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Psychotic disorders

This section focuses on psychotic disorders. Topics of interest include, but are not limited to, schizophrenia, antipsychotics, biochemistry, hallucinations, delusions, neurocognitive functioning and brain imaging.

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  1. Depressive symptoms are common in patients with first episode psychosis (FEP) and have serious consequences for them. The main aims of this study were to examine the course of depression in FEP patients and ex...

    Authors: Nasrettin Sönmez, Kristin Lie Romm, Ole A Andreasssen, Ingrid Melle and Jan Ivar Røssberg

    Citation: BMC Psychiatry 2013 13:106

    Content type: Research article

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  2. Little data is available on the real-world socio-economic burden and outcomes in schizophrenia. This study aimed to assess persistence, compliance, costs and Health-Related Quality-of-Life (HRQoL) in young pat...

    Authors: Paolo A Cortesi, Claudio Mencacci, Ferrannini Luigi, Elvezio Pirfo, Patrizia Berto, Miriam CJM Sturkenboom, Fabiana L Lopes, Maria G Giustra, Lorenzo G Mantovani and Luciana Scalone

    Citation: BMC Psychiatry 2013 13:98

    Content type: Research article

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  3. Currently a large number of atypical antipsychotics available in the market are endorsed as better option for treating schizophrenia than the typical antipsychotics. Information regarding the utilization patte...

    Authors: Indrajit Banerjee, Bedanta Roy, Brijesh Sathian, Indraneel Banerjee, Prasanta Kumar Chakraborty and Archana Saha

    Citation: BMC Psychiatry 2013 13:96

    Content type: Research article

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  4. Recent functional imaging studies on chronic pain of various organic etiologies have shown significant alterations in both the spatial and the temporal dimensions of the functional connectivity of the human br...

    Authors: Alexander Otti, Harald Guendel, Afra Wohlschläger, Claus Zimmer and Michael Noll-Hussong

    Citation: BMC Psychiatry 2013 13:84

    Content type: Research article

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  5. The aim of this paper was to delineate the impact of gender on premorbid history, onset, and 18 month outcomes of first episode psychotic mania (FEPM) patients.

    Authors: Sue M Cotton, Martin Lambert, Michael Berk, Benno G Schimmelmann, Felicity J Butselaar, Patrick D McGorry and Philippe Conus

    Citation: BMC Psychiatry 2013 13:82

    Content type: Research article

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  6. Reducing the duration of untreated psychosis (DUP) is an aspiration of international guidelines for first episode psychosis; however, public health initiatives have met with mixed results. Systematic reviews s...

    Authors: Charlotte Connor, Max Birchwood, Colin Palmer, Sunita Channa, Nick Freemantle, Helen Lester, Paul Patterson and Swaran Singh

    Citation: BMC Psychiatry 2013 13:67

    Content type: Study protocol

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  7. Patients with schizophrenia have lower longevity than the general population as a consequence of a combination of risk factors connected to the disease, lifestyle and the use of medications, which are related ...

    Authors: Cecília Attux, Larissa C Martini, Hélio Elkis, Sérgio Tamai, Andréa Freirias, Maria das Graças Miquelutti Camargo, Mário Dinis Mateus, Jair de Jesus Mari, André F Reis and Rodrigo A Bressan

    Citation: BMC Psychiatry 2013 13:60

    Content type: Research article

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  8. Discontinuation of antipsychotic treatment for schizophrenia can interrupt improvement and exacerbate the illness. Reasons for discontinuing treatment are multifactorial and include adherence, efficacy and tol...

    Authors: Paul Geerts, Guadalupe Martinez and Andreas Schreiner

    Citation: BMC Psychiatry 2013 13:58

    Content type: Research article

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  9. Multiple relapses characterise the course of illness in most patients with schizophrenia, yet the nature of these episodes has not been extensively researched and clinicians may not always be aware of importan...

    Authors: Robin Emsley, Bonginkosi Chiliza, Laila Asmal and Brian H Harvey

    Citation: BMC Psychiatry 2013 13:50

    Content type: Review

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  10. Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk...

    Authors: Jennifer R Murphy, Caroline Rawdon, Ian Kelleher, Deirdre Twomey, Patrick S Markey, Mary Cannon and Richard AP Roche

    Citation: BMC Psychiatry 2013 13:45

    Content type: Research article

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  11. Over the past decade policy makers have emphasised the importance of healthcare technology in the management of long-term conditions. Mobile-phone based assessment may be one method of facilitating clinically-...

    Authors: Jasper E Palmier-Claus, Anne Rogers, John Ainsworth, Matt Machin, Christine Barrowclough, Louise Laverty, Emma Barkus, Shitij Kapur, Til Wykes and Shôn W Lewis

    Citation: BMC Psychiatry 2013 13:34

    Content type: Research article

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  12. The aim of this review was to systematically review and meta-analyze the effects of yoga on symptoms of schizophrenia, quality of life, function, and hospitalization in patients with schizophrenia.

    Authors: Holger Cramer, Romy Lauche, Petra Klose, Jost Langhorst and Gustav Dobos

    Citation: BMC Psychiatry 2013 13:32

    Content type: Research article

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  13. Long acting injections (LAI) have been associated with perceptions of coercion in cross sectional studies but there have been no longitudinal studies of the effects on clinical relationships with newer depot m...

    Authors: Til Wykes, Diana Rose, Paul Williams and Anthony S David

    Citation: BMC Psychiatry 2013 13:28

    Content type: Research article

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  14. Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Bra...

    Authors: Sonia Ruiz de Azua, Carlos Matute, Laura Stertz, Fernando Mosquera, Aitor Palomino, Iris de la Rosa, Sara Barbeito, Patricia Vega, Flávio Kapczinski and Ana González-Pinto

    Citation: BMC Psychiatry 2013 13:27

    Content type: Research article

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  15. Olanzapine rapid-acting intramuscular (IM) injection is an atypical antipsychotic drug already used overseas and recently approved in Japan. The objective of this study was to confirm the efficacy of rapid-act...

    Authors: Hideaki Katagiri, Shinji Fujikoshi, Takuya Suzuki, Kiyoshi Fujita, Naoya Sugiyama, Michihiro Takahashi and Juan-Carlos Gomez

    Citation: BMC Psychiatry 2013 13:20

    Content type: Research article

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    The Erratum to this article has been published in BMC Psychiatry 2014 14:313

  16. The objective of this study was to evaluate whether quality of life (QoL), as measured by the SF36 and the Quality of Life Interview (QoLI), is predictive of relapse for patients with schizophrenia.

    Authors: Laurent Boyer, Aurelie Millier, Emeline Perthame, Samuel Aballea, Pascal Auquier and Mondher Toumi

    Citation: BMC Psychiatry 2013 13:15

    Content type: Research article

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  17. Antonovsky’s sense of coherence (SOC) as well as psychoeducational interventions has a convincing impact on the quality of life (QOL) of patients suffering from schizophrenia. This study explores the influence...

    Authors: Walter Gassmann, Oliver Christ, Jana Lampert and Hartmut Berger

    Citation: BMC Psychiatry 2013 13:10

    Content type: Research article

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  18. Patients with schizophrenia report muscle weakness. The relation of this muscle weakness with performing daily life activities such as walking is however not yet studied. The aim of this study was to quantify ...

    Authors: Davy Vancampfort, Michel Probst, Amber De Herdt, Rui Manuel Nunes Corredeira, Attilio Carraro, Dirk De Wachter and Marc De Hert

    Citation: BMC Psychiatry 2013 13:5

    Content type: Research article

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  19. Despite the potential impact on treatment adherence and recovery, there is a dearth of data on the extent and correlates of internalized stigma in patients with schizophrenia in low income countries. We conduc...

    Authors: Dereje Assefa, Teshome Shibre, Laura Asher and Abebaw Fekadu

    Citation: BMC Psychiatry 2012 12:239

    Content type: Research article

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  20. Metabolic syndrome (MS) is a cluster of the most dangerous cardiac risk factors and is associated with high mortality. Ethnic differences in metabolic syndrome (MS) criteria and prevalence rates have been repo...

    Authors: Waleed M Sweileh, Sa’ed H Zyoud, Salah A Dalal, Sami Ibwini, Ansam F Sawalha and Iyad Ali

    Citation: BMC Psychiatry 2012 12:235

    Content type: Research article

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  21. Studies in developed countries indicate that psychotic-like symptoms are prevalent in the community and are related to trauma exposure and PTSD. No comparable studies have been undertaken in low-income, post-c...

    Authors: Ian Soosay, Derrick Silove, Catherine Bateman-Steel, Zachary Steel, Paul Bebbington, Peter B Jones, Tien Chey, Lorraine Ivancic and Claire Marnane

    Citation: BMC Psychiatry 2012 12:229

    Content type: Research article

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  22. Although persistent negative symptoms (PNS) are known to contribute significantly to poor functional outcome, they remain poorly understood. We examined the heuristic value of various PNS definitions and their...

    Authors: Cindy L Hovington, Michael Bodnar, Ridha Joober, Ashok K Malla and Martin Lepage

    Citation: BMC Psychiatry 2012 12:224

    Content type: Research article

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  23. Little is known about the long-term outcomes for patients with schizophrenia who fail to achieve symptomatic remission. This post-hoc analysis of a 3-year study compared the costs of mental health services and...

    Authors: Virginia S Haynes, Baojin Zhu, Virginia L Stauffer, Bruce J Kinon, Michael D Stensland, Lei Xu and Haya Ascher-Svanum

    Citation: BMC Psychiatry 2012 12:222

    Content type: Research article

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  24. Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of th...

    Authors: Maciej Jakub Lazarczyk, Zahir A Bhuiyan, Nicolas Perrin and Panteleimon Giannakopoulos

    Citation: BMC Psychiatry 2012 12:220

    Content type: Case report

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  25. With many atypical antipsychotics now available in the market, it has become a common clinical practice to switch between atypical agents as a means of achieving the best clinical outcomes. This study aimed to...

    Authors: Jihyung Hong, Diego Novick, Roberto Brugnoli, Jamie Karagianis, Martin Dossenbach and Josep Maria Haro

    Citation: BMC Psychiatry 2012 12:218

    Content type: Research article

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  26. “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics d...

    Authors: Julie Langan, Daniel Martin, Polash Shajahan and Daniel J Smith

    Citation: BMC Psychiatry 2012 12:214

    Content type: Database

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  27. Polydipsia frequently occurs in schizophrenia patients. The excessive water loading in polydipsia occasionally induces a hyponatremic state and leads to water intoxication. Whether polydipsia in schizophrenic ...

    Authors: Tomohisa Nagashima, Makoto Inoue, Soichiro Kitamura, Kuniaki Kiuchi, Jun Kosaka, Koji Okada, Naoko Kishimoto, Toshiaki Taoka, Kimihiko Kichikawa and Toshifumi Kishimoto

    Citation: BMC Psychiatry 2012 12:210

    Content type: Research article

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  28. Antipsychotic drugs are considered a trigger factor for autonomic dysregulation, which has been shown to predict potentially fatal arrhythmias in schizophrenia. However, the dose-dependent effect of antipsycho...

    Authors: Yohko Iwamoto, Chiaki Kawanishi, Ikuko Kishida, Taku Furuno, Mami Fujibayashi, Chie Ishii, Norio Ishii, Toshio Moritani, Masataka Taguri and Yoshio Hirayasu

    Citation: BMC Psychiatry 2012 12:199

    Content type: Research article

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  29. The sole focus of models of insight on bio-medical perspectives to the complete exclusion of local, non-medical and cultural constructs mandates review. This study attempted to investigate the impact of insigh...

    Authors: Shanthi Johnson, Manoranjitham Sathyaseelan, Helen Charles, Visalakshi Jeyaseelan and Kuruthukulangara Sebastian Jacob

    Citation: BMC Psychiatry 2012 12:159

    Content type: Research article

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  30. An appropriate understanding of the association between high-Expressed Emotion (EE) in family members of people with schizophrenia, patients’ and relatives’ correlates is needed to improve adaptation of psycho...

    Authors: Giuseppe Carrà, Carlo Lorenzo Cazzullo and Massimo Clerici

    Citation: BMC Psychiatry 2012 12:140

    Content type: Research article

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  31. Current guidelines suggest specific criteria for oral or long-acting injectable antipsychotic drugs (LAIs). This review aims to describe the demographic and clinical characteristics of the ideal profile of the...

    Authors: Giuseppe Rossi, Sonia Frediani, Roberta Rossi and Andrea Rossi

    Citation: BMC Psychiatry 2012 12:122

    Content type: Research article

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    The Erratum to this article has been published in BMC Psychiatry 2013 13:334

  32. Lack of insight is a core feature of schizophrenia and is associated with structural brain abnormalities. The functional neuroanatomy of insight has only recently been investigated. When people evaluate their ...

    Authors: Nicholas J Bedford, Simon Surguladze, Vincent Giampietro, Michael J Brammer and Anthony S David

    Citation: BMC Psychiatry 2012 12:106

    Content type: Research article

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  33. The authors sought to compare gray matter changes in First Episode Schizophrenia (FES) compared with Fronto-Temporal Lobar Degeneration (FTLD) using meta-analytic methods applied to neuro-imaging studies.

    Authors: Bayanne Olabi, Ian Ellison-Wright, Ed Bullmore and Stephen M Lawrie

    Citation: BMC Psychiatry 2012 12:104

    Content type: Research article

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  34. The ultra high risk state for psychosis has not been studied in young offender populations. Prison populations have higher rates of psychiatric morbidity and substance use disorders. Due to the age profile of ...

    Authors: Darran Flynn, Damian Smith, Luke Quirke, Stephen Monks and Harry G Kennedy

    Citation: BMC Psychiatry 2012 12:100

    Content type: Research article

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  36. To fully assess the various dimensions affected by schizophrenia, clinical trials often include multiple scales measuring various symptom profiles, cognition, quality of life, subjective well-being, and functi...

    Authors: Lei Chen, Glenn Phillips, Joseph Johnston, Bruce J Kinon, Haya Ascher-Svanum, Sara Kollack-Walker, Paul Succop and Dieter Naber

    Citation: BMC Psychiatry 2011 11:203

    Content type: Research article

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  37. The benefits of some second-generation antipsychotics (SGAs) must be weighed against the increased risk for diabetes mellitus. This study examines whether the association between SGAs and diabetes differs by d...

    Authors: Marianne Ulcickas Yood, Gerald N DeLorenze, Charles P Quesenberry Jr, Susan A Oliveria, Ai-Lin Tsai, Edward Kim, Mark J Cziraky, Robert D McQuade, John W Newcomer and Gilbert J L'Italien

    Citation: BMC Psychiatry 2011 11:197

    Content type: Research article

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  38. This observational study explored the prevalence of metabolic syndrome (MetS) in adult in- and outpatients with untreated or treated schizophrenia at baseline, and month-3 after initiation or switch of antipsy...

    Authors: Susanne Kraemer, Anette Minarzyk, Thomas Forst, Daniel Kopf and Hans-Peter Hundemer

    Citation: BMC Psychiatry 2011 11:173

    Content type: Research article

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  39. The Beck Cognitive Insight Scale (BCIS) was designed for the assessment of the cognitive processes involved in self-reflection and the ability to modify erroneous beliefs and misinterpretations. Studies invest...

    Authors: Yu-Chen Kao, Tzong-Shi Wang, Chien-Wen Lu and Yia-Ping Liu

    Citation: BMC Psychiatry 2011 11:170

    Content type: Research article

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  40. Schizophrenia is associated with a two to three fold excess mortality. Both natural and unnatural causes were reported. However, there is dearth of evidence from low and middle income (LAMIC) countries, partic...

    Authors: Solomon Teferra, Teshome Shibre, Abebaw Fekadu, Girmay Medhin, Asfaw Wakwoya, Atalay Alem, Gunnar Kullgren and Lars Jacobsson

    Citation: BMC Psychiatry 2011 11:165

    Content type: Research article

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  41. Low levels of self-esteem have been implicated as both a cause and a consequence of severe mental disorders. The main aims of the study were to examine whether premorbid adjustment has an impact on the subject...

    Authors: Kristin Lie Romm, Jan Ivar Rossberg, Charlotte Fredslund Hansen, Elisabeth Haug, Ole A Andreassen and Ingrid Melle

    Citation: BMC Psychiatry 2011 11:136

    Content type: Research article

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  42. The aim of this study was to determine glutathione levels and antioxidant enzyme activities in the drug-naive first-episode patients with schizophrenia in comparison with healthy control subjects.

    Authors: Monia Raffa, Fatma Atig, Ahmed Mhalla, Abdelhamid Kerkeni and Anwar Mechri

    Citation: BMC Psychiatry 2011 11:124

    Content type: Research article

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