Substance-related disorders, addiction and impulse control

Age of onset of substance use and psychosocial problems among individuals with substance use disorders

Substance use is generally initiated in adolescence or early adulthood and is commonly associated with several physical, psychological, emotional and social problems. The objective of this study is to assess t...

Authors: Anju Poudel and Sital Gautam

Effects of delaying binge drinking on adolescent brain development: a longitudinal neuroimaging study

Onset of alcohol use by 14 relative to 21 years of age strongly predicts elevated risk for severe alcohol use problems, with 27% versus 4% of individuals exhibiting alcohol dependence within 10 years of onset....

Authors: Josiane Bourque, Travis E. Baker, Alain Dagher, Alan C. Evans, Hugh Garavan, Marco Leyton, Jean R. Séguin, Robert Pihl and Patricia J. Conrod

Study protocol: a dose-escalating, phase-2 study of oral lisdexamfetamine in adults with methamphetamine dependence

The treatment of methamphetamine dependence is a continuing global health problem. Agonist type pharmacotherapies have been used successfully to treat opioid and nicotine dependence and are being studied for t...

Authors: Nadine Ezard, Adrian Dunlop, Brendan Clifford, Raimondo Bruno, Andrew Carr, Alexandra Bissaker and Nicholas Lintzeris

Self-control and problematic mobile phone use in Chinese college students: the mediating role of mobile phone use patterns

With the popularity of mobile phones, problematic mobile phone use is getting increasing attention in recent years. Although self-control was found to be a critical predictor of problematic mobile phone use, n...

Authors: Zhaocai Jiang and Xiuxin Zhao

Prevalence and correlates of problematic smartphone use in a large random sample of Chinese undergraduates

Smartphones are becoming a daily necessity for most undergraduates in Mainland China. Because the present scenario of problematic smartphone use (PSU) is largely unexplored, in the current study we aimed to es...

Authors: Jiang Long, Tie-Qiao Liu, Yan-Hui Liao, Chang Qi, Hao-Yu He, Shu-Bao Chen and Joël Billieux

Challenges in detecting and diagnosing substance use in women in the acute psychiatric department: a naturalistic cohort study

This study examines sex differences in substance use and substance use disorder in the acute psychiatric department, and possible interactions between sex and clinical and social factors associated with this p...

Authors: Torill Vassli Sallaup, Arne Einar Vaaler, Valentina Cabral Iversen and Ismail Cuneyt Guzey

Experience of the use of Ketamine to manage opioid withdrawal in an addicted woman: a case report

Opioids are good painkillers, but many patients treated with opioids as painkillers developed a secondary addiction. These patients need to stop misusing opioids, but the mild-to-severe clinical symptoms assoc...

Authors: Laurence Lalanne, Chloe Nicot, Jean-Philippe Lang, Gilles Bertschy and Eric Salvat

Tailoring a brief intervention for illicit drug use and alcohol use in Irish methadone maintained opiate dependent patients: a qualitative process

The World Health Organization (WHO) recommend the tailoring of a brief intervention (BI) programme of research to ensure that it is both culturally and contextually appropriate for the country and the environm...

Authors: Catherine Darker, Brion Sweeney, Eamon Keenan, Lucy Whiston, Rolande Anderson and Joe Barry

Can tobacco dependence provide insights into other drug addictions?

Within the field of addiction research, individuals tend to operate within silos of knowledge focused on specific drug classes. The discovery that tobacco dependence develops in a progression of stages and tha...

Authors: Joseph R. DiFranza

Prevalence and correlates of psychological distress symptoms among patients with substance use disorders in drug rehabilitation centers in urban Nepal: a cross-sectional study

The burden of substance misuse in developing countries is large and increasing, with negative consequences for physical and psychological health. Substance use disorders and psychological distress commonly co-...

Authors: Bishal Gyawali, Bishnu P. Choulagai, Damaru Prasad Paneru, Meraj Ahmad, Anja Leppin and Per Kallestrup

Psychosis associated with acute recreational drug toxicity: a European case series

Psychosis can be associated with acute recreational drug and novel psychoactive substance (NPS) toxicity. However, there is limited data available on how common this is and which drugs are most frequently impl...

Authors: Odd Martin Vallersnes, Alison M. Dines, David M. Wood, Christopher Yates, Fridtjof Heyerdahl, Knut Erik Hovda, Isabelle Giraudon and Paul I. Dargan

Disentangling psychopathology, substance use and dependence: a factor analysis

The notion that substance use can induce symptoms of depression and anxiety is influential in clinical practice, however questions remain about the empirical support for this hypothesis.

Authors: Jaime Delgadillo, Jan R. Böhnke, Elizabeth Hughes and Simon Gilbody

Is employment-focused case management effective for patients with substance use disorders? Results from a controlled multi-site trial in Germany covering a 2-years-period after inpatient rehabilitation

Substance use disorders are associated with unemployment. An employment-focused case management (CMRE) has been conceptualised as a specific intervention to help substance use disorder patients return to compe...

Authors: Susanne Saal, Lukas Forschner, Dietmar Kemmann, Jacqueline Zlatosch and Thomas W. Kallert

Nonmedical use of prescription drugs in the European Union

Nonmedical prescription drug use (NMPDU) refers to the self-treatment of a medical condition using medication without a prescriber’s authorization as well as use to achieve euphoric states. This article report...

Authors: Scott P. Novak, Anders Håkansson, Jose Martinez-Raga, Jens Reimer, Karol Krotki and Sajan Varughese

Association between motor timing and treatment outcomes in patients with alcohol and/or cocaine use disorder in a rehabilitation program

Individuals with Substance Use Disorders (SUDs) have disruptions in the brain’s dopaminergic (DA) system and the functioning of its target neural substrates (striatum and prefrontal cortex). These substrates a...

Authors: S. Y. Young, Y. Delevoye-Turrell, J. J. J. van Hoof, A. E. Goudriaan and S. Seedat

Predictors of time to relapse in amphetamine-type substance users in the matrix treatment program in Iran: a Cox proportional hazard model application

The aim of this study was to determine which predictors influence the risk of relapse among a cohort of amphetamine-type substance (ATS) users in Iran.

Authors: Maryam Moeeni, Emran M. Razaghi, Koen Ponnet, Fatemeh Torabi, Seyed Ali Shafiee and Tahereh Pashaei

Factors associated with high use of general practitioner and psychiatrist services among patients attending an addiction rehabilitation center

This study aimed to 1) identify the characteristics of individuals with substance use disorders (SUDs) who make high use of services provided by general practitioners (GP) and psychiatrists while receiving ser...

Authors: Christophe Huỳnh, André Ngamini Ngui, Sylvia Kairouz, Alain Lesage and Marie-Josée Fleury

Characteristics of individuals presenting to treatment for primary alcohol problems versus other drug problems in the Australian patient pathways study

People seeking treatment for substance use disorders often have additional health and social issues. Although individuals presenting with alcohol as the primary drug of concern (PDOC) account for nearly half o...

Authors: Dan I. Lubman, Joshua B. B. Garfield, Victoria Manning, Lynda Berends, David Best, Janette M. Mugavin, Tina Lam, Penny Buykx, Andrew Larner, Belinda Lloyd, Robin Room and Steve Allsop

The cost-effectiveness of family/family-based therapy for treatment of externalizing disorders, substance use disorders and delinquency: a systematic review

Family therapy and family-based treatment has been commonly applied in children and adolescents in mental health care and has been proven to be effective. There is an increased interest in economic evaluations...

Authors: Maartje Goorden, Saskia J. Schawo, Clazien A.M. Bouwmans-Frijters, Evelien van der Schee, Vincent M. Hendriks and Leona Hakkaart-van Roijen

The efficacy of behavioural activation treatment for co-occurring depression and substance use disorder (the activate study): a randomized controlled trial

Epidemiological studies suggest that compared with the general population, mood disorders are up to 4.7 times more prevalent in substance dependent samples. Comorbid substance use disorder (SUD) and depression...

Authors: Joanne Ross, Maree Teesson, Carl Lejuez, Katherine Mills, Sharlene Kaye, Kathleen Brady, Glenys Dore, Katrina Prior, Xanthe Larkin, Joanne Cassar, Philippa Ewer, Sonja Memedovic, Ivana Kihas and Sarah Louise Masters

Associations between personality disorder characteristics and treatment outcomes in people with co-occurring alcohol misuse and depression

Personality disorders are highly comorbid with alcohol misuse and depressive symptomatology; however, few studies have investigated treatment outcomes in this population. The aim of this study was to examine r...

Authors: Kristen L. McCarter, Sean A. Halpin, Amanda L. Baker, Frances J. Kay-Lambkin, Terry J. Lewin, Louise K. Thornton, David J. Kavanagh and Brian J. Kelly

Drinking to ease the burden: a cross-sectional study on trauma, alcohol abuse and psychopathology in a post-conflict context

It is likely that alcohol use and abuse increase during and after violent conflicts. The most prominent explanation of this phenomenon has been referred to as self-medication hypothesis. It predicts that psych...

Authors: Verena Ertl, Regina Saile, Frank Neuner and Claudia Catani

Medical students’ health behaviour and self-reported mental health status by their country of origin: a cross-sectional study

Numerous previous studies have investigated the lifestyle and self-perceived health status of medical students. This study examined whether students’ country of origin contributed to their mental health and he...

Authors: András Terebessy, Edit Czeglédi, Bettina Claudia Balla, Ferenc Horváth and Péter Balázs

Benzodiazepine prescription for patients in treatment for drug use disorders: a nationwide cohort study in Denmark, 2000–2010

Benzodiazepines are frequently prescribed to patients with drug use disorders. However, it has previously been difficult to distinguish whether this frequent prescribing was due to underlying psychiatric disor...

Authors: Christian Tjagvad, Thomas Clausen, Marte Handal and Svetlana Skurtveit

Psychometric properties of the 7-item game addiction scale among french and German speaking adults

The 7-item Game Addiction Scale (GAS) is a used to screen for addictive game use. Both cross cross-linguistic validation and validation in French and German is needed in adult samples. The objective of the stu...

Authors: Yasser Khazaal, Anne Chatton, Stephane Rothen, Sophia Achab, Gabriel Thorens, Daniele Zullino and Gerhard Gmel

A randomized controlled study of exposure therapy as aftercare for alcohol use disorder: study protocol

It is well documented that individuals with Alcohol Use Disorder (AUD) respond well during evidence-based psychological treatment, but also that a large proportion relapses when discharged from treatment and c...

Authors: Angelina Isabella Mellentin, Bent Nielsen, Anette Søgaard Nielsen, Fei Yu and Elsebeth Stenager

Web-based cognitive behavioral relapse prevention program with tailored feedback for people with methamphetamine and other drug use problems: protocol for a multicenter randomized controlled trial in Japan

Despite the effectiveness of psychosocial programs for recovery from drug use problems, there have been challenges in implementation of treatment. Internet-based and computerized approaches have been known to ...

Authors: Ayumi Takano, Yuki Miyamoto, Norito Kawakami, Toshihiko Matsumoto, Tomohiro Shinozaki and Takashi Sugimoto

Occipital event-related potentials to addiction-related stimuli in detoxified patients with alcohol dependence, and their association with three-month relapse

Understanding the biological underpinnings of relapse in alcohol dependency is a major issue in addiction research. Based on recent evidence regarding the relevance of occipital visual evoked response potentia...

Authors: Carolin Matheus-Roth, Ingmar Schenk, Jens Wiltfang, Norbert Scherbaum and Bernhard W. Müller

Adult attention deficit hyperactivity disorder symptom profiles and concurrent problems with alcohol and cannabis: sex differences in a representative, population survey

Adult attention deficit hyperactivity disorder (ADHD) shows a robust association with alcohol and cannabis misuse, and these relationships are expressed differently in males and females. Manifestation of speci...

Authors: Nathan J. Kolla, Mark van der Maas, Maggie E. Toplak, Patricia G. Erickson, Robert E. Mann, Jane Seeley and Evelyn Vingilis

Clinical features, course and treatment of methamphetamine-induced psychosis in psychiatric inpatients

Over the past few years, methamphetamine-induced psychosis (MIP) has increased in Iran, accounting for a significant percentage of psychiatry hospital admissions. The present study was conducted with an aim to...

Authors: Homa Zarrabi, Mohammadrasoul Khalkhali, Azam Hamidi, Reza Ahmadi and Maryam Zavarmousavi

Double-blind, 12 month follow-up, placebo-controlled trial of mifepristone on cognition in alcoholics: the MIFCOG trial protocol

Increased levels of cortisol during acute alcohol withdrawal have been linked to cognitive deficits and depression. Preclinical research found that the glucocorticoid Type II receptor antagonist, mifepristone,...

Authors: Kim Donoghue, Abigail Rose, Simon Coulton, Joanna Milward, Kylie Reed, Colin Drummond and Hilary Little

Intravenous melatonin abuse leading to recurrent aortic valve endocarditis: a case report and discussion

Reports of inappropriate medication use are widespread. There is a growing literature detailing abuse of drugs not typically thought to have high abuse liability. Melatonin is considered to be generally safe a...

Authors: Mark B. Warren, Jonathan Stabler and Melissa M. Hagman

Readiness to change is a predictor of reduced substance use involvement: findings from a randomized controlled trial of patients attending South African emergency departments

This study examines whether readiness to change is a predictor of substance use outcomes and explores factors associated with RTC substance use among patients at South African emergency departments.

Authors: Bronwyn Myers, Claire van der Westhuizen, Tracey Naledi, Dan J. Stein and Katherine Sorsdahl

Vorvida: study protocol of a randomized controlled trial testing the effectiveness of Internet-based self-help program for the reduction of alcohol consumption for adults

Problem drinking is an important global health concern, causing premature mortality and morbidity. Only few problem drinkers seek professional care, unfortunately, because of multiple barriers such as insuffic...

Authors: Jördis M. Zill, Björn Meyer, Janine Topp, Anne Daubmann, Martin Härter and Jörg Dirmaier

Is adjunctive pharmacotherapy in attention-deficit/hyperactivity disorder cost-effective in Canada: a cost-effectiveness assessment of guanfacine extended-release as an adjunctive therapy to a long-acting stimulant for the treatment of ADHD

Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in children, with worldwide prevalence of ADHD varying from 5.9 to 7.1 %, depending on the reporter. In case of inadequate respo...

Authors: Jean Lachaine, Vanja Sikirica and Karine Mathurin

A debate on working memory and cognitive control: can we learn about the treatment of substance use disorders from the neural correlates of anorexia nervosa?

Anorexia Nervosa (AN) is a debilitating, sometimes fatal eating disorder (ED) whereby restraint of appetite and emotion is concomitant with an inflexible, attention-to-detail perfectionist cognitive style and ...

Authors: Samantha J. Brooks

PHEDRE trial protocol – observational study of the prevalence of problematic use of Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) and analgesics in the French sickle-cell disease population

The use of analgesics can lead to cases of drug abuse and dependence. It can also cause pseudo-addiction in patients suffering from pain. What is the actual situation in patients suffering from severe sickle-c...

Authors: Marie Gérardin, Marie-Laure Couec, Marie Grall-Bronnec, Fanny Feuillet, Laura Wainstein, Morgane Rousselet, Marie-Lyne Pinot, Fanny Perrouin, Olivier Bonnot, Marie-Hélène Drouineau, Pascale Jolliet and Caroline Victorri-Vigneau

Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study)

The proportion of 60+ years with excessive alcohol intake varies in western countries between 6–16 % among men and 2–7 % among women. Specific events related to aging (e.g. loss of job, physical and mental cap...

Authors: Kjeld Andersen, Michael P. Bogenschutz, Gerhard Bühringer, Silke Behrendt, Randi Bilberg, Barbara Braun, Claus Thorn Ekstrøm, Alyssa Forcehimes, Christine Lizarraga, Theresa B. Moyers and Anette Søgaard Nielsen

Erratum to: Evaluating the efficacy of a web-based self-help intervention with and without chat counseling in reducing the cocaine use of problematic cocaine users: the study protocol of a pragmatic three-arm randomized controlled trial

Authors: Michael P. Schaub, Larissa J. Maier, Andreas Wenger, Lars Stark, Oliver Berg, Thilo Beck, Boris B. Quednow and Severin Haug

Baclofen as relapse prevention in the treatment of Gamma- Hydroxybutyrate (GHB) dependence: an open label study

GHB dependence is a growing health problem in several western countries, especially the Netherlands. Attempts to stop using GHB are often followed by relapse shortly after successful detoxification. Craving fo...

Authors: Rama M Kamal, Arnt Schellekens, Cornelis AJ De Jong and Boukje AG Dijkstra

Comparative analysis of distinct phenotypes in gambling disorder based on gambling preferences

Studies examining gambling preferences have identified the importance of the type of gambling practiced on distinct individual profiles. The objectives were to compare clinical, psychopathological and personal...

Authors: Laura Moragas, Roser Granero, Randy Stinchfield, Fernando Fernández-Aranda, Frida Fröberg, Neus Aymamí, Mónica Gómez-Peña, Ana B Fagundo, Mohammed A Islam, Amparo del Pino-Gutiérrez, Zaida Agüera, Lamprini G Savvidou, Jon Arcelus, Gemma L Witcomb, Sarah Sauchelli, José M Menchón…

A randomized controlled trial of smartphone-based mindfulness training for smoking cessation: a study protocol

Tobacco use is responsible for the death of about 1 in 10 individuals worldwide. Mindfulness training has shown preliminary efficacy as a behavioral treatment for smoking cessation. Recent advances in mobile h...

Authors: Kathleen A Garrison, Prasanta Pal, Rahil Rojiani, Jesse Dallery, Stephanie S O’Malley and Judson A Brewer

Khat use in people living with HIV: a facility-based cross-sectional survey from South West Ethiopia

Khat is an evergreen plant with leaves containing the amphetamine-like compounds cathinone and cathine. Many people in the Horn of Africa use khat on a regular basis. Adverse health and social consequences of ...

Authors: Matiwos Soboka, Markos Tesfaye, Garumma Tolu Feyissa and Charlotte Hanlon

Buprenorphine maintenance program with contracted work/education and low tolerance for non-prescribed drug use: a cohort study of outcome for women and men after seven years

A seven-year follow-up of heroin dependent patients treated in a buprenorphine-maintenance program combining contracted work/education and low tolerance for non-prescribed drug use. Gender-specific differences...

Authors: Leif Öhlin, Mats Fridell and Anna Nyhlén

A multi-site randomized study to compare the effects of Eye Movement Desensitization and Reprocessing (EMDR) added to TAU versus TAU to reduce craving and drinking behavior in alcohol dependent outpatients: study protocol

Addiction constitutes a major public health problem, and despite treatment, relapse rates remain very high. Preliminary findings suggest that Eye Movement Desensitization and Reprocessing (EMDR), an evidence-b...

Authors: Wiebren Markus, Gerdien H de Weert – van Oene, Eni S Becker and Cor AJ DeJong

Natural course of behavioral addictions: a 5-year longitudinal study

Resolving the theoretical controversy on the labeling of an increasing number of excessive behaviors as behavioral addictions may also be facilitated by more empirical data on these behavioral problems. For in...

Authors: Barna Konkolÿ Thege, Erica M Woodin, David C Hodgins and Robert J Williams

How is acceptance of the brain disease model of addiction related to Australians’ attitudes towards addicted individuals and treatments for addiction?

We investigated whether beliefs about addiction being a ‘disease’ or ‘brain disease’, and holding certain beliefs about addiction aetiology, are associated with public views about addicted persons and support ...

Authors: Carla Meurk, Adrian Carter, Brad Partridge, Jayne Lucke and Wayne Hall

Substance use in people at clinical high-risk for psychosis

Some high-risk (HR) mental states for psychosis may lack diagnostic specificity and predictive value. Furthermore, psychotic-like experiences found in young populations may act not only as markers for psychosi...

Authors: Debra A Russo, Jan Stochl, Michelle Painter, Peter B Jones and Jesus Perez

The BDNFp.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

Previous studies have indicated that early life adversity, genetic factors and alcohol dependence are associated with reduced brain volume in adolescents. However, data on the interactive effects of early life...

Authors: Shareefa Dalvie, Dan J Stein, Karestan Koenen, Valerie Cardenas, Natalie L Cuzen, Raj Ramesar, George Fein and Samantha J Brooks

Placement matching of alcohol-dependent patients based on a standardized intake assessment: rationale and design of a randomized controlled trial

Despite considerable research on substance-abuse placement matching, evidence is still inconclusive. The aims of this exploratory trial are to evaluate (a) the effects of following matching guidelines on healt...

Authors: Angela Buchholz, Anke Friedrichs, Michael Berner, Hans-Helmut König, Alexander Konnopka, Ludwig Kraus, Levente Kriston, Heinrich Küfner, Daniela Piontek, Fred Rist and Jeanette Röhrig