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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Content type: Research article

    Schizophrenia is a severe mental disease with high morbidity and heritability. The SLC39A8 gene is located in 4q24 and encodes a protein that transports many metal ions. Multiple previous studies found that one o...

    Authors: Xuemin Jian, Jianhua Chen, Zhiqiang Li, Zhijian Song, Juan Zhou, Wei Xu, Yahui Liu, Jiawei Shen, Yonggang Wang, Qizhong Yi and Yongyong Shi

    Citation: BMC Psychiatry 2019 19:293

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  2. Content type: Study protocol

    Problems in social functioning (e.g., unemployment, social isolation), are common in people with a psychotic disorder. Social cognition is a treatment target to improve social functioning, as it is a proximal ...

    Authors: Saskia A. Nijman, Wim Veling, Kirstin Greaves-Lord, Rowina R. Vermeer, Maarten Vos, Catharina E. R. Zandee, Daniëlle C. Zandstra, Chris N. W. Geraets and Gerdina H. M. Pijnenborg

    Citation: BMC Psychiatry 2019 19:272

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  3. Content type: Research article

    The goal of clinicians and healthcare workers providing treatment to patients with psychiatric disorders, has shifted over time from focusing on the symptoms alone towards functional improvement. In this study...

    Authors: Xiao Wei Tan, Esmond Seow, Edimansyah Abdin, Swapna Verma, Kang Sim, Siow Ann Chong and Mythily Subramaniam

    Citation: BMC Psychiatry 2019 19:267

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  4. Content type: Research article

    To measure the serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in deficit schizophrenia (DS), in order to examine the association between these t...

    Authors: Xiaowei Tang, Chao Zhou, Ju Gao, Weiwei Duan, Miao Yu, Wenhuan Xiao, Xiaobin Zhang, Hui Dong, Xiang Wang and Xiangrong Zhang

    Citation: BMC Psychiatry 2019 19:254

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  5. Content type: Research article

    Previous studies have suggested that culture impacts the experience of psychosis. The current study set out to extend these findings by examining cultural variation in subclinical positive psychotic experience...

    Authors: Margriet Vermeiden, Mayke Janssens, Viviane Thewissen, Esther Akinsola, Sanne Peeters, Jennifer Reijnders, Nele Jacobs, Jim van Os and Johan Lataster

    Citation: BMC Psychiatry 2019 19:244

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  6. Content type: Study protocol

    People who suffer a first episode of psychosis experience higher levels of distress and suffering. Early intervention programs combine pharmacological and psychosocial strategies that include different compone...

    Authors: Roberto Mediavilla, Ainoa Muñoz-Sanjose, Beatriz Rodriguez-Vega, Carmen Bayon, Angela Palao, Guillermo Lahera, Pilar Sanchez-Castro, Eva Roman, Susana Cebolla, Alvaro de Diego, Juan Manuel Pastor and Maria Fe Bravo-Ortiz

    Citation: BMC Psychiatry 2019 19:233

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  7. Content type: Research article

    Cognitive Bias Modification (CBM) has been used successfully as a computer-based intervention in disorders such as anxiety. However, CBM to modify interpretations of ambiguous information relevant to paranoia ...

    Authors: C. J. Leung, A. Fosuaah, J. Frerichs, M. Heslin, T. Kabir, T. M. C. Lee, P. McGuire, C. Meek, E. Mouchlianitis, A. S. Nath, E. Peters, S. Shergill, D. Stahl, A. Trotta and J. Yiend

    Citation: BMC Psychiatry 2019 19:225

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  8. Content type: Debate

    One of the most important questions remaining in matters of critical illness in the year 2019 is arguably how to address the diverse neuropsychiatric complications of critical illness.

    Authors: Jan N. M. Schieveld, Emma H. C. W. van de Riet and Jacqueline J. M. H. Strik

    Citation: BMC Psychiatry 2019 19:222

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  9. Content type: Research article

    Among patients with treatment-resistant schizophrenia (TRS), some exhibited further clozapine resistance (CR). This study aimed to investigate whether greater severity of treatment resistance in schizophrenia ...

    Authors: An-Sheng Lin, Hung-Yu Chan, Ying-Chieh Peng and Wei J. Chen

    Citation: BMC Psychiatry 2019 19:220

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  10. Content type: Research article

    Sexual dysfunction is common in patients with schizophrenia, however it is poorly studied in China, especially in primary health care institutions in rural areas. We investigated the prevalence of sexual dysfu...

    Authors: Ying-Hua Huang, Cai-Lan Hou, C. H. Ng, Xie Chen, Qian-Wen Wang, Zhuo-Hui Huang and Fu-Jun Jia

    Citation: BMC Psychiatry 2019 19:218

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  11. Content type: Research article

    Data on the pharmacological management of acute agitation in schizophrenia are scarce. The aim of this study is to investigate the prescription practices in the treatment of agitation in Chinese patients with ...

    Authors: Su-Zhen Zhang, Yong-Gang Mu, Qi Liu, Ying Shi, Li-Hua Guo, Ling-Zhi Li, Fu-De Yang, Yong Wang, Tao Li, Qi-Yi Mei, Hong-Bo He, Zhi-Yu Chen, Zhong-Hua Su, Tie-Bang Liu, Shi-Ping Xie, Qing-Rong Tan…

    Citation: BMC Psychiatry 2019 19:216

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  12. Content type: Research article

    Past studies have focused primarily on clinical insight and less on cognitive insight among individuals with mental illness.

    Authors: Vathsala Sagayadevan, Anitha Jeyagurunathan, Ying Wen Lau, Saleha Shafie, Sherilyn Chang, Hui Lin Ong, Ellaisha Samari, Swapna Kamal Verma, Siow Ann Chong and Mythily Subramaniam

    Citation: BMC Psychiatry 2019 19:201

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  13. Content type: Research article

    Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been rep...

    Authors: Hong-yi He, Jin-lan Tian, Yong-qiong Deng, Xia Xiong, Yang Xu, Yong-mei Liao, Jing Fang, Xia Feng, Xin Ye and Chang-qiang Li

    Citation: BMC Psychiatry 2019 19:193

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  14. Content type: Research article

    Burgeoning evidence suggests that exercise improves physical and mental health in people with schizophrenia. However, little is known about the feasibility and acceptability of high-intensity training in patie...

    Authors: Lene Q. Larsen, Helle Schnor, Britt P. Tersbøl, Bjørn H. Ebdrup, Nikolai B. Nordsborg and Julie Midtgaard

    Citation: BMC Psychiatry 2019 19:192

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  15. Content type: Research article

    Internet-based interventions can make self-management and recovery-oriented information and tools more accessible for people experiencing severe mental illness, including psychosis. The aim of this scoping rev...

    Authors: Anne Williams, John Farhall, Ellie Fossey and Neil Thomas

    Citation: BMC Psychiatry 2019 19:191

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  16. Content type: Research article

    The effect of antipsychotic (AP) drugs on risk of stroke and myocardial infarction (MI) remains unclear due to methodological limitations of, and inconsistencies across, existing studies. We aimed to systemati...

    Authors: Sanja Zivkovic, Chan Hee Koh, Nandita Kaza and Caroline A. Jackson

    Citation: BMC Psychiatry 2019 19:189

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  17. Content type: Study protocol

    Shared decision making (SDM) is often defined as an interactive process that ensures that both patient and practitioner are actively involved in the treatment and that they share all relevant information to ar...

    Authors: Tobias Vitger, Stephen F. Austin, Lone Petersen, Esben S. Tønder, Merete Nordentoft and Lisa Korsbek

    Citation: BMC Psychiatry 2019 19:185

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  18. Content type: Case report

    Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is a severe autoimmune condition, which typically affects young females. The long-term clinical consequences and brain morphology changes after anti-NMDA...

    Authors: Heikki Laurikainen, Iina Isotupa, Mikko Nyman, Tuula Ilonen, Teija Nummelin, Raimo K. R. Salokangas and Jarmo Hietala

    Citation: BMC Psychiatry 2019 19:145

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  19. Content type: Research article

    Over the past decades research has shown that employment has a positive impact on quality of life, global functioning and recovery in individuals with schizophrenia. However, access to vocational rehabilitatio...

    Authors: Stig Evensen, Torbjørn Wisløff, June Ullevoldsæter Lystad, Helen Bull, Egil W. Martinsen, Torill Ueland and Erik Falkum

    Citation: BMC Psychiatry 2019 19:140

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  20. Content type: Research article

    With previously established efficacy of aripiprazole once-monthly injectable formulation (AOM) in pre-registration randomized controlled trials, the current study was designed to evaluate its effectiveness in ...

    Authors: Sally Mustafa, Joanna Bougie, Maia Miguelez, Guerline Clerzius, Emmanouil Rampakakis, Jean Proulx and Ashok Malla

    Citation: BMC Psychiatry 2019 19:114

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  21. Content type: Research article

    Oculomotor dysfunction is one of the most replicated findings in schizophrenia. However the association between saccadic abnormalities and particular clinical syndromes remains unclear. The assessment of sacca...

    Authors: Ilya Obyedkov, Maryna Skuhareuskaya, Oleg Skugarevsky, Victor Obyedkov, Pavel Buslauski, Tatsiana Skuhareuskaya and Napoleon Waszkiewicz

    Citation: BMC Psychiatry 2019 19:110

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  22. Content type: Research article

    Based on genome-wide association studies, a single-nucleotide polymorphism in the NRGN gene (rs12807809) is considered associated with schizophrenia (SZ). Moreover, hippocampal dysfunction is associated with r...

    Authors: Yifan Zhang, Xiaohong Gong, Zhiyang Yin, Lingling Cui, Jian Yang, Pengshuo Wang, Yifang Zhou, Xiaowei Jiang, Shengnan Wei, Fei Wang and Yanqing Tang

    Citation: BMC Psychiatry 2019 19:108

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  23. Content type: Research article

    This study determined the effects of a novel combination of vitamin D and probiotic on metabolic and clinical symptoms in chronic schizophrenia.

    Authors: Amir Ghaderi, Hamid Reza Banafshe, Naghmeh Mirhosseini, Mohamad Moradi, Mohammad-Amin Karimi, Fateme Mehrzad, Fereshteh Bahmani and Zatollah Asemi

    Citation: BMC Psychiatry 2019 19:77

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  24. Content type: Case report

    Cardiometabolic health significantly impacts on the mortality of people with severe mental illness. Clozapine has the greatest efficacy for Treatment Resistant Schizophrenia (TRS) but the greatest negative imp...

    Authors: Alex Till and Ed Silva

    Citation: BMC Psychiatry 2019 19:37

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  25. Content type: Research article

    The development of digital health interventions (DHIs) for severe mental health problems is fast-paced. Researchers are beginning to consult service users to inform DHIs; however, much of this involvement has ...

    Authors: Natalie Berry, Fiona Lobban and Sandra Bucci

    Citation: BMC Psychiatry 2019 19:35

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  26. Content type: Research article

    First-generation antipsychotics (FGAs) are associated with a range of adverse events which can significantly reduce patients’ quality of life and contribute to non-adherence. The aim of this study was to asses...

    Authors: Yirgalem Shewakena Wubeshet, Oumer Sada Mohammed and Tigestu Alemu Desse

    Citation: BMC Psychiatry 2019 19:32

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  27. Content type: Research article

    Cognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two inde...

    Authors: Pengshuo Wang, Jian Yang, Zhiyang Yin, Jia Duan, Ran Zhang, Jiaze Sun, Yixiao Xu, Luyu Liu, Xuemei Chen, Huizi Li, Jiahui Kang, Yue Zhu, Xin Deng, Miao Chang, Shengnan Wei, Yifang Zhou…

    Citation: BMC Psychiatry 2019 19:30

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  28. Content type: Research article

    Many people diagnosed with schizophrenia, bipolar or other psychoses in England receive the majority of their healthcare from primary care. Primary care practitioners may not be well equipped to meet their nee...

    Authors: Elina Baker, Ruth Gwernan-Jones, Nicky Britten, Maria Cox, Catherine McCabe, Ameeta Retzer, Laura Gill, Humera Plappert, Siobhan Reilly, Vanessa Pinfold, Linda Gask, Richard Byng and Max Birchwood

    Citation: BMC Psychiatry 2019 19:7

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  29. Content type: Research article

    People with a psychotic disorder have an increased risk of becoming the victim of a crime. To prevent victimization a body-oriented resilience therapy using kickboxing exercises was developed. This study aims ...

    Authors: Bertine de Vries, Elisabeth C. D. van der Stouwe, Clement O. Waarheid, Stefan H. J. Poel, Erwin M. van der Helm, André Aleman, Johan Arends, Gerdina H. M. Pijnenborg and Jooske T. van Busschbach

    Citation: BMC Psychiatry 2018 18:384

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  30. Content type: Research article

    By combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, this study aimed to explore brain functional alterations in Attenuated Psychosis Syndrome (APS), which could provide compleme...

    Authors: Xiangyun Long, Fei Liu, Nan Huang, Na Liu, Jie Zhang, Jing Chen, Ansi Qi, Xiaofeng Guan and Zheng Lu

    Citation: BMC Psychiatry 2018 18:383

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  31. Content type: Research article

    Cognitive behavioural therapy has been used for schizophrenia, but to which extent it is effective is still controversial. Results of existing meta-analyses are of difficult interpretation, because they mainly...

    Authors: Irene Bighelli, Maximilian Huhn, Johannes Schneider-Thoma, Marc Krause, Cornelia Reitmeir, Sofia Wallis, Felicitas Schwermann, Gabi Pitschel-Walz, Corrado Barbui, Toshi A. Furukawa and Stefan Leucht

    Citation: BMC Psychiatry 2018 18:380

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  32. Content type: Research article

    The aims of this study were to explore the relationship between early reduction in psychotic symptoms and the ultimate response in patients with schizophrenia treated by atypical antipsychotics, and to determi...

    Authors: Yi-Lung Chen, Kun-Po Chen, Chih-Chiang Chiu, Ming-Hong Tai and For-Wey Lung

    Citation: BMC Psychiatry 2018 18:376

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  33. Content type: Research article

    Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, a...

    Authors: Changjun Teng, Jing Zhou, Hui Ma, Yarong Tan, Xin Wu, Chengbin Guan, Huifen Qiao, Jijun Li, Yuan Zhong, Chun Wang and Ning Zhang

    Citation: BMC Psychiatry 2018 18:370

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  34. Content type: Research article

    In this study, the treatment of schizophrenia patients with aripiprazole once-monthly (AOM) was evaluated under real-life conditions in a naturalistic setting.

    Authors: Daniel Schöttle, Wolfgang Janetzky, Daniel Luedecke, Elmar Beck, Christoph U. Correll and Klaus Wiedemann

    Citation: BMC Psychiatry 2018 18:365

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    The Correction to this article has been published in BMC Psychiatry 2018 18:389

  35. Content type: Research article

    Mental health clinicians have previously been reported to express reservations regarding the utility and accuracy of the psychiatric classification systems. In this study we aimed to examine clinicians’ experi...

    Authors: Dana Tzur Bitan, Ariella Grossman Giron, Gady Alon, Shlomo Mendlovic, Yuval Bloch and Aviv Segev

    Citation: BMC Psychiatry 2018 18:317

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  36. Content type: Research article

    Data are limited on the benefits and risks of dose reduction in managing side effects associated with antipsychotic treatment. As an example, antipsychotic dose reduction has been recommended in the management...

    Authors: Stanley N. Caroff, Fan Mu, Rajeev Ayyagari, Traci Schilling, Victor Abler and Benjamin Carroll

    Citation: BMC Psychiatry 2018 18:306

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  37. Content type: Research article

    Despite the availability of numerous antipsychotic medications, many patients with schizophrenia continue to experience side effects that contribute to the overall burden of the illness. The present survey of ...

    Authors: Eric Achtyes, Adam Simmons, Anna Skabeev, Nikki Levy, Ying Jiang, Patricia Marcy and Peter J. Weiden

    Citation: BMC Psychiatry 2018 18:292

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  38. Content type: Research article

    In recent decades atypical antipsychotics have increased treatment options available for schizophrenia, however there is conflicting evidence concerning the trade-off between clinical efficacy and side effects...

    Authors: Rossela Roberts, Abigail Neasham, Chania Lambrinudi and Afshan Khan

    Citation: BMC Psychiatry 2018 18:290

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  39. Content type: Research article

    Amisulpride was introduced into China in 2010 as a second-generation atypical antipsychotic, while olanzapine has been on the market since 1999 as one of the leading treatments for schizophrenia in China. Sinc...

    Authors: Peng Men, Zhanmiao Yi, Chaoyun Li, Shuli Qu, Tengbin Xiong, Xin Yu and Suodi Zhai

    Citation: BMC Psychiatry 2018 18:286

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  40. Content type: Research article

    There is conflicting evidence on the association between antipsychotic polypharmacy and metabolic syndrome in schizophrenia. We conducted a review of published systematic reviews to evaluate evidence on the as...

    Authors: Sharea Ijaz, Blanca Bolea, Simon Davies, Jelena Savović, Alison Richards, Sarah Sullivan and Paul Moran

    Citation: BMC Psychiatry 2018 18:275

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  41. Content type: Research article

    Approximately one-third of schizophrenia patients eventually develop treatment-resistant schizophrenia (TRS). Although the time course of TRS development varies from patient to patient, the details of these va...

    Authors: Nobuhisa Kanahara, Hiroshi Yamanaka, Tomotaka Suzuki, Masayuki Takase and Masaomi Iyo

    Citation: BMC Psychiatry 2018 18:274

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  42. Content type: Study protocol

    While patient involvement in mental health care is repeatedly stressed in policy documents, there are actually few studies that evaluate person-centred care interventions within psychiatric services. We presen...

    Authors: Anneli Goulding, Katarina Allerby, Lilas Ali, Andreas Gremyr and Margda Waern

    Citation: BMC Psychiatry 2018 18:269

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  43. Content type: Research article

    Childhood trauma (CT) has been found to contribute to the onset of schizophrenia and auditory sensory gating deficit is a leading endophenotype for schizophrenia. However, the association between the CT and se...

    Authors: Xian-Bin Li, Qi-Jing Bo, Qing Tian, Ning-Bo Yang, Zhen Mao, Wei Zheng, Yu-Jie Wen and Chuan-Yue Wang

    Citation: BMC Psychiatry 2018 18:258

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  44. Content type: Research article

    People with severe mental illness have markedly reduced life expectancy; cardiometabolic disease is a major cause. Psychiatric hospital inpatients have elevated levels of cardiometabolic risk factors and are t...

    Authors: Petter Andreas Ringen, Ragnhild S. Falk, Bjørnar Antonsen, Ann Faerden, Asgeir Mamen, Eline B. Rognli, Dag K. Solberg, Egil W. Martinsen and Ole A. Andreassen

    Citation: BMC Psychiatry 2018 18:255

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  45. Content type: Research article

    Treatment-resistant schizophrenia (TRS) affects about one-third of individuals with schizophrenia. People with TRS do not experience sustained symptom relief and at the same time have the most severe disease-r...

    Authors: Cecilia Brain, Steven Kymes, Dana B. DiBenedetti, Thomas Brevig and Dawn I. Velligan

    Citation: BMC Psychiatry 2018 18:253

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  46. Content type: Research article

    Community-based rehabilitation (CBR), or community-based inclusive development, is an approach to address the complex health, social and economic needs of people with schizophrenia in low and middle-income cou...

    Authors: Laura Asher, Charlotte Hanlon, Rahel Birhane, Alehegn Habtamu, Julian Eaton, Helen A. Weiss, Vikram Patel, Abebaw Fekadu and Mary De Silva

    Citation: BMC Psychiatry 2018 18:250

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  47. Content type: Research article

    Hyperprolactinemia and glucose and lipid metabolism abnormalities are often found in patients with schizophrenia and are generally considered secondary to the use of antipsychotic drugs. More recent studies ha...

    Authors: Maria Giuseppina Petruzzelli, Mariella Margari, Antonia Peschechera, Concetta de Giambattista, Andrea De Giacomo, Emilia Matera and Francesco Margari

    Citation: BMC Psychiatry 2018 18:246

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  48. Content type: Research article

    Immune dysfunction could play a significant role in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ), conditions with an underlying pro-inflammatory state. Studies on humoral immune responses (...

    Authors: Nora Hamdani, Djaouida Bengoufa, Ophélia Godin, Raphaël Doukhan, Emmanuel Le Guen, Claire Daban-Huard, Meriem Bennabi, Marine Delavest, Jean-Pierre Lépine, Wahid Boukouaci, Hakim Laouamri, Josselin Houenou, Stéphane Jamain, Jean-Romain Richard, Philippe Lecorvosier, Robert Yolken…

    Citation: BMC Psychiatry 2018 18:239

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