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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. The self-evaluation of negative symptoms scale (SNS) is a new easy-to-use self-administered questionnaire allowing clinicians to understand the clinical and genetic factors affecting the negative symptoms in p...

    Authors: Aline Hajj, Souheil Hallit, Karam Chamoun, Hala Sacre, Sahar Obeid, Chadia Haddad, Sonia Dollfus and Lydia Rabbaa Khabbaz

    Citation: BMC Psychiatry 2020 20:240

    Content type: Research article

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  2. Conflicting evidence exists on whether parent or spouse caregivers experience better outcomes when caring for family members with schizophrenia. The current study aims to examine relative caregiving experience...

    Authors: Yu Yu, Tong-xin Li, Yi-lu Li, Dan Qiu, Shi-jun Xi, Shui-yuan Xiao and Jacob Kraemer Tebes

    Citation: BMC Psychiatry 2020 20:226

    Content type: Research article

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  3. It has been shown that iron deficiency anemia (IDA) is associated with psychosocial consequences and psychiatric morbidity. However, the association between adults with IDA and psychiatric disorders has not be...

    Authors: Herng-Sheng Lee, Hsin-Hao Chao, Wan-Ting Huang, Solomon Chih-Cheng Chen and Hsin-Yi Yang

    Citation: BMC Psychiatry 2020 20:216

    Content type: Research article

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  4. Patients with psychiatric disorders, such as major depressive disorder, schizophrenia or obsessive-compulsive disorder, often suffer from cognitive dysfunction. The nature of these dysfunctions and their relat...

    Authors: Dorien H. Nieman, UnYoung Chavez-Baldini, Nienke C. Vulink, Dirk J. A. Smit, Guido van Wingen, Pelle de Koning, Arjen L. Sutterland, Roel J. T. Mocking, Claudi Bockting, Karin J. H. Verweij, Anja Lok and Damiaan Denys

    Citation: BMC Psychiatry 2020 20:212

    Content type: Study protocol

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  5. Delirium is common in critically ill patients and it is associated with poor outcomes. In Tunisia, however, it is still underdiagnosed as there is no validated screening tool. The aim of this study was to tran...

    Authors: Imen Ben Saida, Saiid Kortli, Badii Amamou, Nawres Kacem, Mariem Ghardallou, Eugene Wesley Ely, Helmi Ben Saad and Mohamed Boussarsar

    Citation: BMC Psychiatry 2020 20:206

    Content type: Research article

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  6. Patients with a diagnosis of schizophrenia are at an increased risk for developing metabolic syndrome, which is associated with greater cardiovascular morbidity and mortality. Treatment with some commonly used...

    Authors: Greg W. Mattingly, Peter M. Haddad, Michael Tocco, Jane Xu, Debra Phillips, Andrei Pikalov and Antony Loebel

    Citation: BMC Psychiatry 2020 20:199

    Content type: Research article

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  7. Inpatient psychiatric care is a scarce and expensive resource in the National Health Service (NHS), with chronic bed shortages being partly driven by high re-admission rates. Brief inpatient talking therapies ...

    Authors: Pamela Jacobsen, Emmanuelle Peters, Emily J. Robinson and Paul Chadwick

    Citation: BMC Psychiatry 2020 20:193

    Content type: Research article

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  8. Accurate diagnosis of delirium is very important for prevention and treatment. Present study was designed to validate the 3-Minute Diagnostic Interview for CAM-defined Delirium Chinese version (3D-CAM-CN) in s...

    Authors: Dong-Liang Mu, Pan-Pan Ding, Shu-Zhe Zhou, Mei-Jing Liu, Xin-Yu Sun, Xue-Ying Li and Dong-Xin Wang

    Citation: BMC Psychiatry 2020 20:133

    Content type: Research article

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  9. Psychosis often causes significant distress and impacts not only in the individuals, but also those close to them. Many relatives and friends (‘carers’) provide long-term support and need resources to assist t...

    Authors: Jacqueline Sin, Claire Henderson, Victoria Cornelius, Tao Chen, Jack Elkes, Luke A. Woodham, Aurora Sesé Hernández, Dominique Spence-Polin, Rachel Batchelor and Steve Gillard

    Citation: BMC Psychiatry 2020 20:129

    Content type: Study protocol

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  10. Prescription rates for long-acting injectable (LAI) antipsychotic formulations remain relatively low in Europe despite improved adherence over alternative oral antipsychotic treatments. This apparent under-pre...

    Authors: Maxine X. Patel, Nawal Bent-Ennakhil, Christophe Sapin, Sylvie di Nicola, Jean-Yves Loze, Anna-Greta Nylander and Stephan Heres

    Citation: BMC Psychiatry 2020 20:123

    Content type: Research article

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  11. Good sibling relationships in adulthood are known to be a protective factor for mental health. The present study examined and compared the relationships of siblings with either a healthy brother or sister or o...

    Authors: Léa Plessis, Hélène Wilquin, Jean-Baptiste Pavani and Evelyne Bouteyre

    Citation: BMC Psychiatry 2020 20:122

    Content type: Research article

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  12. This case report highlights the rare occurrence of postpartum psychosis in the setting of peripartum cardiomyopathy, which can have rare presentations like arrhythmias and pulmonary edema; and the challenges o...

    Authors: Odhiambo Henry Owuor, James Amisi Akiruga, Jeremiah Laktabai, Samuel Ateya and Salwa Mohamed Omar

    Citation: BMC Psychiatry 2020 20:114

    Content type: Case report

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  13. Physical health among people with severe mental illness (SMI) is a global concern. However, many people with SMI do not receive regular comprehensive health checks. There is currently no validated physical hea...

    Authors: Camilla Werkkala, Maritta Välimäki, Minna Anttila, Virve Pekurinen and Daniel Bressington

    Citation: BMC Psychiatry 2020 20:112

    Content type: Research article

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  14. Clozapine has remarkable efficacy on both negative and cognitive symptoms of schizophrenia due to its slight activation of NMDA receptor. In fact, much evidence to the contrary. NMDAR is a complex containing s...

    Authors: Xingqin Zhou, Gangming Cai, Shishi Mao, Dong Xu, Xijie Xu, Rongjun Zhang and Zhiwen Yao

    Citation: BMC Psychiatry 2020 20:106

    Content type: Research article

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  15. In this non-interventional study, the functionality and well-being of patients with schizophrenia with aripiprazole once-monthly (AOM) was evaluated under real-life conditions in a naturalistic population.

    Authors: Daniel Schöttle, Wolfgang Janetzky, Daniel Luedecke, Elmar Beck, Christoph U. Correll and Klaus Wiedemann

    Citation: BMC Psychiatry 2020 20:77

    Content type: Research article

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  16. Use of the antipsychotic drug olanzapine by patients with schizophrenia is associated with autonomic nervous system (ANS) dysfunction. It is presumed that there are interindividual differences in ANS dysfuncti...

    Authors: Saki Hattori, Akira Suda, Masatoshi Miyauchi, Yohko Shiraishi, Takashi Saeki, Tadashi Fukushima, Mami Fujibayashi, Natsuki Tsujita, Chie Ishii, Norio Ishii, Tosiho Moritani, Yusuke Saigusa and Ikuko Kishida

    Citation: BMC Psychiatry 2020 20:72

    Content type: Research article

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  17. Cognitive models of psychosis postulate an important role of Theory of mind (ToM) in the formation and maintenance of delusions, but research on this plausible conjecture has gathered conflicting findings. In ...

    Authors: Stephanie Mehl, Klaus Hesse, Anna-Christine Schmidt, Martin W. Landsberg, Daniel Soll, Andreas Bechdolf, Jutta Herrlich, Tilo Kircher, Stefan Klingberg, Bernhard W. Müller, Georg Wiedemann, Andreas Wittorf, Wolfgang Wölwer and Michael Wagner

    Citation: BMC Psychiatry 2020 20:59

    Content type: Research article

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  18. Neurocognitive dysfunction is a common symptom of various major psychiatric disorders, including schizophrenia, major depressive disorder (MDD), and bipolar I disorder (BD). In this study, we investigated whet...

    Authors: Yu-Chi Huang, Yu Lee, Chun-Yi Lee, Pao-Yen Lin, Chi-Fa Hung, Sheng-Yu Lee and Liang-Jen Wang

    Citation: BMC Psychiatry 2020 20:39

    Content type: Research article

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  19. Although insight in schizophrenia spectrum disorders (SSD) has been associated with positive outcomes, the effect size of previous treatments on insight has been relatively small to date. The metacognitive bas...

    Authors: Javier-David Lopez-Morinigo, Verónica González Ruiz-Ruano, Adela Sánchez Escribano Martínez, María Luisa Barrigón Estévez, Laura Mata-Iturralde, Laura Muñoz-Lorenzo, Sergio Sánchez-Alonso, Antonio Artés-Rodríguez, Anthony S. David and Enrique Baca-García

    Citation: BMC Psychiatry 2020 20:30

    Content type: Study protocol

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  20. People with psychosis experience more social isolation than any other diagnostic group and have smaller social networks than the general population. This isolation can have a detrimental effect on quality of l...

    Authors: Helena Tee, Stefan Priebe, Carlos Santos, Penny Xanthopoulou, Martin Webber and Domenico Giacco

    Citation: BMC Psychiatry 2020 20:29

    Content type: Research article

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  21. The underlying mechanism between hope and quality of life is as yet unknown. We aim to examine the potential mediating effect of depression and resilience and the moderated effect of sex in this well-establish...

    Authors: Wei-Liang Wang, Yu-Qiu Zhou, Nan-Nan Chai, Guo-Hua Li and Dong-Wei Liu

    Citation: BMC Psychiatry 2020 20:22

    Content type: Research article

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  22. Depression is common among people with schizophrenia and associated with severe positive and negative symptoms, higher rates of disability, treatment resistance and mortality related to suicide, physical and d...

    Authors: Tolesa Fanta, Desalegn Bekele and Getinet Ayano

    Citation: BMC Psychiatry 2020 20:3

    Content type: Research article

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  23. Postpartum psychosis is a rare, yet severe disorder, in which early identification and immediate intervention are crucial. Despite recommendations for psychological input, little is known about the types of ps...

    Authors: R. Forde, S. Peters and A. Wittkowski

    Citation: BMC Psychiatry 2019 19:411

    Content type: Research article

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  24. Accumulating evidence suggests that serum vascular endothelial growth factor (VEGF) in many neurobiological processes potentially contributes to the pathophysiology of psychiatric disorders, particularly cogni...

    Authors: Yaqin Zhao, Wenhuan Xiao, Kuanyu Chen, Qiongqiong Zhan, Fei Ye, Xiaowei Tang and Xiaobin Zhang

    Citation: BMC Psychiatry 2019 19:403

    Content type: Research article

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  25. People with severe mental illness (SMI) living in low and middle-income countries can experience extended delays to diagnosis, which hinder access to medical treatment. The aims of this study were to describe ...

    Authors: Trang Nguyen, Thach Tran, Sally Green, Arthur Hsueh, Tuan Tran, Ha Tran and Jane Fisher

    Citation: BMC Psychiatry 2019 19:385

    Content type: Research article

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  26. Schizophrenia and other psychotic disorders constitute a huge global burden of disease and they are major contributors to disability as well as premature mortality among homeless people. This systematic review...

    Authors: Getinet Ayano, Getachew Tesfaw and Shegaye Shumet

    Citation: BMC Psychiatry 2019 19:370

    Content type: Research article

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  27. We performed a follow up study about willingness and behaviors to quit smoking among smokers with schizophrenia in Japan.

    Authors: Yuji Higuchi, Masaki Fujiwara, Naoki Nakaya, Maiko Fujimori, Chinatsu Hayashibara, Ryuhei So, Ikuta Shinkawa, Kojiro Sato, Yuji Yada, Masafumi Kodama, Hiroshi Takenaka, Yoshiki Kishi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada and Masatoshi Inagaki

    Citation: BMC Psychiatry 2019 19:367

    Content type: Research article

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  28. Minimal/non-response to antipsychotic treatment, and persistent positive symptoms despite treatment, are common among patients with schizophrenia. The aim of this study was to characterize a US treatment-resis...

    Authors: Christoph U. Correll, Thomas Brevig and Cecilia Brain

    Citation: BMC Psychiatry 2019 19:362

    Content type: Research article

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  29. STEPWISE is a theory-informed self-management education programme that was co-produced with service users, healthcare professionals and interventionists to support weight loss for people with schizophrenia. We...

    Authors: Rebecca Gossage-Worrall, Daniel Hind, Katharine D. Barnard-Kelly, David Shiers, Angela Etherington, Lizzie Swaby and Richard I. G. Holt

    Citation: BMC Psychiatry 2019 19:358

    Content type: Research article

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  30. Schizophrenia is associated with severe cognitive deficits, particularly episodic memory deficits, that interfere with patients’ socio-professional functioning. Retrieval practice (also known as testing effect) i...

    Authors: Camille Jantzi, Amaury C. Mengin, David Serfaty, Elisabeth Bacon, Julien Elowe, François Severac, Nicolas Meyer, Fabrice Berna and Pierre Vidailhet

    Citation: BMC Psychiatry 2019 19:355

    Content type: Research article

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  31. Negative symptoms (NS) may be observed in the general population in an attenuated form and in high-risk mental states. However, they have been less studied in the general population than positive symptoms, in ...

    Authors: Juan F. Rodríguez-Testal, Salvador Perona-Garcelán, Sonia Dollfus, María Valdés-Díaz, Jesús García-Martínez, Miguel Ruíz-Veguilla and Cristina Senín-Calderón

    Citation: BMC Psychiatry 2019 19:327

    Content type: Research article

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  32. The “treatment gap” (TG) for mental disorders, widely advocated by the WHO in low-and middle-income countries, is an important indicator of the extent to which a health system fails to meet the care needs of p...

    Authors: Abebaw Fekadu, Girmay Medhin, Crick Lund, Mary DeSilva, Medhin Selamu, Atalay Alem, Laura Asher, Rahel Birhane, Vikram Patel, Maji Hailemariam, Teshome Shibre, Graham Thornicroft, Martin Prince and Charlotte Hanlon

    Citation: BMC Psychiatry 2019 19:325

    Content type: Research article

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  33. Numerous studies have reported contradicting results on the relationship between cancer mortality and schizophrenia. Our aim is to quantify the mortality rate of common site-specific cancers among patients wit...

    Authors: Liwei Ni, Jian Wu, Yuming Long, Jialong Tao, Jianhao Xu, Xuya Yuan, Na Yu, Runhong Wu and Yusong Zhang

    Citation: BMC Psychiatry 2019 19:323

    Content type: Research article

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  34. For women in most low- and middle-income countries, the diagnosis with serious mental illness (SMI) leads to stigma and challenges related to starting or maintaining marriages. The purpose of this qualitative ...

    Authors: Maji Hailemariam, Senait Ghebrehiwet, Tithi Baul, Juliana L. Restivo, Teshome Shibre, David C. Henderson, Eshetu Girma, Abebaw Fekadu, Solomon Teferra, Charlotte Hanlon, Jennifer E. Johnson and Christina P. C. Borba

    Citation: BMC Psychiatry 2019 19:315

    Content type: Research article

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  35. N-methyl-D-aspartate receptor (NMDAR) hypofunction has been proposed to underlie the pathogenesis of schizophrenia. Specifically, reduced function of NMDARs leads to altered balance between excitation and inhi...

    Authors: Lulu Yao, Zongliang Wang, Di Deng, Rongzhen Yan, Jun Ju and Qiang Zhou

    Citation: BMC Psychiatry 2019 19:314

    Content type: Research article

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  36. A key component of case-management in early intervention services for first-episode psychosis is engaging a person with the service and building a relationship from which therapy and treatment can be facilitat...

    Authors: Rachel M. Tindall, Kelly Allott, Magenta Simmons, Winsome Roberts and Bridget E. Hamilton

    Citation: BMC Psychiatry 2019 19:312

    Content type: Research article

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  37. The aim of present study is to measure plasma clozapine (CLZ) and N-desmethyl clozapine (DMC) as biomarkers to correlate drug concentrations with the appearance of preclinical adverse hematic effects.

    Authors: Mayela Vaquero-Baez, Araceli Díaz-Ruíz, Luis Tristán-López, Carlos Aviña-Cervantes, Carlos Torner, Jesús Ramírez-Bermúdez, Sergio Montes and Camilo Ríos

    Citation: BMC Psychiatry 2019 19:295

    Content type: Research article

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  38. Schizophrenia is a severe mental disease with high morbidity and heritability. The SLC39A8 gene is located in 4q24 and encodes a protein that transports many metal ions. Multiple previous studies found that one o...

    Authors: Xuemin Jian, Jianhua Chen, Zhiqiang Li, Zhijian Song, Juan Zhou, Wei Xu, Yahui Liu, Jiawei Shen, Yonggang Wang, Qizhong Yi and Yongyong Shi

    Citation: BMC Psychiatry 2019 19:293

    Content type: Research article

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  39. Problems in social functioning (e.g., unemployment, social isolation), are common in people with a psychotic disorder. Social cognition is a treatment target to improve social functioning, as it is a proximal ...

    Authors: Saskia A. Nijman, Wim Veling, Kirstin Greaves-Lord, Rowina R. Vermeer, Maarten Vos, Catharina E. R. Zandee, Daniëlle C. Zandstra, Chris N. W. Geraets and Gerdina H. M. Pijnenborg

    Citation: BMC Psychiatry 2019 19:272

    Content type: Study protocol

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  40. The goal of clinicians and healthcare workers providing treatment to patients with psychiatric disorders, has shifted over time from focusing on the symptoms alone towards functional improvement. In this study...

    Authors: Xiao Wei Tan, Esmond Seow, Edimansyah Abdin, Swapna Verma, Kang Sim, Siow Ann Chong and Mythily Subramaniam

    Citation: BMC Psychiatry 2019 19:267

    Content type: Research article

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  41. To measure the serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in deficit schizophrenia (DS), in order to examine the association between these t...

    Authors: Xiaowei Tang, Chao Zhou, Ju Gao, Weiwei Duan, Miao Yu, Wenhuan Xiao, Xiaobin Zhang, Hui Dong, Xiang Wang and Xiangrong Zhang

    Citation: BMC Psychiatry 2019 19:254

    Content type: Research article

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  42. Previous studies have suggested that culture impacts the experience of psychosis. The current study set out to extend these findings by examining cultural variation in subclinical positive psychotic experience...

    Authors: Margriet Vermeiden, Mayke Janssens, Viviane Thewissen, Esther Akinsola, Sanne Peeters, Jennifer Reijnders, Nele Jacobs, Jim van Os and Johan Lataster

    Citation: BMC Psychiatry 2019 19:244

    Content type: Research article

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  43. People who suffer a first episode of psychosis experience higher levels of distress and suffering. Early intervention programs combine pharmacological and psychosocial strategies that include different compone...

    Authors: Roberto Mediavilla, Ainoa Muñoz-Sanjose, Beatriz Rodriguez-Vega, Carmen Bayon, Angela Palao, Guillermo Lahera, Pilar Sanchez-Castro, Eva Roman, Susana Cebolla, Alvaro de Diego, Juan Manuel Pastor and Maria Fe Bravo-Ortiz

    Citation: BMC Psychiatry 2019 19:233

    Content type: Study protocol

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  44. Cognitive Bias Modification (CBM) has been used successfully as a computer-based intervention in disorders such as anxiety. However, CBM to modify interpretations of ambiguous information relevant to paranoia ...

    Authors: C. J. Leung, A. Fosuaah, J. Frerichs, M. Heslin, T. Kabir, T. M. C. Lee, P. McGuire, C. Meek, E. Mouchlianitis, A. S. Nath, E. Peters, S. Shergill, D. Stahl, A. Trotta and J. Yiend

    Citation: BMC Psychiatry 2019 19:225

    Content type: Research article

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  45. One of the most important questions remaining in matters of critical illness in the year 2019 is arguably how to address the diverse neuropsychiatric complications of critical illness.

    Authors: Jan N. M. Schieveld, Emma H. C. W. van de Riet and Jacqueline J. M. H. Strik

    Citation: BMC Psychiatry 2019 19:222

    Content type: Debate

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  46. Among patients with treatment-resistant schizophrenia (TRS), some exhibited further clozapine resistance (CR). This study aimed to investigate whether greater severity of treatment resistance in schizophrenia ...

    Authors: An-Sheng Lin, Hung-Yu Chan, Ying-Chieh Peng and Wei J. Chen

    Citation: BMC Psychiatry 2019 19:220

    Content type: Research article

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  47. Sexual dysfunction is common in patients with schizophrenia, however it is poorly studied in China, especially in primary health care institutions in rural areas. We investigated the prevalence of sexual dysfu...

    Authors: Ying-Hua Huang, Cai-Lan Hou, C. H. Ng, Xie Chen, Qian-Wen Wang, Zhuo-Hui Huang and Fu-Jun Jia

    Citation: BMC Psychiatry 2019 19:218

    Content type: Research article

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