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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. People with psychosis struggle with decisions about their use of antipsychotics. They often want to reduce the dose or stop, while facing uncertainty regarding the effects these decisions will have on their tr...

    Authors: Yaara Zisman-Ilani, David Shern, Patricia Deegan, Julie Kreyenbuhl, Lisa Dixon, Robert Drake, William Torrey, Manish Mishra, Ksenia Gorbenko and Glyn Elwyn

    Citation: BMC Psychiatry 2018 18:142

    Content type: Research article

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  2. Multiple system atrophy (MSA) is an adult-onset, rare, and progressive neurodegenerative disorder characterized by a varying combination of autonomic failure, cerebellar ataxia, and parkinsonism. MSA is catego...

    Authors: Hiroshi Komatsu, Masaaki Kato, Teiko Kinpara, Takashi Ono and Yoshihisa Kakuto

    Citation: BMC Psychiatry 2018 18:141

    Content type: Case report

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  3. Motivational interviewing (MI) may be an effective intervention to improve medication adherence in patients with schizophrenia. However, for this patient group, mixed results have been found in randomized cont...

    Authors: Jos Dobber, Corine Latour, Lieuwe de Haan, Wilma Scholte op Reimer, Ron Peters, Emile Barkhof and Berno van Meijel

    Citation: BMC Psychiatry 2018 18:135

    Content type: Research article

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  4. The adverse impact of unhealthy lifestyle choices and the prescription of antipsychotic medications contribute to weight gain, poor cardiovascular health and reduced life expectancy for people with psychosis. ...

    Authors: Rebecca Pedley, Karina Lovell, Penny Bee, Tim Bradshaw, Judith Gellatly, Kate Ward, Adrine Woodham and Alison Wearden

    Citation: BMC Psychiatry 2018 18:111

    Content type: Research article

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  5. Evidence shows that internet-based self-help interventions are effective in reducing symptoms for a wide range of mental disorders. To date, online interventions treating psychotic disorders have been scarce, ...

    Authors: Nina Rüegg, Steffen Moritz, Thomas Berger, Thies Lüdtke and Stefan Westermann

    Citation: BMC Psychiatry 2018 18:102

    Content type: Study protocol

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  6. Early diagnosis of schizophrenia could improve the outcome of the illness. Unlike classical between-group comparisons, machine learning can identify subtle disease patterns on a single subject level, which cou...

    Authors: Pavol Mikolas, Jaroslav Hlinka, Antonin Skoch, Zbynek Pitra, Thomas Frodl, Filip Spaniel and Tomas Hajek

    Citation: BMC Psychiatry 2018 18:97

    Content type: Research article

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  7. Speech recognition under noisy “cocktail-party” environments involves multiple perceptual/cognitive processes, including target detection, selective attention, irrelevant signal inhibition, sensory/working mem...

    Authors: Yingjun Zheng, Chao Wu, Juanhua Li, Ruikeng Li, Hongjun Peng, Shenglin She, Yuping Ning and Liang Li

    Citation: BMC Psychiatry 2018 18:90

    Content type: Research article

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  8. Nesfatin-1 plays a role in the regulation of emotional states like depression. The aim of this study was to investigate the plasma nesfatin-1levels in Chinese patients with depression and healthy subjects, and...

    Authors: Min-Min Xiao, Jiang-Bo Li, Lan-Lan Jiang, Hui Shao and Bao-Long Wang

    Citation: BMC Psychiatry 2018 18:88

    Content type: Research article

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  9. Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects...

    Authors: Tsubasa Morimoto, Yasuhiro Matsuda, Kiwamu Matsuoka, Fumihiko Yasuno, Emi Ikebuchi, Hiroyuki Kameda, Toshiaki Taoka, Toshiteru Miyasaka, Kimihiko Kichikawa and Toshifumi Kishimoto

    Citation: BMC Psychiatry 2018 18:83

    Content type: Research article

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  10. Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate d...

    Authors: Jinming Li, Yuan Yang, Yuankai Zhu, Liqiang Zhou, Yunfeng Han, Tao Yin, Zhaoting Cheng, Guopeng Zhang, Yanxia Shen and Jing Chen

    Citation: BMC Psychiatry 2018 18:70

    Content type: Research article

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  11. Ritualistic behaviors are common in obsessive compulsive disorder (OCD), while catatonic stupor occasionally occurs in psychotic or mood disorders. Schizoaffective disorder is a specific mental disorder involv...

    Authors: Yuanhan Bai, Xi Yang, Zhiqiang Zeng and Haichen Yang

    Citation: BMC Psychiatry 2018 18:67

    Content type: Case report

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  12. Personality is considered as an important aspect in persons with psychotic disorders. Several studies have investigated personality in schizophrenia. However, no study has investigated stability of personality...

    Authors: Tomas Fagerberg, Erik Söderman, J. Petter Gustavsson, Ingrid Agartz and Erik G. Jönsson

    Citation: BMC Psychiatry 2018 18:54

    Content type: Research article

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    The Correction to this article has been published in BMC Psychiatry 2019 19:109

  13. Patients with schizophrenia have the highest known rates of cigarette smoking, but less is known about their smoking behavior and the differences across geographical regions, including Croatia.

    Authors: Marina Šagud, Bjanka Vuksan-Ćusa, Nenad Jakšić, Alma Mihaljević-Peleš, Maja Živković, Suzana Vlatković, Tea Prgić, Darko Marčinko and Wei Wang

    Citation: BMC Psychiatry 2018 18:18

    Content type: Research article

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  14. The process of assessing the decision-making capacity of potential subjects before their inclusion in clinical trials is a legal requirement and a moral obligation, as it is essential for respecting their auto...

    Authors: Sorin Hostiuc, Mugurel Constantin Rusu, Ionut Negoi and Eduard Drima

    Citation: BMC Psychiatry 2018 18:2

    Content type: Research article

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  15. This study investigated the prevalence of schizophrenia (ICD-10 F 20) and of other non-affective psychosis (NAP, ICD-10 F 21 - F 29) in Sweden. It further assessed health care use, comorbidity and medication f...

    Authors: Erica M. Brostedt, Mussie Msghina, Marie Persson and Björn Wettermark

    Citation: BMC Psychiatry 2017 17:416

    Content type: Research article

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  16. People with psychosis have a reduced life expectancy of 10–20 years, largely due to cardiovascular disease. This trial aimed to determine the effectiveness of a modular health promotion intervention (IMPaCT Th...

    Authors: Fiona Gaughran, Daniel Stahl, Khalida Ismail, Kathryn Greenwood, Zerrin Atakan, Poonam Gardner-Sood, Brendon Stubbs, David Hopkins, Anita Patel, John Lally, Philippa Lowe, Maurice Arbuthnot, Diana Orr, Sarah Corlett, Jonas Eberhard, Anthony S. David…

    Citation: BMC Psychiatry 2017 17:413

    Content type: Research article

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  18. Biomarkers are now widely used in many fields of medicine, and the identification of biomarkers that predict antipsychotic efficacy and adverse reactions is a growing area of psychiatric research. Monoamine mo...

    Authors: A. E. Taraskina, R. F. Nasyrova, A. M. Zabotina, D. N. Sosin, К. А. Sosina, E. E. Ershov, M. N. Grunina and E. M. Krupitsky

    Citation: BMC Psychiatry 2017 17:394

    Content type: Research article

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  19. Schizophrenia has a negative effect on the activity of the temporal and prefrontal cortices in the processing of emotional facial expressions. However no previous research focused on the evaluation of mixed em...

    Authors: Ádám György Szabó, Kinga Farkas, Csilla Marosi, Lajos R. Kozák, Gábor Rudas, János Réthelyi and Gábor Csukly

    Citation: BMC Psychiatry 2017 17:391

    Content type: Research article

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  20. Psychotic disorders are among the most severe psychiatric disorders that have great effects on the individuals and the society. For surveillance of chronic low prevalence conditions such as psychotic disorders...

    Authors: Christine Chan Chee, Francis Chin, Catherine Ha, Nathalie Beltzer and Christophe Bonaldi

    Citation: BMC Psychiatry 2017 17:386

    Content type: Research article

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  21. This study evaluates the psychometric properties of the Malay version of the Brief Psychiatric Rating Scale (BPRS-M) among patients with schizophrenia in a psychiatric outpatient clinic.

    Authors: Anne Yee, Boon Seng Ng, Helenna Maria Hisham Hashim, Mahmoud Danaee and Huai Heng Loh

    Citation: BMC Psychiatry 2017 17:384

    Content type: Research article

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  22. Cognitive deficits are a core feature of early schizophrenia. However, the pathological foundations underlying cognitive deficits are still unknown. The present study examined the association between gray matt...

    Authors: Jingjuan Wang, Li Zhou, Chunlei Cui, Zhening Liu and Jie Lu

    Citation: BMC Psychiatry 2017 17:374

    Content type: Research article

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  23. Antipsychotics have serious metabolic side effects on blood glucose. However, the comparative influence of these drugs on blood glucose levels has not been comprehensively evaluated. We conducted a network met...

    Authors: Yangyu Zhang, Yingyu Liu, Yingying Su, Yueyue You, Yue Ma, Guang Yang, Yan Song, Xinyu Liu, Mohan Wang, Lili Zhang and Changgui Kou

    Citation: BMC Psychiatry 2017 17:373

    Content type: Research article

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  24. There is consensus that the treatment of schizophrenia should combine anti-psychotic medication and psychosocial interventions in order to address complex social, economic and health needs. It is recommended t...

    Authors: Laura Asher, Vikram Patel and Mary J De Silva

    Citation: BMC Psychiatry 2017 17:355

    Content type: Research article

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  25. Nonadherence to antipsychotic treatment increases the likelihood of relapse and progressive symptomatology in patients with schizophrenia. Atypical long-acting injectables, including paliperidone palmitate (PP...

    Authors: Jeffrey P. Anderson, Zeynep Icten, Veronica Alas, Carmela Benson and Kruti Joshi

    Citation: BMC Psychiatry 2017 17:346

    Content type: Research article

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  26. Periodic catatonia has long been a challenging diagnosis and there are no absolute guidelines for treatment when precipitating factors are also unclear. We report a schizophrenia patient with periodic catatoni...

    Authors: Ruei-An Chen and Tiao-Lai Huang

    Citation: BMC Psychiatry 2017 17:337

    Content type: Case report

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  27. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease involving antibodies against the NR1 subunits of NMDARs. The disease shows variable clinical presentation, and involves new-onse...

    Authors: Xia Rong, Zhenzhen Xiong, Bingrong Cao, Juan Chen, Mingli Li and Zhe Li

    Citation: BMC Psychiatry 2017 17:320

    Content type: Case report

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  28. The choice of antipsychotic treatment during pregnancy remains controversial, mainly due to a lack of exposure and outcome data. Randomized clinical trials are practically impossible due to ethical reasons. Ou...

    Authors: Andreea Teodorescu, Petru Ifteni, Marius Alexandru Moga, Victoria Burtea and Nicusor Bigiu

    Citation: BMC Psychiatry 2017 17:311

    Content type: Case report

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  29. Schizophrenia is a chronic and debilitating neuropsychiatric disorder that often requires long-term pharmacotherapy to manage symptoms and prevent relapse. Cariprazine is a potent dopamine D3 and D2 receptor part...

    Authors: Henry A. Nasrallah, Willie Earley, Andrew J. Cutler, Yao Wang, Kaifeng Lu, István Laszlovszky, György Németh and Suresh Durgam

    Citation: BMC Psychiatry 2017 17:305

    Content type: Research article

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  30. Non-adherence is a major public health problem despite treatment advances. Poor drug adherence in patients with psychosis is associated with more frequent relapse, re-hospitalization, increased consumption of ...

    Authors: Rafal A. H. Yeisen, Jone Bjornestad, Inge Joa, Jan Olav Johannessen and Stein Opjordsmoen

    Citation: BMC Psychiatry 2017 17:299

    Content type: Research article

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  31. Mental health is a significant contributor to global burden of disease and the consequences of perinatal psychiatric morbidity can be substantial. We aimed to obtain global estimates of puerperal psychosis pre...

    Authors: Rachel VanderKruik, Maria Barreix, Doris Chou, Tomas Allen, Lale Say and Lee S. Cohen

    Citation: BMC Psychiatry 2017 17:272

    Content type: Research article

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  33. It has been reported that drugs which promote the N-Methyl-D-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfuncti...

    Authors: Kazuo Takiguchi, Akihito Uezato, Michio Itasaka, Hidenori Atsuta, Kenji Narushima, Naoki Yamamoto, Akeo Kurumaji, Makoto Tomita, Kazunari Oshima, Kosaku Shoda, Mai Tamaru, Masahito Nakataki, Mitsutoshi Okazaki, Sayuri Ishiwata, Yasuyoshi Ishiwata, Masato Yasuhara…

    Citation: BMC Psychiatry 2017 17:249

    Content type: Research article

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  34. Antipsychotics are a heterogeneous group of drugs. Although, antipsychotics have been used for years, unexpected side effects may still occur. With this case report we focus on a possible association between p...

    Authors: Camelia-Eugenia Bujor, Torkel Vang, Jimmi Nielsen and Ole Schjerning

    Citation: BMC Psychiatry 2017 17:242

    Content type: Case report

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  35. Given the complex nature of symptom presentation and medication regimens, psychiatric clinics may benefit from additional tools to personalize treatments. Utilizing pharmacogenetic information may be helpful i...

    Authors: Seenae Eum, Mark E. Schneiderhan, Jacob T. Brown, Adam M. Lee and Jeffrey R. Bishop

    Citation: BMC Psychiatry 2017 17:238

    Content type: Case report

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  36. Schizophrenia is a neurological disease characterized by alterations to patients’ cognitive functions and emotional expressions. Relevant studies often use magnetic resonance imaging (MRI) of the brain to expl...

    Authors: Bo-Lin Jian, Chieh-Li Chen, Wen-Lin Chu and Min-Wei Huang

    Citation: BMC Psychiatry 2017 17:229

    Content type: Research article

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  37. In preparation for a randomized controlled trial, a pilot study was conducted to investigate the feasibility, acceptability and effectiveness of a psychotherapy group based on metacognitive-oriented social ski...

    Authors: Felix Inchausti, Nancy V. García-Poveda, Alejandro Ballesteros-Prados, Eduardo Fonseca-Pedrero, Javier Ortuño-Sierra, Sergio Sánchez-Reales, Javier Prado-Abril, José Antonio Aldaz-Armendáriz and Joe Mole

    Citation: BMC Psychiatry 2017 17:217

    Content type: Research article

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  38. Once-monthly paliperidone palmitate (PP1M) is a long-acting injectable antipsychotic that may increase adherence rates, reduce hospitalizations, and lower medical costs compared to oral atypical antipsychotics...

    Authors: Dominic Pilon, Erik Muser, Patrick Lefebvre, Rhiannon Kamstra, Bruno Emond and Kruti Joshi

    Citation: BMC Psychiatry 2017 17:207

    Content type: Research article

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  39. Prepulse inhibition (PPI) and attention were impaired, which may cause psychotic symptoms and (or) hinder the cognitive functions in schizophrenia. However, due to the measurement methods of PPI, findings abou...

    Authors: Ning-Bo Yang, Qing Tian, Yu Fan, Qi-Jing Bo, Liang Zhang, Liang Li and Chuan-Yue Wang

    Citation: BMC Psychiatry 2017 17:135

    Content type: Research article

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  40. In France, negative views on schizophrenia are pervasive, even among health professionals. Prior research suggests that the level of prejudice is lower when the illness is described with the example of a speci...

    Authors: Murielle Villani and Viviane Kovess - Masfety

    Citation: BMC Psychiatry 2017 17:133

    Content type: Research article

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  41. The cardiometabolic health of persons with a severe mental illness (SMI) is alarming with obesity rates of 45-55% and diabetes type 2 rates of 10-15%. Unhealthy lifestyle behaviours play a large role in this. ...

    Authors: Anne Looijmans, Frederike Jörg, Richard Bruggeman, Robert Schoevers and Eva Corpeleijn

    Citation: BMC Psychiatry 2017 17:107

    Content type: Study protocol

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  42. The prevalence of smoking in patients with schizophrenia is higher than that in the general population and is an important medical issue. Short-term smoking cessation tends to worsen psychiatric symptoms in pa...

    Authors: Masatoshi Miyauchi, Ikuko Kishida, Akira Suda, Yohko Shiraishi, Mami Fujibayashi, Masataka Taguri, Chie Ishii, Norio Ishii, Toshio Moritani and Yoshio Hirayasu

    Citation: BMC Psychiatry 2017 17:87

    Content type: Research article

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  43. Schizophrenia is a serious form of mental illness that often requires long term care. Empirical findings indicate that combining a psycho-educational intervention (PEI) with neuroleptic medication to treat sch...

    Authors: Abd Al-HadiHasan, Patrick Callaghan and Joanne S. Lymn

    Citation: BMC Psychiatry 2017 17:68

    Content type: Research article

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  44. Treatment of schizophrenia and major depressive disorder (MDD) with atypical antipsychotics (AAPs) show improved efficacy and reduced side effect burden compared with older antipsychotic medications. However, ...

    Authors: Pierre-Michel Llorca, Christophe Lançon, Ann Hartry, T. Michelle Brown, Dana B. DiBenedetti, Siddhesh A. Kamat and Clément François

    Citation: BMC Psychiatry 2017 17:67

    Content type: Research article

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  45. Suicide is a leading cause of mortality among those afflicted by schizophrenia. Previous studies demonstrated that the stressors associated with immigration may lead to an onset of schizophrenia and suicide se...

    Authors: Nuwan C. Hettige, Ali Bani-Fatemi, James L. Kennedy and Vincenzo De Luca

    Citation: BMC Psychiatry 2017 17:63

    Content type: Research article

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  46. The outcome of first episode psychosis (FEP) is highly variable and difficult to predict. Cognitive insight measured at illness onset has previously been found to predict psychopathology 12-months later. The a...

    Authors: Jennifer A. O’Connor, Lyn Ellett, Olesya Ajnakina, Tabea Schoeler, Anna Kollliakou, Antonella Trotta, Benjamin D. Wiffen, Aurora M. Falcone, Marta Di Forti, Robin M. Murray, Sagnik Bhattacharyya and Anthony S. David

    Citation: BMC Psychiatry 2017 17:54

    Content type: Research article

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  47. The feasibility of shared decision making (SDM) for patients with schizophrenia remains controversial due to the assumed inability of patients to cooperate in treatment decision making. This study evaluated th...

    Authors: Mio Ishii, Yasuyuki Okumura, Naoya Sugiyama, Hana Hasegawa, Toshie Noda, Yoshio Hirayasu and Hiroto Ito

    Citation: BMC Psychiatry 2017 17:52

    Content type: Research article

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  48. Although previous studies found that aberrations in gray matter volume (GMV) and global functional connectivity density (gFCD) are important characteristics of schizophrenia, to the best of our knowledge no st...

    Authors: Chuanjun Zhuo, Jiajia Zhu, Chunli Wang, Hongru Qu, Xiaolei Ma, Hongjun Tian, Mei Liu and Wen Qin

    Citation: BMC Psychiatry 2017 17:45

    Content type: Research article

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  49. The transition from adolescence to adulthood is associated with the emergence of psychosis and other mental health problems, highlighting the importance of this developmental period for the understanding of de...

    Authors: Peter J. Uhlhaas, Ruchika Gajwani, Joachim Gross, Andrew I. Gumley, Stephen M. Lawrie and Matthias Schwannauer

    Citation: BMC Psychiatry 2017 17:43

    Content type: Study protocol

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  50. Although the relationship between cultural beliefs and schizophrenia has received some attention, relatively little work has emerged from African contexts. In this study we draw from a sample of South African ...

    Authors: Megan M. Campbell, Goodman Sibeko, Sumaya Mall, Adam Baldinger, Mohamed Nagdee, Ezra Susser and Dan J. Stein

    Citation: BMC Psychiatry 2017 17:41

    Content type: Research article

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