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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Prepulse inhibition (PPI) and attention were impaired, which may cause psychotic symptoms and (or) hinder the cognitive functions in schizophrenia. However, due to the measurement methods of PPI, findings abou...

    Authors: Ning-Bo Yang, Qing Tian, Yu Fan, Qi-Jing Bo, Liang Zhang, Liang Li and Chuan-Yue Wang

    Citation: BMC Psychiatry 2017 17:135

    Content type: Research article

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  2. In France, negative views on schizophrenia are pervasive, even among health professionals. Prior research suggests that the level of prejudice is lower when the illness is described with the example of a speci...

    Authors: Murielle Villani and Viviane Kovess - Masfety

    Citation: BMC Psychiatry 2017 17:133

    Content type: Research article

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  3. The cardiometabolic health of persons with a severe mental illness (SMI) is alarming with obesity rates of 45-55% and diabetes type 2 rates of 10-15%. Unhealthy lifestyle behaviours play a large role in this. ...

    Authors: Anne Looijmans, Frederike Jörg, Richard Bruggeman, Robert Schoevers and Eva Corpeleijn

    Citation: BMC Psychiatry 2017 17:107

    Content type: Study protocol

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  4. The prevalence of smoking in patients with schizophrenia is higher than that in the general population and is an important medical issue. Short-term smoking cessation tends to worsen psychiatric symptoms in pa...

    Authors: Masatoshi Miyauchi, Ikuko Kishida, Akira Suda, Yohko Shiraishi, Mami Fujibayashi, Masataka Taguri, Chie Ishii, Norio Ishii, Toshio Moritani and Yoshio Hirayasu

    Citation: BMC Psychiatry 2017 17:87

    Content type: Research article

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  5. Schizophrenia is a serious form of mental illness that often requires long term care. Empirical findings indicate that combining a psycho-educational intervention (PEI) with neuroleptic medication to treat sch...

    Authors: Abd Al-HadiHasan, Patrick Callaghan and Joanne S. Lymn

    Citation: BMC Psychiatry 2017 17:68

    Content type: Research article

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  6. Treatment of schizophrenia and major depressive disorder (MDD) with atypical antipsychotics (AAPs) show improved efficacy and reduced side effect burden compared with older antipsychotic medications. However, ...

    Authors: Pierre-Michel Llorca, Christophe Lançon, Ann Hartry, T. Michelle Brown, Dana B. DiBenedetti, Siddhesh A. Kamat and Clément François

    Citation: BMC Psychiatry 2017 17:67

    Content type: Research article

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  7. Suicide is a leading cause of mortality among those afflicted by schizophrenia. Previous studies demonstrated that the stressors associated with immigration may lead to an onset of schizophrenia and suicide se...

    Authors: Nuwan C. Hettige, Ali Bani-Fatemi, James L. Kennedy and Vincenzo De Luca

    Citation: BMC Psychiatry 2017 17:63

    Content type: Research article

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  8. The outcome of first episode psychosis (FEP) is highly variable and difficult to predict. Cognitive insight measured at illness onset has previously been found to predict psychopathology 12-months later. The a...

    Authors: Jennifer A. O’Connor, Lyn Ellett, Olesya Ajnakina, Tabea Schoeler, Anna Kollliakou, Antonella Trotta, Benjamin D. Wiffen, Aurora M. Falcone, Marta Di Forti, Robin M. Murray, Sagnik Bhattacharyya and Anthony S. David

    Citation: BMC Psychiatry 2017 17:54

    Content type: Research article

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  9. The feasibility of shared decision making (SDM) for patients with schizophrenia remains controversial due to the assumed inability of patients to cooperate in treatment decision making. This study evaluated th...

    Authors: Mio Ishii, Yasuyuki Okumura, Naoya Sugiyama, Hana Hasegawa, Toshie Noda, Yoshio Hirayasu and Hiroto Ito

    Citation: BMC Psychiatry 2017 17:52

    Content type: Research article

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  10. Although previous studies found that aberrations in gray matter volume (GMV) and global functional connectivity density (gFCD) are important characteristics of schizophrenia, to the best of our knowledge no st...

    Authors: Chuanjun Zhuo, Jiajia Zhu, Chunli Wang, Hongru Qu, Xiaolei Ma, Hongjun Tian, Mei Liu and Wen Qin

    Citation: BMC Psychiatry 2017 17:45

    Content type: Research article

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  11. The transition from adolescence to adulthood is associated with the emergence of psychosis and other mental health problems, highlighting the importance of this developmental period for the understanding of de...

    Authors: Peter J. Uhlhaas, Ruchika Gajwani, Joachim Gross, Andrew I. Gumley, Stephen M. Lawrie and Matthias Schwannauer

    Citation: BMC Psychiatry 2017 17:43

    Content type: Study protocol

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  12. Although the relationship between cultural beliefs and schizophrenia has received some attention, relatively little work has emerged from African contexts. In this study we draw from a sample of South African ...

    Authors: Megan M. Campbell, Goodman Sibeko, Sumaya Mall, Adam Baldinger, Mohamed Nagdee, Ezra Susser and Dan J. Stein

    Citation: BMC Psychiatry 2017 17:41

    Content type: Research article

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  13. This study aimed to explore the characteristics of event-related potentials induced by facial emotion recognition in patients with first-episode schizophrenia and in their siblings.

    Authors: Chengqing Yang, Tianhong Zhang, Zezhi Li, Anisha Heeramun-Aubeeluck, Na Liu, Nan Huang, Jie Zhang, Leiying He, Hui Li, Yingying Tang, Fazhan Chen, Jijun Wang and Zheng Lu

    Citation: BMC Psychiatry 2017 17:20

    Content type: Research article

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  15. Schizophrenia is a highly heterogeneous disorder, and around a third of patients are treatment-resistant. The only evidence-based treatment for these patients is clozapine, an atypical antipsychotic with relat...

    Authors: Amy L. Gillespie, Ruta Samanaite, Jonathan Mill, Alice Egerton and James H. MacCabe

    Citation: BMC Psychiatry 2017 17:12

    Content type: Research article

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  16. In the last couple of years, schizophrenia was often discussed as autoimmune disease. Several antibodies were suspected, but so far there has been no proof of Gamma-aminobutyric acid (GABA) receptor antibodies...

    Authors: Ida S. Haussleiter, Klaus-Peter Wandinger and Georg Juckel

    Citation: BMC Psychiatry 2017 17:9

    Content type: Case report

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  17. A substantial amount of refugees (10–30%) suffer from Post-Traumatic Stress Disorder (PTSD). In Denmark there are different facilities specialised in psychiatric treatment of trauma-affected refugees. A previo...

    Authors: Mette Nygaard, Charlotte Sonne and Jessica Carlsson

    Citation: BMC Psychiatry 2017 17:5

    Content type: Research article

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  18. Neurocognitive dysfunction is a critical target symptom of schizophrenia treatment. A positive correlation between physical activity level and neurocognitive function has been reported in healthy individuals, ...

    Authors: Yusuke Kurebayashi and Junichi Otaki

    Citation: BMC Psychiatry 2017 17:4

    Content type: Research article

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  19. Data on the haematological outcomes of patients who continue clozapine treatment following neutropenia are very rare as even mild neutropenia results in mandatory discontinuation of clozapine in most countries...

    Authors: Oddur Ingimarsson, James H. MacCabe, Magnús Haraldsson, Halldóra Jónsdóttir and Engilbert Sigurdsson

    Citation: BMC Psychiatry 2016 16:441

    Content type: Research article

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  21. Negative symptoms are considered core symptoms of schizophrenia. The Brief Negative Symptom Scale (BNSS) was developed to measure this symptomatic dimension according to a current consensus definition. The pre...

    Authors: Martin Bischof, Caitriona Obermann, Matthias N. Hartmann, Oliver M. Hager, Matthias Kirschner, Agne Kluge, Gregory P. Strauss and Stefan Kaiser

    Citation: BMC Psychiatry 2016 16:415

    Content type: Research article

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  22. The complexity of schizophrenia lies in the combination of psychiatric, somatic and social needs requiring care. The aim of the study was to compare perceived needs between groups with absence/presence of meta...

    Authors: Leticia Medeiros-Ferreira, José Blas Navarro-Pastor, Antonio Zúñiga-Lagares, Rosanna Romaní, Elisenda Muray and Jordi E. Obiols

    Citation: BMC Psychiatry 2016 16:414

    Content type: Research article

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  23. People with schizophrenia–spectrum disorders (SSD) often have high levels of obesity and poor cardiometabolic health. Certain types of antipsychotics have been shown to contribute towards weight gain and there...

    Authors: Daniel Bressington, Jolene Mui, Mei Ling Tse, Richard Gray, Eric F. C. Cheung and Wai Tong Chien

    Citation: BMC Psychiatry 2016 16:411

    Content type: Research article

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  25. This study aimed to investigate prolactin related symptoms (PRS) in individuals with schizophrenia during risperidone maintenance treatment for one year, as well as to identify the risk factors for PRS.

    Authors: Qijing Bo, Fang Dong, Xianbin Li, Zhimin Wang, Xin Ma and Chuanyue Wang

    Citation: BMC Psychiatry 2016 16:386

    Content type: Research article

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  26. The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conf...

    Authors: Violeta Zaliunaite, Vesta Steibliene, Liv Bode, Aurelija Podlipskyte, Robertas Bunevicius and Hanns Ludwig

    Citation: BMC Psychiatry 2016 16:369

    Content type: Research article

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  27. Psychotic relapse leads to repeated hospitalization and negatively affects the clinical prognosis of the patients. Information on prevalence of relapse among patients with psychotic disorders in Ethiopian sett...

    Authors: Mahlet Fikreyesus, Matiwos Soboka and Garumma Tolu Feyissa

    Citation: BMC Psychiatry 2016 16:354

    Content type: Research article

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  28. This study aimed to explore differences in links between negative symptoms and neurocognitive deficits in adolescent and adult patients with first-episode schizophrenia. Schizophrenia is a mental disorder ofte...

    Authors: Manli Huang, Yi Huang, Liang Yu, Jianbo Hu, Jinkai Chen, Pingbo Jin, Weijuan Xu, Ning Wei, Shaohua Hu, Hongli Qi and Yi Xu

    Citation: BMC Psychiatry 2016 16:344

    Content type: Research article

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  29. The identification of biomarkers of transition from the at-risk mental state (ARMS) to psychotic disorder is important because early treatment of psychosis is associated with improved outcome. Increasing evide...

    Authors: Melanie Föcking, Patrick Dicker, Lorna M. Lopez, Mary Cannon, Miriam R. Schäfer, Patrick D. McGorry, Stefan Smesny, David R. Cotter and G. Paul Amminger

    Citation: BMC Psychiatry 2016 16:326

    Content type: Research article

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  30. Clozapine is an effective treatment for a proportion of people with schizophrenia (SZ) who are resistant to the beneficial effects of other antipsychotic drugs. However, anything from 40–60 % of people on cloz...

    Authors: Susan L. Rossell, Paul S. Francis, Cherrie Galletly, Anthony Harris, Dan Siskind, Michael Berk, Kiymet Bozaoglu, Frances Dark, Olivia Dean, Dennis Liu, Denny Meyer, Erica Neill, Andrea Phillipou, Jerome Sarris and David J. Castle

    Citation: BMC Psychiatry 2016 16:320

    Content type: Study protocol

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  31. Psychosocial interventions have an important role in promoting recovery in people with persisting psychotic disorders such as schizophrenia. Readily available, digital technology provides a means of developing...

    Authors: Neil Thomas, John Farhall, Fiona Foley, Susan L. Rossell, David Castle, Emma Ladd, Denny Meyer, Cathrine Mihalopoulos, Nuwan Leitan, Cassy Nunan, Rosalie Frankish, Tara Smark, Sue Farnan, Bronte McLeod, Leon Sterling, Greg Murray…

    Citation: BMC Psychiatry 2016 16:312

    Content type: Study protocol

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  32. Most measures of functioning in people with severe mental disorders (SMD) have been developed in Western societies. Many of the questions in these scales are culture-bound, fail to capture differentiation of t...

    Authors: Kassahun Habtamu, Atalay Alem, Girmay Medhin, Abebaw Fekadu, Martin Prince and Charlotte Hanlon

    Citation: BMC Psychiatry 2016 16:311

    Content type: Research article

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  34. Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain prior to the emergence of clinical symptoms. Recent evidence from neuroimaging studies usin...

    Authors: Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F. Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R. Schäfer and G. Paul Amminger

    Citation: BMC Psychiatry 2016 16:287

    Content type: Research article

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  35. For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resi...

    Authors: Melissa Pyle, John Norrie, Matthias Schwannauer, David Kingdon, Andrew Gumley, Douglas Turkington, Rory Byrne, Suzy Syrett, Graeme MacLennan, Robert Dudley, Hamish J. McLeod, Helen Griffiths, Samantha Bowe, Thomas R. E. Barnes, Paul French, Paul Hutton…

    Citation: BMC Psychiatry 2016 16:280

    Content type: Study protocol

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  36. The suffering people experience following a first episode of psychosis is great, and has been well-investigated. Conversely, potential positive outcomes following a first episode of psychosis have been under-i...

    Authors: Gerald Jordan, Ashok Malla and Srividya N. Iyer

    Citation: BMC Psychiatry 2016 16:262

    Content type: Study protocol

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  37. The Internet and mobile technology are changing the way people learn about and manage their illnesses. Little is known about online mental health information seeking behaviour by people with psychosis. This pa...

    Authors: Golnar Aref-Adib, Puffin O’Hanlon, Kate Fullarton, Nicola Morant, Andrew Sommerlad, Sonia Johnson and David Osborn

    Citation: BMC Psychiatry 2016 16:232

    Content type: Research article

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  38. Neurosyphilis is caused by the invasion of Treponema pallidum into the central nervous system. General paresis (GP) is a type of neurosyphilis. The main manifestation of general paresis is dementia; however, t...

    Authors: Wang Yanhua, Shi Haishan, Hou Le, Zhong Xiaomei, Chen Xinru, Li Ling, Wu Zhangying, Zheng Dong, Zhang Yuefen, Tan Yan, Luo Xinni, Liu Sha and Ning Yuping

    Citation: BMC Psychiatry 2016 16:230

    Content type: Research article

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  39. Schizophrenia is a disabling disease that impacts all major life areas. There is a growing need for meeting the challenge of disability from a perspective that extends symptomatic reduction. Therefore, this st...

    Authors: Izabela Nowak, Carla Sabariego, Piotr Świtaj and Marta Anczewska

    Citation: BMC Psychiatry 2016 16:228

    Content type: Research article

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  40. Individuals with a psychotic disorder are at an increased risk of becoming victim of a crime or other forms of aggression. Research has revealed several possible risk factors (e.g. impaired social cognition, a...

    Authors: Elisabeth C. D. van der Stouwe, Bertine de Vries, André Aleman, Johan Arends, Clement Waarheid, Aniek Meerdink, Erwin van der Helm, Jooske T. van Busschbach and Gerdina H. M. Pijnenborg

    Citation: BMC Psychiatry 2016 16:227

    Content type: Study protocol

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  41. Increasing numbers of patients with elevated anti-N-methyl-D-aspartate (NMDA) receptor antibody titers presenting exclusively with psychiatric symptoms have been reported. The aim of the present study was to c...

    Authors: Yoshihito Ando, Haruo Shimazaki, Katsutoshi Shiota, Syuichi Tetsuka, Koichi Nakao, Tatsuhiro Shimada, Kazumi Kurata, Jinichi Kuroda, Akihiro Yamashita, Hayato Sato, Mamoru Sato, Shinkichi Eto, Yasunori Onishi, Keiko Tanaka and Satoshi Kato

    Citation: BMC Psychiatry 2016 16:226

    Content type: Research article

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  42. Impaired interpretation of nonverbal emotional cues in patients with schizophrenia has been reported in several studies and a clinical relevance of these deficits for social functioning has been assumed. Howev...

    Authors: Bastian D. Vogel, Carolin Brück, Heike Jacob, Mark Eberle and Dirk Wildgruber

    Citation: BMC Psychiatry 2016 16:218

    Content type: Research article

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  43. Women with schizophrenia are a vulnerable risk group for intimate partner violence (1PV). There are few surveys that highlight the pattern, prevalence and association of IPV with psychopathology in these vulne...

    Authors: Taiwo Opekitan Afe, Thomas Chimezie Emedoh, Olawale Ogunsemi and Abosede Adekeji Adegbohun

    Citation: BMC Psychiatry 2016 16:197

    Content type: Research article

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  44. Many patients with a non-affective psychotic disorder suffer from impairments in social functioning and social cognition. To target these impairments, mentalization-based treatment for psychotic disorder, a ps...

    Authors: Jonas Weijers, Coriene ten Kate, Elisabeth Eurelings-Bontekoe, Wolfgang Viechtbauer, Rutger Rampaart, Anthony Bateman and Jean-Paul Selten

    Citation: BMC Psychiatry 2016 16:191

    Content type: Study protocol

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  45. A novel staffing model integrating peer support workers and clinical staff within a unified team is being trialled at community based residential rehabilitation units in Australia. A mixed-methods protocol for...

    Authors: Stephen Parker, Frances Dark, Ellie Newman, Nicole Korman, Carla Meurk, Dan Siskind and Meredith Harris

    Citation: BMC Psychiatry 2016 16:179

    Content type: Study protocol

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  46. Long-term improvement of health-related quality of life (HRQoL) in schizophrenia may improve adherence and reduce relapse and rehospitalization. This analysis examines long-term changes in HRQoL among patients...

    Authors: George Awad, Daisy Ng-Mak, Krithika Rajagopalan, Jay Hsu, Andrei Pikalov and Antony Loebel

    Citation: BMC Psychiatry 2016 16:176

    Content type: Research article

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  47. Recently, long-acting injection (LAI) of second-generation antipsychotics has become a valuable strategy for the treatment of schizophrenia. However, few studies have compared the effects of different LAI anti...

    Authors: Yoshiteru Takekita, Yosuke Koshikawa, Chiara Fabbri, Shiho Sakai, Naotaka Sunada, Ai Onohara, Keiichiro Nishida, Masafumi Yoshimura, Masaki Kato, Alessandro Serretti and Toshihiko Kinoshita

    Citation: BMC Psychiatry 2016 16:172

    Content type: Research article

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  48. Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects.

    Authors: Hiroki Matsuura, Sohei Kimoto, Izumi Harada, Satoshi Naemura, Kazuhiko Yamamuro and Toshifumi Kishimoto

    Citation: BMC Psychiatry 2016 16:161

    Content type: Case report

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