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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Life expectancy in patients with schizophrenia is reduced by 20 years for males and 15 years for females compared to the general population. About 60% of the excess mortality is due to physical illnesses, with...

    Authors: Helene Speyer, Hans Christian Brix Nørgaard, Carsten Hjorthøj, Thomas Axel Madsen, Søren Drivsholm, Charlotta Pisinger, Christian Gluud, Ole Mors, Jesper Krogh and Merete Nordentoft

    Citation: BMC Psychiatry 2015 15:119

    Content type: Study protocol

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  2. Polyunsaturated fatty acid (PUFA) metabolism abnormalities have been long implicated in the etiology of schizophrenia. Although several randomized clinical trials have been carried out to assess the efficacy o...

    Authors: Tomasz Pawełczyk, Marta Grancow, Magdalena Kotlicka-Antczak, Elżbieta Trafalska, Piotr Gębski, Janusz Szemraj, Natalia Żurner and Agnieszka Pawełczyk

    Citation: BMC Psychiatry 2015 15:97

    Content type: Study protocol

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  3. Only three observational studies investigated whether exposure to antipsychotics is associated with an increased risk of pulmonary embolism, with conflicting results. This study was therefore carried out to es...

    Authors: Valentino Conti, Mauro Venegoni, Alfredo Cocci, Ida Fortino, Antonio Lora and Corrado Barbui

    Citation: BMC Psychiatry 2015 15:92

    Content type: Research article

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  4. Evidence has been accumulating that it may be possible to achieve prevention in psychotic disorders. The aim of the Prevention Of Psychosis (POP) study is to reduce the annual incidence of psychotic disorders ...

    Authors: Inge Joa, Jens Gisselgård, Kolbjørn Brønnick, Thomas McGlashan and Jan Olav Johannessen

    Citation: BMC Psychiatry 2015 15:89

    Content type: Study protocol

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  5. Most women with psychotic disorders and bipolar disorders have children but their pregnancies are at risk of adverse psychiatric and fetal outcome. The extent of modifiable risk factors – both clinical and soc...

    Authors: Clare L Taylor, Robert Stewart, Jack Ogden, Matthew Broadbent, Dharmintra Pasupathy and Louise M Howard

    Citation: BMC Psychiatry 2015 15:88

    Content type: Research article

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  6. Capgras delusion is a delusional misidentification syndrome, in which the patient is convinced that someone that is well known to them, usually a close relative, has been replaced by an impostor or double. Alt...

    Authors: Lucrezia Islam, Sylvie Piacentini, Paola Soliveri, Silvio Scarone and Orsola Gambini

    Citation: BMC Psychiatry 2015 15:73

    Content type: Case report

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  7. Psycho-educational interventions for people diagnosed with schizophrenia (PDwS) and their primary caregivers appear promising, however, the majority of trials have significant methodological shortcomings. Ther...

    Authors: Abd Alhadi Hasan, Patrick Callaghan and Joanne S Lymn

    Citation: BMC Psychiatry 2015 15:72

    Content type: Research article

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  8. Schizophrenia is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, and the L-arginine:ADMA ratio are ma...

    Authors: Anders Jorgensen, Ulla Knorr, Mia Greisen Soendergaard, Jens Lykkesfeldt, Anders Fink-Jensen, Henrik Enghusen Poulsen, Martin Balslev Jorgensen, Niels Vidiendal Olsen and Jonatan Myrup Staalsø

    Citation: BMC Psychiatry 2015 15:67

    Content type: Research article

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  9. Olanzapine long-acting injection (LAI) for the treatment of schizophrenia was associated with a cluster of symptoms termed post-injection delirium/sedation syndrome (PDSS) in a small percentage (~2%) of patien...

    Authors: Chris J Bushe, Deborah Falk, Ernie Anand, Marta Casillas, Elena Perrin, Rashna Chhabra-Khanna and Holland C Detke

    Citation: BMC Psychiatry 2015 15:65

    Content type: Research article

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  10. Adults with serious mental illness have a mortality rate two to three times higher than the overall US population, much of which is due to somatic conditions, especially cardiovascular disease. Given the dispr...

    Authors: Julia B Baller, Emma E McGinty, Susan T Azrin, Denise Juliano-Bult and Gail L Daumit

    Citation: BMC Psychiatry 2015 15:55

    Content type: Research article

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  11. The functional outcome of people with severe mental disorders (SMD) is purported to be better in low- and middle-income countries compared to high-income countries; however, cross-cultural measures of function...

    Authors: Kassahun Habtamu, Atalay Alem and Charlotte Hanlon

    Citation: BMC Psychiatry 2015 15:34

    Content type: Research article

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  13. Specialized Early Intervention services (SEI) for first episode psychosis are shown to be effective for the treatment of positive and negative symptoms, medication adherence, rates of relapse, substance abuse ...

    Authors: Danyael Lutgens, Srividya Iyer, Ridha Joober, Thomas G Brown, Ross Norman, Eric Latimer, Norbert Schmitz, Amal Abdel Baki, Sherezad Abadi and Ashok Malla

    Citation: BMC Psychiatry 2015 15:22

    Content type: Study protocol

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  14. Non-adherence to antipsychotic medication in schizophrenic patients is common and associated with symptom relapse and poorer long-term outcomes. The risk factors for treatment non-adherence include dosing freq...

    Authors: Pei-Yin Pan, Meei-Shyuan Lee and Chin-Bin Yeh

    Citation: BMC Psychiatry 2015 15:1

    Content type: Research article

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  15. Recruitment to mental health research can be challenging. ‘Consent for Contact’ (C4C) is a novel framework which may expedite recruitment and contribute to equitable access to research. This paper discusses st...

    Authors: Constantina Papoulias, Dan Robotham, Gareth Drake, Diana Rose and Til Wykes

    Citation: BMC Psychiatry 2014 14:377

    Content type: Research article

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  16. Quality of life (QoL) is considered an important outcome in health research. It can be rated by the patient, or by an external assessor. We wished to identify the predictors of any discrepancies between these ...

    Authors: Karen P Hayhurst, Jennifer A Massie, Graham Dunn, Shôn W Lewis and Richard J Drake

    Citation: BMC Psychiatry 2014 14:365

    Content type: Research article

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  17. The concept of cenesthopathy was first introduced by Dupré and Camus in 1907 to describe clinically unexplainable bodily sensations mainly attributed to psychiatric pathology. If it occurs in oral regions, it ...

    Authors: Akihito Uezato, Akira Toyofuku, Yojiro Umezaki, Motoko Watanabe, Akira Toriihara, Makoto Tomita, Naoki Yamamoto, Akeo Kurumaji and Toru Nishikawa

    Citation: BMC Psychiatry 2014 14:1696

    Content type: Research article

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  18. Pomaglumetad methionil (LY2140023 monohydrate) is a potent and highly selective agonist for the metabotropic glutamate mGluR2 and mGluR3 receptors. We present results of a pivotal clinical study H8Y-MC-HBBM as...

    Authors: AnnCatherine M Downing, Bruce J Kinon, Brian A Millen, Lu Zhang, Lin Liu, Margarita A Morozova, Ronald Brenner, Tami Jo Rayle, Laura Nisenbaum, Fangyi Zhao and Juan Carlos Gomez

    Citation: BMC Psychiatry 2014 14:351

    Content type: Research article

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  20. Early intervention services for psychotic disorders optimally interlock strategies to deliver: (i) Early Detection (ED) to shorten the time between onset of psychotic symptoms and effective treatment (i.e. Dur...

    Authors: Vinod H Srihari, Cenk Tek, Jessica Pollard, Suzannah Zimmet, Jane Keat, John D Cahill, Suat Kucukgoncu, Barbara C Walsh, Fangyong Li, Ralitza Gueorguieva, Nina Levine, Raquelle I Mesholam-Gately, Michelle Friedman-Yakoobian, Larry J Seidman, Matcheri S Keshavan, Thomas H McGlashan…

    Citation: BMC Psychiatry 2014 14:335

    Content type: Study protocol

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  21. People with chronic psychosis often display theory of mind impairments that are not fully accounted for by other, more general neurocognitive deficits. In these patients, both theory of mind and neurocognitive...

    Authors: Robyn Langdon, Michael H Connors, Megan Still, Philip B Ward and Stanley Catts

    Citation: BMC Psychiatry 2014 14:316

    Content type: Research article

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  22. Non-adherence with antipsychotic medication is a frequently occurring problem, particularly among patients with psychotic disorders. Prior research has generally shown encouraging results for interventions bas...

    Authors: Ernst L Noordraven, Charlotte H Audier, Anton BP Staring, Andre I Wierdsma, Peter Blanken, Bas EA van der Hoorn, Leona Hakkaart-van Roijen and Cornelis L Mulder

    Citation: BMC Psychiatry 2014 14:343

    Content type: Study protocol

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  23. In schizophrenia, medication adherence is critical to achieve better patient outcomes and to avoid relapses, which are responsible for a significant proportion of total healthcare costs for this chronic illnes...

    Authors: Tatiana Dilla, Jörgen Möller, Paul O’Donohoe, María Álvarez, José A Sacristán, Michael Happich and Antje Tockhorn

    Citation: BMC Psychiatry 2014 14:298

    Content type: Research article

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  24. The objective of this study was to characterize real-world treatment patterns in the prescription of antipsychotic polypharmacy (≥2 concurrent antipsychotics) compared with antipsychotic monotherapy for patien...

    Authors: Maxine D Fisher, Kathleen Reilly, Keith Isenberg and Kathleen F Villa

    Citation: BMC Psychiatry 2014 14:341

    Content type: Research article

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  25. The prevalence of negative symptoms in schizophrenic patients seems to be an important indicator for treatment response and prognosis. Although negative symptoms have often been attributed to frontal lobe anom...

    Authors: Tobias Hornig, Gabi Valerius, Bernd Feige, Emanuel Bubl, Hans M Olbrich and Ludger Tebartz van Elst

    Citation: BMC Psychiatry 2014 14:326

    Content type: Research article

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  26. Severe mentally ill (SMI) patients have a reduced life expectancy of 13-30 years compared to the general population, largely due to an increased risk of cardiovascular mortality. Unhealthy lifestyle behaviours...

    Authors: Anne Looijmans, Frederike Jörg, Robert A Schoevers, Richard Bruggeman, Ronald P Stolk and Eva Corpeleijn

    Citation: BMC Psychiatry 2014 14:293

    Content type: Study protocol

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  27. Despite strong research interest in psychosis risk identification and the potential for early intervention, few papers have sought to document the implementation and evaluation of specialised psychosis related...

    Authors: Agatha M Conrad, Terry J Lewin, Ketrina A Sly, Ulrich Schall, Sean A Halpin, Mick Hunter and Vaughan J Carr

    Citation: BMC Psychiatry 2014 14:318

    Content type: Research article

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  29. The first of the atypical antipsychotics introduced in the 1970s, clozapine remains the most efficacious neuroleptic to this day. However, serious and potentially fatal side effects have necessitated careful r...

    Authors: Bradley Linton, Rachel Fu, Penny A MacDonald and Hooman Ganjavi

    Citation: BMC Psychiatry 2014 14:299

    Content type: Case report

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  33. Schizophrenia is a debilitating mental disorder that presents impairments in neurocognition and social cognition. Several studies have suggested that the etiology of schizophrenia can be partly explained by ox...

    Authors: Cristina Gonzalez-Liencres, Cumhur Tas, Elliot C Brown, Soner Erdin, Ece Onur, Zeynep Cubukcoglu, Omer Aydemir, Aysen Esen-Danaci and Martin Brüne

    Citation: BMC Psychiatry 2014 14:268

    Content type: Research article

    Published on:

  34. Socioeconomic status has important associations with disease-specific mortality in the general population. Although individuals with Severe Mental Illnesses (SMI) experience significant premature mortality, th...

    Authors: Julie Langan Martin, Gary McLean, John Park, Daniel J Martin, Moira Connolly, Stewart W Mercer and Daniel J Smith

    Citation: BMC Psychiatry 2014 14:261

    Content type: Research article

    Published on:

  35. Schizophrenia is one of the most disabling and severely stigmatized mental disorders. Together with social stigma, internalized stigma and perceived stigma can trigger a vicious cycle and diminishes the stigma...

    Authors: Berhanu Boru Bifftu, Berihun Assefa Dachew and Bewket Tadesse Tiruneh

    Citation: BMC Psychiatry 2014 14:259

    Content type: Research article

    Published on:

  37. Self-report instruments for the assessment of depressive symptoms in patients with psychotic disorders are scarce. The Quick Inventory of Depressive Symptoms (QIDS-SR16) may be a useful self-report instrument, bu...

    Authors: Irene M Lako, Johanna TW Wigman, Rianne MC Klaassen, Cees J Slooff, Katja Taxis and Agna A Bartels-Velthuis

    Citation: BMC Psychiatry 2014 14:247

    Content type: Research article

    Published on:

  38. Relapse in people with schizophrenia is a major challenge for mental health service providers in Tanzania and other countries. Approximately 10% of people with schizophrenia are re-admitted due to relapse at M...

    Authors: Adellah E Sariah, Anne H Outwater and Khadija IY Malima

    Citation: BMC Psychiatry 2014 14:240

    Content type: Research article

    Published on:

  39. The strengths-based approach is considered a paradigm shift from the deficits- focused service delivery models. The aim of this review was to systematically review randomised controlled trials (RCTs) and quasi...

    Authors: Nashwa Ibrahim, Maria Michail and Patrick Callaghan

    Citation: BMC Psychiatry 2014 14:243

    Content type: Research article

    Published on:

  40. Sub Saharan African is experiencing the largest increase in the prevalence of type 2 diabetes mellitus and cardiovascular disease globally. Metabolic syndrome (MetS) is a cluster of risk factors for these cond...

    Authors: Shamima Saloojee, Jonathan K Burns and Ayesha A Motala

    Citation: BMC Psychiatry 2014 14:228

    Content type: Research article

    Published on:

  42. Suicide completion is a tragic outcome in secondary mental healthcare. However, the extent to which demographic and clinical characteristics, suicide method and service use-related factors vary across psychiat...

    Authors: Javier-David Lopez-Morinigo, Andrea C Fernandes, Chin-Kuo Chang, Richard D Hayes, Matthew Broadbent, Robert Stewart, Anthony S David and Rina Dutta

    Citation: BMC Psychiatry 2014 14:213

    Content type: Research article

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  44. A combination of psychosocial interventions and medications has been highly recommended as a successful treatment package for schizophrenia. Its cost-effectiveness has not been fully explored yet. The aim of t...

    Authors: Zhanchou Zhang, Jinguo Zhai, Qinling Wei, Jingfeng Qi, Xiaofeng Guo and Jingping Zhao

    Citation: BMC Psychiatry 2014 14:212

    Content type: Research article

    Published on:

  45. Early signs based relapse prevention interventions for psychosis show promise. In order to examine how they might be improved we sought to better understand the early relapse process, service users’ abilities ...

    Authors: Emily Eisner, Christine Barrowclough, Fiona Lobban and Richard Drake

    Citation: BMC Psychiatry 2014 14:201

    Content type: Research article

    Published on:

  46. Cognitive behavior therapy for psychosis has been a prominent intervention in the psychological treatment of psychosis. It is, however, a challenging therapy to deliver and, in the context of increasingly rigo...

    Authors: Neil Thomas, Frances Shawyer, David J Castle, David Copolov, Steven C Hayes and John Farhall

    Citation: BMC Psychiatry 2014 14:198

    Content type: Study protocol

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  47. Psychosocial dysfunction is one of schizophrenia’s core features, often leading to a deprecation of independent living and significant failure to maintain a competent quality of life. Cognitive and occupationa...

    Authors: Eleni Jelastopulu, Evangelia Giourou, Giorgos Merekoulias, Angeliki Mestousi, Eleftherios Moratis and Evangelos C Alexopoulos

    Citation: BMC Psychiatry 2014 14:197

    Content type: Research article

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  48. Obesity among patients with schizophrenia is a growing concern because being overweight is widely regarded as a major risk factor for cardiovascular disease and premature death. Dietary patterns have been sugg...

    Authors: Norio Sugawara, Norio Yasui-Furukori, Yasushi Sato, Manabu Saito, Hanako Furukori, Taku Nakagami, Masamichi Ishioka and Sunao Kaneko

    Citation: BMC Psychiatry 2014 14:184

    Content type: Research article

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  49. People with schizophrenia face prejudice and discrimination from a number of sources including professionals and families. The degree of stigma perceived and experienced varies across cultures and communities....

    Authors: Sandra Saldivia, Ariadne Runte-Geidel, Pamela Grandón, Francisco Torres-González, Miguel Xavier, Claudio Antonioli, Dinarte A Ballester, Roberto Melipillán, Emiliano Galende, Benjamín Vicente, José Miguel Caldas, Helen Killaspy, Rachel Gibbons and Michael King

    Citation: BMC Psychiatry 2014 14:182

    Content type: Research article

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  50. Caring for a young person experiencing first-episode psychosis is challenging and can affect carers’ well-being adversely. While some face-to-face approaches have achieved promising outcomes, they are costly a...

    Authors: Terence V McCann and Dan I Lubman

    Citation: BMC Psychiatry 2014 14:168

    Content type: Research article

    Published on:

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