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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. A novel staffing model integrating peer support workers and clinical staff within a unified team is being trialled at community based residential rehabilitation units in Australia. A mixed-methods protocol for...

    Authors: Stephen Parker, Frances Dark, Ellie Newman, Nicole Korman, Carla Meurk, Dan Siskind and Meredith Harris

    Citation: BMC Psychiatry 2016 16:179

    Content type: Study protocol

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  2. Long-term improvement of health-related quality of life (HRQoL) in schizophrenia may improve adherence and reduce relapse and rehospitalization. This analysis examines long-term changes in HRQoL among patients...

    Authors: George Awad, Daisy Ng-Mak, Krithika Rajagopalan, Jay Hsu, Andrei Pikalov and Antony Loebel

    Citation: BMC Psychiatry 2016 16:176

    Content type: Research article

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  3. Recently, long-acting injection (LAI) of second-generation antipsychotics has become a valuable strategy for the treatment of schizophrenia. However, few studies have compared the effects of different LAI anti...

    Authors: Yoshiteru Takekita, Yosuke Koshikawa, Chiara Fabbri, Shiho Sakai, Naotaka Sunada, Ai Onohara, Keiichiro Nishida, Masafumi Yoshimura, Masaki Kato, Alessandro Serretti and Toshihiko Kinoshita

    Citation: BMC Psychiatry 2016 16:172

    Content type: Research article

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  4. Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects.

    Authors: Hiroki Matsuura, Sohei Kimoto, Izumi Harada, Satoshi Naemura, Kazuhiko Yamamuro and Toshifumi Kishimoto

    Citation: BMC Psychiatry 2016 16:161

    Content type: Case report

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  5. Cardiovascular risk (CVR) has been observed to be higher in patients with severe mental illness (SMI) than in the general population. However, some studies suggest that CVR is not equally increased in differen...

    Authors: Quintí Foguet-Boreu, Maria Isabel Fernandez San Martin, Gemma Flores Mateo, Edurne Zabaleta del Olmo, Luís Ayerbe García-Morzon, Maria Perez-Piñar López, Luis Miguel Martin-López, Javier Montes Hidalgo and Concepción Violán

    Citation: BMC Psychiatry 2016 16:141

    Content type: Research article

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  6. Idiopathic pulmonary arterial hypertension (IPAH) is a progressive and fatal cardiovascular disease if left untreated. In patients with IPAH with psychiatric illness or other complications, careful attention i...

    Authors: Mizue Hobo, Akihito Uezato, Mitsunori Nishiyama, Mayumi Suzuki, Jiro Kurata, Koshi Makita, Naoki Yamamoto and Toru Nishikawa

    Citation: BMC Psychiatry 2016 16:130

    Content type: Case report

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  7. No evidence based approach to reduce duration of untreated psychosis (DUP) has been effective in the UK. Existing interventions have many components and have been difficult to replicate. The majority of DUP in...

    Authors: Charlotte Connor, Max Birchwood, Nick Freemantle, Colin Palmer, Sunita Channa, Clare Barker, Paul Patterson and Swaran Singh

    Citation: BMC Psychiatry 2016 16:127

    Content type: Research article

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  8. The aim of this study was to investigate whether childhood trauma was associated with more severe clinical features in patients with first-episode psychosis, both at the initial assessment and after one year.

    Authors: Monica Aas, Ole A. Andreassen, Sofie R. Aminoff, Ann Færden, Kristin L. Romm, Ragnar Nesvåg, Akiah O. Berg, Carmen Simonsen, Ingrid Agartz and Ingrid Melle

    Citation: BMC Psychiatry 2016 16:126

    Content type: Research article

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  9. Co-occurring substance use increases the risk of hospitalisation in people with severe mental illness, whereas Assertive Community Treatment (ACT) generally reduces hospitalisation in patients with severe ment...

    Authors: Hanne Clausen, Torleif Ruud, Sigrun Odden, Jūratė Šaltytė Benth, Kristin Sverdvik Heiervang, Hanne Kilen Stuen, Helen Killaspy, Robert E. Drake and Anne Landheim

    Citation: BMC Psychiatry 2016 16:125

    Content type: Research article

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  10. The use of Routine Outcome Monitoring (ROM) in mental health care has increased widely during the past decade. Little is known, however, on the implementation and applicability of ROM outcome in daily clinical...

    Authors: Magda Tasma, Marte Swart, Gert Wolters, Edith Liemburg, Richard Bruggeman, Henderikus Knegtering and Stynke Castelein

    Citation: BMC Psychiatry 2016 16:107

    Content type: Research article

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  11. Poor adherence to medication in schizophrenia spectrum disorders leads to inadequate symptom control. Adherence therapy (AT) is an intervention that seeks to reduce patients’ psychiatric symptoms by enhancing ...

    Authors: Richard Gray, Daniel Bressington, Ada Ivanecka, Sheila Hardy, Martin Jones, Michael Schulz, Suparpit von Bormann, Jacquie White, Kathryn Hoehn Anderson and Wai-Tong Chien

    Citation: BMC Psychiatry 2016 16:90

    Content type: Research article

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  12. Drug-induced eosinophilic myocarditis is a life-threatening and frequently overlooked condition. The prevalence of myocarditis in clozapine-treated patients may be as high as 3 %. An association between olanza...

    Authors: Torkel Vang, Mary Rosenzweig, Christina Hedegaard Bruhn, Christoffer Polcwiartek, Jørgen Kim Kanters and Jimmi Nielsen

    Citation: BMC Psychiatry 2016 16:70

    Content type: Case report

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  13. Bitopertin, a glycine reuptake inhibitor, was investigated as a novel treatment for schizophrenia. We report all the results of a double-blind randomized study assessing safety and efficacy following 52-week a...

    Authors: Yoshio Hirayasu, Shin-Ichi Sato, Hideaki Takahashi, Sayaka Iida, Norifumi Shuto, Seitaro Yoshida, Takashi Funatogawa, Takahito Yamada and Teruhiko Higuchi

    Citation: BMC Psychiatry 2016 16:66

    Content type: Research article

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  14. Inflammatory processes have been implicated in the etiology of schizophrenia and related psychoses, in which cognitive deficits represent core symptoms. The aim of the present study was to investigate possible...

    Authors: Erik Johnsen, Farivar Fathian, Rune A. Kroken, Vidar M. Steen, Hugo A. Jørgensen, Rolf Gjestad and Else-Marie Løberg

    Citation: BMC Psychiatry 2016 16:60

    Content type: Research article

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  15. Psychological interventions are increasingly recommended as adjunctive treatments for psychosis, but their implementation in clinical practice is still insufficient. The individualized metacognitive therapy pr...

    Authors: Brooke C. Schneider, Martin Brüne, Francesca Bohn, Ruth Veckenstedt, Katharina Kolbeck, Eva Krieger, Anna Becker, Kim Alisha Drommelschmidt, Susanne Englisch, Sarah Eisenacher, Sie-In Lee-Grimm, Matthias Nagel, Mathias Zink and Steffen Moritz

    Citation: BMC Psychiatry 2016 16:51

    Content type: Study protocol

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  16. Current practice guidelines for schizophrenia care recommend that antipsychotic medication is essential for patients’ long-term maintenance treatment but their non-adherence to this medication is still a main ...

    Authors: Wai Tong Chien, Jolene Mui, Richard Gray and Eric Cheung

    Citation: BMC Psychiatry 2016 16:42

    Content type: Research article

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  17. Previous qualitative studies have found that exercise may facilitate symptomatic and functional recovery in people with long-term schizophrenia. This study examined the perceived effects of exercise as experie...

    Authors: Joseph Firth, Rebekah Carney, Lauren Jerome, Rebecca Elliott, Paul French and Alison R. Yung

    Citation: BMC Psychiatry 2016 16:36

    Content type: Research article

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  18. The exact cerebral structural and functional mechanisms under the auditory verbal hallucinations (AVHs) in schizophrenia are still unclear. The Deutsch “high-low” word illusion might trigger attentional respon...

    Authors: You Xu, Hao Chai, Bingren Zhang, Qianqian Gao, Hongying Fan, Leilei Zheng, Hongjing Mao, Yonghua Zhang and Wei Wang

    Citation: BMC Psychiatry 2016 16:33

    Content type: Research article

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  19. Music therapy (MT) has been used as adjunct therapy for schizophrenia for decades. However, its role is still inconclusive. A recent meta-analysis demonstrated that MT for schizophrenic patients only significa...

    Authors: Ping-Tao Tseng, Yen-Wen Chen, Pao-Yen Lin, Kun-Yu Tu, Hung-Yu Wang, Yu-Shian Cheng, Yi-Chung Chang, Chih-Hua Chang, Weilun Chung and Ching-Kuan Wu

    Citation: BMC Psychiatry 2016 16:16

    Content type: Research article

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    The Erratum to this article has been published in BMC Psychiatry 2016 16:150

  20. Previous studies showed functional improvement in stable patients with schizophrenia treated with risperidone long-acting injection (LAI). We therefore re-investigated functional improvement with risperidone LAI ...

    Authors: Elisabeth Giraud-Baro, Daniel Dassa, Florent De Vathaire, Ricardo P. Garay and Joelle Obeid

    Citation: BMC Psychiatry 2016 16:8

    Content type: Research article

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  21. Evidence is accumulating that cognitive remediation therapy (CRT) is an effective intervention for patients with schizophrenia or schizoaffective disorder. To date there has been no randomised controlled trial...

    Authors: Ken O’Reilly, Gary Donohoe, Danny O’Sullivan, Ciaran Coyle, Ronan Mullaney, Paul O’Connell, Catherine Maddock, Andrea Nulty, Padraic O’Flynn, Carina O’Connell and Harry G Kennedy

    Citation: BMC Psychiatry 2016 16:5

    Content type: Study protocol

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  22. Studies demonstrate ethnic variations in pathways to care during first episode psychosis (FEP). There are no extant studies, however, that have statistically examined the influence of culturally mediated illne...

    Authors: Swaran P. Singh, Luke Brown, Catherine Winsper, Ruchika Gajwani, Zoebia Islam, Rubina Jasani, Helen Parsons, Fatemeh Rabbie-Khan and Max Birchwood

    Citation: BMC Psychiatry 2015 15:287

    Content type: Research article

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  23. Disruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis. However, the impact of environmental risk factors for psyc...

    Authors: Lisa Buchy, Tyrone D. Cannon, Alan Anticevic, Kristina Lyngberg, Kristin S. Cadenhead, Barbara A. Cornblatt, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Carrie E. Bearden, Daniel H. Mathalon and Jean Addington

    Citation: BMC Psychiatry 2015 15:276

    Content type: Research article

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  24. Severe mental disorders like psychotic disorders including schizophrenia and schizoaffective disorders have a 12-month-prevalence of 2.6, bipolar disorders of 1.5 % in Germany. The relapse risk is high; so man...

    Authors: Ulrike Stentzel, Hans-Jörgen Grabe, Lara Strobel, Peter Penndorf, Jens Langosch, Harald J. Freyberger, Wolfgang Hoffmann and Neeltje van den Berg

    Citation: BMC Psychiatry 2015 15:273

    Content type: Study protocol

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  25. Clozapine is the treatment of choice for medication refractory psychosis, but it does not benefit half of those put on it. There are numerous studies of potential post-clozapine strategies, but little data to ...

    Authors: Derek K. Tracy, Dan W. Joyce, S. Neil Sarkar, Maria-Jesus Mateos Fernandez and Sukhwinder S. Shergill

    Citation: BMC Psychiatry 2015 15:174

    Content type: Research article

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    The Correction to this article has been published in BMC Psychiatry 2019 19:160

  26. Life expectancy in patients with schizophrenia is reduced by 20 years for males and 15 years for females compared to the general population. About 60% of the excess mortality is due to physical illnesses, with...

    Authors: Helene Speyer, Hans Christian Brix Nørgaard, Carsten Hjorthøj, Thomas Axel Madsen, Søren Drivsholm, Charlotta Pisinger, Christian Gluud, Ole Mors, Jesper Krogh and Merete Nordentoft

    Citation: BMC Psychiatry 2015 15:119

    Content type: Study protocol

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  27. Polyunsaturated fatty acid (PUFA) metabolism abnormalities have been long implicated in the etiology of schizophrenia. Although several randomized clinical trials have been carried out to assess the efficacy o...

    Authors: Tomasz Pawełczyk, Marta Grancow, Magdalena Kotlicka-Antczak, Elżbieta Trafalska, Piotr Gębski, Janusz Szemraj, Natalia Żurner and Agnieszka Pawełczyk

    Citation: BMC Psychiatry 2015 15:97

    Content type: Study protocol

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  28. Only three observational studies investigated whether exposure to antipsychotics is associated with an increased risk of pulmonary embolism, with conflicting results. This study was therefore carried out to es...

    Authors: Valentino Conti, Mauro Venegoni, Alfredo Cocci, Ida Fortino, Antonio Lora and Corrado Barbui

    Citation: BMC Psychiatry 2015 15:92

    Content type: Research article

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  29. Evidence has been accumulating that it may be possible to achieve prevention in psychotic disorders. The aim of the Prevention Of Psychosis (POP) study is to reduce the annual incidence of psychotic disorders ...

    Authors: Inge Joa, Jens Gisselgård, Kolbjørn Brønnick, Thomas McGlashan and Jan Olav Johannessen

    Citation: BMC Psychiatry 2015 15:89

    Content type: Study protocol

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  30. Most women with psychotic disorders and bipolar disorders have children but their pregnancies are at risk of adverse psychiatric and fetal outcome. The extent of modifiable risk factors – both clinical and soc...

    Authors: Clare L Taylor, Robert Stewart, Jack Ogden, Matthew Broadbent, Dharmintra Pasupathy and Louise M Howard

    Citation: BMC Psychiatry 2015 15:88

    Content type: Research article

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  31. Capgras delusion is a delusional misidentification syndrome, in which the patient is convinced that someone that is well known to them, usually a close relative, has been replaced by an impostor or double. Alt...

    Authors: Lucrezia Islam, Sylvie Piacentini, Paola Soliveri, Silvio Scarone and Orsola Gambini

    Citation: BMC Psychiatry 2015 15:73

    Content type: Case report

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  32. Psycho-educational interventions for people diagnosed with schizophrenia (PDwS) and their primary caregivers appear promising, however, the majority of trials have significant methodological shortcomings. Ther...

    Authors: Abd Alhadi Hasan, Patrick Callaghan and Joanne S Lymn

    Citation: BMC Psychiatry 2015 15:72

    Content type: Research article

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  33. Schizophrenia is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, and the L-arginine:ADMA ratio are ma...

    Authors: Anders Jorgensen, Ulla Knorr, Mia Greisen Soendergaard, Jens Lykkesfeldt, Anders Fink-Jensen, Henrik Enghusen Poulsen, Martin Balslev Jorgensen, Niels Vidiendal Olsen and Jonatan Myrup Staalsø

    Citation: BMC Psychiatry 2015 15:67

    Content type: Research article

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  34. Olanzapine long-acting injection (LAI) for the treatment of schizophrenia was associated with a cluster of symptoms termed post-injection delirium/sedation syndrome (PDSS) in a small percentage (~2%) of patien...

    Authors: Chris J Bushe, Deborah Falk, Ernie Anand, Marta Casillas, Elena Perrin, Rashna Chhabra-Khanna and Holland C Detke

    Citation: BMC Psychiatry 2015 15:65

    Content type: Research article

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  35. Adults with serious mental illness have a mortality rate two to three times higher than the overall US population, much of which is due to somatic conditions, especially cardiovascular disease. Given the dispr...

    Authors: Julia B Baller, Emma E McGinty, Susan T Azrin, Denise Juliano-Bult and Gail L Daumit

    Citation: BMC Psychiatry 2015 15:55

    Content type: Research article

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  36. The functional outcome of people with severe mental disorders (SMD) is purported to be better in low- and middle-income countries compared to high-income countries; however, cross-cultural measures of function...

    Authors: Kassahun Habtamu, Atalay Alem and Charlotte Hanlon

    Citation: BMC Psychiatry 2015 15:34

    Content type: Research article

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  37. Specialized Early Intervention services (SEI) for first episode psychosis are shown to be effective for the treatment of positive and negative symptoms, medication adherence, rates of relapse, substance abuse ...

    Authors: Danyael Lutgens, Srividya Iyer, Ridha Joober, Thomas G Brown, Ross Norman, Eric Latimer, Norbert Schmitz, Amal Abdel Baki, Sherezad Abadi and Ashok Malla

    Citation: BMC Psychiatry 2015 15:22

    Content type: Study protocol

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  38. Non-adherence to antipsychotic medication in schizophrenic patients is common and associated with symptom relapse and poorer long-term outcomes. The risk factors for treatment non-adherence include dosing freq...

    Authors: Pei-Yin Pan, Meei-Shyuan Lee and Chin-Bin Yeh

    Citation: BMC Psychiatry 2015 15:1

    Content type: Research article

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  39. Recruitment to mental health research can be challenging. ‘Consent for Contact’ (C4C) is a novel framework which may expedite recruitment and contribute to equitable access to research. This paper discusses st...

    Authors: Constantina Papoulias, Dan Robotham, Gareth Drake, Diana Rose and Til Wykes

    Citation: BMC Psychiatry 2014 14:377

    Content type: Research article

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  40. Quality of life (QoL) is considered an important outcome in health research. It can be rated by the patient, or by an external assessor. We wished to identify the predictors of any discrepancies between these ...

    Authors: Karen P Hayhurst, Jennifer A Massie, Graham Dunn, Shôn W Lewis and Richard J Drake

    Citation: BMC Psychiatry 2014 14:365

    Content type: Research article

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  41. The concept of cenesthopathy was first introduced by Dupré and Camus in 1907 to describe clinically unexplainable bodily sensations mainly attributed to psychiatric pathology. If it occurs in oral regions, it ...

    Authors: Akihito Uezato, Akira Toyofuku, Yojiro Umezaki, Motoko Watanabe, Akira Toriihara, Makoto Tomita, Naoki Yamamoto, Akeo Kurumaji and Toru Nishikawa

    Citation: BMC Psychiatry 2014 14:1696

    Content type: Research article

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  42. Pomaglumetad methionil (LY2140023 monohydrate) is a potent and highly selective agonist for the metabotropic glutamate mGluR2 and mGluR3 receptors. We present results of a pivotal clinical study H8Y-MC-HBBM as...

    Authors: AnnCatherine M Downing, Bruce J Kinon, Brian A Millen, Lu Zhang, Lin Liu, Margarita A Morozova, Ronald Brenner, Tami Jo Rayle, Laura Nisenbaum, Fangyi Zhao and Juan Carlos Gomez

    Citation: BMC Psychiatry 2014 14:351

    Content type: Research article

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