Substance-related disorders, addiction and impulse control

Factors associated with high use of general practitioner and psychiatrist services among patients attending an addiction rehabilitation center

This study aimed to 1) identify the characteristics of individuals with substance use disorders (SUDs) who make high use of services provided by general practitioners (GP) and psychiatrists while receiving ser...

Authors: Christophe Huỳnh, André Ngamini Ngui, Sylvia Kairouz, Alain Lesage and Marie-Josée Fleury

Characteristics of individuals presenting to treatment for primary alcohol problems versus other drug problems in the Australian patient pathways study

People seeking treatment for substance use disorders often have additional health and social issues. Although individuals presenting with alcohol as the primary drug of concern (PDOC) account for nearly half o...

Authors: Dan I. Lubman, Joshua B. B. Garfield, Victoria Manning, Lynda Berends, David Best, Janette M. Mugavin, Tina Lam, Penny Buykx, Andrew Larner, Belinda Lloyd, Robin Room and Steve Allsop

The cost-effectiveness of family/family-based therapy for treatment of externalizing disorders, substance use disorders and delinquency: a systematic review

Family therapy and family-based treatment has been commonly applied in children and adolescents in mental health care and has been proven to be effective. There is an increased interest in economic evaluations...

Authors: Maartje Goorden, Saskia J. Schawo, Clazien A.M. Bouwmans-Frijters, Evelien van der Schee, Vincent M. Hendriks and Leona Hakkaart-van Roijen

The efficacy of behavioural activation treatment for co-occurring depression and substance use disorder (the activate study): a randomized controlled trial

Epidemiological studies suggest that compared with the general population, mood disorders are up to 4.7 times more prevalent in substance dependent samples. Comorbid substance use disorder (SUD) and depression...

Authors: Joanne Ross, Maree Teesson, Carl Lejuez, Katherine Mills, Sharlene Kaye, Kathleen Brady, Glenys Dore, Katrina Prior, Xanthe Larkin, Joanne Cassar, Philippa Ewer, Sonja Memedovic, Ivana Kihas and Sarah Louise Masters

Associations between personality disorder characteristics and treatment outcomes in people with co-occurring alcohol misuse and depression

Personality disorders are highly comorbid with alcohol misuse and depressive symptomatology; however, few studies have investigated treatment outcomes in this population. The aim of this study was to examine r...

Authors: Kristen L. McCarter, Sean A. Halpin, Amanda L. Baker, Frances J. Kay-Lambkin, Terry J. Lewin, Louise K. Thornton, David J. Kavanagh and Brian J. Kelly

Drinking to ease the burden: a cross-sectional study on trauma, alcohol abuse and psychopathology in a post-conflict context

It is likely that alcohol use and abuse increase during and after violent conflicts. The most prominent explanation of this phenomenon has been referred to as self-medication hypothesis. It predicts that psych...

Authors: Verena Ertl, Regina Saile, Frank Neuner and Claudia Catani

Medical students’ health behaviour and self-reported mental health status by their country of origin: a cross-sectional study

Numerous previous studies have investigated the lifestyle and self-perceived health status of medical students. This study examined whether students’ country of origin contributed to their mental health and he...

Authors: András Terebessy, Edit Czeglédi, Bettina Claudia Balla, Ferenc Horváth and Péter Balázs

Benzodiazepine prescription for patients in treatment for drug use disorders: a nationwide cohort study in Denmark, 2000–2010

Benzodiazepines are frequently prescribed to patients with drug use disorders. However, it has previously been difficult to distinguish whether this frequent prescribing was due to underlying psychiatric disor...

Authors: Christian Tjagvad, Thomas Clausen, Marte Handal and Svetlana Skurtveit

Psychometric properties of the 7-item game addiction scale among french and German speaking adults

The 7-item Game Addiction Scale (GAS) is a used to screen for addictive game use. Both cross cross-linguistic validation and validation in French and German is needed in adult samples. The objective of the stu...

Authors: Yasser Khazaal, Anne Chatton, Stephane Rothen, Sophia Achab, Gabriel Thorens, Daniele Zullino and Gerhard Gmel

A randomized controlled study of exposure therapy as aftercare for alcohol use disorder: study protocol

It is well documented that individuals with Alcohol Use Disorder (AUD) respond well during evidence-based psychological treatment, but also that a large proportion relapses when discharged from treatment and c...

Authors: Angelina Isabella Mellentin, Bent Nielsen, Anette Søgaard Nielsen, Fei Yu and Elsebeth Stenager

Web-based cognitive behavioral relapse prevention program with tailored feedback for people with methamphetamine and other drug use problems: protocol for a multicenter randomized controlled trial in Japan

Despite the effectiveness of psychosocial programs for recovery from drug use problems, there have been challenges in implementation of treatment. Internet-based and computerized approaches have been known to ...

Authors: Ayumi Takano, Yuki Miyamoto, Norito Kawakami, Toshihiko Matsumoto, Tomohiro Shinozaki and Takashi Sugimoto

Occipital event-related potentials to addiction-related stimuli in detoxified patients with alcohol dependence, and their association with three-month relapse

Understanding the biological underpinnings of relapse in alcohol dependency is a major issue in addiction research. Based on recent evidence regarding the relevance of occipital visual evoked response potentia...

Authors: Carolin Matheus-Roth, Ingmar Schenk, Jens Wiltfang, Norbert Scherbaum and Bernhard W. Müller

Adult attention deficit hyperactivity disorder symptom profiles and concurrent problems with alcohol and cannabis: sex differences in a representative, population survey

Adult attention deficit hyperactivity disorder (ADHD) shows a robust association with alcohol and cannabis misuse, and these relationships are expressed differently in males and females. Manifestation of speci...

Authors: Nathan J. Kolla, Mark van der Maas, Maggie E. Toplak, Patricia G. Erickson, Robert E. Mann, Jane Seeley and Evelyn Vingilis

Clinical features, course and treatment of methamphetamine-induced psychosis in psychiatric inpatients

Over the past few years, methamphetamine-induced psychosis (MIP) has increased in Iran, accounting for a significant percentage of psychiatry hospital admissions. The present study was conducted with an aim to...

Authors: Homa Zarrabi, Mohammadrasoul Khalkhali, Azam Hamidi, Reza Ahmadi and Maryam Zavarmousavi

Double-blind, 12 month follow-up, placebo-controlled trial of mifepristone on cognition in alcoholics: the MIFCOG trial protocol

Increased levels of cortisol during acute alcohol withdrawal have been linked to cognitive deficits and depression. Preclinical research found that the glucocorticoid Type II receptor antagonist, mifepristone,...

Authors: Kim Donoghue, Abigail Rose, Simon Coulton, Joanna Milward, Kylie Reed, Colin Drummond and Hilary Little

Intravenous melatonin abuse leading to recurrent aortic valve endocarditis: a case report and discussion

Reports of inappropriate medication use are widespread. There is a growing literature detailing abuse of drugs not typically thought to have high abuse liability. Melatonin is considered to be generally safe a...

Authors: Mark B. Warren, Jonathan Stabler and Melissa M. Hagman

Readiness to change is a predictor of reduced substance use involvement: findings from a randomized controlled trial of patients attending South African emergency departments

This study examines whether readiness to change is a predictor of substance use outcomes and explores factors associated with RTC substance use among patients at South African emergency departments.

Authors: Bronwyn Myers, Claire van der Westhuizen, Tracey Naledi, Dan J. Stein and Katherine Sorsdahl

Vorvida: study protocol of a randomized controlled trial testing the effectiveness of Internet-based self-help program for the reduction of alcohol consumption for adults

Problem drinking is an important global health concern, causing premature mortality and morbidity. Only few problem drinkers seek professional care, unfortunately, because of multiple barriers such as insuffic...

Authors: Jördis M. Zill, Björn Meyer, Janine Topp, Anne Daubmann, Martin Härter and Jörg Dirmaier

Is adjunctive pharmacotherapy in attention-deficit/hyperactivity disorder cost-effective in Canada: a cost-effectiveness assessment of guanfacine extended-release as an adjunctive therapy to a long-acting stimulant for the treatment of ADHD

Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in children, with worldwide prevalence of ADHD varying from 5.9 to 7.1 %, depending on the reporter. In case of inadequate respo...

Authors: Jean Lachaine, Vanja Sikirica and Karine Mathurin

A debate on working memory and cognitive control: can we learn about the treatment of substance use disorders from the neural correlates of anorexia nervosa?

Anorexia Nervosa (AN) is a debilitating, sometimes fatal eating disorder (ED) whereby restraint of appetite and emotion is concomitant with an inflexible, attention-to-detail perfectionist cognitive style and ...

Authors: Samantha J. Brooks

PHEDRE trial protocol – observational study of the prevalence of problematic use of Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) and analgesics in the French sickle-cell disease population

The use of analgesics can lead to cases of drug abuse and dependence. It can also cause pseudo-addiction in patients suffering from pain. What is the actual situation in patients suffering from severe sickle-c...

Authors: Marie Gérardin, Marie-Laure Couec, Marie Grall-Bronnec, Fanny Feuillet, Laura Wainstein, Morgane Rousselet, Marie-Lyne Pinot, Fanny Perrouin, Olivier Bonnot, Marie-Hélène Drouineau, Pascale Jolliet and Caroline Victorri-Vigneau

Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study)

The proportion of 60+ years with excessive alcohol intake varies in western countries between 6–16 % among men and 2–7 % among women. Specific events related to aging (e.g. loss of job, physical and mental cap...

Authors: Kjeld Andersen, Michael P. Bogenschutz, Gerhard Bühringer, Silke Behrendt, Randi Bilberg, Barbara Braun, Claus Thorn Ekstrøm, Alyssa Forcehimes, Christine Lizarraga, Theresa B. Moyers and Anette Søgaard Nielsen

Erratum to: Evaluating the efficacy of a web-based self-help intervention with and without chat counseling in reducing the cocaine use of problematic cocaine users: the study protocol of a pragmatic three-arm randomized controlled trial

Authors: Michael P. Schaub, Larissa J. Maier, Andreas Wenger, Lars Stark, Oliver Berg, Thilo Beck, Boris B. Quednow and Severin Haug

Baclofen as relapse prevention in the treatment of Gamma- Hydroxybutyrate (GHB) dependence: an open label study

GHB dependence is a growing health problem in several western countries, especially the Netherlands. Attempts to stop using GHB are often followed by relapse shortly after successful detoxification. Craving fo...

Authors: Rama M Kamal, Arnt Schellekens, Cornelis AJ De Jong and Boukje AG Dijkstra

Comparative analysis of distinct phenotypes in gambling disorder based on gambling preferences

Studies examining gambling preferences have identified the importance of the type of gambling practiced on distinct individual profiles. The objectives were to compare clinical, psychopathological and personal...

Authors: Laura Moragas, Roser Granero, Randy Stinchfield, Fernando Fernández-Aranda, Frida Fröberg, Neus Aymamí, Mónica Gómez-Peña, Ana B Fagundo, Mohammed A Islam, Amparo del Pino-Gutiérrez, Zaida Agüera, Lamprini G Savvidou, Jon Arcelus, Gemma L Witcomb, Sarah Sauchelli, José M Menchón…

A randomized controlled trial of smartphone-based mindfulness training for smoking cessation: a study protocol

Tobacco use is responsible for the death of about 1 in 10 individuals worldwide. Mindfulness training has shown preliminary efficacy as a behavioral treatment for smoking cessation. Recent advances in mobile h...

Authors: Kathleen A Garrison, Prasanta Pal, Rahil Rojiani, Jesse Dallery, Stephanie S O’Malley and Judson A Brewer

Khat use in people living with HIV: a facility-based cross-sectional survey from South West Ethiopia

Khat is an evergreen plant with leaves containing the amphetamine-like compounds cathinone and cathine. Many people in the Horn of Africa use khat on a regular basis. Adverse health and social consequences of ...

Authors: Matiwos Soboka, Markos Tesfaye, Garumma Tolu Feyissa and Charlotte Hanlon

Buprenorphine maintenance program with contracted work/education and low tolerance for non-prescribed drug use: a cohort study of outcome for women and men after seven years

A seven-year follow-up of heroin dependent patients treated in a buprenorphine-maintenance program combining contracted work/education and low tolerance for non-prescribed drug use. Gender-specific differences...

Authors: Leif Öhlin, Mats Fridell and Anna Nyhlén

A multi-site randomized study to compare the effects of Eye Movement Desensitization and Reprocessing (EMDR) added to TAU versus TAU to reduce craving and drinking behavior in alcohol dependent outpatients: study protocol

Addiction constitutes a major public health problem, and despite treatment, relapse rates remain very high. Preliminary findings suggest that Eye Movement Desensitization and Reprocessing (EMDR), an evidence-b...

Authors: Wiebren Markus, Gerdien H de Weert – van Oene, Eni S Becker and Cor AJ DeJong

Natural course of behavioral addictions: a 5-year longitudinal study

Resolving the theoretical controversy on the labeling of an increasing number of excessive behaviors as behavioral addictions may also be facilitated by more empirical data on these behavioral problems. For in...

Authors: Barna Konkolÿ Thege, Erica M Woodin, David C Hodgins and Robert J Williams

How is acceptance of the brain disease model of addiction related to Australians’ attitudes towards addicted individuals and treatments for addiction?

We investigated whether beliefs about addiction being a ‘disease’ or ‘brain disease’, and holding certain beliefs about addiction aetiology, are associated with public views about addicted persons and support ...

Authors: Carla Meurk, Adrian Carter, Brad Partridge, Jayne Lucke and Wayne Hall

Substance use in people at clinical high-risk for psychosis

Some high-risk (HR) mental states for psychosis may lack diagnostic specificity and predictive value. Furthermore, psychotic-like experiences found in young populations may act not only as markers for psychosi...

Authors: Debra A Russo, Jan Stochl, Michelle Painter, Peter B Jones and Jesus Perez

The BDNFp.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

Previous studies have indicated that early life adversity, genetic factors and alcohol dependence are associated with reduced brain volume in adolescents. However, data on the interactive effects of early life...

Authors: Shareefa Dalvie, Dan J Stein, Karestan Koenen, Valerie Cardenas, Natalie L Cuzen, Raj Ramesar, George Fein and Samantha J Brooks

Placement matching of alcohol-dependent patients based on a standardized intake assessment: rationale and design of a randomized controlled trial

Despite considerable research on substance-abuse placement matching, evidence is still inconclusive. The aims of this exploratory trial are to evaluate (a) the effects of following matching guidelines on healt...

Authors: Angela Buchholz, Anke Friedrichs, Michael Berner, Hans-Helmut König, Alexander Konnopka, Ludwig Kraus, Levente Kriston, Heinrich Küfner, Daniela Piontek, Fred Rist and Jeanette Röhrig

Everyday life consequences of substance use in adult patients with a substance use disorder (SUD) and co-occurring attention deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD): a patient’s perspective

Although the prevalence of substance use disorder (SUD) with co-occurring attention deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) is relatively high in adult patients, there is hardly...

Authors: Linda M Kronenberg, Karin Slager-Visscher, Peter JJ Goossens, Wim van den Brink and Theo van Achterberg

Association of symptoms of attention-deficit/hyperactivity disorder with symptoms of excessive exercising in an adult general population sample

An increasing number of studies suggest that physical activity can alleviate symptoms of ADHD in children. In adults there are currently insufficient data available on this subject. Interestingly, ADHD and for...

Authors: Nikolas AA Berger, Astrid Müller, Elmar Brähler, Alexandra Philipsen and Martina de Zwaan

Study protocol: the JEU cohort study – transversal multiaxial evaluation and 5-year follow-up of a cohort of French gamblers

There is abundant literature on how to distinguish problem gambling (PG) from social gambling, but there are very few studies of the long-term evolution of gambling practice. As a consequence, the correlates o...

Authors: Gaëlle Challet-Bouju, Jean-Benoit Hardouin, Jean-Luc Vénisse, Lucia Romo, Marc Valleur, David Magalon, Mélina Fatséas, Isabelle Chéreau-Boudet, Mohamed-Ali Gorsane and Marie Grall-Bronnec

Risk assessment and reward processing in problem gambling investigated by event-related potentials and fMRI-constrained source analysis

The temporo-spatial dynamics of risk assessment and reward processing in problem gamblers with a focus on an ecologically valid design has not been examined previously.

Authors: Stephan F Miedl, Thorsten Fehr, Manfred Herrmann and Gerhard Meyer

Longitudinal cohort study of depression, post-traumatic stress, and alcohol use in South African women who attend alcohol serving venues

In South Africa, alcohol use poses a public health burden. Hazardous alcohol use often co-occurs with psychological distress (e.g., depression and post-traumatic stress). However, the majority of the research ...

Authors: Laurie A Abler, Kathleen J Sikkema, Melissa H Watt, Lisa A Eaton, Karmel W Choi, Seth C Kalichman, Donald Skinner and Desiree Pieterse

The association between internet addiction and psychiatric co-morbidity: a meta-analysis

This study evaluates the association between Internal Addiction (IA) and psychiatric co-morbidity in the literature.

Authors: Roger C Ho, Melvyn WB Zhang, Tammy Y Tsang, Anastasia H Toh, Fang Pan, Yanxia Lu, Cecilia Cheng, Paul S Yip, Lawrence T Lam, Ching-Man Lai, Hiroko Watanabe and Kwok-Kei Mak

Adult attention-deficit/hyperactivity disorder and nicotine use: a qualitative study of patient perceptions

Adult Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with high rates of comorbid substance use disorders, and cigarette smoking has a particularly high prevalence in this population. However, th...

Authors: Michael Liebrenz, Anja Frei, Carl Erik Fisher, Alex Gamma, Anna Buadze and Dominique Eich

Parent-adolescent interaction and risk of adolescent internet addiction: a population-based study in Shanghai

Family-based intervention is essential for adolescents with behavioral problems. However, limited data are available on the relationship between family-based factors and adolescent internet addiction (AIA). We...

Authors: Jian Xu, Li-xiao Shen, Chong-huai Yan, Howard Hu, Fang Yang, Lu Wang, Sudha Rani Kotha, Fengxiu Ouyang, Li-na Zhang, Xiang-peng Liao, Jun Zhang, Jin-song Zhang and Xiao-ming Shen

Neurobehavioral consequences of chronic intrauterine opioid exposure in infants and preschool children: a systematic review and meta-analysis

It is assumed within the accumulated literature that children born of pregnant opioid dependent mothers have impaired neurobehavioral function as a consequence of chronic intrauterine opioid use.

Authors: Alex Baldacchino, Kathleen Arbuckle, Dennis J Petrie and Colin McCowan

Prevalence, sociodemographic factors, psychological distress, and coping strategies related to compulsive buying: a cross sectional study in Galicia, Spain

Compulsive buying has become a serious problem affecting a growing number of people in contemporary consumer societies. Nevertheless, research examining its prevalence in representative samples from the genera...

Authors: José Manuel Otero-López and Estíbaliz Villardefrancos

Perceived need for substance use treatment among young women from disadvantaged communities in Cape Town, South Africa

Initiation of treatment for substance use disorders is low among young women from disadvantaged communities in Cape Town, South Africa. Yet little is known about the factors that influence perceived need for t...

Authors: Bronwyn Myers, Tracy L Kline, Irene A Doherty, Tara Carney and Wendee M Wechsberg

Treatment for illegal drug use disorders: the role of comorbid mood and anxiety disorders

Our aim was to examine whether comorbid mood and anxiety disorders influence patterns of treatment or the perceived unmet need for treatment among those not receiving treatment for illegal drug use disorders.

Authors: Maria Melchior, Elena Prokofyeva, Nadia Younès, Pamela J Surkan and Silvia S Martins

The effectiveness of integrated treatment in patients with substance use disorders co-occurring with anxiety and/or depression - a group randomized trial

Integrated Treatment (IT) has proved effective in treating patients with Substance Use Disorders (SUD) co-occurring with severe Mental Disorders (MD), less is known about the effectiveness of IT for patients w...

Authors: Linda E Wüsthoff, Helge Waal and Rolf W Gråwe

Improving the retention rate for residential treatment of substance abuse by sequential intervention for social anxiety

Residential drug rehabilitation is often seen as a treatment of last resort for people with severe substance abuse issues. These clients present with more severe symptoms, and frequent psychiatric comorbiditie...

Authors: Petra K Staiger, Michael Kyrios, James S Williams, Nicolas Kambouropoulos, Alexandra Howard and Stefan Gruenert

The CLIMATE schools combined study: a cluster randomised controlled trial of a universal Internet-based prevention program for youth substance misuse, depression and anxiety

Anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders and frequently co-occur. While programs for the prevention and reduction of symptoms ...

Authors: Maree Teesson, Nicola C Newton, Tim Slade, Cath Chapman, Steve Allsop, Leanne Hides, Nyanda McBride, Louise Mewton, Zoe Tonks, Louise Birrell, Louise Brownhill and Gavin Andrews

Identifying perceived barriers to monitoring service quality among substance abuse treatment providers in South Africa

A performance measurement system is planned for South African substance abuse treatment services. Provider-level barriers to implementing these systems have been identified in the United States, but little is ...

Authors: Bronwyn Myers, Zainonisa Petersen, Rehana Kader, J Randy Koch, Ron Manderscheid, Rajen Govender and Charles DH Parry