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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Content type: Research article

    Childhood trauma (CT) has been found to contribute to the onset of schizophrenia and auditory sensory gating deficit is a leading endophenotype for schizophrenia. However, the association between the CT and se...

    Authors: Xian-Bin Li, Qi-Jing Bo, Qing Tian, Ning-Bo Yang, Zhen Mao, Wei Zheng, Yu-Jie Wen and Chuan-Yue Wang

    Citation: BMC Psychiatry 2018 18:258

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  2. Content type: Research article

    People with severe mental illness have markedly reduced life expectancy; cardiometabolic disease is a major cause. Psychiatric hospital inpatients have elevated levels of cardiometabolic risk factors and are t...

    Authors: Petter Andreas Ringen, Ragnhild S. Falk, Bjørnar Antonsen, Ann Faerden, Asgeir Mamen, Eline B. Rognli, Dag K. Solberg, Egil W. Martinsen and Ole A. Andreassen

    Citation: BMC Psychiatry 2018 18:255

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  3. Content type: Research article

    Treatment-resistant schizophrenia (TRS) affects about one-third of individuals with schizophrenia. People with TRS do not experience sustained symptom relief and at the same time have the most severe disease-r...

    Authors: Cecilia Brain, Steven Kymes, Dana B. DiBenedetti, Thomas Brevig and Dawn I. Velligan

    Citation: BMC Psychiatry 2018 18:253

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  4. Content type: Research article

    Community-based rehabilitation (CBR), or community-based inclusive development, is an approach to address the complex health, social and economic needs of people with schizophrenia in low and middle-income cou...

    Authors: Laura Asher, Charlotte Hanlon, Rahel Birhane, Alehegn Habtamu, Julian Eaton, Helen A. Weiss, Vikram Patel, Abebaw Fekadu and Mary De Silva

    Citation: BMC Psychiatry 2018 18:250

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  5. Content type: Research article

    Hyperprolactinemia and glucose and lipid metabolism abnormalities are often found in patients with schizophrenia and are generally considered secondary to the use of antipsychotic drugs. More recent studies ha...

    Authors: Maria Giuseppina Petruzzelli, Mariella Margari, Antonia Peschechera, Concetta de Giambattista, Andrea De Giacomo, Emilia Matera and Francesco Margari

    Citation: BMC Psychiatry 2018 18:246

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  6. Content type: Research article

    Immune dysfunction could play a significant role in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ), conditions with an underlying pro-inflammatory state. Studies on humoral immune responses (...

    Authors: Nora Hamdani, Djaouida Bengoufa, Ophélia Godin, Raphaël Doukhan, Emmanuel Le Guen, Claire Daban-Huard, Meriem Bennabi, Marine Delavest, Jean-Pierre Lépine, Wahid Boukouaci, Hakim Laouamri, Josselin Houenou, Stéphane Jamain, Jean-Romain Richard, Philippe Lecorvosier, Robert Yolken…

    Citation: BMC Psychiatry 2018 18:239

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  7. Content type: Research article

    There are interindividual differences in the adverse effects of atypical antipsychotics, which include autonomic nervous system (ANS) dysfunction. Accordingly, to clarify the interindividual differences in the...

    Authors: Saki Hattori, Akira Suda, Ikuko Kishida, Masatoshi Miyauchi, Yohko Shiraishi, Mami Fujibayashi, Natsuki Tsujita, Chie Ishii, Norio Ishii, Toshio Moritani, Masataka Taguri and Yoshio Hirayasu

    Citation: BMC Psychiatry 2018 18:231

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  8. Content type: Research article

    Widespread cortical gray matter alternations in people with schizophrenia are correlated with both psychotic symptoms and cognitive/behavioral abnormalities, including the impairments of exploratory eye moveme...

    Authors: Linlin Qiu, Hao Yan, Risheng Zhu, Jun Yan, Huishu Yuan, Yonghua Han, Weihua Yue, Lin Tian and Dai Zhang

    Citation: BMC Psychiatry 2018 18:226

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  9. Content type: Research article

    Anxiety and depressive symptoms and psychotic experiences constitute common features of emerging mental disorders in young people. Psychotic experiences and the ultra-high risk (UHR) state for psychosis appear...

    Authors: Kareen Heinze, Ashleigh Lin, Barnaby Nelson, Renate L. E. P. Reniers, Rachel Upthegrove, Latoya Clarke, Ayesha Roche, Angelique Lowrie and Stephen J. Wood

    Citation: BMC Psychiatry 2018 18:214

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  10. Content type: Research article

    Non-adherence to medication remains a major challenge in the long-term management of patients with schizophrenia. Next to lack of insight into the illness, adverse effects of antipsychotic drugs, cognitive def...

    Authors: Christian G. Widschwendter, Georg Kemmler, Maria A. Rettenbacher, Nursen Yalcin-Siedentopf and Alex Hofer

    Citation: BMC Psychiatry 2018 18:212

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  11. Content type: Research article

    A body of studies has focused on the olfactory impairment among people with schizophrenia. The effect of sex on this relationship has attracted the attention of researchers. These issues have not been studied ...

    Authors: Xiacan Chen, Jiajun Xu, Bin Li, Wanjun Guo, Jun Zhang and Junmei Hu

    Citation: BMC Psychiatry 2018 18:199

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  12. Content type: Research article

    Research on antepartum psychiatric morbidities investigating depressive and anxiety symptoms in expectant mothers and fathers is lacking in low- and middle-income countries. This study aimed to estimate the pr...

    Authors: Hashima E. Nasreen, Jamalludin Ab Rahman, Razman Mohd Rus, Mira Kartiwi, Rosnah Sutan and Maigun Edhborg

    Citation: BMC Psychiatry 2018 18:195

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  13. Content type: Research article

    Patients with schizophrenia have an increased prevalence of metabolic disturbances compared with the general population. However, the mechanisms underlying the metabolic side effects of antipsychotics are unkn...

    Authors: Shin Ono, Takuro Sugai, Yutaro Suzuki, Manabu Yamazaki, Kazutaka Shimoda, Takao Mori, Yuji Ozeki, Hiroshi Matsuda, Norio Sugawara, Norio Yasui-Furukori, Kurefu Okamoto, Toyoaki Sagae and Toshiyuki Someya

    Citation: BMC Psychiatry 2018 18:180

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  14. Content type: Research article

    The management of schizophrenia is evolving towards a more comprehensive model based on functional recovery. The concept of functional recovery goes beyond clinical remission and encompasses multiple aspects o...

    Authors: Guillermo Lahera, José L. Gálvez, Pedro Sánchez, Miguel Martínez-Roig, J. V. Pérez-Fuster, Paz García-Portilla, Berta Herrera and Miquel Roca

    Citation: BMC Psychiatry 2018 18:176

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  15. Content type: Research article

    Routinely monitoring of symptoms and medical needs can improve the diagnostics and treatment of medical problems, including psychiatric. However, several studies show that few clinicians use Routine Outcome Mo...

    Authors: Magda Tasma, Lukas O. Roebroek, Edith J. Liemburg, Henderikus Knegtering, Philippe A. Delespaul, Albert Boonstra, Marte Swart and Stynke Castelein

    Citation: BMC Psychiatry 2018 18:163

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  16. Content type: Research article

    People with severe mental illnesses (SMI) such as schizophrenia and bipolar disorder have an increased risk of developing type 2 diabetes and have poorer health outcomes than those with diabetes alone. To main...

    Authors: Kathleen Mulligan, Hayley McBain, Frederique Lamontagne-Godwin, Jacqui Chapman, Chris Flood, Mark Haddad, Julia Jones and Alan Simpson

    Citation: BMC Psychiatry 2018 18:165

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  17. Content type: Research article

    Schizophrenia and bipolar disorder are characterized by a high disease burden. Antipsychotic medication is an essential part of the treatment. However, non-adherence is a major problem. Our aim was to examine ...

    Authors: Ulrike Stentzel, Neeltje van den Berg, Lara N. Schulze, Thea Schwaneberg, Franziska Radicke, Jens M. Langosch, Harald J. Freyberger, Wolfgang Hoffmann and Hans-Jörgen Grabe

    Citation: BMC Psychiatry 2018 18:155

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  18. Content type: Research article

    Sexual dysfunction is remarkably prevalent amongst psychiatric patients than general population. This might be due to either the nature of the illness itself or the unwanted effect of the medication they are t...

    Authors: Tolesa Fanta, Kibrom Haile, Dessie Abebaw, Dawit Assefa and Getahun Hibdye

    Citation: BMC Psychiatry 2018 18:158

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  19. Content type: Research article

    People with psychosis struggle with decisions about their use of antipsychotics. They often want to reduce the dose or stop, while facing uncertainty regarding the effects these decisions will have on their tr...

    Authors: Yaara Zisman-Ilani, David Shern, Patricia Deegan, Julie Kreyenbuhl, Lisa Dixon, Robert Drake, William Torrey, Manish Mishra, Ksenia Gorbenko and Glyn Elwyn

    Citation: BMC Psychiatry 2018 18:142

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  20. Content type: Case report

    Multiple system atrophy (MSA) is an adult-onset, rare, and progressive neurodegenerative disorder characterized by a varying combination of autonomic failure, cerebellar ataxia, and parkinsonism. MSA is catego...

    Authors: Hiroshi Komatsu, Masaaki Kato, Teiko Kinpara, Takashi Ono and Yoshihisa Kakuto

    Citation: BMC Psychiatry 2018 18:141

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  21. Content type: Research article

    Motivational interviewing (MI) may be an effective intervention to improve medication adherence in patients with schizophrenia. However, for this patient group, mixed results have been found in randomized cont...

    Authors: Jos Dobber, Corine Latour, Lieuwe de Haan, Wilma Scholte op Reimer, Ron Peters, Emile Barkhof and Berno van Meijel

    Citation: BMC Psychiatry 2018 18:135

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  22. Content type: Research article

    The adverse impact of unhealthy lifestyle choices and the prescription of antipsychotic medications contribute to weight gain, poor cardiovascular health and reduced life expectancy for people with psychosis. ...

    Authors: Rebecca Pedley, Karina Lovell, Penny Bee, Tim Bradshaw, Judith Gellatly, Kate Ward, Adrine Woodham and Alison Wearden

    Citation: BMC Psychiatry 2018 18:111

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  23. Content type: Study protocol

    Evidence shows that internet-based self-help interventions are effective in reducing symptoms for a wide range of mental disorders. To date, online interventions treating psychotic disorders have been scarce, ...

    Authors: Nina Rüegg, Steffen Moritz, Thomas Berger, Thies Lüdtke and Stefan Westermann

    Citation: BMC Psychiatry 2018 18:102

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  24. Content type: Research article

    Early diagnosis of schizophrenia could improve the outcome of the illness. Unlike classical between-group comparisons, machine learning can identify subtle disease patterns on a single subject level, which cou...

    Authors: Pavol Mikolas, Jaroslav Hlinka, Antonin Skoch, Zbynek Pitra, Thomas Frodl, Filip Spaniel and Tomas Hajek

    Citation: BMC Psychiatry 2018 18:97

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  25. Content type: Research article

    Speech recognition under noisy “cocktail-party” environments involves multiple perceptual/cognitive processes, including target detection, selective attention, irrelevant signal inhibition, sensory/working mem...

    Authors: Yingjun Zheng, Chao Wu, Juanhua Li, Ruikeng Li, Hongjun Peng, Shenglin She, Yuping Ning and Liang Li

    Citation: BMC Psychiatry 2018 18:90

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  26. Content type: Research article

    Nesfatin-1 plays a role in the regulation of emotional states like depression. The aim of this study was to investigate the plasma nesfatin-1levels in Chinese patients with depression and healthy subjects, and...

    Authors: Min-Min Xiao, Jiang-Bo Li, Lan-Lan Jiang, Hui Shao and Bao-Long Wang

    Citation: BMC Psychiatry 2018 18:88

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  27. Content type: Research article

    Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects...

    Authors: Tsubasa Morimoto, Yasuhiro Matsuda, Kiwamu Matsuoka, Fumihiko Yasuno, Emi Ikebuchi, Hiroyuki Kameda, Toshiaki Taoka, Toshiteru Miyasaka, Kimihiko Kichikawa and Toshifumi Kishimoto

    Citation: BMC Psychiatry 2018 18:83

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  28. Content type: Research article

    Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate d...

    Authors: Jinming Li, Yuan Yang, Yuankai Zhu, Liqiang Zhou, Yunfeng Han, Tao Yin, Zhaoting Cheng, Guopeng Zhang, Yanxia Shen and Jing Chen

    Citation: BMC Psychiatry 2018 18:70

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  29. Content type: Case report

    Ritualistic behaviors are common in obsessive compulsive disorder (OCD), while catatonic stupor occasionally occurs in psychotic or mood disorders. Schizoaffective disorder is a specific mental disorder involv...

    Authors: Yuanhan Bai, Xi Yang, Zhiqiang Zeng and Haichen Yang

    Citation: BMC Psychiatry 2018 18:67

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  30. Content type: Research article

    Personality is considered as an important aspect in persons with psychotic disorders. Several studies have investigated personality in schizophrenia. However, no study has investigated stability of personality...

    Authors: Tomas Fagerberg, Erik Söderman, J. Petter Gustavsson, Ingrid Agartz and Erik G. Jönsson

    Citation: BMC Psychiatry 2018 18:54

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  31. Content type: Research article

    Patients with schizophrenia have the highest known rates of cigarette smoking, but less is known about their smoking behavior and the differences across geographical regions, including Croatia.

    Authors: Marina Šagud, Bjanka Vuksan-Ćusa, Nenad Jakšić, Alma Mihaljević-Peleš, Maja Živković, Suzana Vlatković, Tea Prgić, Darko Marčinko and Wei Wang

    Citation: BMC Psychiatry 2018 18:18

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  32. Content type: Research article

    The process of assessing the decision-making capacity of potential subjects before their inclusion in clinical trials is a legal requirement and a moral obligation, as it is essential for respecting their auto...

    Authors: Sorin Hostiuc, Mugurel Constantin Rusu, Ionut Negoi and Eduard Drima

    Citation: BMC Psychiatry 2018 18:2

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  33. Content type: Research article

    This study investigated the prevalence of schizophrenia (ICD-10 F 20) and of other non-affective psychosis (NAP, ICD-10 F 21 - F 29) in Sweden. It further assessed health care use, comorbidity and medication f...

    Authors: Erica M. Brostedt, Mussie Msghina, Marie Persson and Björn Wettermark

    Citation: BMC Psychiatry 2017 17:416

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  34. Content type: Research article

    People with psychosis have a reduced life expectancy of 10–20 years, largely due to cardiovascular disease. This trial aimed to determine the effectiveness of a modular health promotion intervention (IMPaCT Th...

    Authors: Fiona Gaughran, Daniel Stahl, Khalida Ismail, Kathryn Greenwood, Zerrin Atakan, Poonam Gardner-Sood, Brendon Stubbs, David Hopkins, Anita Patel, John Lally, Philippa Lowe, Maurice Arbuthnot, Diana Orr, Sarah Corlett, Jonas Eberhard, Anthony S. David…

    Citation: BMC Psychiatry 2017 17:413

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  35. Content type: Research article

    Schizophrenia has a negative effect on the activity of the temporal and prefrontal cortices in the processing of emotional facial expressions. However no previous research focused on the evaluation of mixed em...

    Authors: Ádám György Szabó, Kinga Farkas, Csilla Marosi, Lajos R. Kozák, Gábor Rudas, János Réthelyi and Gábor Csukly

    Citation: BMC Psychiatry 2017 17:391

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  36. Content type: Research article

    Biomarkers are now widely used in many fields of medicine, and the identification of biomarkers that predict antipsychotic efficacy and adverse reactions is a growing area of psychiatric research. Monoamine mo...

    Authors: A. E. Taraskina, R. F. Nasyrova, A. M. Zabotina, D. N. Sosin, К. А. Sosina, E. E. Ershov, M. N. Grunina and E. M. Krupitsky

    Citation: BMC Psychiatry 2017 17:394

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  37. Content type: Research article

    Psychotic disorders are among the most severe psychiatric disorders that have great effects on the individuals and the society. For surveillance of chronic low prevalence conditions such as psychotic disorders...

    Authors: Christine Chan Chee, Francis Chin, Catherine Ha, Nathalie Beltzer and Christophe Bonaldi

    Citation: BMC Psychiatry 2017 17:386

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  38. Content type: Research article

    This study evaluates the psychometric properties of the Malay version of the Brief Psychiatric Rating Scale (BPRS-M) among patients with schizophrenia in a psychiatric outpatient clinic.

    Authors: Anne Yee, Boon Seng Ng, Helenna Maria Hisham Hashim, Mahmoud Danaee and Huai Heng Loh

    Citation: BMC Psychiatry 2017 17:384

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  39. Content type: Research article

    Cognitive deficits are a core feature of early schizophrenia. However, the pathological foundations underlying cognitive deficits are still unknown. The present study examined the association between gray matt...

    Authors: Jingjuan Wang, Li Zhou, Chunlei Cui, Zhening Liu and Jie Lu

    Citation: BMC Psychiatry 2017 17:374

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  40. Content type: Research article

    Antipsychotics have serious metabolic side effects on blood glucose. However, the comparative influence of these drugs on blood glucose levels has not been comprehensively evaluated. We conducted a network met...

    Authors: Yangyu Zhang, Yingyu Liu, Yingying Su, Yueyue You, Yue Ma, Guang Yang, Yan Song, Xinyu Liu, Mohan Wang, Lili Zhang and Changgui Kou

    Citation: BMC Psychiatry 2017 17:373

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  41. Content type: Research article

    There is consensus that the treatment of schizophrenia should combine anti-psychotic medication and psychosocial interventions in order to address complex social, economic and health needs. It is recommended t...

    Authors: Laura Asher, Vikram Patel and Mary J De Silva

    Citation: BMC Psychiatry 2017 17:355

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  42. Content type: Research article

    Nonadherence to antipsychotic treatment increases the likelihood of relapse and progressive symptomatology in patients with schizophrenia. Atypical long-acting injectables, including paliperidone palmitate (PP...

    Authors: Jeffrey P. Anderson, Zeynep Icten, Veronica Alas, Carmela Benson and Kruti Joshi

    Citation: BMC Psychiatry 2017 17:346

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  43. Content type: Case report

    Periodic catatonia has long been a challenging diagnosis and there are no absolute guidelines for treatment when precipitating factors are also unclear. We report a schizophrenia patient with periodic catatoni...

    Authors: Ruei-An Chen and Tiao-Lai Huang

    Citation: BMC Psychiatry 2017 17:337

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  44. Content type: Case report

    Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease involving antibodies against the NR1 subunits of NMDARs. The disease shows variable clinical presentation, and involves new-onse...

    Authors: Xia Rong, Zhenzhen Xiong, Bingrong Cao, Juan Chen, Mingli Li and Zhe Li

    Citation: BMC Psychiatry 2017 17:320

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  45. Content type: Case report

    The choice of antipsychotic treatment during pregnancy remains controversial, mainly due to a lack of exposure and outcome data. Randomized clinical trials are practically impossible due to ethical reasons. Ou...

    Authors: Andreea Teodorescu, Petru Ifteni, Marius Alexandru Moga, Victoria Burtea and Nicusor Bigiu

    Citation: BMC Psychiatry 2017 17:311

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  46. Content type: Research article

    Schizophrenia is a chronic and debilitating neuropsychiatric disorder that often requires long-term pharmacotherapy to manage symptoms and prevent relapse. Cariprazine is a potent dopamine D3 and D2 receptor part...

    Authors: Henry A. Nasrallah, Willie Earley, Andrew J. Cutler, Yao Wang, Kaifeng Lu, István Laszlovszky, György Németh and Suresh Durgam

    Citation: BMC Psychiatry 2017 17:305

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  47. Content type: Research article

    Non-adherence is a major public health problem despite treatment advances. Poor drug adherence in patients with psychosis is associated with more frequent relapse, re-hospitalization, increased consumption of ...

    Authors: Rafal A. H. Yeisen, Jone Bjornestad, Inge Joa, Jan Olav Johannessen and Stein Opjordsmoen

    Citation: BMC Psychiatry 2017 17:299

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  48. Content type: Research article

    Mental health is a significant contributor to global burden of disease and the consequences of perinatal psychiatric morbidity can be substantial. We aimed to obtain global estimates of puerperal psychosis pre...

    Authors: Rachel VanderKruik, Maria Barreix, Doris Chou, Tomas Allen, Lale Say and Lee S. Cohen

    Citation: BMC Psychiatry 2017 17:272

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