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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Inflammatory processes have been implicated in the etiology of schizophrenia and related psychoses, in which cognitive deficits represent core symptoms. The aim of the present study was to investigate possible...

    Authors: Erik Johnsen, Farivar Fathian, Rune A. Kroken, Vidar M. Steen, Hugo A. Jørgensen, Rolf Gjestad and Else-Marie Løberg

    Citation: BMC Psychiatry 2016 16:60

    Content type: Research article

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  2. Psychological interventions are increasingly recommended as adjunctive treatments for psychosis, but their implementation in clinical practice is still insufficient. The individualized metacognitive therapy pr...

    Authors: Brooke C. Schneider, Martin Brüne, Francesca Bohn, Ruth Veckenstedt, Katharina Kolbeck, Eva Krieger, Anna Becker, Kim Alisha Drommelschmidt, Susanne Englisch, Sarah Eisenacher, Sie-In Lee-Grimm, Matthias Nagel, Mathias Zink and Steffen Moritz

    Citation: BMC Psychiatry 2016 16:51

    Content type: Study protocol

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  3. Current practice guidelines for schizophrenia care recommend that antipsychotic medication is essential for patients’ long-term maintenance treatment but their non-adherence to this medication is still a main ...

    Authors: Wai Tong Chien, Jolene Mui, Richard Gray and Eric Cheung

    Citation: BMC Psychiatry 2016 16:42

    Content type: Research article

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  4. Previous qualitative studies have found that exercise may facilitate symptomatic and functional recovery in people with long-term schizophrenia. This study examined the perceived effects of exercise as experie...

    Authors: Joseph Firth, Rebekah Carney, Lauren Jerome, Rebecca Elliott, Paul French and Alison R. Yung

    Citation: BMC Psychiatry 2016 16:36

    Content type: Research article

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  5. The exact cerebral structural and functional mechanisms under the auditory verbal hallucinations (AVHs) in schizophrenia are still unclear. The Deutsch “high-low” word illusion might trigger attentional respon...

    Authors: You Xu, Hao Chai, Bingren Zhang, Qianqian Gao, Hongying Fan, Leilei Zheng, Hongjing Mao, Yonghua Zhang and Wei Wang

    Citation: BMC Psychiatry 2016 16:33

    Content type: Research article

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  6. Music therapy (MT) has been used as adjunct therapy for schizophrenia for decades. However, its role is still inconclusive. A recent meta-analysis demonstrated that MT for schizophrenic patients only significa...

    Authors: Ping-Tao Tseng, Yen-Wen Chen, Pao-Yen Lin, Kun-Yu Tu, Hung-Yu Wang, Yu-Shian Cheng, Yi-Chung Chang, Chih-Hua Chang, Weilun Chung and Ching-Kuan Wu

    Citation: BMC Psychiatry 2016 16:16

    Content type: Research article

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    The Erratum to this article has been published in BMC Psychiatry 2016 16:150

  7. Previous studies showed functional improvement in stable patients with schizophrenia treated with risperidone long-acting injection (LAI). We therefore re-investigated functional improvement with risperidone LAI ...

    Authors: Elisabeth Giraud-Baro, Daniel Dassa, Florent De Vathaire, Ricardo P. Garay and Joelle Obeid

    Citation: BMC Psychiatry 2016 16:8

    Content type: Research article

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  8. Evidence is accumulating that cognitive remediation therapy (CRT) is an effective intervention for patients with schizophrenia or schizoaffective disorder. To date there has been no randomised controlled trial...

    Authors: Ken O’Reilly, Gary Donohoe, Danny O’Sullivan, Ciaran Coyle, Ronan Mullaney, Paul O’Connell, Catherine Maddock, Andrea Nulty, Padraic O’Flynn, Carina O’Connell and Harry G Kennedy

    Citation: BMC Psychiatry 2016 16:5

    Content type: Study protocol

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  9. Studies demonstrate ethnic variations in pathways to care during first episode psychosis (FEP). There are no extant studies, however, that have statistically examined the influence of culturally mediated illne...

    Authors: Swaran P. Singh, Luke Brown, Catherine Winsper, Ruchika Gajwani, Zoebia Islam, Rubina Jasani, Helen Parsons, Fatemeh Rabbie-Khan and Max Birchwood

    Citation: BMC Psychiatry 2015 15:287

    Content type: Research article

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  10. Disruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis. However, the impact of environmental risk factors for psyc...

    Authors: Lisa Buchy, Tyrone D. Cannon, Alan Anticevic, Kristina Lyngberg, Kristin S. Cadenhead, Barbara A. Cornblatt, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Carrie E. Bearden, Daniel H. Mathalon and Jean Addington

    Citation: BMC Psychiatry 2015 15:276

    Content type: Research article

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  11. Severe mental disorders like psychotic disorders including schizophrenia and schizoaffective disorders have a 12-month-prevalence of 2.6, bipolar disorders of 1.5 % in Germany. The relapse risk is high; so man...

    Authors: Ulrike Stentzel, Hans-Jörgen Grabe, Lara Strobel, Peter Penndorf, Jens Langosch, Harald J. Freyberger, Wolfgang Hoffmann and Neeltje van den Berg

    Citation: BMC Psychiatry 2015 15:273

    Content type: Study protocol

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  12. Clozapine is the treatment of choice for medication refractory psychosis, but it does not benefit half of those put on it. There are numerous studies of potential post-clozapine strategies, but little data to ...

    Authors: Derek K. Tracy, Dan W. Joyce, S. Neil Sarkar, Maria-Jesus Mateos Fernandez and Sukhwinder S. Shergill

    Citation: BMC Psychiatry 2015 15:174

    Content type: Research article

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    The Correction to this article has been published in BMC Psychiatry 2019 19:160

  13. Life expectancy in patients with schizophrenia is reduced by 20 years for males and 15 years for females compared to the general population. About 60% of the excess mortality is due to physical illnesses, with...

    Authors: Helene Speyer, Hans Christian Brix Nørgaard, Carsten Hjorthøj, Thomas Axel Madsen, Søren Drivsholm, Charlotta Pisinger, Christian Gluud, Ole Mors, Jesper Krogh and Merete Nordentoft

    Citation: BMC Psychiatry 2015 15:119

    Content type: Study protocol

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  14. Polyunsaturated fatty acid (PUFA) metabolism abnormalities have been long implicated in the etiology of schizophrenia. Although several randomized clinical trials have been carried out to assess the efficacy o...

    Authors: Tomasz Pawełczyk, Marta Grancow, Magdalena Kotlicka-Antczak, Elżbieta Trafalska, Piotr Gębski, Janusz Szemraj, Natalia Żurner and Agnieszka Pawełczyk

    Citation: BMC Psychiatry 2015 15:97

    Content type: Study protocol

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  15. Only three observational studies investigated whether exposure to antipsychotics is associated with an increased risk of pulmonary embolism, with conflicting results. This study was therefore carried out to es...

    Authors: Valentino Conti, Mauro Venegoni, Alfredo Cocci, Ida Fortino, Antonio Lora and Corrado Barbui

    Citation: BMC Psychiatry 2015 15:92

    Content type: Research article

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  16. Evidence has been accumulating that it may be possible to achieve prevention in psychotic disorders. The aim of the Prevention Of Psychosis (POP) study is to reduce the annual incidence of psychotic disorders ...

    Authors: Inge Joa, Jens Gisselgård, Kolbjørn Brønnick, Thomas McGlashan and Jan Olav Johannessen

    Citation: BMC Psychiatry 2015 15:89

    Content type: Study protocol

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  17. Most women with psychotic disorders and bipolar disorders have children but their pregnancies are at risk of adverse psychiatric and fetal outcome. The extent of modifiable risk factors – both clinical and soc...

    Authors: Clare L Taylor, Robert Stewart, Jack Ogden, Matthew Broadbent, Dharmintra Pasupathy and Louise M Howard

    Citation: BMC Psychiatry 2015 15:88

    Content type: Research article

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  18. Capgras delusion is a delusional misidentification syndrome, in which the patient is convinced that someone that is well known to them, usually a close relative, has been replaced by an impostor or double. Alt...

    Authors: Lucrezia Islam, Sylvie Piacentini, Paola Soliveri, Silvio Scarone and Orsola Gambini

    Citation: BMC Psychiatry 2015 15:73

    Content type: Case report

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  19. Psycho-educational interventions for people diagnosed with schizophrenia (PDwS) and their primary caregivers appear promising, however, the majority of trials have significant methodological shortcomings. Ther...

    Authors: Abd Alhadi Hasan, Patrick Callaghan and Joanne S Lymn

    Citation: BMC Psychiatry 2015 15:72

    Content type: Research article

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  20. Schizophrenia is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, and the L-arginine:ADMA ratio are ma...

    Authors: Anders Jorgensen, Ulla Knorr, Mia Greisen Soendergaard, Jens Lykkesfeldt, Anders Fink-Jensen, Henrik Enghusen Poulsen, Martin Balslev Jorgensen, Niels Vidiendal Olsen and Jonatan Myrup Staalsø

    Citation: BMC Psychiatry 2015 15:67

    Content type: Research article

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  21. Olanzapine long-acting injection (LAI) for the treatment of schizophrenia was associated with a cluster of symptoms termed post-injection delirium/sedation syndrome (PDSS) in a small percentage (~2%) of patien...

    Authors: Chris J Bushe, Deborah Falk, Ernie Anand, Marta Casillas, Elena Perrin, Rashna Chhabra-Khanna and Holland C Detke

    Citation: BMC Psychiatry 2015 15:65

    Content type: Research article

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  22. Adults with serious mental illness have a mortality rate two to three times higher than the overall US population, much of which is due to somatic conditions, especially cardiovascular disease. Given the dispr...

    Authors: Julia B Baller, Emma E McGinty, Susan T Azrin, Denise Juliano-Bult and Gail L Daumit

    Citation: BMC Psychiatry 2015 15:55

    Content type: Research article

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  23. The functional outcome of people with severe mental disorders (SMD) is purported to be better in low- and middle-income countries compared to high-income countries; however, cross-cultural measures of function...

    Authors: Kassahun Habtamu, Atalay Alem and Charlotte Hanlon

    Citation: BMC Psychiatry 2015 15:34

    Content type: Research article

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  24. Specialized Early Intervention services (SEI) for first episode psychosis are shown to be effective for the treatment of positive and negative symptoms, medication adherence, rates of relapse, substance abuse ...

    Authors: Danyael Lutgens, Srividya Iyer, Ridha Joober, Thomas G Brown, Ross Norman, Eric Latimer, Norbert Schmitz, Amal Abdel Baki, Sherezad Abadi and Ashok Malla

    Citation: BMC Psychiatry 2015 15:22

    Content type: Study protocol

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  25. Non-adherence to antipsychotic medication in schizophrenic patients is common and associated with symptom relapse and poorer long-term outcomes. The risk factors for treatment non-adherence include dosing freq...

    Authors: Pei-Yin Pan, Meei-Shyuan Lee and Chin-Bin Yeh

    Citation: BMC Psychiatry 2015 15:1

    Content type: Research article

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  26. Recruitment to mental health research can be challenging. ‘Consent for Contact’ (C4C) is a novel framework which may expedite recruitment and contribute to equitable access to research. This paper discusses st...

    Authors: Constantina Papoulias, Dan Robotham, Gareth Drake, Diana Rose and Til Wykes

    Citation: BMC Psychiatry 2014 14:377

    Content type: Research article

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  27. Quality of life (QoL) is considered an important outcome in health research. It can be rated by the patient, or by an external assessor. We wished to identify the predictors of any discrepancies between these ...

    Authors: Karen P Hayhurst, Jennifer A Massie, Graham Dunn, Shôn W Lewis and Richard J Drake

    Citation: BMC Psychiatry 2014 14:365

    Content type: Research article

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  28. The concept of cenesthopathy was first introduced by Dupré and Camus in 1907 to describe clinically unexplainable bodily sensations mainly attributed to psychiatric pathology. If it occurs in oral regions, it ...

    Authors: Akihito Uezato, Akira Toyofuku, Yojiro Umezaki, Motoko Watanabe, Akira Toriihara, Makoto Tomita, Naoki Yamamoto, Akeo Kurumaji and Toru Nishikawa

    Citation: BMC Psychiatry 2014 14:1696

    Content type: Research article

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  29. Pomaglumetad methionil (LY2140023 monohydrate) is a potent and highly selective agonist for the metabotropic glutamate mGluR2 and mGluR3 receptors. We present results of a pivotal clinical study H8Y-MC-HBBM as...

    Authors: AnnCatherine M Downing, Bruce J Kinon, Brian A Millen, Lu Zhang, Lin Liu, Margarita A Morozova, Ronald Brenner, Tami Jo Rayle, Laura Nisenbaum, Fangyi Zhao and Juan Carlos Gomez

    Citation: BMC Psychiatry 2014 14:351

    Content type: Research article

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  30. Early intervention services for psychotic disorders optimally interlock strategies to deliver: (i) Early Detection (ED) to shorten the time between onset of psychotic symptoms and effective treatment (i.e. Dur...

    Authors: Vinod H Srihari, Cenk Tek, Jessica Pollard, Suzannah Zimmet, Jane Keat, John D Cahill, Suat Kucukgoncu, Barbara C Walsh, Fangyong Li, Ralitza Gueorguieva, Nina Levine, Raquelle I Mesholam-Gately, Michelle Friedman-Yakoobian, Larry J Seidman, Matcheri S Keshavan, Thomas H McGlashan…

    Citation: BMC Psychiatry 2014 14:335

    Content type: Study protocol

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  31. People with chronic psychosis often display theory of mind impairments that are not fully accounted for by other, more general neurocognitive deficits. In these patients, both theory of mind and neurocognitive...

    Authors: Robyn Langdon, Michael H Connors, Megan Still, Philip B Ward and Stanley Catts

    Citation: BMC Psychiatry 2014 14:316

    Content type: Research article

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  32. Non-adherence with antipsychotic medication is a frequently occurring problem, particularly among patients with psychotic disorders. Prior research has generally shown encouraging results for interventions bas...

    Authors: Ernst L Noordraven, Charlotte H Audier, Anton BP Staring, Andre I Wierdsma, Peter Blanken, Bas EA van der Hoorn, Leona Hakkaart-van Roijen and Cornelis L Mulder

    Citation: BMC Psychiatry 2014 14:343

    Content type: Study protocol

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  33. In schizophrenia, medication adherence is critical to achieve better patient outcomes and to avoid relapses, which are responsible for a significant proportion of total healthcare costs for this chronic illnes...

    Authors: Tatiana Dilla, Jörgen Möller, Paul O’Donohoe, María Álvarez, José A Sacristán, Michael Happich and Antje Tockhorn

    Citation: BMC Psychiatry 2014 14:298

    Content type: Research article

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  34. The objective of this study was to characterize real-world treatment patterns in the prescription of antipsychotic polypharmacy (≥2 concurrent antipsychotics) compared with antipsychotic monotherapy for patien...

    Authors: Maxine D Fisher, Kathleen Reilly, Keith Isenberg and Kathleen F Villa

    Citation: BMC Psychiatry 2014 14:341

    Content type: Research article

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  35. The prevalence of negative symptoms in schizophrenic patients seems to be an important indicator for treatment response and prognosis. Although negative symptoms have often been attributed to frontal lobe anom...

    Authors: Tobias Hornig, Gabi Valerius, Bernd Feige, Emanuel Bubl, Hans M Olbrich and Ludger Tebartz van Elst

    Citation: BMC Psychiatry 2014 14:326

    Content type: Research article

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  36. Severe mentally ill (SMI) patients have a reduced life expectancy of 13-30 years compared to the general population, largely due to an increased risk of cardiovascular mortality. Unhealthy lifestyle behaviours...

    Authors: Anne Looijmans, Frederike Jörg, Robert A Schoevers, Richard Bruggeman, Ronald P Stolk and Eva Corpeleijn

    Citation: BMC Psychiatry 2014 14:293

    Content type: Study protocol

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  37. Despite strong research interest in psychosis risk identification and the potential for early intervention, few papers have sought to document the implementation and evaluation of specialised psychosis related...

    Authors: Agatha M Conrad, Terry J Lewin, Ketrina A Sly, Ulrich Schall, Sean A Halpin, Mick Hunter and Vaughan J Carr

    Citation: BMC Psychiatry 2014 14:318

    Content type: Research article

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  38. The first of the atypical antipsychotics introduced in the 1970s, clozapine remains the most efficacious neuroleptic to this day. However, serious and potentially fatal side effects have necessitated careful r...

    Authors: Bradley Linton, Rachel Fu, Penny A MacDonald and Hooman Ganjavi

    Citation: BMC Psychiatry 2014 14:299

    Content type: Case report

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  39. Schizophrenia is a debilitating mental disorder that presents impairments in neurocognition and social cognition. Several studies have suggested that the etiology of schizophrenia can be partly explained by ox...

    Authors: Cristina Gonzalez-Liencres, Cumhur Tas, Elliot C Brown, Soner Erdin, Ece Onur, Zeynep Cubukcoglu, Omer Aydemir, Aysen Esen-Danaci and Martin Brüne

    Citation: BMC Psychiatry 2014 14:268

    Content type: Research article

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  40. Socioeconomic status has important associations with disease-specific mortality in the general population. Although individuals with Severe Mental Illnesses (SMI) experience significant premature mortality, th...

    Authors: Julie Langan Martin, Gary McLean, John Park, Daniel J Martin, Moira Connolly, Stewart W Mercer and Daniel J Smith

    Citation: BMC Psychiatry 2014 14:261

    Content type: Research article

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  41. Schizophrenia is one of the most disabling and severely stigmatized mental disorders. Together with social stigma, internalized stigma and perceived stigma can trigger a vicious cycle and diminishes the stigma...

    Authors: Berhanu Boru Bifftu, Berihun Assefa Dachew and Bewket Tadesse Tiruneh

    Citation: BMC Psychiatry 2014 14:259

    Content type: Research article

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