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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Content type: Research article

    This study determined the effects of a novel combination of vitamin D and probiotic on metabolic and clinical symptoms in chronic schizophrenia.

    Authors: Amir Ghaderi, Hamid Reza Banafshe, Naghmeh Mirhosseini, Mohamad Moradi, Mohammad-Amin Karimi, Fateme Mehrzad, Fereshteh Bahmani and Zatollah Asemi

    Citation: BMC Psychiatry 2019 19:77

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  2. Content type: Case report

    Cardiometabolic health significantly impacts on the mortality of people with severe mental illness. Clozapine has the greatest efficacy for Treatment Resistant Schizophrenia (TRS) but the greatest negative imp...

    Authors: Alex Till and Ed Silva

    Citation: BMC Psychiatry 2019 19:37

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  3. Content type: Research article

    The development of digital health interventions (DHIs) for severe mental health problems is fast-paced. Researchers are beginning to consult service users to inform DHIs; however, much of this involvement has ...

    Authors: Natalie Berry, Fiona Lobban and Sandra Bucci

    Citation: BMC Psychiatry 2019 19:35

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  4. Content type: Research article

    First-generation antipsychotics (FGAs) are associated with a range of adverse events which can significantly reduce patients’ quality of life and contribute to non-adherence. The aim of this study was to asses...

    Authors: Yirgalem Shewakena Wubeshet, Oumer Sada Mohammed and Tigestu Alemu Desse

    Citation: BMC Psychiatry 2019 19:32

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  5. Content type: Research article

    Cognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two inde...

    Authors: Pengshuo Wang, Jian Yang, Zhiyang Yin, Jia Duan, Ran Zhang, Jiaze Sun, Yixiao Xu, Luyu Liu, Xuemei Chen, Huizi Li, Jiahui Kang, Yue Zhu, Xin Deng, Miao Chang, Shengnan Wei, Yifang Zhou…

    Citation: BMC Psychiatry 2019 19:30

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  6. Content type: Research article

    Many people diagnosed with schizophrenia, bipolar or other psychoses in England receive the majority of their healthcare from primary care. Primary care practitioners may not be well equipped to meet their nee...

    Authors: Elina Baker, Ruth Gwernan-Jones, Nicky Britten, Maria Cox, Catherine McCabe, Ameeta Retzer, Laura Gill, Humera Plappert, Siobhan Reilly, Vanessa Pinfold, Linda Gask, Richard Byng and Max Birchwood

    Citation: BMC Psychiatry 2019 19:7

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  7. Content type: Research article

    People with a psychotic disorder have an increased risk of becoming the victim of a crime. To prevent victimization a body-oriented resilience therapy using kickboxing exercises was developed. This study aims ...

    Authors: Bertine de Vries, Elisabeth C. D. van der Stouwe, Clement O. Waarheid, Stefan H. J. Poel, Erwin M. van der Helm, André Aleman, Johan Arends, Gerdina H. M. Pijnenborg and Jooske T. van Busschbach

    Citation: BMC Psychiatry 2018 18:384

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  8. Content type: Research article

    By combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, this study aimed to explore brain functional alterations in Attenuated Psychosis Syndrome (APS), which could provide compleme...

    Authors: Xiangyun Long, Fei Liu, Nan Huang, Na Liu, Jie Zhang, Jing Chen, Ansi Qi, Xiaofeng Guan and Zheng Lu

    Citation: BMC Psychiatry 2018 18:383

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  9. Content type: Research article

    Cognitive behavioural therapy has been used for schizophrenia, but to which extent it is effective is still controversial. Results of existing meta-analyses are of difficult interpretation, because they mainly...

    Authors: Irene Bighelli, Maximilian Huhn, Johannes Schneider-Thoma, Marc Krause, Cornelia Reitmeir, Sofia Wallis, Felicitas Schwermann, Gabi Pitschel-Walz, Corrado Barbui, Toshi A. Furukawa and Stefan Leucht

    Citation: BMC Psychiatry 2018 18:380

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  10. Content type: Research article

    The aims of this study were to explore the relationship between early reduction in psychotic symptoms and the ultimate response in patients with schizophrenia treated by atypical antipsychotics, and to determi...

    Authors: Yi-Lung Chen, Kun-Po Chen, Chih-Chiang Chiu, Ming-Hong Tai and For-Wey Lung

    Citation: BMC Psychiatry 2018 18:376

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  11. Content type: Research article

    Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, a...

    Authors: Changjun Teng, Jing Zhou, Hui Ma, Yarong Tan, Xin Wu, Chengbin Guan, Huifen Qiao, Jijun Li, Yuan Zhong, Chun Wang and Ning Zhang

    Citation: BMC Psychiatry 2018 18:370

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  12. Content type: Research article

    In this study, the treatment of schizophrenia patients with aripiprazole once-monthly (AOM) was evaluated under real-life conditions in a naturalistic setting.

    Authors: Daniel Schöttle, Wolfgang Janetzky, Daniel Luedecke, Elmar Beck, Christoph U. Correll and Klaus Wiedemann

    Citation: BMC Psychiatry 2018 18:365

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    The Correction to this article has been published in BMC Psychiatry 2018 18:389

  14. Content type: Research article

    Mental health clinicians have previously been reported to express reservations regarding the utility and accuracy of the psychiatric classification systems. In this study we aimed to examine clinicians’ experi...

    Authors: Dana Tzur Bitan, Ariella Grossman Giron, Gady Alon, Shlomo Mendlovic, Yuval Bloch and Aviv Segev

    Citation: BMC Psychiatry 2018 18:317

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  15. Content type: Research article

    Data are limited on the benefits and risks of dose reduction in managing side effects associated with antipsychotic treatment. As an example, antipsychotic dose reduction has been recommended in the management...

    Authors: Stanley N. Caroff, Fan Mu, Rajeev Ayyagari, Traci Schilling, Victor Abler and Benjamin Carroll

    Citation: BMC Psychiatry 2018 18:306

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  16. Content type: Research article

    Despite the availability of numerous antipsychotic medications, many patients with schizophrenia continue to experience side effects that contribute to the overall burden of the illness. The present survey of ...

    Authors: Eric Achtyes, Adam Simmons, Anna Skabeev, Nikki Levy, Ying Jiang, Patricia Marcy and Peter J. Weiden

    Citation: BMC Psychiatry 2018 18:292

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  17. Content type: Research article

    In recent decades atypical antipsychotics have increased treatment options available for schizophrenia, however there is conflicting evidence concerning the trade-off between clinical efficacy and side effects...

    Authors: Rossela Roberts, Abigail Neasham, Chania Lambrinudi and Afshan Khan

    Citation: BMC Psychiatry 2018 18:290

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  18. Content type: Research article

    Amisulpride was introduced into China in 2010 as a second-generation atypical antipsychotic, while olanzapine has been on the market since 1999 as one of the leading treatments for schizophrenia in China. Sinc...

    Authors: Peng Men, Zhanmiao Yi, Chaoyun Li, Shuli Qu, Tengbin Xiong, Xin Yu and Suodi Zhai

    Citation: BMC Psychiatry 2018 18:286

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  19. Content type: Research article

    There is conflicting evidence on the association between antipsychotic polypharmacy and metabolic syndrome in schizophrenia. We conducted a review of published systematic reviews to evaluate evidence on the as...

    Authors: Sharea Ijaz, Blanca Bolea, Simon Davies, Jelena Savović, Alison Richards, Sarah Sullivan and Paul Moran

    Citation: BMC Psychiatry 2018 18:275

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  20. Content type: Research article

    Approximately one-third of schizophrenia patients eventually develop treatment-resistant schizophrenia (TRS). Although the time course of TRS development varies from patient to patient, the details of these va...

    Authors: Nobuhisa Kanahara, Hiroshi Yamanaka, Tomotaka Suzuki, Masayuki Takase and Masaomi Iyo

    Citation: BMC Psychiatry 2018 18:274

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  22. Content type: Study protocol

    While patient involvement in mental health care is repeatedly stressed in policy documents, there are actually few studies that evaluate person-centred care interventions within psychiatric services. We presen...

    Authors: Anneli Goulding, Katarina Allerby, Lilas Ali, Andreas Gremyr and Margda Waern

    Citation: BMC Psychiatry 2018 18:269

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  23. Content type: Research article

    Childhood trauma (CT) has been found to contribute to the onset of schizophrenia and auditory sensory gating deficit is a leading endophenotype for schizophrenia. However, the association between the CT and se...

    Authors: Xian-Bin Li, Qi-Jing Bo, Qing Tian, Ning-Bo Yang, Zhen Mao, Wei Zheng, Yu-Jie Wen and Chuan-Yue Wang

    Citation: BMC Psychiatry 2018 18:258

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  24. Content type: Research article

    People with severe mental illness have markedly reduced life expectancy; cardiometabolic disease is a major cause. Psychiatric hospital inpatients have elevated levels of cardiometabolic risk factors and are t...

    Authors: Petter Andreas Ringen, Ragnhild S. Falk, Bjørnar Antonsen, Ann Faerden, Asgeir Mamen, Eline B. Rognli, Dag K. Solberg, Egil W. Martinsen and Ole A. Andreassen

    Citation: BMC Psychiatry 2018 18:255

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  25. Content type: Research article

    Treatment-resistant schizophrenia (TRS) affects about one-third of individuals with schizophrenia. People with TRS do not experience sustained symptom relief and at the same time have the most severe disease-r...

    Authors: Cecilia Brain, Steven Kymes, Dana B. DiBenedetti, Thomas Brevig and Dawn I. Velligan

    Citation: BMC Psychiatry 2018 18:253

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  26. Content type: Research article

    Community-based rehabilitation (CBR), or community-based inclusive development, is an approach to address the complex health, social and economic needs of people with schizophrenia in low and middle-income cou...

    Authors: Laura Asher, Charlotte Hanlon, Rahel Birhane, Alehegn Habtamu, Julian Eaton, Helen A. Weiss, Vikram Patel, Abebaw Fekadu and Mary De Silva

    Citation: BMC Psychiatry 2018 18:250

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  27. Content type: Research article

    Hyperprolactinemia and glucose and lipid metabolism abnormalities are often found in patients with schizophrenia and are generally considered secondary to the use of antipsychotic drugs. More recent studies ha...

    Authors: Maria Giuseppina Petruzzelli, Mariella Margari, Antonia Peschechera, Concetta de Giambattista, Andrea De Giacomo, Emilia Matera and Francesco Margari

    Citation: BMC Psychiatry 2018 18:246

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  28. Content type: Research article

    Immune dysfunction could play a significant role in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ), conditions with an underlying pro-inflammatory state. Studies on humoral immune responses (...

    Authors: Nora Hamdani, Djaouida Bengoufa, Ophélia Godin, Raphaël Doukhan, Emmanuel Le Guen, Claire Daban-Huard, Meriem Bennabi, Marine Delavest, Jean-Pierre Lépine, Wahid Boukouaci, Hakim Laouamri, Josselin Houenou, Stéphane Jamain, Jean-Romain Richard, Philippe Lecorvosier, Robert Yolken…

    Citation: BMC Psychiatry 2018 18:239

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  29. Content type: Research article

    There are interindividual differences in the adverse effects of atypical antipsychotics, which include autonomic nervous system (ANS) dysfunction. Accordingly, to clarify the interindividual differences in the...

    Authors: Saki Hattori, Akira Suda, Ikuko Kishida, Masatoshi Miyauchi, Yohko Shiraishi, Mami Fujibayashi, Natsuki Tsujita, Chie Ishii, Norio Ishii, Toshio Moritani, Masataka Taguri and Yoshio Hirayasu

    Citation: BMC Psychiatry 2018 18:231

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  30. Content type: Research article

    Widespread cortical gray matter alternations in people with schizophrenia are correlated with both psychotic symptoms and cognitive/behavioral abnormalities, including the impairments of exploratory eye moveme...

    Authors: Linlin Qiu, Hao Yan, Risheng Zhu, Jun Yan, Huishu Yuan, Yonghua Han, Weihua Yue, Lin Tian and Dai Zhang

    Citation: BMC Psychiatry 2018 18:226

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  31. Content type: Research article

    Anxiety and depressive symptoms and psychotic experiences constitute common features of emerging mental disorders in young people. Psychotic experiences and the ultra-high risk (UHR) state for psychosis appear...

    Authors: Kareen Heinze, Ashleigh Lin, Barnaby Nelson, Renate L. E. P. Reniers, Rachel Upthegrove, Latoya Clarke, Ayesha Roche, Angelique Lowrie and Stephen J. Wood

    Citation: BMC Psychiatry 2018 18:214

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  32. Content type: Research article

    Non-adherence to medication remains a major challenge in the long-term management of patients with schizophrenia. Next to lack of insight into the illness, adverse effects of antipsychotic drugs, cognitive def...

    Authors: Christian G. Widschwendter, Georg Kemmler, Maria A. Rettenbacher, Nursen Yalcin-Siedentopf and Alex Hofer

    Citation: BMC Psychiatry 2018 18:212

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  33. Content type: Research article

    A body of studies has focused on the olfactory impairment among people with schizophrenia. The effect of sex on this relationship has attracted the attention of researchers. These issues have not been studied ...

    Authors: Xiacan Chen, Jiajun Xu, Bin Li, Wanjun Guo, Jun Zhang and Junmei Hu

    Citation: BMC Psychiatry 2018 18:199

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  34. Content type: Research article

    Research on antepartum psychiatric morbidities investigating depressive and anxiety symptoms in expectant mothers and fathers is lacking in low- and middle-income countries. This study aimed to estimate the pr...

    Authors: Hashima E. Nasreen, Jamalludin Ab Rahman, Razman Mohd Rus, Mira Kartiwi, Rosnah Sutan and Maigun Edhborg

    Citation: BMC Psychiatry 2018 18:195

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  35. Content type: Research article

    Patients with schizophrenia have an increased prevalence of metabolic disturbances compared with the general population. However, the mechanisms underlying the metabolic side effects of antipsychotics are unkn...

    Authors: Shin Ono, Takuro Sugai, Yutaro Suzuki, Manabu Yamazaki, Kazutaka Shimoda, Takao Mori, Yuji Ozeki, Hiroshi Matsuda, Norio Sugawara, Norio Yasui-Furukori, Kurefu Okamoto, Toyoaki Sagae and Toshiyuki Someya

    Citation: BMC Psychiatry 2018 18:180

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  36. Content type: Research article

    The management of schizophrenia is evolving towards a more comprehensive model based on functional recovery. The concept of functional recovery goes beyond clinical remission and encompasses multiple aspects o...

    Authors: Guillermo Lahera, José L. Gálvez, Pedro Sánchez, Miguel Martínez-Roig, J. V. Pérez-Fuster, Paz García-Portilla, Berta Herrera and Miquel Roca

    Citation: BMC Psychiatry 2018 18:176

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  37. Content type: Research article

    People with severe mental illnesses (SMI) such as schizophrenia and bipolar disorder have an increased risk of developing type 2 diabetes and have poorer health outcomes than those with diabetes alone. To main...

    Authors: Kathleen Mulligan, Hayley McBain, Frederique Lamontagne-Godwin, Jacqui Chapman, Chris Flood, Mark Haddad, Julia Jones and Alan Simpson

    Citation: BMC Psychiatry 2018 18:165

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  38. Content type: Research article

    Routinely monitoring of symptoms and medical needs can improve the diagnostics and treatment of medical problems, including psychiatric. However, several studies show that few clinicians use Routine Outcome Mo...

    Authors: Magda Tasma, Lukas O. Roebroek, Edith J. Liemburg, Henderikus Knegtering, Philippe A. Delespaul, Albert Boonstra, Marte Swart and Stynke Castelein

    Citation: BMC Psychiatry 2018 18:163

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  39. Content type: Research article

    Sexual dysfunction is remarkably prevalent amongst psychiatric patients than general population. This might be due to either the nature of the illness itself or the unwanted effect of the medication they are t...

    Authors: Tolesa Fanta, Kibrom Haile, Dessie Abebaw, Dawit Assefa and Getahun Hibdye

    Citation: BMC Psychiatry 2018 18:158

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  40. Content type: Research article

    Schizophrenia and bipolar disorder are characterized by a high disease burden. Antipsychotic medication is an essential part of the treatment. However, non-adherence is a major problem. Our aim was to examine ...

    Authors: Ulrike Stentzel, Neeltje van den Berg, Lara N. Schulze, Thea Schwaneberg, Franziska Radicke, Jens M. Langosch, Harald J. Freyberger, Wolfgang Hoffmann and Hans-Jörgen Grabe

    Citation: BMC Psychiatry 2018 18:155

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  41. Content type: Research article

    People with psychosis struggle with decisions about their use of antipsychotics. They often want to reduce the dose or stop, while facing uncertainty regarding the effects these decisions will have on their tr...

    Authors: Yaara Zisman-Ilani, David Shern, Patricia Deegan, Julie Kreyenbuhl, Lisa Dixon, Robert Drake, William Torrey, Manish Mishra, Ksenia Gorbenko and Glyn Elwyn

    Citation: BMC Psychiatry 2018 18:142

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  42. Content type: Case report

    Multiple system atrophy (MSA) is an adult-onset, rare, and progressive neurodegenerative disorder characterized by a varying combination of autonomic failure, cerebellar ataxia, and parkinsonism. MSA is catego...

    Authors: Hiroshi Komatsu, Masaaki Kato, Teiko Kinpara, Takashi Ono and Yoshihisa Kakuto

    Citation: BMC Psychiatry 2018 18:141

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  43. Content type: Research article

    Motivational interviewing (MI) may be an effective intervention to improve medication adherence in patients with schizophrenia. However, for this patient group, mixed results have been found in randomized cont...

    Authors: Jos Dobber, Corine Latour, Lieuwe de Haan, Wilma Scholte op Reimer, Ron Peters, Emile Barkhof and Berno van Meijel

    Citation: BMC Psychiatry 2018 18:135

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  44. Content type: Research article

    The adverse impact of unhealthy lifestyle choices and the prescription of antipsychotic medications contribute to weight gain, poor cardiovascular health and reduced life expectancy for people with psychosis. ...

    Authors: Rebecca Pedley, Karina Lovell, Penny Bee, Tim Bradshaw, Judith Gellatly, Kate Ward, Adrine Woodham and Alison Wearden

    Citation: BMC Psychiatry 2018 18:111

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  45. Content type: Study protocol

    Evidence shows that internet-based self-help interventions are effective in reducing symptoms for a wide range of mental disorders. To date, online interventions treating psychotic disorders have been scarce, ...

    Authors: Nina Rüegg, Steffen Moritz, Thomas Berger, Thies Lüdtke and Stefan Westermann

    Citation: BMC Psychiatry 2018 18:102

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  46. Content type: Research article

    Early diagnosis of schizophrenia could improve the outcome of the illness. Unlike classical between-group comparisons, machine learning can identify subtle disease patterns on a single subject level, which cou...

    Authors: Pavol Mikolas, Jaroslav Hlinka, Antonin Skoch, Zbynek Pitra, Thomas Frodl, Filip Spaniel and Tomas Hajek

    Citation: BMC Psychiatry 2018 18:97

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  47. Content type: Research article

    Speech recognition under noisy “cocktail-party” environments involves multiple perceptual/cognitive processes, including target detection, selective attention, irrelevant signal inhibition, sensory/working mem...

    Authors: Yingjun Zheng, Chao Wu, Juanhua Li, Ruikeng Li, Hongjun Peng, Shenglin She, Yuping Ning and Liang Li

    Citation: BMC Psychiatry 2018 18:90

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  48. Content type: Research article

    Nesfatin-1 plays a role in the regulation of emotional states like depression. The aim of this study was to investigate the plasma nesfatin-1levels in Chinese patients with depression and healthy subjects, and...

    Authors: Min-Min Xiao, Jiang-Bo Li, Lan-Lan Jiang, Hui Shao and Bao-Long Wang

    Citation: BMC Psychiatry 2018 18:88

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  49. Content type: Research article

    Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects...

    Authors: Tsubasa Morimoto, Yasuhiro Matsuda, Kiwamu Matsuoka, Fumihiko Yasuno, Emi Ikebuchi, Hiroyuki Kameda, Toshiaki Taoka, Toshiteru Miyasaka, Kimihiko Kichikawa and Toshifumi Kishimoto

    Citation: BMC Psychiatry 2018 18:83

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  50. Content type: Research article

    Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate d...

    Authors: Jinming Li, Yuan Yang, Yuankai Zhu, Liqiang Zhou, Yunfeng Han, Tao Yin, Zhaoting Cheng, Guopeng Zhang, Yanxia Shen and Jing Chen

    Citation: BMC Psychiatry 2018 18:70

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