatment outcomes and cost-effectiveness of treatmen...

    Authors: Frédérique C. W. van Krugten, Maartje Goorden, Anton J. L. M. van Balkom, Patricia van Oppen, Henricus G. Ruhé, Digna J. F. van Schaik, Werner B. F. Brouwer and Leona Hakkaart-van Roijen

    Citation: BMC Psychiatry 2019 19:179

    Content type: Research article

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