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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. There is a strong association between weight gain and metabolic events in patients with schizophrenia receiving many of the second-generation antipsychotic agents. We explored the relationship between body mas...

    Authors: Jennifer Kern Sliwa, Dong-Jing Fu, Cynthia A Bossie, Ibrahim Turkoz and Larry Alphs

    Citation: BMC Psychiatry 2014 14:52

    Content type: Research article

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  2. Cytochrome P450 1A2 gene (CYP1A2) polymorphisms have been suggested to be associated with increased side effects to antipsychotics. However, studies on this are scarce and have been conducted with either various ...

    Authors: Merja Viikki, Olli Kampman, Niko Seppälä, Nina Mononen, Terho Lehtimäki and Esa Leinonen

    Citation: BMC Psychiatry 2014 14:50

    Content type: Research article

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  3. People with serious mental illness are at an increased risk of physical ill health. Mortality rates are around twice those of the general population with higher levels of cardiovascular disease, metabolic dise...

    Authors: Robert Pearsall, Susan Hughes, John Geddes and Anthony Pelosi

    Citation: BMC Psychiatry 2014 14:38

    Content type: Research article

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  4. Recruitment is one of the most serious challenges in performing randomized controlled trials. Often clinical trials with participants diagnosed with schizophrenia are terminated prematurely because of recruitm...

    Authors: Rikke Jørgensen, Povl Munk-Jørgensen, Paul H Lysaker, Kelly D Buck, Lars Hansson and Vibeke Zoffmann

    Citation: BMC Psychiatry 2014 14:28

    Content type: Research article

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  5. Metacognitive dysfunction has been widely recognized as a feature of schizophrenia. As it is linked with deficits in several aspects of daily life functioning, improvement of metacognition may lead to improvem...

    Authors: Rozanne JM Van Donkersgoed, Steven De Jong, Mark Van der Gaag, André Aleman, Paul H Lysaker, Lex Wunderink and GHM Pijnenborg

    Citation: BMC Psychiatry 2014 14:27

    Content type: Study protocol

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  6. Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the...

    Authors: Kelly A Newell and Natalie Matosin

    Citation: BMC Psychiatry 2014 14:23

    Content type: Debate

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  7. Schizophrenia is one of the most serious forms of mental illness among people being treated in psychiatric clinics in developing and developed countries. Providing care for people diagnosed with schizophrenia ...

    Authors: Abd Alhadi Hasan, Patrick Callaghan and Joanne S Lymn

    Citation: BMC Psychiatry 2014 14:17

    Content type: Study protocol

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  8. Bipolar disorder (BPD) is prevalent and is associated with a significant economic burden. Asenapine, the first tetracyclic antipsychotic approved in Canada for the treatment of BPD, has shown a comparable effi...

    Authors: Jean Lachaine, Catherine Beauchemin, Karine Mathurin, Dominique Gilbert and Maud Beillat

    Citation: BMC Psychiatry 2014 14:16

    Content type: Research article

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  9. Poor adherence to antipsychotic medication is a widespread problem, and the largest predictor of relapse in patients with psychosis. Electronic reminders are increasingly used to improve medication adherence f...

    Authors: Katherine Bogart, Sook Kuan Wong, Christine Lewis, Anthony Akenzua, Daniel Hayes, Athanasios Prountzos, Chike Ify Okocha and Eugenia Kravariti

    Citation: BMC Psychiatry 2014 14:15

    Content type: Research article

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  10. Depot antipsychotic injections are an important tool for the management of patients with schizophrenia who have difficulty with adherence to oral medication. However, pain and discomfort at the injection site ...

    Authors: Susan Atkins, Holland C Detke, David P McDonnell, Michael G Case and Shufang Wang

    Citation: BMC Psychiatry 2014 14:7

    Content type: Research article

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  11. The results of multiple studies on the association between antipsychotic use and structural brain changes in schizophrenia have been assessed only in qualitative literature reviews to date. We aimed to perform...

    Authors: Ulysses S Torres, Eduardo Portela-Oliveira, Stefan Borgwardt and Geraldo F Busatto

    Citation: BMC Psychiatry 2013 13:342

    Content type: Research article

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  12. Long-acting injectable (LAI) formulations are not widely used in routine practice even though they offer advantages in terms of relapse prevention. As part of a process to improve the quality of care, the Fren...

    Authors: Pierre Michel Llorca, Mocrane Abbar, Philippe Courtet, Sebastien Guillaume, Sylvie Lancrenon and Ludovic Samalin

    Citation: BMC Psychiatry 2013 13:340

    Content type: Research article

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  13. This study aimed to examine factors associated with treatment adherence in first-episode psychosis (FEP) patients followed up over 8 years, especially involuntary first admission and stopping cannabis use.

    Authors: Sara Barbeito, Patricia Vega, Sonia Ruiz de Azúa, Margarita Saenz, Mónica Martinez-Cengotitabengoa, Itxaso González-Ortega, Cristina Bermudez, Margarita Hernanz, Blanca Fernández de Corres and Ana González-Pinto

    Citation: BMC Psychiatry 2013 13:326

    Content type: Research article

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  14. Previous evidence has shown that schizotypal personality disorder (SPD) is part of the schizophrenia spectrum. Few studies have examined latent classes in the developmental trajectories of SPD features over ti...

    Authors: Fu-lei Geng, Ting Xu, Yi Wang, Hai-song Shi, Chao Yan, David L Neumann, David HK Shum, Simon SY Lui, Eric FC Cheung and Raymond CK Chan

    Citation: BMC Psychiatry 2013 13:323

    Content type: Research article

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  15. Substance misuse is a well-recognized co-morbidity to psychosis and has been linked to poor prognostic outcomes in patients. Researchers have yet to investigate the difference in rates and characteristics betw...

    Authors: Melissa A Weibell, Inge Joa, Jørgen Bramness, Jan Olav Johannessen, Patrick D McGorry, Wenche ten Velden Hegelstad and Tor Ketil Larsen

    Citation: BMC Psychiatry 2013 13:319

    Content type: Research article

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  16. In their study ‘Mental Health in the General Population: Images and Realities’ Jean-Luc Roelandt et al. found a huge divide between the French public’s conceptualizations of insanity and depression. The study ...

    Authors: Matthias C Angermeyer, Aurélie Millier, Cécile Rémuzat, Tarek Refaï and Mondher Toumi

    Citation: BMC Psychiatry 2013 13:313

    Content type: Research article

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  17. Digital technologies are increasingly directed at improved monitoring, management and treatment of mental health. However, their potential contribution to social networks and self-management support for people...

    Authors: Gavin Daker-White and Anne Rogers

    Citation: BMC Psychiatry 2013 13:279

    Content type: Research article

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  18. A disturbance in connectivity between different brain regions, rather than abnormalities within the separate regions themselves, could be responsible for the clinical symptoms and cognitive dysfunctions observ...

    Authors: Denise Bernier, Jacob Cookey, David McAllindon, Robert Bartha, Christopher C Hanstock, Aaron J Newman, Sherry H Stewart and Philip G Tibbo

    Citation: BMC Psychiatry 2013 13:264

    Content type: Study protocol

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  19. Cardiovascular morbidity and mortality is increased in individuals with severe mental illnesses.

    Authors: Fiona Gaughran, Daniel Stahl, Khalida Ismail, Zerrin Atakan, John Lally, Poonam Gardner-Sood, Anita Patel, Anthony David, David Hopkins, Bee Harries, Philippa Lowe, Diana Orr, Maurice Arbuthnot, Robin M Murray, Kathryn E Greenwood and Shubulade Smith

    Citation: BMC Psychiatry 2013 13:263

    Content type: Study protocol

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  20. The research goal is to better understand prescriber, patient, and caregiver perspectives about long-acting injectable (LAI) antipsychotic therapy and how these perspectives affect LAI use. Addressing these pe...

    Authors: Steven Potkin, Rimal Bera, Donna Zubek and Gina Lau

    Citation: BMC Psychiatry 2013 13:261

    Content type: Research article

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  21. Despite the recent increase of research interest in involuntary treatment and the use of coercive measures, gender differences among coerced schizophrenia patients still remain understudied. It is well recogni...

    Authors: Alexander Nawka, Lucie Kalisova, Jiri Raboch, Domenico Giacco, Libor Cihal, Georgi Onchev, Anastasia Karastergiou, Zahava Solomon, Andrea Fiorillo, Valeria Del Vecchio, Algirdas Dembinskas, Andrzej Kiejna, Petr Nawka, Francisco Torres-Gonzales, Stefan Priebe, Lars Kjellin…

    Citation: BMC Psychiatry 2013 13:257

    Content type: Research article

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  22. To investigate whether schizophrenia patients with both suicide attempts and non-suicidal self-harm have earlier age of onset of psychotic and depressive symptoms and higher levels of clinical symptoms compare...

    Authors: Erlend Mork, Fredrik A Walby, Jill M Harkavy-Friedman, Elizabeth A Barrett, Nils E Steen, Steinar Lorentzen, Ole A Andreassen, Ingrid Melle and Lars Mehlum

    Citation: BMC Psychiatry 2013 13:255

    Content type: Research article

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  23. This study aimed to assess antipsychotic adherence patterns and all-cause and schizophrenia-related health care utilization and costs sequentially during critical clinical periods (i.e., before and after schiz...

    Authors: Michael Markowitz, Sudeep Karve, Jessica Panish, Sean D Candrilli and Larry Alphs

    Citation: BMC Psychiatry 2013 13:246

    Content type: Research article

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  24. Schizotypy, or the set of personality traits related to schizophrenia, is considered an endophenotypic manifestation that is more represented in first-degree relatives of patients with schizophrenia than in th...

    Authors: Maria Chiara Torti, Antonino Buzzanca, Chiara Squarcione, Carla Salerno, Alessia Mirigliani, Fabio Di Fabio and Massimo Biondi

    Citation: BMC Psychiatry 2013 13:245

    Content type: Research article

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  25. It is desirable to establish evidence for the selection of antipsychotics from the viewpoint of recovery of social activity in individual patient with schizophrenia receiving medication. From this perspective,...

    Authors: Jun Ishigooka, Kazuyuki Nakagome, Tetsuro Ohmori and Nakao Iwata

    Citation: BMC Psychiatry 2013 13:243

    Content type: Study protocol

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  26. Hallucinations are prevalent in schizophrenia and related psychotic disorders and may have severe consequences for the affected patients. Antipsychotic drug trials that specifically address the anti-hallucinat...

    Authors: Erik Johnsen, Igne Sinkeviciute, Else-Marie Løberg, Rune A Kroken, Kenneth Hugdahl and Hugo A Jørgensen

    Citation: BMC Psychiatry 2013 13:241

    Content type: Research article

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  27. Individuals diagnosed with serious mental illnesses are at increased risk of obesity- and cardiovascular-related morbidity and early mortality. Lifestyle interventions aimed at weight loss, even those adapted ...

    Authors: Bobbi Jo H Yarborough, Michael C Leo, Scott Stumbo, Nancy A Perrin and Carla A Green

    Citation: BMC Psychiatry 2013 13:238

    Content type: Study protocol

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  28. This study aims to compare severity criteria defined by the Remission in Schizophrenia Working Group (RSWGcr) with other criteria in relation to functional and neurocognitive outcome.

    Authors: Federica Pinna, Massimo Tusconi, Marta Bosia, Roberto Cavallaro and Bernardo Carpiniello

    Citation: BMC Psychiatry 2013 13:235

    Content type: Research article

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  29. The Scale to Assess Unawareness in Mental Disorder (SUMD) is widely used in clinical trials and epidemiological studies but more rarely in clinical practice because of its length (74 items). In clinical practi...

    Authors: Pierre Michel, Karine Baumstarck, Pascal Auquier, Xavier Amador, Rémy Dumas, Jessica Fernandez, Christophe Lancon and Laurent Boyer

    Citation: BMC Psychiatry 2013 13:229

    Content type: Research article

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  30. Severe mental disorders have a chronic course associated with a high risk for co-morbid somatic illnesses and premature mortality and oral health is critical for overall systemic health. But general health car...

    Authors: Valerie Bertaud-Gounot, Viviane Kovess-Masfety, Catherine Perrus, Gilda Trohel and Frederique Richard

    Citation: BMC Psychiatry 2013 13:227

    Content type: Research article

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  31. Hospitalization is a costly and distressing event associated with relapse during schizophrenia treatment. No information is available on the predictors of psychiatric hospitalization during maintenance treatme...

    Authors: Haya Ascher-Svanum, Diego Novick, Josep Maria Haro, Jordan Bertsch, David McDonnell and Holland Detke

    Citation: BMC Psychiatry 2013 13:224

    Content type: Research article

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  32. Among schizophrenia patients relapsed on an oral antipsychotic (AP), this study compared the impact of switching to atypical AP long-acting injectable therapy (LAT) versus continuing oral APs on hospitalizatio...

    Authors: Marie-Hélène Lafeuille, François Laliberté-Auger, Patrick Lefebvre, Christian Frois, John Fastenau and Mei Sheng Duh

    Citation: BMC Psychiatry 2013 13:221

    Content type: Research article

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  33. Olfactory function tests are sensitive tools for assessing sensory-cognitive processing in schizophrenia. However, associations of central olfactory measures with clinical outcome parameters have not been simu...

    Authors: Anne Kästner, Dörthe Malzahn, Martin Begemann, Constanze Hilmes, Heike Bickeböller and Hannelore Ehrenreich

    Citation: BMC Psychiatry 2013 13:218

    Content type: Research article

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  34. There is a lack of empirical studies of patients’ level of humiliation during the hospital admission process and its implications for the clinical setting. We wanted to explore associations between self-rated ...

    Authors: Marit F Svindseth, Jim A Nøttestad and Alv A Dahl

    Citation: BMC Psychiatry 2013 13:217

    Content type: Research article

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  35. This study focuses on people with complex and severe mental health problems who require inpatient rehabilitation. The majority have a diagnosis of schizophrenia whose recovery has been delayed due to non-respo...

    Authors: Helen Killaspy, Sarah Cook, Tim Mundy, Thomas Craig, Frank Holloway, Gerard Leavey, Louise Marston, Paul McCrone, Leonardo Koeser, Maurice Arbuthnott, Rumana Z Omar and Michael King

    Citation: BMC Psychiatry 2013 13:216

    Content type: Study protocol

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  36. Prolactin elevations occur in people treated with antipsychotic medications and are often much higher in women than in men. Hyperprolactinemia is known to cause amenorrhea, oligomenorrhea, galactorrhea and gyn...

    Authors: Deanna L Kelly, Heidi J Wehring, Amber K Earl, Kelli M Sullivan, Faith B Dickerson, Stephanie Feldman, Robert P McMahon, Robert W Buchanan, Dale Warfel, William R Keller, Bernard A Fischer and Joo-Cheol Shim

    Citation: BMC Psychiatry 2013 13:214

    Content type: Study protocol

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  37. The aim of this study is to compare the 12-year follow-up effects on in- and outpatient services of 2 years of integrated treatment for recent-onset schizophrenia versus treatment as usual in a randomized cont...

    Authors: Víðir Sigrúnarson, Rolf W Gråwe and Gunnar Morken

    Citation: BMC Psychiatry 2013 13:200

    Content type: Research article

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  38. Cognitive deficits are stable features of schizophrenia that are linked to functional outcome. Cognitive remediation approaches have been proven successful in ameliorating these deficits, although effect sizes...

    Authors: Wolfgang Trapp, Michael Landgrebe, Katharina Hoesl, Stefan Lautenbacher, Bernd Gallhofer, Wilfried Günther and Goeran Hajak

    Citation: BMC Psychiatry 2013 13:184

    Content type: Research article

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  39. Analysis of the prescribing patterns of antipsychotic drugs can improve therapeutic outcomes. The purpose of this study was to evaluate the prescribing pattern of antipsychotics and its conformance to internat...

    Authors: Waleed M Sweileh, Jihad Bani Odeh, Sa’ed H Zyoud, Ansam F Sawalha and Manal S Ihbeasheh

    Citation: BMC Psychiatry 2013 13:179

    Content type: Research article

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  40. Obesity is a growing health problem leading to high rates of mortality and morbidity in patients with severe mental illness (SMI). The increased rate of obesity is largely attributed to antipsychotic use. The ...

    Authors: Cenk Tek, Sinan Guloksuz, Vinod H Srihari and Erin L Reutenauer

    Citation: BMC Psychiatry 2013 13:176

    Content type: Study protocol

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  41. Levels of non-adherence to antipsychotic medication in persons with schizophrenia in rural African settings have been shown to be comparable to those found in high-income countries. Improved understanding of t...

    Authors: Solomon Teferra, Charlotte Hanlon, Teferra Beyero, Lars Jacobsson and Teshome Shibre

    Citation: BMC Psychiatry 2013 13:168

    Content type: Research article

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  42. Previous studies have demonstrated functional and structural temporal lobe abnormalities located close to the auditory cortical regions in schizophrenia. The goal of this study was to determine whether functio...

    Authors: Kuan-Yi Wu, Ching-Wen Chao, Ching-I Hung, Wei-Hong Chen, Yung-Ting Chen and Sheng-Fu Liang

    Citation: BMC Psychiatry 2013 13:158

    Content type: Research article

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  43. Obsessive-compulsive disorder (OCD) in patients with psychotic disorders has been reported to be a frequent co-morbid disorder in patients with psychotic disorders. The aim of the study determine the prevalenc...

    Authors: Kristen Hagen, Bjarne Hansen, Inge Joa and Tor Ketil Larsen

    Citation: BMC Psychiatry 2013 13:156

    Content type: Research article

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  44. Depot formulations of antipsychotics provide a potential solution to the poor adherence to oral therapies in schizophrenia. However, there have been few comparative studies on the effectiveness and tolerabilit...

    Authors: Laura Lammers, Bree Zehm and Richard Williams

    Citation: BMC Psychiatry 2013 13:155

    Content type: Research article

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  45. Approximately half of service users with schizophrenia or bipolar disorder do not fully follow treatment recommendations. Studies of adherence have not adequately explored the frequency, consequences and meani...

    Authors: Susanne Gibson, Sarah L Brand, Sarah Burt, Zoë V R Boden and Outi Benson

    Citation: BMC Psychiatry 2013 13:153

    Content type: Research article

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  46. The neurotrophic factor, S100B, is released primarily from astrocytes, with serum and CSF levels of S100B reported as altered in schizophrenia. However, many of these reports are contradictory. Here, serum lev...

    Authors: Kara O’Connell, Jogin Thakore and Kumlesh K Dev

    Citation: BMC Psychiatry 2013 13:146

    Content type: Research article

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