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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Schizophrenia is associated with severe cognitive deficits, particularly episodic memory deficits, that interfere with patients’ socio-professional functioning. Retrieval practice (also known as testing effect) i...

    Authors: Camille Jantzi, Amaury C. Mengin, David Serfaty, Elisabeth Bacon, Julien Elowe, François Severac, Nicolas Meyer, Fabrice Berna and Pierre Vidailhet

    Citation: BMC Psychiatry 2019 19:355

    Content type: Research article

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  3. Negative symptoms (NS) may be observed in the general population in an attenuated form and in high-risk mental states. However, they have been less studied in the general population than positive symptoms, in ...

    Authors: Juan F. Rodríguez-Testal, Salvador Perona-Garcelán, Sonia Dollfus, María Valdés-Díaz, Jesús García-Martínez, Miguel Ruíz-Veguilla and Cristina Senín-Calderón

    Citation: BMC Psychiatry 2019 19:327

    Content type: Research article

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  4. The “treatment gap” (TG) for mental disorders, widely advocated by the WHO in low-and middle-income countries, is an important indicator of the extent to which a health system fails to meet the care needs of p...

    Authors: Abebaw Fekadu, Girmay Medhin, Crick Lund, Mary DeSilva, Medhin Selamu, Atalay Alem, Laura Asher, Rahel Birhane, Vikram Patel, Maji Hailemariam, Teshome Shibre, Graham Thornicroft, Martin Prince and Charlotte Hanlon

    Citation: BMC Psychiatry 2019 19:325

    Content type: Research article

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  5. Numerous studies have reported contradicting results on the relationship between cancer mortality and schizophrenia. Our aim is to quantify the mortality rate of common site-specific cancers among patients wit...

    Authors: Liwei Ni, Jian Wu, Yuming Long, Jialong Tao, Jianhao Xu, Xuya Yuan, Na Yu, Runhong Wu and Yusong Zhang

    Citation: BMC Psychiatry 2019 19:323

    Content type: Research article

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  6. For women in most low- and middle-income countries, the diagnosis with serious mental illness (SMI) leads to stigma and challenges related to starting or maintaining marriages. The purpose of this qualitative ...

    Authors: Maji Hailemariam, Senait Ghebrehiwet, Tithi Baul, Juliana L. Restivo, Teshome Shibre, David C. Henderson, Eshetu Girma, Abebaw Fekadu, Solomon Teferra, Charlotte Hanlon, Jennifer E. Johnson and Christina P. C. Borba

    Citation: BMC Psychiatry 2019 19:315

    Content type: Research article

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  7. N-methyl-D-aspartate receptor (NMDAR) hypofunction has been proposed to underlie the pathogenesis of schizophrenia. Specifically, reduced function of NMDARs leads to altered balance between excitation and inhi...

    Authors: Lulu Yao, Zongliang Wang, Di Deng, Rongzhen Yan, Jun Ju and Qiang Zhou

    Citation: BMC Psychiatry 2019 19:314

    Content type: Research article

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  8. A key component of case-management in early intervention services for first-episode psychosis is engaging a person with the service and building a relationship from which therapy and treatment can be facilitat...

    Authors: Rachel M. Tindall, Kelly Allott, Magenta Simmons, Winsome Roberts and Bridget E. Hamilton

    Citation: BMC Psychiatry 2019 19:312

    Content type: Research article

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  9. The aim of present study is to measure plasma clozapine (CLZ) and N-desmethyl clozapine (DMC) as biomarkers to correlate drug concentrations with the appearance of preclinical adverse hematic effects.

    Authors: Mayela Vaquero-Baez, Araceli Díaz-Ruíz, Luis Tristán-López, Carlos Aviña-Cervantes, Carlos Torner, Jesús Ramírez-Bermúdez, Sergio Montes and Camilo Ríos

    Citation: BMC Psychiatry 2019 19:295

    Content type: Research article

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  10. Schizophrenia is a severe mental disease with high morbidity and heritability. The SLC39A8 gene is located in 4q24 and encodes a protein that transports many metal ions. Multiple previous studies found that one o...

    Authors: Xuemin Jian, Jianhua Chen, Zhiqiang Li, Zhijian Song, Juan Zhou, Wei Xu, Yahui Liu, Jiawei Shen, Yonggang Wang, Qizhong Yi and Yongyong Shi

    Citation: BMC Psychiatry 2019 19:293

    Content type: Research article

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  11. Problems in social functioning (e.g., unemployment, social isolation), are common in people with a psychotic disorder. Social cognition is a treatment target to improve social functioning, as it is a proximal ...

    Authors: Saskia A. Nijman, Wim Veling, Kirstin Greaves-Lord, Rowina R. Vermeer, Maarten Vos, Catharina E. R. Zandee, Daniëlle C. Zandstra, Chris N. W. Geraets and Gerdina H. M. Pijnenborg

    Citation: BMC Psychiatry 2019 19:272

    Content type: Study protocol

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  12. The goal of clinicians and healthcare workers providing treatment to patients with psychiatric disorders, has shifted over time from focusing on the symptoms alone towards functional improvement. In this study...

    Authors: Xiao Wei Tan, Esmond Seow, Edimansyah Abdin, Swapna Verma, Kang Sim, Siow Ann Chong and Mythily Subramaniam

    Citation: BMC Psychiatry 2019 19:267

    Content type: Research article

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  13. To measure the serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in deficit schizophrenia (DS), in order to examine the association between these t...

    Authors: Xiaowei Tang, Chao Zhou, Ju Gao, Weiwei Duan, Miao Yu, Wenhuan Xiao, Xiaobin Zhang, Hui Dong, Xiang Wang and Xiangrong Zhang

    Citation: BMC Psychiatry 2019 19:254

    Content type: Research article

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  14. Previous studies have suggested that culture impacts the experience of psychosis. The current study set out to extend these findings by examining cultural variation in subclinical positive psychotic experience...

    Authors: Margriet Vermeiden, Mayke Janssens, Viviane Thewissen, Esther Akinsola, Sanne Peeters, Jennifer Reijnders, Nele Jacobs, Jim van Os and Johan Lataster

    Citation: BMC Psychiatry 2019 19:244

    Content type: Research article

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  15. People who suffer a first episode of psychosis experience higher levels of distress and suffering. Early intervention programs combine pharmacological and psychosocial strategies that include different compone...

    Authors: Roberto Mediavilla, Ainoa Muñoz-Sanjose, Beatriz Rodriguez-Vega, Carmen Bayon, Angela Palao, Guillermo Lahera, Pilar Sanchez-Castro, Eva Roman, Susana Cebolla, Alvaro de Diego, Juan Manuel Pastor and Maria Fe Bravo-Ortiz

    Citation: BMC Psychiatry 2019 19:233

    Content type: Study protocol

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  16. Cognitive Bias Modification (CBM) has been used successfully as a computer-based intervention in disorders such as anxiety. However, CBM to modify interpretations of ambiguous information relevant to paranoia ...

    Authors: C. J. Leung, A. Fosuaah, J. Frerichs, M. Heslin, T. Kabir, T. M. C. Lee, P. McGuire, C. Meek, E. Mouchlianitis, A. S. Nath, E. Peters, S. Shergill, D. Stahl, A. Trotta and J. Yiend

    Citation: BMC Psychiatry 2019 19:225

    Content type: Research article

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  17. One of the most important questions remaining in matters of critical illness in the year 2019 is arguably how to address the diverse neuropsychiatric complications of critical illness.

    Authors: Jan N. M. Schieveld, Emma H. C. W. van de Riet and Jacqueline J. M. H. Strik

    Citation: BMC Psychiatry 2019 19:222

    Content type: Debate

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  18. Among patients with treatment-resistant schizophrenia (TRS), some exhibited further clozapine resistance (CR). This study aimed to investigate whether greater severity of treatment resistance in schizophrenia ...

    Authors: An-Sheng Lin, Hung-Yu Chan, Ying-Chieh Peng and Wei J. Chen

    Citation: BMC Psychiatry 2019 19:220

    Content type: Research article

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  19. Sexual dysfunction is common in patients with schizophrenia, however it is poorly studied in China, especially in primary health care institutions in rural areas. We investigated the prevalence of sexual dysfu...

    Authors: Ying-Hua Huang, Cai-Lan Hou, C. H. Ng, Xie Chen, Qian-Wen Wang, Zhuo-Hui Huang and Fu-Jun Jia

    Citation: BMC Psychiatry 2019 19:218

    Content type: Research article

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  20. Data on the pharmacological management of acute agitation in schizophrenia are scarce. The aim of this study is to investigate the prescription practices in the treatment of agitation in Chinese patients with ...

    Authors: Su-Zhen Zhang, Yong-Gang Mu, Qi Liu, Ying Shi, Li-Hua Guo, Ling-Zhi Li, Fu-De Yang, Yong Wang, Tao Li, Qi-Yi Mei, Hong-Bo He, Zhi-Yu Chen, Zhong-Hua Su, Tie-Bang Liu, Shi-Ping Xie, Qing-Rong Tan…

    Citation: BMC Psychiatry 2019 19:216

    Content type: Research article

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  21. Past studies have focused primarily on clinical insight and less on cognitive insight among individuals with mental illness.

    Authors: Vathsala Sagayadevan, Anitha Jeyagurunathan, Ying Wen Lau, Saleha Shafie, Sherilyn Chang, Hui Lin Ong, Ellaisha Samari, Swapna Kamal Verma, Siow Ann Chong and Mythily Subramaniam

    Citation: BMC Psychiatry 2019 19:201

    Content type: Research article

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  22. Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been rep...

    Authors: Hong-yi He, Jin-lan Tian, Yong-qiong Deng, Xia Xiong, Yang Xu, Yong-mei Liao, Jing Fang, Xia Feng, Xin Ye and Chang-qiang Li

    Citation: BMC Psychiatry 2019 19:193

    Content type: Research article

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  23. Burgeoning evidence suggests that exercise improves physical and mental health in people with schizophrenia. However, little is known about the feasibility and acceptability of high-intensity training in patie...

    Authors: Lene Q. Larsen, Helle Schnor, Britt P. Tersbøl, Bjørn H. Ebdrup, Nikolai B. Nordsborg and Julie Midtgaard

    Citation: BMC Psychiatry 2019 19:192

    Content type: Research article

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  24. Internet-based interventions can make self-management and recovery-oriented information and tools more accessible for people experiencing severe mental illness, including psychosis. The aim of this scoping rev...

    Authors: Anne Williams, John Farhall, Ellie Fossey and Neil Thomas

    Citation: BMC Psychiatry 2019 19:191

    Content type: Research article

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  25. The effect of antipsychotic (AP) drugs on risk of stroke and myocardial infarction (MI) remains unclear due to methodological limitations of, and inconsistencies across, existing studies. We aimed to systemati...

    Authors: Sanja Zivkovic, Chan Hee Koh, Nandita Kaza and Caroline A. Jackson

    Citation: BMC Psychiatry 2019 19:189

    Content type: Research article

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  26. Shared decision making (SDM) is often defined as an interactive process that ensures that both patient and practitioner are actively involved in the treatment and that they share all relevant information to ar...

    Authors: Tobias Vitger, Stephen F. Austin, Lone Petersen, Esben S. Tønder, Merete Nordentoft and Lisa Korsbek

    Citation: BMC Psychiatry 2019 19:185

    Content type: Study protocol

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  27. Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is a severe autoimmune condition, which typically affects young females. The long-term clinical consequences and brain morphology changes after anti-NMDA...

    Authors: Heikki Laurikainen, Iina Isotupa, Mikko Nyman, Tuula Ilonen, Teija Nummelin, Raimo K. R. Salokangas and Jarmo Hietala

    Citation: BMC Psychiatry 2019 19:145

    Content type: Case report

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  28. Over the past decades research has shown that employment has a positive impact on quality of life, global functioning and recovery in individuals with schizophrenia. However, access to vocational rehabilitatio...

    Authors: Stig Evensen, Torbjørn Wisløff, June Ullevoldsæter Lystad, Helen Bull, Egil W. Martinsen, Torill Ueland and Erik Falkum

    Citation: BMC Psychiatry 2019 19:140

    Content type: Research article

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  29. With previously established efficacy of aripiprazole once-monthly injectable formulation (AOM) in pre-registration randomized controlled trials, the current study was designed to evaluate its effectiveness in ...

    Authors: Sally Mustafa, Joanna Bougie, Maia Miguelez, Guerline Clerzius, Emmanouil Rampakakis, Jean Proulx and Ashok Malla

    Citation: BMC Psychiatry 2019 19:114

    Content type: Research article

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  30. Oculomotor dysfunction is one of the most replicated findings in schizophrenia. However the association between saccadic abnormalities and particular clinical syndromes remains unclear. The assessment of sacca...

    Authors: Ilya Obyedkov, Maryna Skuhareuskaya, Oleg Skugarevsky, Victor Obyedkov, Pavel Buslauski, Tatsiana Skuhareuskaya and Napoleon Waszkiewicz

    Citation: BMC Psychiatry 2019 19:110

    Content type: Research article

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  31. Based on genome-wide association studies, a single-nucleotide polymorphism in the NRGN gene (rs12807809) is considered associated with schizophrenia (SZ). Moreover, hippocampal dysfunction is associated with r...

    Authors: Yifan Zhang, Xiaohong Gong, Zhiyang Yin, Lingling Cui, Jian Yang, Pengshuo Wang, Yifang Zhou, Xiaowei Jiang, Shengnan Wei, Fei Wang and Yanqing Tang

    Citation: BMC Psychiatry 2019 19:108

    Content type: Research article

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  32. This study determined the effects of a novel combination of vitamin D and probiotic on metabolic and clinical symptoms in chronic schizophrenia.

    Authors: Amir Ghaderi, Hamid Reza Banafshe, Naghmeh Mirhosseini, Mohamad Moradi, Mohammad-Amin Karimi, Fateme Mehrzad, Fereshteh Bahmani and Zatollah Asemi

    Citation: BMC Psychiatry 2019 19:77

    Content type: Research article

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  33. Cardiometabolic health significantly impacts on the mortality of people with severe mental illness. Clozapine has the greatest efficacy for Treatment Resistant Schizophrenia (TRS) but the greatest negative imp...

    Authors: Alex Till and Ed Silva

    Citation: BMC Psychiatry 2019 19:37

    Content type: Case report

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  34. The development of digital health interventions (DHIs) for severe mental health problems is fast-paced. Researchers are beginning to consult service users to inform DHIs; however, much of this involvement has ...

    Authors: Natalie Berry, Fiona Lobban and Sandra Bucci

    Citation: BMC Psychiatry 2019 19:35

    Content type: Research article

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  35. First-generation antipsychotics (FGAs) are associated with a range of adverse events which can significantly reduce patients’ quality of life and contribute to non-adherence. The aim of this study was to asses...

    Authors: Yirgalem Shewakena Wubeshet, Oumer Sada Mohammed and Tigestu Alemu Desse

    Citation: BMC Psychiatry 2019 19:32

    Content type: Research article

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  36. Cognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two inde...

    Authors: Pengshuo Wang, Jian Yang, Zhiyang Yin, Jia Duan, Ran Zhang, Jiaze Sun, Yixiao Xu, Luyu Liu, Xuemei Chen, Huizi Li, Jiahui Kang, Yue Zhu, Xin Deng, Miao Chang, Shengnan Wei, Yifang Zhou…

    Citation: BMC Psychiatry 2019 19:30

    Content type: Research article

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  37. Many people diagnosed with schizophrenia, bipolar or other psychoses in England receive the majority of their healthcare from primary care. Primary care practitioners may not be well equipped to meet their nee...

    Authors: Elina Baker, Ruth Gwernan-Jones, Nicky Britten, Maria Cox, Catherine McCabe, Ameeta Retzer, Laura Gill, Humera Plappert, Siobhan Reilly, Vanessa Pinfold, Linda Gask, Richard Byng and Max Birchwood

    Citation: BMC Psychiatry 2019 19:7

    Content type: Research article

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  38. People with a psychotic disorder have an increased risk of becoming the victim of a crime. To prevent victimization a body-oriented resilience therapy using kickboxing exercises was developed. This study aims ...

    Authors: Bertine de Vries, Elisabeth C. D. van der Stouwe, Clement O. Waarheid, Stefan H. J. Poel, Erwin M. van der Helm, André Aleman, Johan Arends, Gerdina H. M. Pijnenborg and Jooske T. van Busschbach

    Citation: BMC Psychiatry 2018 18:384

    Content type: Research article

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  39. By combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, this study aimed to explore brain functional alterations in Attenuated Psychosis Syndrome (APS), which could provide compleme...

    Authors: Xiangyun Long, Fei Liu, Nan Huang, Na Liu, Jie Zhang, Jing Chen, Ansi Qi, Xiaofeng Guan and Zheng Lu

    Citation: BMC Psychiatry 2018 18:383

    Content type: Research article

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  40. Cognitive behavioural therapy has been used for schizophrenia, but to which extent it is effective is still controversial. Results of existing meta-analyses are of difficult interpretation, because they mainly...

    Authors: Irene Bighelli, Maximilian Huhn, Johannes Schneider-Thoma, Marc Krause, Cornelia Reitmeir, Sofia Wallis, Felicitas Schwermann, Gabi Pitschel-Walz, Corrado Barbui, Toshi A. Furukawa and Stefan Leucht

    Citation: BMC Psychiatry 2018 18:380

    Content type: Research article

    Published on:

  41. The aims of this study were to explore the relationship between early reduction in psychotic symptoms and the ultimate response in patients with schizophrenia treated by atypical antipsychotics, and to determi...

    Authors: Yi-Lung Chen, Kun-Po Chen, Chih-Chiang Chiu, Ming-Hong Tai and For-Wey Lung

    Citation: BMC Psychiatry 2018 18:376

    Content type: Research article

    Published on:

  42. Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, a...

    Authors: Changjun Teng, Jing Zhou, Hui Ma, Yarong Tan, Xin Wu, Chengbin Guan, Huifen Qiao, Jijun Li, Yuan Zhong, Chun Wang and Ning Zhang

    Citation: BMC Psychiatry 2018 18:370

    Content type: Research article

    Published on:

  43. In this study, the treatment of schizophrenia patients with aripiprazole once-monthly (AOM) was evaluated under real-life conditions in a naturalistic setting.

    Authors: Daniel Schöttle, Wolfgang Janetzky, Daniel Luedecke, Elmar Beck, Christoph U. Correll and Klaus Wiedemann

    Citation: BMC Psychiatry 2018 18:365

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Psychiatry 2018 18:389

  45. Mental health clinicians have previously been reported to express reservations regarding the utility and accuracy of the psychiatric classification systems. In this study we aimed to examine clinicians’ experi...

    Authors: Dana Tzur Bitan, Ariella Grossman Giron, Gady Alon, Shlomo Mendlovic, Yuval Bloch and Aviv Segev

    Citation: BMC Psychiatry 2018 18:317

    Content type: Research article

    Published on:

  46. Data are limited on the benefits and risks of dose reduction in managing side effects associated with antipsychotic treatment. As an example, antipsychotic dose reduction has been recommended in the management...

    Authors: Stanley N. Caroff, Fan Mu, Rajeev Ayyagari, Traci Schilling, Victor Abler and Benjamin Carroll

    Citation: BMC Psychiatry 2018 18:306

    Content type: Research article

    Published on:

  47. Despite the availability of numerous antipsychotic medications, many patients with schizophrenia continue to experience side effects that contribute to the overall burden of the illness. The present survey of ...

    Authors: Eric Achtyes, Adam Simmons, Anna Skabeev, Nikki Levy, Ying Jiang, Patricia Marcy and Peter J. Weiden

    Citation: BMC Psychiatry 2018 18:292

    Content type: Research article

    Published on:

  48. In recent decades atypical antipsychotics have increased treatment options available for schizophrenia, however there is conflicting evidence concerning the trade-off between clinical efficacy and side effects...

    Authors: Rossela Roberts, Abigail Neasham, Chania Lambrinudi and Afshan Khan

    Citation: BMC Psychiatry 2018 18:290

    Content type: Research article

    Published on:

  49. Amisulpride was introduced into China in 2010 as a second-generation atypical antipsychotic, while olanzapine has been on the market since 1999 as one of the leading treatments for schizophrenia in China. Sinc...

    Authors: Peng Men, Zhanmiao Yi, Chaoyun Li, Shuli Qu, Tengbin Xiong, Xin Yu and Suodi Zhai

    Citation: BMC Psychiatry 2018 18:286

    Content type: Research article

    Published on:

  50. Approximately one-third of schizophrenia patients eventually develop treatment-resistant schizophrenia (TRS). Although the time course of TRS development varies from patient to patient, the details of these va...

    Authors: Nobuhisa Kanahara, Hiroshi Yamanaka, Tomotaka Suzuki, Masayuki Takase and Masaomi Iyo

    Citation: BMC Psychiatry 2018 18:274

    Content type: Research article

    Published on:

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