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Mood disorders

Section edited by Florian Seemüller

This section is dedicated to covering all aspects of a wide range of mood disorders. Topics of interest include, but are not limited to, biological psychiatry, depression, psychoneuroendocrinology, bipolar disorders, antidepressants, psychopharmacology, neuroimaging, transcranial/cortical stimulation, electroencephalography and co-morbid conditions associated with mood disorders.


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  1. Shared decision-making (SDM) is a model of interaction between doctors and patients in which both actors contribute to the medical decision-making process. SDM has raised great interest in mental healthcare ov...

    Authors: L. Samalin, M. Honciuc, L. Boyer, I. de Chazeron, O. Blanc, M. Abbar and P. M. Llorca

    Citation: BMC Psychiatry 2018 18:103

    Content type: Study protocol

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  3. The fundamental mechanism underlying emotional processing in major depressive disorder (MDD) remains unclear. To better understand the neural correlates of emotional processing in MDD, we investigated the role...

    Authors: Jian Li, E. Kale Edmiston, Yanqing Tang, Guoguang Fan, Ke Xu, Fei Wang and Jiansong Xu

    Citation: BMC Psychiatry 2018 18:96

    Content type: Research article

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  4. Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these facto...

    Authors: Helge Toft, Sudan Prasad Neupane, Jørgen G. Bramness, Terje Tilden, Bruce E. Wampold and Lars Lien

    Citation: BMC Psychiatry 2018 18:95

    Content type: Research article

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  5. Major depressive disorder (MDD) is a mixed disorder with the highly irregular course, inconsistent response to treatment and has no well-known mechanism for the pathophysiology. Major causes of depression are ...

    Authors: Md Rabiul Islam, Md Reazul Islam, M. M. A. Shalahuddin Qusar, Mohammad Safiqul Islam, Md Humayun Kabir, G. K. M. Mustafizur Rahman, Md Saiful Islam and Abul Hasnat

    Citation: BMC Psychiatry 2018 18:94

    Content type: Research article

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  6. Chronic obstructive pulmonary disease (COPD) is a serious disease frequently accompanied by anxiety and depression. Few studies have focused on anxiety and depression for mild COPD patients in China. This stud...

    Authors: Tian Xiao, Hua Qiu, Yue Chen, Xianfeng Zhou, Kang Wu, Xiaonan Ruan, Na Wang and Chaowei Fu

    Citation: BMC Psychiatry 2018 18:89

    Content type: Research article

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  7. Patients who require a switch in their antidepressant therapy may have different clinical profiles and treatment needs compared with patients initiating or maintaining a first-line antidepressant therapy.

    Authors: Josep Maria Haro, François-Xavier Lamy, Bengt Jönsson, Martin Knapp, Mélanie Brignone, Hugo Caillou, Ylana Chalem, Lene Hammer-Helmich, Benoît Rive and Delphine Saragoussi

    Citation: BMC Psychiatry 2018 18:80

    Content type: Research article

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  8. Celiac disease is a multi-system disorder with manifestations that may result in psychiatric disorders. We assessed the prevalence of medication use to treat psychiatric disorders in celiac disease patients.

    Authors: Haley M. Zylberberg, Jonas F. Ludvigsson, Peter H. R. Green and Benjamin Lebwohl

    Citation: BMC Psychiatry 2018 18:76

    Content type: Research article

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  9. Some authors have hypothesized that Treatment-Resistant Unipolar Depression (TRD-UP) should be considered within the bipolar spectrum disorders and that hidden bipolarity may be a risk factor for TRD-UP. Howev...

    Authors: Nicolas A. Nuñez, Stefano Comai, Eduard Dumitrescu, Maykel F. Ghabrash, John Tabaka, Marie Saint-Laurent, Stephen Vida, Theodore Kolivakis, Allan Fielding, Nancy Low, Pablo Cervantes, Linda Booij and Gabriella Gobbi

    Citation: BMC Psychiatry 2018 18:68

    Content type: Research article

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  10. Depression is the principal cause of disability in the world. High prevalence rates of depression in general populations and college students have been found worldwide and in various cultural groups. Low-inten...

    Authors: Alicia Salamanca-Sanabria, Derek Richards, Ladislav Timulak, Leónidas Castro-Camacho, Mónica Mojica-Perilla and Yamilena Parra-Villa

    Citation: BMC Psychiatry 2018 18:53

    Content type: Study protocol

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  11. The risk of relapse in major depressive disorder (MDD) is associated with high worldwide disease burden. Cognitive behavioral therapy (CBT) and its modifications might be effective in relapse prevention. The a...

    Authors: Zuojie Zhang, Lingli Zhang, Guorong Zhang, Jianing Jin and Zhenyang Zheng

    Citation: BMC Psychiatry 2018 18:50

    Content type: Research article

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  12. Depression is a leading source of morbidity and health loss in Australian women. This study investigates the determinants of antenatal depressive symptoms and postnatal depressive symptoms in an Australian pop...

    Authors: Felix Akpojene Ogbo, John Eastwood, Alexandra Hendry, Bin Jalaludin, Kingsley E. Agho, Bryanne Barnett and Andrew Page

    Citation: BMC Psychiatry 2018 18:49

    Content type: Research article

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  13. Bereavement can result in severe mental health problems, including persistent, severe and disabling grief symptoms, termed complicated grief. Grief rumination (i.e., repetitive thought about the causes and con...

    Authors: Bettina K. Doering, Antonia Barke, Thilo Friehs and Maarten C. Eisma

    Citation: BMC Psychiatry 2018 18:43

    Content type: Research article

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  15. Lithium remains first choice as maintenance treatment for bipolar affective disorder. Yet, about half of all individuals may stop their treatment at some point, despite lithium’s proven benefits concerning the...

    Authors: Louise Öhlund, Michael Ott, Sofia Oja, Malin Bergqvist, Robert Lundqvist, Mikael Sandlund, Ellinor Salander Renberg and Ursula Werneke

    Citation: BMC Psychiatry 2018 18:37

    Content type: Research article

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    The Correction to this article has been published in BMC Psychiatry 2018 18:322

  16. Miscarriages are a common pregnancy complication affecting about 10–15% of pregnancies. Miscarriages may be associated with a myriad of psychiatric morbidity at various timelines after the event. Depression ha...

    Authors: Steve Kyende Mutiso, Alfred Murage and Abraham Mwaniki Mukaindo

    Citation: BMC Psychiatry 2018 18:32

    Content type: Research article

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  17. This forms the first study of a group-based psychoeducation program for inpatients following remission of a manic episode in patients suffering from bipolar I disorder in a Chinese population. The aim was to e...

    Authors: Runsen Chen, Yingjun Xi, Xue Wang, Yaqiong Li, Yuyang He and Jiong Luo

    Citation: BMC Psychiatry 2018 18:26

    Content type: Research article

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  19. Experience sampling, a method for real-time self-monitoring of affective experiences, holds opportunities for person-tailored treatment. By focussing on dynamic patterns of positive affect, experience sampling...

    Authors: Claudia J. P. Simons, Marjan Drukker, Silvia Evers, Ghislaine A. P. G. van Mastrigt, Petra Höhn, Ingrid Kramer, Frenk Peeters, Philippe Delespaul, Claudia Menne-Lothmann, Jessica A. Hartmann, Jim van Os and Marieke Wichers

    Citation: BMC Psychiatry 2017 17:415

    Content type: Research article

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  20. A number of epidemiological studies have examined the effect of meat consumption on depression. However, no conclusion has been reached. The aim of this study was to examine the relationship between meat consu...

    Authors: Yi Zhang, Ye Yang, Ming-sheng Xie, Xiang Ding, Hui Li, Zhi-chen Liu and Shi-fang Peng

    Citation: BMC Psychiatry 2017 17:409

    Content type: Research article

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  21. Few actigraphy studies in mood disorders have simultaneously included unipolar (UP) and bipolar (BD) depression or BD mixed states as a separate subgroup from mania. This study compared objectively measured ac...

    Authors: Karoline Krane-Gartiser, Arne E. Vaaler, Ole Bernt Fasmer, Kjetil Sørensen, Gunnar Morken and Jan Scott

    Citation: BMC Psychiatry 2017 17:404

    Content type: Research article

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  22. Patients with chronic depression (persisting symptoms for ≥2 years) are a clinically relevant group with extensive (co)morbidity, high functional impairment and associated costs in primary care. The General Pr...

    Authors: Florian Wolf, Antje Freytag, Sven Schulz, Thomas Lehmann, Susann Schaffer, Horst Christian Vollmar, Thomas Kühlein and Jochen Gensichen

    Citation: BMC Psychiatry 2017 17:401

    Content type: Research article

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  23. Guidance of patients treated with antidepressants is paramount for successful therapy. The aim was to assess patients’ needs and suggestions for improvement of guidance by physicians and pharmacists during sec...

    Authors: Mariёtte Nederlof, Daniёlle C. Cath, Lennart J. Stoker, Toine C. G. Egberts and Eibert R. Heerdink

    Citation: BMC Psychiatry 2017 17:388

    Content type: Research article

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  24. Depression is one of the most common diagnosed psychiatric disorders in the world. Besides individual risk factors, it is also found that environment and socio-cultural factors are the other main risk factors ...

    Authors: Mehmet Çakıcı, Özlem Gökçe, Asra Babayiğit, Ebru Çakıcı and Ayhan Eş

    Citation: BMC Psychiatry 2017 17:387

    Content type: Research article

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  25. The manifestation of major depressive disorder (MDD) may include cognitive symptoms that can precede the onset of MDD and persist beyond the resolution of acute depressive episodes. However, little is known ab...

    Authors: Bjarke Ebert, Kamilla Miskowiak, Morten Kloster, Jon Johansen, Cara Eckholm, Torbjörn Wærner, Mads Holme and Louise Meldgaard Bruun

    Citation: BMC Psychiatry 2017 17:370

    Content type: Research article

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  26. Despite the availability of evidence based treatments, many people with major depression receive no or delayed professional treatment, which may put them at risk for adverse outcomes. The aim of this study was...

    Authors: A. M. Boerema, M. ten Have, A. Kleiboer, R. de Graaf, J. Nuyen, P. Cuijpers and A. T. F. Beekman

    Citation: BMC Psychiatry 2017 17:367

    Content type: Research article

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  27. Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable t...

    Authors: Bingren Zhang, Jiawei Wang, Qisha Zhu, Guorong Ma, Chanchan Shen, Hongying Fan and Wei Wang

    Citation: BMC Psychiatry 2017 17:362

    Content type: Research article

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  28. In clinical practice, some patients diagnosed with anxiety disorder (AD) may develop bipolar disorder (BD) many years later, and some cases of AD may be cured by the use of mood stabilizers. However, the relat...

    Authors: Na Du, Ya-ling Zhou, Xu Zhang, Jing Guo and Xue-li Sun

    Citation: BMC Psychiatry 2017 17:351

    Content type: Research article

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  29. In Western European countries, the prevalence of depressive symptoms is higher among ethnic minority groups, compared to the host population. We explored whether these inequalities reflect variance in the way ...

    Authors: Henrike Galenkamp, Karien Stronks, Marieke B. Snijder and Eske M. Derks

    Citation: BMC Psychiatry 2017 17:349

    Content type: Research article

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  30. Increased prevalence of depression is found in both type 2 diabetes (T2D) and type 1 diabetes (T1D). Melancholia and atypical depression differ by cortisol secretion and clinical features. The aim was to compa...

    Authors: Eva O. Melin, Maria Thunander, Mona Landin-Olsson, Magnus Hillman and Hans O. Thulesius

    Citation: BMC Psychiatry 2017 17:335

    Content type: Research article

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  31. The prevalence of depressive symptoms in hypothyroidism is high. Considering that hypothyroidism and depression share some clinical features, some researchers use the “brain hypothyroidism” hypothesis to expla...

    Authors: A Talaei, N Rafee, F Rafei and A Chehrei

    Citation: BMC Psychiatry 2017 17:327

    Content type: Research article

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  32. There is a physical inactivity pandemic around the world despite the known benefits of engaging in physical activity. This is true for individuals who would receive notable benefits from physical activity, in ...

    Authors: Joanie Sims-Gould, Sara Vazirian, Neville Li, Ronald Remick and Karim Khan

    Citation: BMC Psychiatry 2017 17:319

    Content type: Research article

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  33. Anxiety and depression are associated with a range of adverse outcomes and represent a large global burden to individuals and health care systems. Prevention programs are an important way to avert a proportion...

    Authors: M. Deady, I. Choi, R. A. Calvo, N. Glozier, H. Christensen and S. B. Harvey

    Citation: BMC Psychiatry 2017 17:310

    Content type: Research article

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  34. The aim of this study was to explore the relationships between depressive symptoms and health-related quality of life (HRQOL) measurements for inpatients with major depressive disorder (MDD) before and after 6...

    Authors: Wei-Cheng Yang, Ching-Hua Lin, Fu-Chiang Wang and Mei-Jou Lu

    Citation: BMC Psychiatry 2017 17:309

    Content type: Research article

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  35. Psychotherapy is successful for the majority of patients, but not for every patient. Hence, further knowledge is needed on how treatments should be adapted for those who do not profit or deteriorate. In the la...

    Authors: Wolfgang Lutz, Dirk Zimmermann, Viola N. L. S. Müller, Anne-Katharina Deisenhofer and Julian A. Rubel

    Citation: BMC Psychiatry 2017 17:306

    Content type: Study protocol

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  36. Antenatal depressive symptoms affect around 12.3% of women in in low and middle income countries (LMICs) and data are accumulating about associations with adverse outcomes for mother and child. Studies from ru...

    Authors: Tesera Bitew, Charlotte Hanlon, Eskinder Kebede, Simone Honikman and Abebaw Fekadu

    Citation: BMC Psychiatry 2017 17:301

    Content type: Research article

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  37. Men who have sex with men (MSM) continue to be at an increased risk of Violence, HIV transmission and Mental Disorders such as depression on top of many other bio-psycho-socio challenges they face as a result ...

    Authors: Lucy R. Mgopa, Jessie Mbwambo, Samuel Likindikoki and Pedro Pallangyo

    Citation: BMC Psychiatry 2017 17:296

    Content type: Research article

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  38. The prevalence of major depressive disorder (MDD) in Spanish primary care (PC) centres is high. However, MDD is frequently underdiagnosed and consequently only some patients receive the appropriate treatment. ...

    Authors: Roger Muñoz-Navarro, Antonio Cano-Vindel, Leonardo Adrián Medrano, Florian Schmitz, Paloma Ruiz-Rodríguez, Carmen Abellán-Maeso, Maria Antonia Font-Payeras and Ana María Hermosilla-Pasamar

    Citation: BMC Psychiatry 2017 17:291

    Content type: Research article

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  39. The distributional pattern of total scores on depression screening scales in the general population has not been well studied. Recent studies suggest that the total scores on depression screening scales follow...

    Authors: Shinichiro Tomitaka, Yohei Kawasaki, Kazuki Ide, Maiko Akutagawa, Hiroshi Yamada, Yutaka Ono and Toshiaki A. Furukawa

    Citation: BMC Psychiatry 2017 17:290

    Content type: Research article

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  40. Depression is projected to be the primary cause of disability worldwide by 2030. In a recent survey, the most commonly cited unmet need among 42.4% of depressed Albertans was the lack of sufficient, accessible...

    Authors: Vincent I. O. Agyapong, Michal Juhás, Arto Ohinmaa, Joy Omeje, Kelly Mrklas, Victoria Y. M. Suen, Serdar M. Dursun and Andrew J. Greenshaw

    Citation: BMC Psychiatry 2017 17:286

    Content type: Research article

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  41. There remains a paucity of research on control attribution and depression within Asian populations. This study examines: (1) Success/Failure condition as a moderator between depression and negative affect or s...

    Authors: Si-Ning Yeo, Hani Zainal, Catherine S. Tang, Eddie M. Tong, Cyrus S. Ho and Roger C. Ho

    Citation: BMC Psychiatry 2017 17:285

    Content type: Research article

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  43. Previous studies have examined associations between sitting time and negative health outcomes and mental health. However, the relationship between overall sitting time and major depressive disorder (MDD) in So...

    Authors: Jin Young Nam, Juyeong Kim, Kyoung Hee Cho, Jaewoo Choi, Jaeyong Shin and Eun-Cheol Park

    Citation: BMC Psychiatry 2017 17:274

    Content type: Research article

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  44. Interactions between the digestive system, brain functions and immunoglobulin G (IgG) mediated immunity against food antigens became recently a topic of growing interest in psychiatry research. Psychological s...

    Authors: Leszek Rudzki, Dariusz Pawlak, Krystyna Pawlak, Napoleon Waszkiewicz, Aleksandra Małus, Beata Konarzewska, Mirosława Gałęcka, Anna Bartnicka, Lucyna Ostrowska and Agata Szulc

    Citation: BMC Psychiatry 2017 17:268

    Content type: Research article

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  45. Acculturation is a long-term, multi-dimensional process occurring when subjects of different cultures stay in continuous contact. Previous studies have suggested that elevated rates of depression among differe...

    Authors: Hanna Janssen-Kallenberg, Holger Schulz, Ulrike Kluge, Jens Strehle, Hans-Ulrich Wittchen, Uwe Wolfradt, Uwe Koch-Gromus, Andreas Heinz, Mike Mösko and Demet Dingoyan

    Citation: BMC Psychiatry 2017 17:264

    Content type: Research article

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  46. Despite the availability of evidence-based treatments for depression, a large proportion of patients remains untreated or adequate treatment is initiated with delay. This situation is particularly critical in ...

    Authors: Birgit Watzke, Elisa Haller, Maya Steinmann, Daniela Heddaeus, Martin Härter, Hans-Helmut König, Karl Wegscheider and Thomas Rosemann

    Citation: BMC Psychiatry 2017 17:263

    Content type: Study protocol

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  47. Seasonal affective disorder (SAD) is a seasonally recurrent type of major depression. This predictable aspect makes it promising for preventive treatment. However, evidence for the efficacy and harm of prevent...

    Authors: B. Nussbaumer-Streit, D. Winkler, M. Spies, S. Kasper and E. Pjrek

    Citation: BMC Psychiatry 2017 17:247

    Content type: Research article

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  48. Prevalence rates of minor and major depression vary from 0.7 to 6.8 (minor) and 3.8 to 10.9 (major) for the general population. Twenty-two percent of older, long-term unemployed people suffer from major depres...

    Authors: Sabrina Pfeil, Katrin Holtz, Kathrin-Andrea Kopf, Ulrich Hegerl and Christine Rummel-Kluge

    Citation: BMC Psychiatry 2017 17:243

    Content type: Research article

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  50. Several studies have indicated that obsessive-compulsive disorder (OCD) is a common comorbidity in patients with psychotic disorders, but there is sparse knowledge about the relationship between symptoms of OC...

    Authors: Kristen Hagen, Stian Solem, Håvard Berg Opstad, Bjarne Hansen and Roger Hagen

    Citation: BMC Psychiatry 2017 17:233

    Content type: Research article

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