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Mood disorders

Section edited by Florian Seemüller

This section is dedicated to covering all aspects of a wide range of mood disorders. Topics of interest include, but are not limited to, biological psychiatry, depression, psychoneuroendocrinology, bipolar disorders, antidepressants, psychopharmacology, neuroimaging, transcranial/cortical stimulation, electroencephalography and co-morbid conditions associated with mood disorders.


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  1. People in green professions are exposed to a variety of risk factors, which could possibly enhance the development of depression. Amongst possible prevention approaches, internet- and mobile-based intervention...

    Authors: Lina Braun, Ingrid Titzler, David Daniel Ebert, Claudia Buntrock, Yannik Terhorst, Johanna Freund, Janika Thielecke and Harald Baumeister

    Citation: BMC Psychiatry 2019 19:278

    Content type: Study protocol

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  2. Although massive studies have explored the risk factors of suicidal ideation (SI), the prevalence of SI and its associated factors in the hypertensive individuals are largely unknown. This study aims to invest...

    Authors: Dandan Ge, Xinyi Zhang, Xiaolei Guo, Jie Chu, Long Sun and Chengchao Zhou

    Citation: BMC Psychiatry 2019 19:266

    Content type: Research article

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  3. Several international guidelines for the acute treatment of moderate to severe unipolar depression recommend a first-line treatment with antidepressants (AD). This is based on the assumption that AD obviously ...

    Authors: Martin Plöderl and Michael P. Hengartner

    Citation: BMC Psychiatry 2019 19:265

    Content type: Debate

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  4. Clear guidance for successive antidepressant pharmacological treatments for non-responders in major depression is not well established.

    Authors: D. Bennabi, T. Charpeaud, A. Yrondi, J.-B. Genty, S. Destouches, S. Lancrenon, N. Alaïli, F. Bellivier, T. Bougerol, V. Camus, J.-M. Dorey, O. Doumy, F. Haesebaert, J. Holtzmann, C. Lançon, M. Lefebvre…

    Citation: BMC Psychiatry 2019 19:262

    Content type: Research article

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  5. Functional somatic symptoms in depression disorder may cause inappropriate illness behavior hindering the treatment process. Health anxiety may play a role in this relationship, but few studies have examined i...

    Authors: Yue-Jiao Ma, Dong-Fang Wang, Ming Yuan, Jiang Long, Shu-Bao Chen, Qiu-Xia Wu, Xu-Yi Wang and Tie-Qiao Liu

    Citation: BMC Psychiatry 2019 19:260

    Content type: Research article

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  6. Antenatal depression is a prevalent mental disorder in women who have undergone caesarean section, and it often presages adverse postoperative outcomes. Because of the lack of a laboratory-based diagnostic str...

    Authors: Zhuoxi Wu, Peng Zhao, Zhonghong Long, Jie Li, Guiying Yang, Qingling Zhang, Guangyou Duan and Hong Li

    Citation: BMC Psychiatry 2019 19:259

    Content type: Research article

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  7. With the advent of the recovery movement in mental health, a humanistic paradigm shift has occurred, placing the focus on personal recovery (i.e., hope, identity, and life meaning) instead of functional or clinic...

    Authors: Sunny H. W. Chan, Samson Tse, K. F. Chung, C. H. Yu, Raymond C. K. Chung and Herman H. M. Lo

    Citation: BMC Psychiatry 2019 19:255

    Content type: Study protocol

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  8. Mental illnesses among children and adolescents are under-recognized and under-treated problems. Depression is one of today’s all-too-silent health crises in caregivers. Although primary caregivers of children...

    Authors: Woredaw Minichil, Wondale Getinet, Habtamu Derajew and Sofia Seid

    Citation: BMC Psychiatry 2019 19:249

    Content type: Research article

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  11. Postpartum depression was associated with maternal suffering and diminished functioning, increased risk of marital conflict as well as adverse child outcomes. Perceived social support during pregnancy was asso...

    Authors: Yuexin Gan, Ran Xiong, Junjiao Song, Xinli Xiong, Fei Yu, Weiming Gao, Hui Hu, Jinsong Zhang, Ying Tian, Xiaobo Gu, Jun Zhang and Dan Chen

    Citation: BMC Psychiatry 2019 19:232

    Content type: Research article

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  12. Research suggests that young people with major depressive disorder (MDD) experience neurocognitive deficits and that these are associated with poorer functional and clinical outcomes. However, we are yet to un...

    Authors: Catherine Morey-Nase, Lisa J. Phillips, Shayden Bryce, Sarah Hetrick, Andrea L. Wright, Emma Caruana and Kelly Allott

    Citation: BMC Psychiatry 2019 19:209

    Content type: Research article

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  13. Both depressive disorder and subclinical depressive symptoms during adolescence are a major public health concern. Therefore, it is important that depression is detected at an early stage and is treated preven...

    Authors: Marieke W. H. van den Heuvel, Denise H. M. Bodden, Mirjam Moerbeek, Filip Smit and Rutger C. M. E. Engels

    Citation: BMC Psychiatry 2019 19:200

    Content type: Study protocol

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  14. Traumatic events can trigger postpartum depression. Pregnant women in Brazil today are facing an extremely stressful experience. Thus, the objective here was to analyze the prevalence of symptoms of depression...

    Authors: Eleomar Vilela Moraes, Olegário Rosa Toledo, Flávia Lúcia David, Bruna Nascimento Godoi, Keila Araujo Monteiro, Thaisa Cimardi Deluqui, Thais Wérica Teixeira, Andiara Luiza Carvalho and Mariza Martins Avelino

    Citation: BMC Psychiatry 2019 19:199

    Content type: Research article

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  15. In an 8-week, randomized, placebo-controlled, double-blind study, an extended-release formulation of quetiapine, quetiapine XR, demonstrated efficacy and safety in Japanese patients with bipolar depression. Bi...

    Authors: Shigenobu Kanba, Mitsukuni Murasaki, Tsukasa Koyama, Masahiro Takeuchi, Yuriko Shimizu, Eri Arita, Kentaro Kuroishi, Masahiro Takeuchi and Shinya Kamei

    Citation: BMC Psychiatry 2019 19:198

    Content type: Research article

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  16. Safety monitoring of medicines is essential during therapy for bipolar disorder (BD). We determined the extent of safety monitoring performed according to the International Society for Bipolar Disorders (ISBD)...

    Authors: Uthpali Mannapperuma, Priyadarshani Galappatthy, Raveendra Laal Jayakody, Jayan Mendis, Varuni Asanka de Silva and Raveen Hanwella

    Citation: BMC Psychiatry 2019 19:194

    Content type: Research article

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  17. Postpartum depression (PPD) is a major depressive disorder that occurs after childbirth. Objective diagnostic and predictive methods for PPD are important for early detection and appropriate intervention. DNA ...

    Authors: Yukako Nakamura, Masahiro Nakatochi, Shohko Kunimoto, Takashi Okada, Branko Aleksic, Miho Toyama, Tomoko Shiino, Mako Morikawa, Aya Yamauchi, Akira Yoshimi, Yoko Furukawa-Hibi, Taku Nagai, Masako Ohara, Chika Kubota, Kiyofumi Yamada, Masahiko Ando…

    Citation: BMC Psychiatry 2019 19:190

    Content type: Research article

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  18. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, which has yielded promising results in treating major depressive disorder. However, its effect on treatment-resista...

    Authors: Min-Shan Li, Xiang-Dong Du, Hsiao-Chi Chu, Yen-Ying Liao, Wen Pan, Zhe Li and Galen Chin-Lun Hung

    Citation: BMC Psychiatry 2019 19:180

    Content type: Research article

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  19. Selection of the optimal initial treatment in patients with major depressive disorder (MDD) in need of highly specialized care has the potential to benefit treatment outcomes and cost-effectiveness of treatmen...

    Authors: Frédérique C. W. van Krugten, Maartje Goorden, Anton J. L. M. van Balkom, Patricia van Oppen, Henricus G. Ruhé, Digna J. F. van Schaik, Werner B. F. Brouwer and Leona Hakkaart-van Roijen

    Citation: BMC Psychiatry 2019 19:179

    Content type: Research article

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  22. Abnormalities in heart rate during sleep linked to impaired neuro-cardiac modulation may provide new information about physiological sleep signatures of depression. This study assessed the validity of an algor...

    Authors: Mysa Saad, Laura B. Ray, Brad Bujaki, Amir Parvaresh, Iryna Palamarchuk, Joseph De Koninck, Alan Douglass, Elliott K. Lee, Louis J. Soucy, Stuart Fogel, Charles M. Morin, Célyne Bastien, Zul Merali and Rébecca Robillard

    Citation: BMC Psychiatry 2019 19:168

    Content type: Research article

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  23. Besides classical approaches for treating depression, physical activity has been demonstrated to be an effective option. Bouldering psychotherapy (BPT) combines psychotherapeutic interventions with action-orie...

    Authors: Lisa Dorscht, Nina Karg, Stephanie Book, Elmar Graessel, Johannes Kornhuber and Katharina Luttenberger

    Citation: BMC Psychiatry 2019 19:154

    Content type: Study protocol

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  24. Following treatment, many depressed patients have significant residual symptoms. However, large randomised controlled trials (RCT) in this population are lacking. When Attention bias modification training (ABM...

    Authors: Rune Jonassen, Catherine J. Harmer, Eva Hilland, Luigi A. Maglanoc, Brage Kraft, Michael Browning, Tore C. Stiles, Vegard Ø. Haaland, Torkil Berge and Nils Inge Landrø

    Citation: BMC Psychiatry 2019 19:141

    Content type: Research article

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  25. The current study aims to systematically assess and compare the antidepressant outcomes of repetitive transcranial magnetic stimulation (rTMS) with the figure-of-eight (F8)-coil and deep transcranial magnetic ...

    Authors: Helena M. Gellersen and Karina Karolina Kedzior

    Citation: BMC Psychiatry 2019 19:139

    Content type: Research article

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  26. Stigmatization of people with mental illness is still a significant problem even in Western society. Media is an important vector for public messaging that may lead to stigma (and potentially counteract it). T...

    Authors: Nele Cornelia Goepfert, Steffen Conrad von Heydendorff, Harald Dreßing and Josef Bailer

    Citation: BMC Psychiatry 2019 19:138

    Content type: Research article

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  27. Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive inte...

    Authors: Muriel Vicent-Gil, Beatriz Raventós, Eduardo D. Marín-Martínez, Sara González-Simarro, Anabel Martínez-Arán, Caterina del Mar Bonnin, Joan Trujols, Josefina Pérez-Blanco, Javier de Diego-Adeliño, Dolors Puigdemont, Maria Serra-Blasco, Narcís Cardoner and Maria J. Portella

    Citation: BMC Psychiatry 2019 19:135

    Content type: Study protocol

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  28. There are evidence-based interventions for depression that include different components. However, the efficacy of their therapeutic components is unknown. Another important issue related to depression interven...

    Authors: Adriana Mira, Amanda Díaz-García, Diana Castilla, Daniel Campos, Sonia Romero, Juana Bretón-López, Azucena García-Palacios, Rosa Baños and Cristina Botella

    Citation: BMC Psychiatry 2019 19:133

    Content type: Study protocol

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  29. Despite multiple pharmacological interventions, many people with bipolar disorder (BD) experience substantial residual mood symptoms, even in the absence of severe mood episodes, which have a negative impact o...

    Authors: I. Hanssen, M. J. Huijbers, M. W. H. Lochmann-van Bennekom, E. J. Regeer, A. W. M. M. Stevens, S. M. A. A. Evers, M. Wensing, R. W. Kupka and A. E. M. Speckens

    Citation: BMC Psychiatry 2019 19:130

    Content type: Study protocol

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  31. The transition phase from inpatient to outpatient care for patients suffering from Major Depressive Disorder represents a vulnerable period associated with a risk of depression worsening and suicide. Our group...

    Authors: Signe Dunker Svendsen, Anne Sofie Aggestrup, Lasse Benn Nørregaard, Philip Løventoft, Anne Præstegaard, Konstantin V. Danilenko, Mads Frost, Ulla Knorr, Ida Hageman, Lars Vedel Kessing and Klaus Martiny

    Citation: BMC Psychiatry 2019 19:124

    Content type: Study protocol

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  32. Depression has been associated with a higher risk of cardiovascular events and a higher mortality in patients with one or more comorbidities. This study investigated whether continuative use of antidepressants...

    Authors: Silvia Cocchio, Tatjana Baldovin, Patrizia Furlan, Alessandra Buja, Patrizia Casale, Marco Fonzo, Vincenzo Baldo and Chiara Bertoncello

    Citation: BMC Psychiatry 2019 19:122

    Content type: Research article

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  33. Clinical outcomes for patients with heterogeneous somatoform disorder (bodily distress disorder, including medically unexplained symptoms) are suboptimal, new treatments are required to improve acceptance. Bod...

    Authors: Frank Röhricht, Heribert Sattel, Christian Kuhn and Claas Lahmann

    Citation: BMC Psychiatry 2019 19:120

    Content type: Research article

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  34. About one in five patients with depression experiences a chronic course. Despite the great burden associated with this disease, there is no current screening instrument for Persistent Depressive Disorder (PDD)...

    Authors: Elisa Brinkmann, Sarah Glanert, Michael Hüppe, Ana Sofia Moncada Garay, Sophie Tschepe, Ulrich Schweiger and Jan Philipp Klein

    Citation: BMC Psychiatry 2019 19:119

    Content type: Research article

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  35. Controversial findings regarding the association between pro-inflammatory cytokines and depression have been reported in pregnant subjects. Scarce data about anxiety and its relationships with cytokines are av...

    Authors: P. Leff Gelman, I. Mancilla-Herrera, M. Flores-Ramos, M. F. Saravia Takashima, F. M. Cruz Coronel, C. Cruz Fuentes, A. Pérez Molina, J. Hernández-Ruiz, F. S. Silva-Aguilera, B. Farfan-Labonne, D. Chinchilla-Ochoa, S. Garza Morales and I. Camacho-Arroyo

    Citation: BMC Psychiatry 2019 19:104

    Content type: Research article

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  37. The treatment of major depressive disorder, a highly prevalent disorder associated with pronounced burden, is a large challenge to healthcare systems worldwide. Internet based self-management interventions see...

    Authors: Caroline Oehler, Frauke Görges, Daniel Böttger, Juliane Hug, Nicole Koburger, Elisabeth Kohls and Christine Rummel-Kluge

    Citation: BMC Psychiatry 2019 19:90

    Content type: Study protocol

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  38. Depression and anxiety are prevalent and associated with a worse prognosis in coronary heart disease (CHD) patients. However, the influence of disease severity on mood symptoms is unknown. The specific associa...

    Authors: Han Yin, Yuting Liu, Huan Ma, Guihao Liu, Lan Guo and Qingshan Geng

    Citation: BMC Psychiatry 2019 19:85

    Content type: Research article

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  39. Depression among tuberculosis patients, especially in settings with low economic status is common. Screening for depression in all levels of health facilities can identify patients who need support and treatme...

    Authors: Tamirat Tesfaye Dasa, Aklilu Abrham Roba, Fitsum Weldegebreal, Frehiwot Mesfin, Abiyot Asfaw, Habtamu Mitiku, Zelalem Teklemariam, Bahubali Jinnappa Geddugol, Mahantash Naganuri, Hilina Befikadu and Eden Tesfaye

    Citation: BMC Psychiatry 2019 19:82

    Content type: Research article

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  40. Depression is a global problem, affecting populations worldwide, but is too often under-diagnosed. The identification of depression among patients with diabetes is important because depression is prevalent in ...

    Authors: Michael Udedi, Adamson S. Muula, Robert C. Stewart and Brian W. Pence

    Citation: BMC Psychiatry 2019 19:81

    Content type: Research article

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  41. Clinical Practice Guidelines (CPGs) should follow an adequate methodology using an evidence-based approach in order to provide reliable recommendations. However, little is known regarding the quality of CPGs f...

    Authors: Jessica Hanae Zafra-Tanaka, Sergio Goicochea-Lugo, David Villarreal-Zegarra and Alvaro Taype-Rondan

    Citation: BMC Psychiatry 2019 19:76

    Content type: Research article

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  42. Rebound cholinergic syndrome is a rare, but well known unwanted phenomenon occurring after abrupt clozapine discontinuation. There have been previous reported cases of cholinergic rebound in the literature; ho...

    Authors: Andrea Galova, Patricia Berney, Jules Desmeules, Ioannis Sergentanis and Marie Besson

    Citation: BMC Psychiatry 2019 19:73

    Content type: Case report

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  43. There is a growing body of literature highlighting the role that wearable and mobile remote measurement technology (RMT) can play in measuring symptoms of major depressive disorder (MDD). Outcomes assessment t...

    Authors: F. Matcham, C. Barattieri di San Pietro, V. Bulgari, G. de Girolamo, R. Dobson, H. Eriksson, A. A. Folarin, J. M. Haro, M. Kerz, F. Lamers, Q. Li, N. V. Manyakov, D. C. Mohr, I. Myin-Germeys, V. Narayan, Penninx BWJH…

    Citation: BMC Psychiatry 2019 19:72

    Content type: Study protocol

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  44. The World Health Organization (WHO) has included comorbidity between depression and a chronic disease among the 10 leading global health priorities. Although there is a high prevalence of multimorbidity, healt...

    Authors: Alicia Monreal-Bartolomé, Alberto Barceló-Soler, Adoración Castro, Mª. Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, Maria Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M. Baños, Yolanda López-Del-Hoyo and Javier García-Campayo

    Citation: BMC Psychiatry 2019 19:66

    Content type: Study protocol

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  45. The role of dietary patterns in the prevention of unipolar depression has been analyzed in several epidemiological studies. The primary aims of this study are to determine the effectiveness of an extra-olive o...

    Authors: A. Sánchez-Villegas, B. Cabrera-Suárez, P. Molero, A. González-Pinto, C. Chiclana-Actis, C. Cabrera, F. Lahortiga-Ramos, M. Florido-Rodríguez, P. Vega-Pérez, R. Vega-Pérez, J. Pla, M. J. Calviño-Cabada, F. Ortuño, S. Navarro, Y. Almeida and J. L. Hernández-Fleta

    Citation: BMC Psychiatry 2019 19:63

    Content type: Study protocol

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  46. Major Depressive Disorder (MDD) is the leading cause of disability worldwide. The cardinal features of MDD are depressed mood and anhedonia. Anhedonia is defined as a “markedly diminished interest or pleasure ...

    Authors: Vera E. Heininga, Egon Dejonckheere, Marlies Houben, Jasmien Obbels, Pascal Sienaert, Bart Leroy, Joris van Roy and Peter Kuppens

    Citation: BMC Psychiatry 2019 19:59

    Content type: Research article

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  47. Depressive symptoms are common in patients with coronary artery disease (CAD) and are associated with an unfavourable outcome. Establishing prognostic patient profiles prior to the beginning of mental health care...

    Authors: Frank Vitinius, Steffen Escherich, Hans-Christian Deter, Martin Hellmich, Jana Jünger, Katja Petrowski, Karl-Heinz Ladwig, Frank Lambertus, Matthias Michal, Cora Weber, Martina de Zwaan, Christoph Herrmann-Lingen, Joram Ronel and Christian Albus

    Citation: BMC Psychiatry 2019 19:57

    Content type: Research article

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  48. Inpatients with depression have a poor long term outcome with high rates of suicide, high levels of morbidity and frequent re-admission. Current treatment often relies on pharmacological intervention and focus...

    Authors: Ian R. E. Averill, Ben Beaglehole, Katie M. Douglas, Jennifer Jordan, Marie T. Crowe, Maree Inder, Cameron J. Lacey, Christopher M. Frampton, Christopher R. Bowie and Richard J. Porter

    Citation: BMC Psychiatry 2019 19:52

    Content type: Study protocol

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  49. Recommendations for pharmacological treatments of major depression with specific comorbid psychiatric conditions are lacking.

    Authors: D. Bennabi, A. Yrondi, T. Charpeaud, J.-B. Genty, S. Destouches, S. Lancrenon, N. Allaili, F. Bellivier, T. Bougerol, V. Camus, O. Doumy, J.-M. Dorey, F. Haesebaert, J. Holtzmann, C. Lançon, M. Lefebvre…

    Citation: BMC Psychiatry 2019 19:50

    Content type: Research article

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  50. Parents are vulnerable to psychological distress symptoms in the postpartum period. It is routine to screen for depressive symptoms, but anxiety, stress, fatigue, irritability and insomnia symptoms are less of...

    Authors: Nathan Wilson, Karen Wynter, Clare Anderson, Shanthakumar M. W. Rajaratnam, Jane Fisher and Bei Bei

    Citation: BMC Psychiatry 2019 19:48

    Content type: Research article

    Published on:

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