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Mood disorders

Section edited by Florian Seemüller

This section is dedicated to covering all aspects of a wide range of mood disorders. Topics of interest include, but are not limited to, biological psychiatry, depression, psychoneuroendocrinology, bipolar disorders, antidepressants, psychopharmacology, neuroimaging, transcranial/cortical stimulation, electroencephalography and co-morbid conditions associated with mood disorders.


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  1. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, which has yielded promising results in treating major depressive disorder. However, its effect on treatment-resista...

    Authors: Min-Shan Li, Xiang-Dong Du, Hsiao-Chi Chu, Yen-Ying Liao, Wen Pan, Zhe Li and Galen Chin-Lun Hung

    Citation: BMC Psychiatry 2019 19:180

    Content type: Research article

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  2. Selection of the optimal initial treatment in patients with major depressive disorder (MDD) in need of highly specialized care has the potential to benefit treatment outcomes and cost-effectiveness of treatmen...

    Authors: Frédérique C. W. van Krugten, Maartje Goorden, Anton J. L. M. van Balkom, Patricia van Oppen, Henricus G. Ruhé, Digna J. F. van Schaik, Werner B. F. Brouwer and Leona Hakkaart-van Roijen

    Citation: BMC Psychiatry 2019 19:179

    Content type: Research article

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  4. Abnormalities in heart rate during sleep linked to impaired neuro-cardiac modulation may provide new information about physiological sleep signatures of depression. This study assessed the validity of an algor...

    Authors: Mysa Saad, Laura B. Ray, Brad Bujaki, Amir Parvaresh, Iryna Palamarchuk, Joseph De Koninck, Alan Douglass, Elliott K. Lee, Louis J. Soucy, Stuart Fogel, Charles M. Morin, Célyne Bastien, Zul Merali and Rébecca Robillard

    Citation: BMC Psychiatry 2019 19:168

    Content type: Research article

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  5. Besides classical approaches for treating depression, physical activity has been demonstrated to be an effective option. Bouldering psychotherapy (BPT) combines psychotherapeutic interventions with action-orie...

    Authors: Lisa Dorscht, Nina Karg, Stephanie Book, Elmar Graessel, Johannes Kornhuber and Katharina Luttenberger

    Citation: BMC Psychiatry 2019 19:154

    Content type: Study protocol

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  6. Following treatment, many depressed patients have significant residual symptoms. However, large randomised controlled trials (RCT) in this population are lacking. When Attention bias modification training (ABM...

    Authors: Rune Jonassen, Catherine J. Harmer, Eva Hilland, Luigi A. Maglanoc, Brage Kraft, Michael Browning, Tore C. Stiles, Vegard Ø. Haaland, Torkil Berge and Nils Inge Landrø

    Citation: BMC Psychiatry 2019 19:141

    Content type: Research article

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  7. The current study aims to systematically assess and compare the antidepressant outcomes of repetitive transcranial magnetic stimulation (rTMS) with the figure-of-eight (F8)-coil and deep transcranial magnetic ...

    Authors: Helena M. Gellersen and Karina Karolina Kedzior

    Citation: BMC Psychiatry 2019 19:139

    Content type: Research article

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  8. Stigmatization of people with mental illness is still a significant problem even in Western society. Media is an important vector for public messaging that may lead to stigma (and potentially counteract it). T...

    Authors: Nele Cornelia Goepfert, Steffen Conrad von Heydendorff, Harald Dreßing and Josef Bailer

    Citation: BMC Psychiatry 2019 19:138

    Content type: Research article

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  9. Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive inte...

    Authors: Muriel Vicent-Gil, Beatriz Raventós, Eduardo D. Marín-Martínez, Sara González-Simarro, Anabel Martínez-Arán, Caterina del Mar Bonnin, Joan Trujols, Josefina Pérez-Blanco, Javier de Diego-Adeliño, Dolors Puigdemont, Maria Serra-Blasco, Narcís Cardoner and Maria J. Portella

    Citation: BMC Psychiatry 2019 19:135

    Content type: Study protocol

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  10. There are evidence-based interventions for depression that include different components. However, the efficacy of their therapeutic components is unknown. Another important issue related to depression interven...

    Authors: Adriana Mira, Amanda Díaz-García, Diana Castilla, Daniel Campos, Sonia Romero, Juana Bretón-López, Azucena García-Palacios, Rosa Baños and Cristina Botella

    Citation: BMC Psychiatry 2019 19:133

    Content type: Study protocol

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  11. Despite multiple pharmacological interventions, many people with bipolar disorder (BD) experience substantial residual mood symptoms, even in the absence of severe mood episodes, which have a negative impact o...

    Authors: I. Hanssen, M. J. Huijbers, M. W. H. Lochmann-van Bennekom, E. J. Regeer, A. W. M. M. Stevens, S. M. A. A. Evers, M. Wensing, R. W. Kupka and A. E. M. Speckens

    Citation: BMC Psychiatry 2019 19:130

    Content type: Study protocol

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  13. The transition phase from inpatient to outpatient care for patients suffering from Major Depressive Disorder represents a vulnerable period associated with a risk of depression worsening and suicide. Our group...

    Authors: Signe Dunker Svendsen, Anne Sofie Aggestrup, Lasse Benn Nørregaard, Philip Løventoft, Anne Præstegaard, Konstantin V. Danilenko, Mads Frost, Ulla Knorr, Ida Hageman, Lars Vedel Kessing and Klaus Martiny

    Citation: BMC Psychiatry 2019 19:124

    Content type: Study protocol

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  14. Depression has been associated with a higher risk of cardiovascular events and a higher mortality in patients with one or more comorbidities. This study investigated whether continuative use of antidepressants...

    Authors: Silvia Cocchio, Tatjana Baldovin, Patrizia Furlan, Alessandra Buja, Patrizia Casale, Marco Fonzo, Vincenzo Baldo and Chiara Bertoncello

    Citation: BMC Psychiatry 2019 19:122

    Content type: Research article

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  15. Clinical outcomes for patients with heterogeneous somatoform disorder (bodily distress disorder, including medically unexplained symptoms) are suboptimal, new treatments are required to improve acceptance. Bod...

    Authors: Frank Röhricht, Heribert Sattel, Christian Kuhn and Claas Lahmann

    Citation: BMC Psychiatry 2019 19:120

    Content type: Research article

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  16. About one in five patients with depression experiences a chronic course. Despite the great burden associated with this disease, there is no current screening instrument for Persistent Depressive Disorder (PDD)...

    Authors: Elisa Brinkmann, Sarah Glanert, Michael Hüppe, Ana Sofia Moncada Garay, Sophie Tschepe, Ulrich Schweiger and Jan Philipp Klein

    Citation: BMC Psychiatry 2019 19:119

    Content type: Research article

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  17. Controversial findings regarding the association between pro-inflammatory cytokines and depression have been reported in pregnant subjects. Scarce data about anxiety and its relationships with cytokines are av...

    Authors: P. Leff Gelman, I. Mancilla-Herrera, M. Flores-Ramos, M. F. Saravia Takashima, F. M. Cruz Coronel, C. Cruz Fuentes, A. Pérez Molina, J. Hernández-Ruiz, F. S. Silva-Aguilera, B. Farfan-Labonne, D. Chinchilla-Ochoa, S. Garza Morales and I. Camacho-Arroyo

    Citation: BMC Psychiatry 2019 19:104

    Content type: Research article

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  19. The treatment of major depressive disorder, a highly prevalent disorder associated with pronounced burden, is a large challenge to healthcare systems worldwide. Internet based self-management interventions see...

    Authors: Caroline Oehler, Frauke Görges, Daniel Böttger, Juliane Hug, Nicole Koburger, Elisabeth Kohls and Christine Rummel-Kluge

    Citation: BMC Psychiatry 2019 19:90

    Content type: Study protocol

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  20. Depression and anxiety are prevalent and associated with a worse prognosis in coronary heart disease (CHD) patients. However, the influence of disease severity on mood symptoms is unknown. The specific associa...

    Authors: Han Yin, Yuting Liu, Huan Ma, Guihao Liu, Lan Guo and Qingshan Geng

    Citation: BMC Psychiatry 2019 19:85

    Content type: Research article

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  21. Depression among tuberculosis patients, especially in settings with low economic status is common. Screening for depression in all levels of health facilities can identify patients who need support and treatme...

    Authors: Tamirat Tesfaye Dasa, Aklilu Abrham Roba, Fitsum Weldegebreal, Frehiwot Mesfin, Abiyot Asfaw, Habtamu Mitiku, Zelalem Teklemariam, Bahubali Jinnappa Geddugol, Mahantash Naganuri, Hilina Befikadu and Eden Tesfaye

    Citation: BMC Psychiatry 2019 19:82

    Content type: Research article

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  22. Depression is a global problem, affecting populations worldwide, but is too often under-diagnosed. The identification of depression among patients with diabetes is important because depression is prevalent in ...

    Authors: Michael Udedi, Adamson S. Muula, Robert C. Stewart and Brian W. Pence

    Citation: BMC Psychiatry 2019 19:81

    Content type: Research article

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  23. Clinical Practice Guidelines (CPGs) should follow an adequate methodology using an evidence-based approach in order to provide reliable recommendations. However, little is known regarding the quality of CPGs f...

    Authors: Jessica Hanae Zafra-Tanaka, Sergio Goicochea-Lugo, David Villarreal-Zegarra and Alvaro Taype-Rondan

    Citation: BMC Psychiatry 2019 19:76

    Content type: Research article

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  24. Rebound cholinergic syndrome is a rare, but well known unwanted phenomenon occurring after abrupt clozapine discontinuation. There have been previous reported cases of cholinergic rebound in the literature; ho...

    Authors: Andrea Galova, Patricia Berney, Jules Desmeules, Ioannis Sergentanis and Marie Besson

    Citation: BMC Psychiatry 2019 19:73

    Content type: Case report

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  25. There is a growing body of literature highlighting the role that wearable and mobile remote measurement technology (RMT) can play in measuring symptoms of major depressive disorder (MDD). Outcomes assessment t...

    Authors: F. Matcham, C. Barattieri di San Pietro, V. Bulgari, G. de Girolamo, R. Dobson, H. Eriksson, A. A. Folarin, J. M. Haro, M. Kerz, F. Lamers, Q. Li, N. V. Manyakov, D. C. Mohr, I. Myin-Germeys, V. Narayan, Penninx BWJH…

    Citation: BMC Psychiatry 2019 19:72

    Content type: Study protocol

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  26. The World Health Organization (WHO) has included comorbidity between depression and a chronic disease among the 10 leading global health priorities. Although there is a high prevalence of multimorbidity, healt...

    Authors: Alicia Monreal-Bartolomé, Alberto Barceló-Soler, Adoración Castro, Mª. Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, Maria Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M. Baños, Yolanda López-Del-Hoyo and Javier García-Campayo

    Citation: BMC Psychiatry 2019 19:66

    Content type: Study protocol

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  27. The role of dietary patterns in the prevention of unipolar depression has been analyzed in several epidemiological studies. The primary aims of this study are to determine the effectiveness of an extra-olive o...

    Authors: A. Sánchez-Villegas, B. Cabrera-Suárez, P. Molero, A. González-Pinto, C. Chiclana-Actis, C. Cabrera, F. Lahortiga-Ramos, M. Florido-Rodríguez, P. Vega-Pérez, R. Vega-Pérez, J. Pla, M. J. Calviño-Cabada, F. Ortuño, S. Navarro, Y. Almeida and J. L. Hernández-Fleta

    Citation: BMC Psychiatry 2019 19:63

    Content type: Study protocol

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  28. Major Depressive Disorder (MDD) is the leading cause of disability worldwide. The cardinal features of MDD are depressed mood and anhedonia. Anhedonia is defined as a “markedly diminished interest or pleasure ...

    Authors: Vera E. Heininga, Egon Dejonckheere, Marlies Houben, Jasmien Obbels, Pascal Sienaert, Bart Leroy, Joris van Roy and Peter Kuppens

    Citation: BMC Psychiatry 2019 19:59

    Content type: Research article

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  29. Depressive symptoms are common in patients with coronary artery disease (CAD) and are associated with an unfavourable outcome. Establishing prognostic patient profiles prior to the beginning of mental health care...

    Authors: Frank Vitinius, Steffen Escherich, Hans-Christian Deter, Martin Hellmich, Jana Jünger, Katja Petrowski, Karl-Heinz Ladwig, Frank Lambertus, Matthias Michal, Cora Weber, Martina de Zwaan, Christoph Herrmann-Lingen, Joram Ronel and Christian Albus

    Citation: BMC Psychiatry 2019 19:57

    Content type: Research article

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  30. Inpatients with depression have a poor long term outcome with high rates of suicide, high levels of morbidity and frequent re-admission. Current treatment often relies on pharmacological intervention and focus...

    Authors: Ian R. E. Averill, Ben Beaglehole, Katie M. Douglas, Jennifer Jordan, Marie T. Crowe, Maree Inder, Cameron J. Lacey, Christopher M. Frampton, Christopher R. Bowie and Richard J. Porter

    Citation: BMC Psychiatry 2019 19:52

    Content type: Study protocol

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  31. Recommendations for pharmacological treatments of major depression with specific comorbid psychiatric conditions are lacking.

    Authors: D. Bennabi, A. Yrondi, T. Charpeaud, J.-B. Genty, S. Destouches, S. Lancrenon, N. Allaili, F. Bellivier, T. Bougerol, V. Camus, O. Doumy, J.-M. Dorey, F. Haesebaert, J. Holtzmann, C. Lançon, M. Lefebvre…

    Citation: BMC Psychiatry 2019 19:50

    Content type: Research article

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  32. Parents are vulnerable to psychological distress symptoms in the postpartum period. It is routine to screen for depressive symptoms, but anxiety, stress, fatigue, irritability and insomnia symptoms are less of...

    Authors: Nathan Wilson, Karen Wynter, Clare Anderson, Shanthakumar M. W. Rajaratnam, Jane Fisher and Bei Bei

    Citation: BMC Psychiatry 2019 19:48

    Content type: Research article

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  33. Anxiety and depressive disorders are common mental disorders. A substantial part of patients does not achieve symptomatic remission after treatment in specialized services. Current care as usual (CAU) for thes...

    Authors: Maringa H. H. Zoun, Bauke Koekkoek, Henny Sinnema, Christina M. van der Feltz-Cornelis, Anton J. L. M. van Balkom, Aart H. Schene, Filip Smit and Jan Spijker

    Citation: BMC Psychiatry 2019 19:46

    Content type: Research article

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  34. Self-harm and depression are strong risk factors for repeat self-harm and suicide. We aimed to investigate the feasibility of a randomised controlled trial (RCT) of remotely delivered problem-solving cognitive...

    Authors: Kapil Sayal, James Roe, Harriet Ball, Christopher Atha, Catherine Kaylor-Hughes, Boliang Guo, Ellen Townsend and Richard Morriss

    Citation: BMC Psychiatry 2019 19:42

    Content type: Research article

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  35. Depression and anxiety are prevalent mental disorders among the working population with potentially high personal and financial cost. The overall aim of this study was to test the applicability of an outreach ...

    Authors: Helle Østermark Sørensen, Jan B. Valentin, Malene Krogsgaard Bording, Jens Ivar Larsen, Anelia Larsen and Øyvind Omland

    Citation: BMC Psychiatry 2019 19:40

    Content type: Research article

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  36. People with a family history of major depressive disorder (MDD) or bipolar disorder (BD) report specific psychoeducational needs that are unmet by existing online interventions. This trial aimed to test whethe...

    Authors: Llewellyn Mills, Bettina Meiser, Raghib Ahmad, Peter R. Schofield, Michelle Peate, Charlene Levitan, Lyndal Trevena, Kristine Barlow-Stewart, Timothy Dobbins, Helen Christensen, Kerry A. Sherman, Kate Dunlop and Philip B. Mitchell

    Citation: BMC Psychiatry 2019 19:29

    Content type: Research article

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  37. Patients with Major Depressive Disorder (MDD) who are non-improvers after two weeks of antidepressant treatment have a high risk of treatment failure. Recently, we did not find differences in outcomes in non-i...

    Authors: Nadine Dreimüller, Stefanie Wagner, Alice Engel, Dieter F. Braus, Sibylle C. Roll, Stefan Elsner, André Tadić and Klaus Lieb

    Citation: BMC Psychiatry 2019 19:24

    Content type: Research article

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  38. Although currently available evidence suggests that physical exercise can be beneficial for depressed patients and might be comparable to antidepressant treatment, the best way of implementing this recommendat...

    Authors: Jesús López-Torres Hidalgo

    Citation: BMC Psychiatry 2019 19:21

    Content type: Study protocol

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  39. The clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in treatment resistant patients (at least 4 medication trials) appears to be well accepted and forms the coverage policies and rTMS’...

    Authors: Jeffrey Voigt, Linda Carpenter and Andrew Leuchter

    Citation: BMC Psychiatry 2019 19:13

    Content type: Research article

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  40. Although depression is associated with changes in the hypothalamic-pituitary-thyroid axis, its relationship with subclinical hypothyroidism (SCH) is controversial. To date, there is a lack of data on the impro...

    Authors: Huai Heng Loh, Lee Ling Lim, Anne Yee and Huai Seng Loh

    Citation: BMC Psychiatry 2019 19:12

    Content type: Research article

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  41. Because the collection of mental health information through interviews is expensive and time consuming, interest in using population-based administrative health data to conduct research on depression has incre...

    Authors: Chelsea Doktorchik, Scott Patten, Cathy Eastwood, Mingkai Peng, Guanmin Chen, Cynthia A. Beck, Nathalie Jetté, Tyler Williamson and Hude Quan

    Citation: BMC Psychiatry 2019 19:9

    Content type: Research article

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  45. Although an “epidemic” of depression is frequently claimed, empirical evidence is inconsistent, depending on country, study design and depression assessment. Little is known about changes in depression over ti...

    Authors: Julia Bretschneider, Silke Janitza, Frank Jacobi, Julia Thom, Ulfert Hapke, Tobias Kurth and Ulrike E. Maske

    Citation: BMC Psychiatry 2018 18:394

    Content type: Research article

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  46. The Edinburgh Postnatal Depression Scale (EPDS) is widely used in many countries to screen women for depression in the perinatal period. However, across studies the psychometric properties and cutoff scores of...

    Authors: Johanne Smith-Nielsen, Stephen Matthey, Theis Lange and Mette Skovgaard Væver

    Citation: BMC Psychiatry 2018 18:393

    Content type: Research article

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  47. Research has shown that a history of childhood adversities is common in patients with psychiatric disorders but few studies have investigated links between specific types of adversity and specific psychiatric ...

    Authors: Antonella Bruni, Elvira Anna Carbone, Valentina Pugliese, Matteo Aloi, Giuseppina Calabrò, Gregorio Cerminara, Cristina Segura-García and Pasquale De Fazio

    Citation: BMC Psychiatry 2018 18:391

    Content type: Research article

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  48. Clinical studies have shown that bipolar patients have increased serum uric acid levels. High serum uric acid levels could play a role contributing to high prevalence of metabolic syndrome. Metabolic syndrome ...

    Authors: Jingxu Chen, Hongmei Chen, Junhui Feng, Ligang Zhang, Juyan Li, Ran Li, Shaoli Wang, Ian Wilson, Alison Jones, Yunlong Tan, Fude Yang and Xu-Feng Huang

    Citation: BMC Psychiatry 2018 18:390

    Content type: Research article

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  49. Seasonal affective disorder (SAD) is a seasonally recurrent type of major depression that has detrimental effects on patients’ lives during winter. Little is known about how it affects patients during summer a...

    Authors: Barbara Nussbaumer-Streit, Edda Pjrek, Christina Kien, Gerald Gartlehner, Lucie Bartova, Michaela-Elena Friedrich, Siegfried Kasper and Dietmar Winkler

    Citation: BMC Psychiatry 2018 18:372

    Content type: Research article

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  50. Treatment of depression in cardiac patients is difficult. Patients’ illness beliefs regarding depression are associated with outcomes. The aim of the mixed-methods study was to test whether patients in routine...

    Authors: Julia Luise Magaard, Bernd Löwe, Anna Levke Brütt and Sebastian Kohlmann

    Citation: BMC Psychiatry 2018 18:366

    Content type: Research article

    Published on:

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