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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. The objective of this study was to characterize real-world treatment patterns in the prescription of antipsychotic polypharmacy (≥2 concurrent antipsychotics) compared with antipsychotic monotherapy for patien...

    Authors: Maxine D Fisher, Kathleen Reilly, Keith Isenberg and Kathleen F Villa

    Citation: BMC Psychiatry 2014 14:341

    Content type: Research article

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  2. The prevalence of negative symptoms in schizophrenic patients seems to be an important indicator for treatment response and prognosis. Although negative symptoms have often been attributed to frontal lobe anom...

    Authors: Tobias Hornig, Gabi Valerius, Bernd Feige, Emanuel Bubl, Hans M Olbrich and Ludger Tebartz van Elst

    Citation: BMC Psychiatry 2014 14:326

    Content type: Research article

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  3. Severe mentally ill (SMI) patients have a reduced life expectancy of 13-30 years compared to the general population, largely due to an increased risk of cardiovascular mortality. Unhealthy lifestyle behaviours...

    Authors: Anne Looijmans, Frederike Jörg, Robert A Schoevers, Richard Bruggeman, Ronald P Stolk and Eva Corpeleijn

    Citation: BMC Psychiatry 2014 14:293

    Content type: Study protocol

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  4. Despite strong research interest in psychosis risk identification and the potential for early intervention, few papers have sought to document the implementation and evaluation of specialised psychosis related...

    Authors: Agatha M Conrad, Terry J Lewin, Ketrina A Sly, Ulrich Schall, Sean A Halpin, Mick Hunter and Vaughan J Carr

    Citation: BMC Psychiatry 2014 14:318

    Content type: Research article

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  5. The first of the atypical antipsychotics introduced in the 1970s, clozapine remains the most efficacious neuroleptic to this day. However, serious and potentially fatal side effects have necessitated careful r...

    Authors: Bradley Linton, Rachel Fu, Penny A MacDonald and Hooman Ganjavi

    Citation: BMC Psychiatry 2014 14:299

    Content type: Case report

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  6. Schizophrenia is a debilitating mental disorder that presents impairments in neurocognition and social cognition. Several studies have suggested that the etiology of schizophrenia can be partly explained by ox...

    Authors: Cristina Gonzalez-Liencres, Cumhur Tas, Elliot C Brown, Soner Erdin, Ece Onur, Zeynep Cubukcoglu, Omer Aydemir, Aysen Esen-Danaci and Martin Brüne

    Citation: BMC Psychiatry 2014 14:268

    Content type: Research article

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  7. Socioeconomic status has important associations with disease-specific mortality in the general population. Although individuals with Severe Mental Illnesses (SMI) experience significant premature mortality, th...

    Authors: Julie Langan Martin, Gary McLean, John Park, Daniel J Martin, Moira Connolly, Stewart W Mercer and Daniel J Smith

    Citation: BMC Psychiatry 2014 14:261

    Content type: Research article

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  8. Schizophrenia is one of the most disabling and severely stigmatized mental disorders. Together with social stigma, internalized stigma and perceived stigma can trigger a vicious cycle and diminishes the stigma...

    Authors: Berhanu Boru Bifftu, Berihun Assefa Dachew and Bewket Tadesse Tiruneh

    Citation: BMC Psychiatry 2014 14:259

    Content type: Research article

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  9. Self-report instruments for the assessment of depressive symptoms in patients with psychotic disorders are scarce. The Quick Inventory of Depressive Symptoms (QIDS-SR16) may be a useful self-report instrument, bu...

    Authors: Irene M Lako, Johanna TW Wigman, Rianne MC Klaassen, Cees J Slooff, Katja Taxis and Agna A Bartels-Velthuis

    Citation: BMC Psychiatry 2014 14:247

    Content type: Research article

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  10. Relapse in people with schizophrenia is a major challenge for mental health service providers in Tanzania and other countries. Approximately 10% of people with schizophrenia are re-admitted due to relapse at M...

    Authors: Adellah E Sariah, Anne H Outwater and Khadija IY Malima

    Citation: BMC Psychiatry 2014 14:240

    Content type: Research article

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  11. The strengths-based approach is considered a paradigm shift from the deficits- focused service delivery models. The aim of this review was to systematically review randomised controlled trials (RCTs) and quasi...

    Authors: Nashwa Ibrahim, Maria Michail and Patrick Callaghan

    Citation: BMC Psychiatry 2014 14:243

    Content type: Research article

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  12. Sub Saharan African is experiencing the largest increase in the prevalence of type 2 diabetes mellitus and cardiovascular disease globally. Metabolic syndrome (MetS) is a cluster of risk factors for these cond...

    Authors: Shamima Saloojee, Jonathan K Burns and Ayesha A Motala

    Citation: BMC Psychiatry 2014 14:228

    Content type: Research article

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  13. Suicide completion is a tragic outcome in secondary mental healthcare. However, the extent to which demographic and clinical characteristics, suicide method and service use-related factors vary across psychiat...

    Authors: Javier-David Lopez-Morinigo, Andrea C Fernandes, Chin-Kuo Chang, Richard D Hayes, Matthew Broadbent, Robert Stewart, Anthony S David and Rina Dutta

    Citation: BMC Psychiatry 2014 14:213

    Content type: Research article

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  14. A combination of psychosocial interventions and medications has been highly recommended as a successful treatment package for schizophrenia. Its cost-effectiveness has not been fully explored yet. The aim of t...

    Authors: Zhanchou Zhang, Jinguo Zhai, Qinling Wei, Jingfeng Qi, Xiaofeng Guo and Jingping Zhao

    Citation: BMC Psychiatry 2014 14:212

    Content type: Research article

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  15. Early signs based relapse prevention interventions for psychosis show promise. In order to examine how they might be improved we sought to better understand the early relapse process, service users’ abilities ...

    Authors: Emily Eisner, Christine Barrowclough, Fiona Lobban and Richard Drake

    Citation: BMC Psychiatry 2014 14:201

    Content type: Research article

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  16. Cognitive behavior therapy for psychosis has been a prominent intervention in the psychological treatment of psychosis. It is, however, a challenging therapy to deliver and, in the context of increasingly rigo...

    Authors: Neil Thomas, Frances Shawyer, David J Castle, David Copolov, Steven C Hayes and John Farhall

    Citation: BMC Psychiatry 2014 14:198

    Content type: Study protocol

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  17. Psychosocial dysfunction is one of schizophrenia’s core features, often leading to a deprecation of independent living and significant failure to maintain a competent quality of life. Cognitive and occupationa...

    Authors: Eleni Jelastopulu, Evangelia Giourou, Giorgos Merekoulias, Angeliki Mestousi, Eleftherios Moratis and Evangelos C Alexopoulos

    Citation: BMC Psychiatry 2014 14:197

    Content type: Research article

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  18. Obesity among patients with schizophrenia is a growing concern because being overweight is widely regarded as a major risk factor for cardiovascular disease and premature death. Dietary patterns have been sugg...

    Authors: Norio Sugawara, Norio Yasui-Furukori, Yasushi Sato, Manabu Saito, Hanako Furukori, Taku Nakagami, Masamichi Ishioka and Sunao Kaneko

    Citation: BMC Psychiatry 2014 14:184

    Content type: Research article

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  19. People with schizophrenia face prejudice and discrimination from a number of sources including professionals and families. The degree of stigma perceived and experienced varies across cultures and communities....

    Authors: Sandra Saldivia, Ariadne Runte-Geidel, Pamela Grandón, Francisco Torres-González, Miguel Xavier, Claudio Antonioli, Dinarte A Ballester, Roberto Melipillán, Emiliano Galende, Benjamín Vicente, José Miguel Caldas, Helen Killaspy, Rachel Gibbons and Michael King

    Citation: BMC Psychiatry 2014 14:182

    Content type: Research article

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  20. Caring for a young person experiencing first-episode psychosis is challenging and can affect carers’ well-being adversely. While some face-to-face approaches have achieved promising outcomes, they are costly a...

    Authors: Terence V McCann and Dan I Lubman

    Citation: BMC Psychiatry 2014 14:168

    Content type: Research article

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  21. Considering that depressive and anxiety symptoms are common in schizophrenia, this study investigated whether the severity of a psychotic episode in an acute phase schizophrenia cohort is predictive of concurr...

    Authors: Kalai Naidu, Werdie (CW) van Staden and Mike van der Linde

    Citation: BMC Psychiatry 2014 14:166

    Content type: Research article

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  22. Despite improvements in psychiatric inpatient care, patient restrictions in psychiatric hospitals are still in use. Studying perceptions among patients who have been secluded or physically restrained during th...

    Authors: Päivi Soininen, Hanna Putkonen, Grigori Joffe, Jyrki Korkeila and Maritta Välimäki

    Citation: BMC Psychiatry 2014 14:162

    Content type: Research article

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  23. Personality traits and schizophrenia present gender differences; however, gender has not been considered in most studies on personality and schizophrenia. This study aims to identify the different personality ...

    Authors: Carmen Miralles, Yolanda Alonso, Begoña Verge, Sònia Setó, Ana M Gaviria, Lorena Moreno, María J Cortés, Alfonso Gutiérrez-Zotes, Elisabet Vilella and Lourdes Martorell

    Citation: BMC Psychiatry 2014 14:151

    Content type: Research article

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  24. People with severe mental disorders (SMD) are at higher risk of suicide. However, research into suicide attempts and completed suicide in people with SMD in low- and middle-income countries is mostly limited t...

    Authors: Teshome Shibre, Charlotte Hanlon, Girmay Medhin, Atalay Alem, Derege Kebede, Solomon Teferra, Gunnar Kullgren, Lars Jacobsson and Abebaw Fekadu

    Citation: BMC Psychiatry 2014 14:150

    Content type: Research article

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  25. The purpose of this article was to conduct a review of the types of training offered to people with schizophrenia in order to help them develop strategies to cope with or compensate for neurocognitive or socio...

    Authors: Karine Paquin, Alexa Larouche Wilson, Caroline Cellard, Tania Lecomte and Stéphane Potvin

    Citation: BMC Psychiatry 2014 14:139

    Content type: Research article

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  26. Individuals with serious mental illness are at a higher risk of physical ill health. Mortality rates are at least twice those of the general population with higher levels of cardiovascular disease, metabolic d...

    Authors: Robert Pearsall, Daniel J Smith, Anthony Pelosi and John Geddes

    Citation: BMC Psychiatry 2014 14:117

    Content type: Research article

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  27. Research has shown that individuals with schizophrenia use caffeine at higher rates than the general population; however, no qualitative research has been undertaken investigating problematic caffeine use and ...

    Authors: Lisa Thompson, Amy Pennay, Adam Zimmermann, Merrilee Cox and Dan I Lubman

    Citation: BMC Psychiatry 2014 14:116

    Content type: Research article

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  28. In Japan, combination therapy with high doses of antipsychotic drugs is common, but as a consequence, many patients with schizophrenia report extrapyramidal and autonomic nervous system side effects. To resolv...

    Authors: Tsuruhei Sukegawa, Ataru Inagaki, Yoshio Yamanouchi, Toshiya Inada, Takashi Yoshio, Reiji Yoshimura and Nakao Iwata

    Citation: BMC Psychiatry 2014 14:103

    Content type: Study protocol

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  29. Gray and white matter brain changes have been found in schizophrenia but the anatomical organizing process underlying these changes remains unknown. We aimed to identify gray and white matter volumetric change...

    Authors: Ian Ellison-Wright, Pradeep J Nathan, Edward T Bullmore, Rashid Zaman, Robert B Dudas, Mark Agius, Emilio Fernandez-Egea, Ulrich Müller, Chris M Dodds, Natalie J Forde, Cathy Scanlon, Alexander Leemans, Colm McDonald and Dara M Cannon

    Citation: BMC Psychiatry 2014 14:99

    Content type: Research article

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  30. The aim of our study is to provide data on the incidence of psychotic disorders in France and compare the incidence rates in populations with different levels of urbanization.

    Authors: Andrei Szöke, Thomas Charpeaud, Anne-Marie Galliot, Jeanne Vilain, Jean-Romain Richard, Marion Leboyer, Pierre-Michel Llorca and Franck Schürhoff

    Citation: BMC Psychiatry 2014 14:78

    Content type: Research article

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  31. Epilepsy has long been considered to be a risk factor for psychosis. However there is a lack of consistency in findings across studies on the effect size of this risk which reflects methodological differences ...

    Authors: Maurice J Clancy, Mary C Clarke, Dearbhla J Connor, Mary Cannon and David R Cotter

    Citation: BMC Psychiatry 2014 14:75

    Content type: Research article

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  32. The pathways to care in a first onset psychosis are diverse and may influence the chances of early treatment and therefore the duration of untreated psychosis. We test which pathways to care are associated wit...

    Authors: Kamaldeep Bhui, Simone Ullrich and Jeremy W Coid

    Citation: BMC Psychiatry 2014 14:72

    Content type: Research article

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  33. People with severe mental illness have significantly poorer physical health compared to the general population; previous health screening studies conducted outside Asian countries have demonstrated the potenti...

    Authors: Daniel Bressington, Jolene Mui, Sabina Hulbert, Eric Cheung, Stephen Bradford and Richard Gray

    Citation: BMC Psychiatry 2014 14:57

    Content type: Research article

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  34. Patients with schizophrenia frequently switch between antipsychotics, underscoring the need to achieve and maintain important treatment outcomes such as health-related quality of life (HRQoL) following the swi...

    Authors: George Awad, Mariam Hassan, Antony Loebel, Jay Hsu, Andrei Pikalov and Krithika Rajagopalan

    Citation: BMC Psychiatry 2014 14:53

    Content type: Research article

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  35. There is a strong association between weight gain and metabolic events in patients with schizophrenia receiving many of the second-generation antipsychotic agents. We explored the relationship between body mas...

    Authors: Jennifer Kern Sliwa, Dong-Jing Fu, Cynthia A Bossie, Ibrahim Turkoz and Larry Alphs

    Citation: BMC Psychiatry 2014 14:52

    Content type: Research article

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  36. Cytochrome P450 1A2 gene (CYP1A2) polymorphisms have been suggested to be associated with increased side effects to antipsychotics. However, studies on this are scarce and have been conducted with either various ...

    Authors: Merja Viikki, Olli Kampman, Niko Seppälä, Nina Mononen, Terho Lehtimäki and Esa Leinonen

    Citation: BMC Psychiatry 2014 14:50

    Content type: Research article

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  37. People with serious mental illness are at an increased risk of physical ill health. Mortality rates are around twice those of the general population with higher levels of cardiovascular disease, metabolic dise...

    Authors: Robert Pearsall, Susan Hughes, John Geddes and Anthony Pelosi

    Citation: BMC Psychiatry 2014 14:38

    Content type: Research article

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  38. Recruitment is one of the most serious challenges in performing randomized controlled trials. Often clinical trials with participants diagnosed with schizophrenia are terminated prematurely because of recruitm...

    Authors: Rikke Jørgensen, Povl Munk-Jørgensen, Paul H Lysaker, Kelly D Buck, Lars Hansson and Vibeke Zoffmann

    Citation: BMC Psychiatry 2014 14:28

    Content type: Research article

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  39. Metacognitive dysfunction has been widely recognized as a feature of schizophrenia. As it is linked with deficits in several aspects of daily life functioning, improvement of metacognition may lead to improvem...

    Authors: Rozanne JM Van Donkersgoed, Steven De Jong, Mark Van der Gaag, André Aleman, Paul H Lysaker, Lex Wunderink and GHM Pijnenborg

    Citation: BMC Psychiatry 2014 14:27

    Content type: Study protocol

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  40. Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the...

    Authors: Kelly A Newell and Natalie Matosin

    Citation: BMC Psychiatry 2014 14:23

    Content type: Debate

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