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BMC Psychiatry

Psychiatric molecular genetics

Section edited by Cathy Barr

This section focuses on the role of molecular genetics in psychiatry. Topics of interest include, but are not limited to, gene-environment interaction in psychiatric disorders, pharmacogenetics, linkage, association studies, cognitive endophenotypes, epigenetics, gene expression and genome-wide association studies.

  1. Content type: Research article

    It is well established that there is a link between inflammation and depression, with several studies reporting increased circulating levels of the pro-inflammatory cytokine, interleukin-6 (IL6), in depressed ind...

    Authors: Joanne Ryan, Lauren Pilkington, Katharina Neuhaus, Karen Ritchie, Marie-Laure Ancelin and Richard Saffery

    Citation: BMC Psychiatry 2017 17:354

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  2. Content type: Research article

    Despite many attempts to understand the genetic architecture of depression, little progress has been made. The majority of these studies, however, have been carried out in adults and do not account for the pot...

    Authors: Hannah Sallis, Jonathan Evans, Robyn Wootton, Eva Krapohl, Albertine J Oldehinkel, George Davey Smith and Lavinia Paternoster

    Citation: BMC Psychiatry 2017 17:321

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  3. Content type: Research article

    A 12-week, double-blind, parallel, multi-center randomized controlled trial in 316 adult patients with major depressive disorder (MDD) was conducted to evaluate the effectiveness of pharmacogenetic (PGx) testi...

    Authors: Víctor Pérez, Ariana Salavert, Jordi Espadaler, Miquel Tuson, Jerónimo Saiz-Ruiz, Cristina Sáez-Navarro, Julio Bobes, Enrique Baca-García, Eduard Vieta, José M. Olivares, Roberto Rodriguez-Jimenez, José M. Villagrán, Josep Gascón, Josep Cañete-Crespillo, Montse Solé, Pilar A. Saiz…

    Citation: BMC Psychiatry 2017 17:250

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  4. Content type: Research article

    Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI...

    Authors: Yansong Liu, Zaohuo Cheng, Jun Wang, Chunhui Jin, Jianmin Yuan, Guoqiang Wang, Fuquan Zhang and Xudong Zhao

    Citation: BMC Psychiatry 2016 16:206

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  5. Content type: Research article

    It is common practice, when using quantitative real time polymerase chain reaction (qPCR), to normalise levels of mRNA to reference gene mRNA which, by definition, should not vary between tissue, with any dise...

    Authors: Brian Dean, Madhara Udawela and Elizabeth Scarr

    Citation: BMC Psychiatry 2016 16:154

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  6. Content type: Study protocol

    Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization a...

    Authors: Ketil J. Oedegaard, Martin Alda, Anit Anand, Ole A. Andreassen, Yokesh Balaraman, Wade H. Berrettini, Abesh Bhattacharjee, Kristen J. Brennand, Katherine E. Burdick, Joseph R. Calabrese, Cynthia V. Calkin, Ana Claasen, William H. Coryell, David Craig, Anna DeModena, Mark Frye…

    Citation: BMC Psychiatry 2016 16:129

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  7. Content type: Research article

    Several lines of evidence indicate mitochondrial impairment in the pathophysiology of autism. As one of the most common biomarkers for mitochondrial dysfunction, mitochondrial DNA (mtDNA) copy number has also ...

    Authors: Shan Chen, Zongchang Li, Ying He, Fengyu Zhang, Hong Li, Yanhui Liao, Zhen Wei, Guobin Wan, Xi Xiang, Maolin Hu, Kun Xia, Xiaogang Chen and Jinsong Tang

    Citation: BMC Psychiatry 2015 15:50

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  8. Content type: Research article

    There have been several reports suggesting that adverse childhood experiences such as physical maltreatment and long institutionalization influence telomere length. However, there has been no study examining t...

    Authors: Masanori Enokido, Akihito Suzuki, Ryoichi Sadahiro, Yoshihiko Matsumoto, Fumikazu Kuwahata, Nana Takahashi, Kaoru Goto and Koichi Otani

    Citation: BMC Psychiatry 2014 14:277

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  9. Content type: Research article

    It is debatable whether or not glucocorticoid receptor (GR) polymorphisms moderate susceptibility to PTSD. Our objective was to examine the effects of stressful life events, social support, GR genotypes, and gene...

    Authors: Yulong Lian, Jing Xiao, Qian Wang, Li Ning, Suzhen Guan, Hua Ge, Fuye Li and Jiwen Liu

    Citation: BMC Psychiatry 2014 14:232

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  10. Content type: Research article

    It is widely acknowledged that suicidal behavior (SB) has a genetic influence. As a consequence, molecular genetic studies have been mostly conducted on serotonergic genes. One of the most promising candidate ...

    Authors: Thelma Beatriz González-Castro, Isela Juárez-Rojop, María Lilia López-Narváez and Carlos Alfonso Tovilla-Zárate

    Citation: BMC Psychiatry 2014 14:196

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  11. Content type: Study protocol

    Suicidal behavior is a leading cause of injury and death worldwide. Several studies have provided a possible relationship between genetic factors and suicidal behavior. Also, these studies have shown evidence ...

    Authors: Carlos Alfonso Tovilla-Zárate, Thelma Beatriz González-Castro, Isela Juárez-Rojop, Sherezada Pool García, Martha Patricia Velázquez-Sánchez, Mario Villar-Soto, Alma Genis, Humberto Nicolini, María Lilia López-Narváez and María Antonia Jiménez-Santos

    Citation: BMC Psychiatry 2014 14:29

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  12. Content type: Study protocol

    Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and str...

    Authors: Robert C Culverhouse, Lucy Bowes, Naomi Breslau, John I Nurnberger Jr, Margit Burmeister, David M Fergusson, Marcus Munafò, Nancy L Saccone and Laura J Bierut

    Citation: BMC Psychiatry 2013 13:304

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  13. Content type: Research article

    The Hermansky–Pudlak Syndrome Type 4 (HPS4) gene, which encodes a subunit protein of the biogenesis of lysosome-related organelles complex (BLOC)-3, which is involved in late endosomal trafficking, is associated ...

    Authors: Go Kuratomi, Atsushi Saito, Yuji Ozeki, Takashi Watanabe, Kumiko Fujii, Kazutaka Shimoda, Toshihiko Inukai, Harunobu Mori, Kenichi Ohmori and Kazufumi Akiyama

    Citation: BMC Psychiatry 2013 13:276

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  14. Content type: Research article

    Depressive Disorders (DD) are a great financial and social burden. Females display 70% higher rate of depression than males and more than 30% of these patients do not respond to conventional medications. Thus ...

    Authors: Eli Iacob, Kathleen C Light, Scott C Tadler, Howard R Weeks, Andrea T White, Ronald W Hughen, Timothy A VanHaitsma, Lowry Bushnell and Alan R Light

    Citation: BMC Psychiatry 2013 13:273

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  15. Content type: Research article

    Numerous genome-wide gene expression studies of bipolar disorder (BP) have been carried out. These studies are heterogeneous, underpowered and use overlapping samples. We conducted a systematic review of these...

    Authors: Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T Judy, Fernando S Goes, James B Potash and Peter P Zandi

    Citation: BMC Psychiatry 2013 13:213

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  16. Content type: Research article

    The serotonin transporter (5-HTT) gene may play an important role in the onset and development of mental disorders. Past studies have tested whether a functional polymorphism in the 5-HTT gene linked promoter ...

    Authors: Qing-sen Ming, Yun Zhang, Qiao-lian Chai, Hai-yan Chen, Chan-juan Hou, Meng-cheng Wang, Yu-ping Wang, Lin Cai, Xiong-zhao Zhu, Jin-yao Yi and Shu-qiao Yao

    Citation: BMC Psychiatry 2013 13:142

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  17. Content type: Research article

    The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present study was to exami...

    Authors: Thelma Beatriz González-Castro, Carlos Tovilla-Zárate, Isela Juárez-Rojop, Sherezada Pool García, Martha Patricia Velázquez-Sánchez, Alma Genis, Humberto Nicolini and Lilia López Narváez

    Citation: BMC Psychiatry 2013 13:25

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  18. Content type: Research article

    The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine...

    Authors: Carlos Tovilla-Zárate, Isela Juárez-Rojop, Teresa Ramón-Frias, Mario Villar-Soto, Sherezada Pool-García, Beatriz Camarena Medellín, Alma D Genis Mendoza, Lilia López Narvaez and Nicolini Humberto

    Citation: BMC Psychiatry 2011 11:151

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