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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Previous evidence has shown that schizotypal personality disorder (SPD) is part of the schizophrenia spectrum. Few studies have examined latent classes in the developmental trajectories of SPD features over ti...

    Authors: Fu-lei Geng, Ting Xu, Yi Wang, Hai-song Shi, Chao Yan, David L Neumann, David HK Shum, Simon SY Lui, Eric FC Cheung and Raymond CK Chan

    Citation: BMC Psychiatry 2013 13:323

    Content type: Research article

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  2. Substance misuse is a well-recognized co-morbidity to psychosis and has been linked to poor prognostic outcomes in patients. Researchers have yet to investigate the difference in rates and characteristics betw...

    Authors: Melissa A Weibell, Inge Joa, Jørgen Bramness, Jan Olav Johannessen, Patrick D McGorry, Wenche ten Velden Hegelstad and Tor Ketil Larsen

    Citation: BMC Psychiatry 2013 13:319

    Content type: Research article

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  3. In their study ‘Mental Health in the General Population: Images and Realities’ Jean-Luc Roelandt et al. found a huge divide between the French public’s conceptualizations of insanity and depression. The study ...

    Authors: Matthias C Angermeyer, Aurélie Millier, Cécile Rémuzat, Tarek Refaï and Mondher Toumi

    Citation: BMC Psychiatry 2013 13:313

    Content type: Research article

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  4. Digital technologies are increasingly directed at improved monitoring, management and treatment of mental health. However, their potential contribution to social networks and self-management support for people...

    Authors: Gavin Daker-White and Anne Rogers

    Citation: BMC Psychiatry 2013 13:279

    Content type: Research article

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  5. A disturbance in connectivity between different brain regions, rather than abnormalities within the separate regions themselves, could be responsible for the clinical symptoms and cognitive dysfunctions observ...

    Authors: Denise Bernier, Jacob Cookey, David McAllindon, Robert Bartha, Christopher C Hanstock, Aaron J Newman, Sherry H Stewart and Philip G Tibbo

    Citation: BMC Psychiatry 2013 13:264

    Content type: Study protocol

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  6. Cardiovascular morbidity and mortality is increased in individuals with severe mental illnesses.

    Authors: Fiona Gaughran, Daniel Stahl, Khalida Ismail, Zerrin Atakan, John Lally, Poonam Gardner-Sood, Anita Patel, Anthony David, David Hopkins, Bee Harries, Philippa Lowe, Diana Orr, Maurice Arbuthnot, Robin M Murray, Kathryn E Greenwood and Shubulade Smith

    Citation: BMC Psychiatry 2013 13:263

    Content type: Study protocol

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  7. The research goal is to better understand prescriber, patient, and caregiver perspectives about long-acting injectable (LAI) antipsychotic therapy and how these perspectives affect LAI use. Addressing these pe...

    Authors: Steven Potkin, Rimal Bera, Donna Zubek and Gina Lau

    Citation: BMC Psychiatry 2013 13:261

    Content type: Research article

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  8. Despite the recent increase of research interest in involuntary treatment and the use of coercive measures, gender differences among coerced schizophrenia patients still remain understudied. It is well recogni...

    Authors: Alexander Nawka, Lucie Kalisova, Jiri Raboch, Domenico Giacco, Libor Cihal, Georgi Onchev, Anastasia Karastergiou, Zahava Solomon, Andrea Fiorillo, Valeria Del Vecchio, Algirdas Dembinskas, Andrzej Kiejna, Petr Nawka, Francisco Torres-Gonzales, Stefan Priebe, Lars Kjellin…

    Citation: BMC Psychiatry 2013 13:257

    Content type: Research article

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  9. To investigate whether schizophrenia patients with both suicide attempts and non-suicidal self-harm have earlier age of onset of psychotic and depressive symptoms and higher levels of clinical symptoms compare...

    Authors: Erlend Mork, Fredrik A Walby, Jill M Harkavy-Friedman, Elizabeth A Barrett, Nils E Steen, Steinar Lorentzen, Ole A Andreassen, Ingrid Melle and Lars Mehlum

    Citation: BMC Psychiatry 2013 13:255

    Content type: Research article

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  10. This study aimed to assess antipsychotic adherence patterns and all-cause and schizophrenia-related health care utilization and costs sequentially during critical clinical periods (i.e., before and after schiz...

    Authors: Michael Markowitz, Sudeep Karve, Jessica Panish, Sean D Candrilli and Larry Alphs

    Citation: BMC Psychiatry 2013 13:246

    Content type: Research article

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  11. Schizotypy, or the set of personality traits related to schizophrenia, is considered an endophenotypic manifestation that is more represented in first-degree relatives of patients with schizophrenia than in th...

    Authors: Maria Chiara Torti, Antonino Buzzanca, Chiara Squarcione, Carla Salerno, Alessia Mirigliani, Fabio Di Fabio and Massimo Biondi

    Citation: BMC Psychiatry 2013 13:245

    Content type: Research article

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  12. It is desirable to establish evidence for the selection of antipsychotics from the viewpoint of recovery of social activity in individual patient with schizophrenia receiving medication. From this perspective,...

    Authors: Jun Ishigooka, Kazuyuki Nakagome, Tetsuro Ohmori and Nakao Iwata

    Citation: BMC Psychiatry 2013 13:243

    Content type: Study protocol

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  13. Hallucinations are prevalent in schizophrenia and related psychotic disorders and may have severe consequences for the affected patients. Antipsychotic drug trials that specifically address the anti-hallucinat...

    Authors: Erik Johnsen, Igne Sinkeviciute, Else-Marie Løberg, Rune A Kroken, Kenneth Hugdahl and Hugo A Jørgensen

    Citation: BMC Psychiatry 2013 13:241

    Content type: Research article

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  14. Individuals diagnosed with serious mental illnesses are at increased risk of obesity- and cardiovascular-related morbidity and early mortality. Lifestyle interventions aimed at weight loss, even those adapted ...

    Authors: Bobbi Jo H Yarborough, Michael C Leo, Scott Stumbo, Nancy A Perrin and Carla A Green

    Citation: BMC Psychiatry 2013 13:238

    Content type: Study protocol

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  15. This study aims to compare severity criteria defined by the Remission in Schizophrenia Working Group (RSWGcr) with other criteria in relation to functional and neurocognitive outcome.

    Authors: Federica Pinna, Massimo Tusconi, Marta Bosia, Roberto Cavallaro and Bernardo Carpiniello

    Citation: BMC Psychiatry 2013 13:235

    Content type: Research article

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  16. The Scale to Assess Unawareness in Mental Disorder (SUMD) is widely used in clinical trials and epidemiological studies but more rarely in clinical practice because of its length (74 items). In clinical practi...

    Authors: Pierre Michel, Karine Baumstarck, Pascal Auquier, Xavier Amador, Rémy Dumas, Jessica Fernandez, Christophe Lancon and Laurent Boyer

    Citation: BMC Psychiatry 2013 13:229

    Content type: Research article

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  17. Severe mental disorders have a chronic course associated with a high risk for co-morbid somatic illnesses and premature mortality and oral health is critical for overall systemic health. But general health car...

    Authors: Valerie Bertaud-Gounot, Viviane Kovess-Masfety, Catherine Perrus, Gilda Trohel and Frederique Richard

    Citation: BMC Psychiatry 2013 13:227

    Content type: Research article

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  18. Hospitalization is a costly and distressing event associated with relapse during schizophrenia treatment. No information is available on the predictors of psychiatric hospitalization during maintenance treatme...

    Authors: Haya Ascher-Svanum, Diego Novick, Josep Maria Haro, Jordan Bertsch, David McDonnell and Holland Detke

    Citation: BMC Psychiatry 2013 13:224

    Content type: Research article

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  19. Among schizophrenia patients relapsed on an oral antipsychotic (AP), this study compared the impact of switching to atypical AP long-acting injectable therapy (LAT) versus continuing oral APs on hospitalizatio...

    Authors: Marie-Hélène Lafeuille, François Laliberté-Auger, Patrick Lefebvre, Christian Frois, John Fastenau and Mei Sheng Duh

    Citation: BMC Psychiatry 2013 13:221

    Content type: Research article

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  20. Olfactory function tests are sensitive tools for assessing sensory-cognitive processing in schizophrenia. However, associations of central olfactory measures with clinical outcome parameters have not been simu...

    Authors: Anne Kästner, Dörthe Malzahn, Martin Begemann, Constanze Hilmes, Heike Bickeböller and Hannelore Ehrenreich

    Citation: BMC Psychiatry 2013 13:218

    Content type: Research article

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  21. There is a lack of empirical studies of patients’ level of humiliation during the hospital admission process and its implications for the clinical setting. We wanted to explore associations between self-rated ...

    Authors: Marit F Svindseth, Jim A Nøttestad and Alv A Dahl

    Citation: BMC Psychiatry 2013 13:217

    Content type: Research article

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  22. This study focuses on people with complex and severe mental health problems who require inpatient rehabilitation. The majority have a diagnosis of schizophrenia whose recovery has been delayed due to non-respo...

    Authors: Helen Killaspy, Sarah Cook, Tim Mundy, Thomas Craig, Frank Holloway, Gerard Leavey, Louise Marston, Paul McCrone, Leonardo Koeser, Maurice Arbuthnott, Rumana Z Omar and Michael King

    Citation: BMC Psychiatry 2013 13:216

    Content type: Study protocol

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  23. Prolactin elevations occur in people treated with antipsychotic medications and are often much higher in women than in men. Hyperprolactinemia is known to cause amenorrhea, oligomenorrhea, galactorrhea and gyn...

    Authors: Deanna L Kelly, Heidi J Wehring, Amber K Earl, Kelli M Sullivan, Faith B Dickerson, Stephanie Feldman, Robert P McMahon, Robert W Buchanan, Dale Warfel, William R Keller, Bernard A Fischer and Joo-Cheol Shim

    Citation: BMC Psychiatry 2013 13:214

    Content type: Study protocol

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  24. The aim of this study is to compare the 12-year follow-up effects on in- and outpatient services of 2 years of integrated treatment for recent-onset schizophrenia versus treatment as usual in a randomized cont...

    Authors: Víðir Sigrúnarson, Rolf W Gråwe and Gunnar Morken

    Citation: BMC Psychiatry 2013 13:200

    Content type: Research article

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  25. Cognitive deficits are stable features of schizophrenia that are linked to functional outcome. Cognitive remediation approaches have been proven successful in ameliorating these deficits, although effect sizes...

    Authors: Wolfgang Trapp, Michael Landgrebe, Katharina Hoesl, Stefan Lautenbacher, Bernd Gallhofer, Wilfried Günther and Goeran Hajak

    Citation: BMC Psychiatry 2013 13:184

    Content type: Research article

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  26. Analysis of the prescribing patterns of antipsychotic drugs can improve therapeutic outcomes. The purpose of this study was to evaluate the prescribing pattern of antipsychotics and its conformance to internat...

    Authors: Waleed M Sweileh, Jihad Bani Odeh, Sa’ed H Zyoud, Ansam F Sawalha and Manal S Ihbeasheh

    Citation: BMC Psychiatry 2013 13:179

    Content type: Research article

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  27. Obesity is a growing health problem leading to high rates of mortality and morbidity in patients with severe mental illness (SMI). The increased rate of obesity is largely attributed to antipsychotic use. The ...

    Authors: Cenk Tek, Sinan Guloksuz, Vinod H Srihari and Erin L Reutenauer

    Citation: BMC Psychiatry 2013 13:176

    Content type: Study protocol

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  28. Levels of non-adherence to antipsychotic medication in persons with schizophrenia in rural African settings have been shown to be comparable to those found in high-income countries. Improved understanding of t...

    Authors: Solomon Teferra, Charlotte Hanlon, Teferra Beyero, Lars Jacobsson and Teshome Shibre

    Citation: BMC Psychiatry 2013 13:168

    Content type: Research article

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  29. Previous studies have demonstrated functional and structural temporal lobe abnormalities located close to the auditory cortical regions in schizophrenia. The goal of this study was to determine whether functio...

    Authors: Kuan-Yi Wu, Ching-Wen Chao, Ching-I Hung, Wei-Hong Chen, Yung-Ting Chen and Sheng-Fu Liang

    Citation: BMC Psychiatry 2013 13:158

    Content type: Research article

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  30. Obsessive-compulsive disorder (OCD) in patients with psychotic disorders has been reported to be a frequent co-morbid disorder in patients with psychotic disorders. The aim of the study determine the prevalenc...

    Authors: Kristen Hagen, Bjarne Hansen, Inge Joa and Tor Ketil Larsen

    Citation: BMC Psychiatry 2013 13:156

    Content type: Research article

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  31. Depot formulations of antipsychotics provide a potential solution to the poor adherence to oral therapies in schizophrenia. However, there have been few comparative studies on the effectiveness and tolerabilit...

    Authors: Laura Lammers, Bree Zehm and Richard Williams

    Citation: BMC Psychiatry 2013 13:155

    Content type: Research article

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  32. Approximately half of service users with schizophrenia or bipolar disorder do not fully follow treatment recommendations. Studies of adherence have not adequately explored the frequency, consequences and meani...

    Authors: Susanne Gibson, Sarah L Brand, Sarah Burt, Zoë V R Boden and Outi Benson

    Citation: BMC Psychiatry 2013 13:153

    Content type: Research article

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  33. The neurotrophic factor, S100B, is released primarily from astrocytes, with serum and CSF levels of S100B reported as altered in schizophrenia. However, many of these reports are contradictory. Here, serum lev...

    Authors: Kara O’Connell, Jogin Thakore and Kumlesh K Dev

    Citation: BMC Psychiatry 2013 13:146

    Content type: Research article

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  34. We compared the time to discontinuation due to lack of tolerability over 24 weeks in patients suffering from schizophrenia treated with pomaglumetad methionil (LY2140023 monohydrate, the prodrug of metabotropi...

    Authors: David H Adams, Bruce J Kinon, Simin Baygani, Brian A Millen, Isabella Velona, Sara Kollack-Walker and David P Walling

    Citation: BMC Psychiatry 2013 13:143

    Content type: Research article

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  35. In research on theory of mind (ToM), false belief paradigms are commonly used. Previous studies have reported that there is heterogeneity in the magnitude of impairment on false belief tasks. Moreover, intact ...

    Authors: Yong-guang Wang, David L Roberts and Bai-hua Xu

    Citation: BMC Psychiatry 2013 13:141

    Content type: Research article

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  36. Persons with severe mental disorders (PSMD) form a highly heterogeneous group. Identifying subgroups sharing similar PSMD profiles may help to develop treatment plans and appropriate services for their needs. ...

    Authors: Marie-Josée Fleury, Guy Grenier, Jean-Marie Bamvita and Jacques Tremblay

    Citation: BMC Psychiatry 2013 13:137

    Content type: Research article

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  37. The Screen for Cognitive Impairment in Psychiatry (SCIP) is a simple and easy to administer scale developed for screening cognitive deficits. This study presents the diagnostic-specific standardization data fo...

    Authors: Juana Gómez-Benito, Georgina Guilera, Óscar Pino, Emilio Rojo, Rafael Tabarés-Seisdedos, Gemma Safont, Anabel Martínez-Arán, Manuel Franco, Manuel J Cuesta, Benedicto Crespo-Facorro, Miguel Bernardo, Eduard Vieta, Scot E Purdon, Francisco Mesa and Javier Rejas

    Citation: BMC Psychiatry 2013 13:127

    Content type: Research article

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  38. Siblings of individuals with first episode psychosis are natural partners to promote service users’ recovery and are themselves vulnerable to mental ill health due to the negative impact of psychosis within th...

    Authors: Jacqueline Sin, Claire Henderson, Vanessa Pinfold and Ian Norman

    Citation: BMC Psychiatry 2013 13:123

    Content type: Study protocol

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  39. Studies have reported that up to 60% of individuals with schizophrenia are overweight or obese. This study explored the relationship between obesity and cognitive performance in Chinese patients with schizophr...

    Authors: Xiaofeng Guo, Zhanchou Zhang, Qinling Wei, Hailong Lv, Renrong Wu and Jingping Zhao

    Citation: BMC Psychiatry 2013 13:109

    Content type: Research article

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  40. Obesity is becoming more prevalent and thus growing as a public health concern in patients with schizophrenia. This investigation evaluated the relationship between body weight and the self-reported quality of...

    Authors: Norio Sugawara, Norio Yasui-Furukori, Yasushi Sato, Manabu Saito, Hanako Furukori, Taku Nakagami, Shuhei Kudo and Sunao Kaneko

    Citation: BMC Psychiatry 2013 13:108

    Content type: Research article

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  41. Depressive symptoms are common in patients with first episode psychosis (FEP) and have serious consequences for them. The main aims of this study were to examine the course of depression in FEP patients and ex...

    Authors: Nasrettin Sönmez, Kristin Lie Romm, Ole A Andreasssen, Ingrid Melle and Jan Ivar Røssberg

    Citation: BMC Psychiatry 2013 13:106

    Content type: Research article

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  42. Little data is available on the real-world socio-economic burden and outcomes in schizophrenia. This study aimed to assess persistence, compliance, costs and Health-Related Quality-of-Life (HRQoL) in young pat...

    Authors: Paolo A Cortesi, Claudio Mencacci, Ferrannini Luigi, Elvezio Pirfo, Patrizia Berto, Miriam CJM Sturkenboom, Fabiana L Lopes, Maria G Giustra, Lorenzo G Mantovani and Luciana Scalone

    Citation: BMC Psychiatry 2013 13:98

    Content type: Research article

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  43. Currently a large number of atypical antipsychotics available in the market are endorsed as better option for treating schizophrenia than the typical antipsychotics. Information regarding the utilization patte...

    Authors: Indrajit Banerjee, Bedanta Roy, Brijesh Sathian, Indraneel Banerjee, Prasanta Kumar Chakraborty and Archana Saha

    Citation: BMC Psychiatry 2013 13:96

    Content type: Research article

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  44. Recent functional imaging studies on chronic pain of various organic etiologies have shown significant alterations in both the spatial and the temporal dimensions of the functional connectivity of the human br...

    Authors: Alexander Otti, Harald Guendel, Afra Wohlschläger, Claus Zimmer and Michael Noll-Hussong

    Citation: BMC Psychiatry 2013 13:84

    Content type: Research article

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  45. The aim of this paper was to delineate the impact of gender on premorbid history, onset, and 18 month outcomes of first episode psychotic mania (FEPM) patients.

    Authors: Sue M Cotton, Martin Lambert, Michael Berk, Benno G Schimmelmann, Felicity J Butselaar, Patrick D McGorry and Philippe Conus

    Citation: BMC Psychiatry 2013 13:82

    Content type: Research article

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  46. Reducing the duration of untreated psychosis (DUP) is an aspiration of international guidelines for first episode psychosis; however, public health initiatives have met with mixed results. Systematic reviews s...

    Authors: Charlotte Connor, Max Birchwood, Colin Palmer, Sunita Channa, Nick Freemantle, Helen Lester, Paul Patterson and Swaran Singh

    Citation: BMC Psychiatry 2013 13:67

    Content type: Study protocol

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  47. Patients with schizophrenia have lower longevity than the general population as a consequence of a combination of risk factors connected to the disease, lifestyle and the use of medications, which are related ...

    Authors: Cecília Attux, Larissa C Martini, Hélio Elkis, Sérgio Tamai, Andréa Freirias, Maria das Graças Miquelutti Camargo, Mário Dinis Mateus, Jair de Jesus Mari, André F Reis and Rodrigo A Bressan

    Citation: BMC Psychiatry 2013 13:60

    Content type: Research article

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  48. Discontinuation of antipsychotic treatment for schizophrenia can interrupt improvement and exacerbate the illness. Reasons for discontinuing treatment are multifactorial and include adherence, efficacy and tol...

    Authors: Paul Geerts, Guadalupe Martinez and Andreas Schreiner

    Citation: BMC Psychiatry 2013 13:58

    Content type: Research article

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