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  1. Most interventions for depression have shown small or no effects. ‘Third wave‘ cognitive therapy and mentalization-based therapy have both gained some ground as treatments of psychological problems. No randomi...

    Authors: Janus Christian Jakobsen, Christian Gluud, Mickey Kongerslev, Kirsten Aaskov Larsen, Per Sørensen, Per Winkel, Theis Lange, Ulf Søgaard and Erik Simonsen

    Citation: BMC Psychiatry 2012 12:232

    Content type: Study protocol

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  2. From 2006 to 2009, the Dutch government provided €5 m annually for a nationwide program to reduce seclusion in psychiatric hospitals by 10% a year. We aimed to establish whether the numbers of both seclusion a...

    Authors: Fleur J Vruwink, Cornelis L Mulder, Eric O Noorthoorn, Daan Uitenbroek and Henk LI Nijman

    Citation: BMC Psychiatry 2012 12:231

    Content type: Research article

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  3. Studies show the effectiveness of group psychoeducation in reducing symptoms in people with depression. However, few controlled studies that have included aspects of personal care and healthy lifestyle (diet, ...

    Authors: Rocío Casañas, Rosa Catalán, Jose Luis del Val, Jordi Real, Sergi Valero and Miquel Casas

    Citation: BMC Psychiatry 2012 12:230

    Content type: Research article

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  4. Studies in developed countries indicate that psychotic-like symptoms are prevalent in the community and are related to trauma exposure and PTSD. No comparable studies have been undertaken in low-income, post-c...

    Authors: Ian Soosay, Derrick Silove, Catherine Bateman-Steel, Zachary Steel, Paul Bebbington, Peter B Jones, Tien Chey, Lorraine Ivancic and Claire Marnane

    Citation: BMC Psychiatry 2012 12:229

    Content type: Research article

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  5. The Bipolar Comprehensive Outcomes Study (BCOS) is a 2-year, prospective, non-interventional, observational study designed to explore the clinical and functional outcomes associated with ‘real-world’ treatment...

    Authors: Jayashri Kulkarni, Sacha Filia, Lesley Berk, Kate Filia, Seetal Dodd, Anthony de Castella, Alan JM Brnabic, Amanda J Lowry, Katarina Kelin, William Montgomery, Paul B Fitzgerald and Michael Berk

    Citation: BMC Psychiatry 2012 12:228

    Content type: Research article

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  6. Inflammatory Bowel Disease (IBD) patients report poorer quality of life (QoL) and more anxiety and depressive symptoms than controls from the general population. Cognitive behavioral therapy (CBT) is effective...

    Authors: Floor Bennebroek Evertsz’, Claudi LH Bockting, Pieter CF Stokkers, Chris Hinnen, Robbert Sanderman and Mirjam AG Sprangers

    Citation: BMC Psychiatry 2012 12:227

    Content type: Study protocol

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  7. Prior studies have suggested that the darkness of winter impacts the level of mental distress and sleeping problems. Our study investigated whether people living in the sub-arctic had more sleeping problems or...

    Authors: May Trude Johnsen, Rolf Wynn and Trond Bratlid

    Citation: BMC Psychiatry 2012 12:225

    Content type: Research article

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  8. Although persistent negative symptoms (PNS) are known to contribute significantly to poor functional outcome, they remain poorly understood. We examined the heuristic value of various PNS definitions and their...

    Authors: Cindy L Hovington, Michael Bodnar, Ridha Joober, Ashok K Malla and Martin Lepage

    Citation: BMC Psychiatry 2012 12:224

    Content type: Research article

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  9. ADHD is a common childhood onset mental health disorder that persists into adulthood in two-thirds of cases. One of the most prevalent and impairing comorbidities of ADHD in adults are substance use disorders....

    Authors: Zoe Huntley, Stefanos Maltezos, Charlotte Williams, Alun Morinan, Amy Hammon, David Ball, E Jane Marshall, Francis Keaney, Susan Young, Patrik Bolton, Karen Glaser, Raoul Howe-Forbes, Jonna Kuntsi, Kiriakos Xenitidis, Declan Murphy and Philip J Asherson

    Citation: BMC Psychiatry 2012 12:223

    Content type: Research article

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  10. Little is known about the long-term outcomes for patients with schizophrenia who fail to achieve symptomatic remission. This post-hoc analysis of a 3-year study compared the costs of mental health services and...

    Authors: Virginia S Haynes, Baojin Zhu, Virginia L Stauffer, Bruce J Kinon, Michael D Stensland, Lei Xu and Haya Ascher-Svanum

    Citation: BMC Psychiatry 2012 12:222

    Content type: Research article

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  11. Use of amphetamine and methamphetamine is widespread in the general population and common among patients with psychiatric disorders. Amphetamines may induce symptoms of psychosis very similar to those of acute...

    Authors: Jørgen G Bramness, Øystein Hoel Gundersen, Joar Guterstam, Eline Borger Rognli, Maija Konstenius, Else-Marie Løberg, Sigrid Medhus, Lars Tanum and Johan Franck

    Citation: BMC Psychiatry 2012 12:221

    Content type: Debate

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  12. Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of th...

    Authors: Maciej Jakub Lazarczyk, Zahir A Bhuiyan, Nicolas Perrin and Panteleimon Giannakopoulos

    Citation: BMC Psychiatry 2012 12:220

    Content type: Case report

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  13. ADHD guidelines in the UK suggest that children and adults who respond to pharmacological treatment should continue for as long as remains clinically effective, subject to regular review. To what extent patien...

    Authors: Suzanne McCarthy, Lynda Wilton, Macey L Murray, Paul Hodgkins, Philip Asherson and Ian CK Wong

    Citation: BMC Psychiatry 2012 12:219

    Content type: Research article

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  14. With many atypical antipsychotics now available in the market, it has become a common clinical practice to switch between atypical agents as a means of achieving the best clinical outcomes. This study aimed to...

    Authors: Jihyung Hong, Diego Novick, Roberto Brugnoli, Jamie Karagianis, Martin Dossenbach and Josep Maria Haro

    Citation: BMC Psychiatry 2012 12:218

    Content type: Research article

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  15. Experimental animal studies and one population-based study have suggested an increased risk for adverse neurodevelopmental outcome after prenatal exposure to SSRIs. We describe the methods and design of a popu...

    Authors: Heli Malm, Miia Artama, Alan S Brown, Mika Gissler, David Gyllenberg, Susanna Hinkka-Yli-Salomäki, Ian McKeague and Andre Sourander

    Citation: BMC Psychiatry 2012 12:217

    Content type: Study protocol

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  16. Numerous medications have been tested on patients with pervasive developmental disorder not otherwise specified (PDD-NOS) and Asperger’s disorder. Although many of these medications have been demonstrated to b...

    Authors: Tsuyoshi Miyaoka, Rei Wake, Motohide Furuya, Kristian Liaury, Masa Ieda, Kazunori Kawakami, Keiko Tsuchie, Takuji Inagaki and Jun Horiguchi

    Citation: BMC Psychiatry 2012 12:215

    Content type: Research article

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  17. “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics d...

    Authors: Julie Langan, Daniel Martin, Polash Shajahan and Daniel J Smith

    Citation: BMC Psychiatry 2012 12:214

    Content type: Database

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  18. Synchronous neural oscillatory activity in the gamma range (30–80 Hz) has been shown to be abnormal in individuals with autism spectrum disorders (ASD) and their first-degree relatives in response to simple au...

    Authors: Kristina L McFadden, Susan Hepburn, Erin Winterrowd, Gwenda L Schmidt and Donald C Rojas

    Citation: BMC Psychiatry 2012 12:213

    Content type: Research article

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  19. Children with attention-deficit/hyperactivity disorder (ADHD) are two to three times more likely to experience sleep problems. The purpose of this study is to determine the relative contributions of circadian ...

    Authors: Reut Gruber, Laura Fontil, Lana Bergmame, Sabrina T Wiebe, Rhonda Amsel, Sonia Frenette and Julie Carrier

    Citation: BMC Psychiatry 2012 12:212

    Content type: Research article

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  20. Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops after exposure to a life-threatening traumatic experience. Meta-analyses of the brainstem showed that midsagittal area of the pons was...

    Authors: Dongjuan Liu, Bing Xiao, Fang Han, Enhua Wang and Yuxiu Shi

    Citation: BMC Psychiatry 2012 12:211

    Content type: Research article

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  21. Polydipsia frequently occurs in schizophrenia patients. The excessive water loading in polydipsia occasionally induces a hyponatremic state and leads to water intoxication. Whether polydipsia in schizophrenic ...

    Authors: Tomohisa Nagashima, Makoto Inoue, Soichiro Kitamura, Kuniaki Kiuchi, Jun Kosaka, Koji Okada, Naoko Kishimoto, Toshiaki Taoka, Kimihiko Kichikawa and Toshifumi Kishimoto

    Citation: BMC Psychiatry 2012 12:210

    Content type: Research article

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  22. Treatment disengagement and non-completion poses a major problem for the successful treatment of patients with severe mental illness. Motivation for treatment has long been proposed as a major determinant of t...

    Authors: Eline C Jochems, Cornelis L Mulder, Arno van Dam, Hugo J Duivenvoorden, Sylvia CM Scheffer, Willem van der Spek and Christina M van der Feltz-Cornelis

    Citation: BMC Psychiatry 2012 12:209

    Content type: Study protocol

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  23. The everyday practical capabilities of dementia patients have a direct influence on a patient’s independence and thus on the person’s quality of life and on the amount of care needed. These capabilities are th...

    Authors: Katharina Luttenberger, Anke Schmiedeberg and Elmar Gräßel

    Citation: BMC Psychiatry 2012 12:208

    Content type: Research article

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  24. With an ageing population in most Western countries, people are living longer but often with one or more chronic physical health problems. Older people in physically poor health are at greater risk of developi...

    Authors: Louise Sharpe, Catherine B Gittins, Helen M Correia, Tanya Meade, Michael K Nicholas, Patrick J Raue, Sarah McDonald and Patricia A Areán

    Citation: BMC Psychiatry 2012 12:207

    Content type: Study protocol

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  25. Anxiety disorders are highly prevalent in primary care and cause a substantial burden of disease. Screening on risk status, followed by preventive interventions in those at risk may prevent the onset of anxiet...

    Authors: Neeltje M Batelaan, Jan H Smit, Pim Cuijpers, Harm WJ van Marwijk, Berend Terluin and Anton JLM van Balkom

    Citation: BMC Psychiatry 2012 12:206

    Content type: Research article

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  26. Patients with schizophrenia and their families have suffered greatly from stigmatizing effects. Although many efforts have been made to eradicate both prejudice and stigma, they still prevail even among medica...

    Authors: Ataru Omori, Amane Tateno, Takashi Ideno, Hidehiko Takahashi, Yoshitaka Kawashima, Kazuhisa Takemura and Yoshiro Okubo

    Citation: BMC Psychiatry 2012 12:205

    Content type: Research article

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  27. There is increasing evidence for the effectiveness of structured psychological therapies for bipolar disorder. To date however there have been no psychological interventions specifically designed for individua...

    Authors: Steven Jones, Lee D Mulligan, Heather Law, Graham Dunn, Mary Welford, Gina Smith and Anthony P Morrison

    Citation: BMC Psychiatry 2012 12:204

    Content type: Study protocol

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  28. The Brief Symptom Inventory (BSI), Mood & Anxiety Symptom Questionnaire −30 (MASQ-D30), Short Form Health Survey 36 (SF-36), and Dimensional Assessment of Personality Pathology-Short Form (DAPP-SF) are generic...

    Authors: Yvonne WM Schulte-van Maaren, Ingrid VE Carlier, Frans G Zitman, Albert M van Hemert, Margot WM de Waal, Martijn S van Noorden and Erik J Giltay

    Citation: BMC Psychiatry 2012 12:203

    Content type: Research article

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  29. Depression is a highly prevalent and disabling mental disorder with an incidence rate which appears to be increasing in the developed world. This fact seems to be at least partially related to lifestyle factor...

    Authors: Mauro Garcia-Toro, Miquel Roca, Saray Monzón, Margalida Vives, Bárbara Oliván, Enric Vicens, Joan Salva and Margalida Gili

    Citation: BMC Psychiatry 2012 12:201

    Content type: Study protocol

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  30. Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP), and to assess its relationsh...

    Authors: Ana Gonzalez-Pinto, Monica Martinez-Cengotitabengoa, Celso Arango, Immaculada Baeza, Soraya Otero-Cuesta, Montserrat Graell-Berna, César Soutullo, Juan Carlos Leza and Juan Antonio Micó

    Citation: BMC Psychiatry 2012 12:200

    Content type: Research article

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  31. Antipsychotic drugs are considered a trigger factor for autonomic dysregulation, which has been shown to predict potentially fatal arrhythmias in schizophrenia. However, the dose-dependent effect of antipsycho...

    Authors: Yohko Iwamoto, Chiaki Kawanishi, Ikuko Kishida, Taku Furuno, Mami Fujibayashi, Chie Ishii, Norio Ishii, Toshio Moritani, Masataka Taguri and Yoshio Hirayasu

    Citation: BMC Psychiatry 2012 12:199

    Content type: Research article

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  32. Depression is predicted to become one of the two most burdensome diseases worldwide by 2020 and is common in people with chronic physical conditions. However, depression is relatively uncommon in Asia. Family ...

    Authors: Hairong Nan, Paul H Lee, Ian McDowell, Michael Y Ni, Sunita M Stewart and Tai Hing Lam

    Citation: BMC Psychiatry 2012 12:198

    Content type: Research article

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  33. The situation for older persons with mental disorders other than dementia disorders has scarcely been studied. The older population is increasing worldwide and along with this increase the prevalence of mental...

    Authors: Gunilla Martinsson, Ingegerd Fagerberg, Lena Wiklund-Gustin and Christina Lindholm

    Citation: BMC Psychiatry 2012 12:197

    Content type: Research article

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  34. The increasing burden on mental health services has led to the growing use of peer support in psychological interventions. Four theoretical mechanisms have been proposed to underpin effective peer support: adv...

    Authors: Judith G Proudfoot, Amisha Jayawant, Alexis E Whitton, Gordon Parker, Vijaya Manicavasagar, Meg Smith and Jennifer Nicholas

    Citation: BMC Psychiatry 2012 12:196

    Content type: Research article

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  35. Symptoms such as medically unexplained vaginal discharge (MUVD) are common and bothersome, leading to potentially unnecessary use of resources.

    Authors: Loulou Kobeissi, Ziyad Mahfoud, Brigitte Khoury, Fayssal El Kak, Zeina Ghantous, Marwan Khawaja, Rima Nakkash, Sami Ramia, Huda Zurayk, Ricardo Araya and Tim J Peters

    Citation: BMC Psychiatry 2012 12:195

    Content type: Research article

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  36. Methylphenidate (MPH), a psycho-stimulant, is the most widely administered drug for the pharmacological management of patients with attention deficit hyperactivity disorder (ADHD). This study attempts to deter...

    Authors: Yu-Shu Huang, Liang-Jen Wang and Chih-Ken Chen

    Citation: BMC Psychiatry 2012 12:194

    Content type: Research article

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  37. Schizophrenia is a significantly disabling disease that affects all major areas of life. There is a lack of comprehensive synthesis of research findings on the full extent of psychosocial difficulties (PSDs) e...

    Authors: Piotr Świtaj, Marta Anczewska, Anna Chrostek, Carla Sabariego, Alarcos Cieza, Jerome Bickenbach and Somnath Chatterji

    Citation: BMC Psychiatry 2012 12:193

    Content type: Research article

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  38. Treatment guidelines for major depressive disorder (MDD) are based on results from randomized clinical trials, among others in psychotherapy efficacy trials. However, patients in these trials differ from routi...

    Authors: Rosalind van der Lem, Wouter WH de Wever, Nic JA van der Wee, Tineke van Veen, Pim Cuijpers and Frans G Zitman

    Citation: BMC Psychiatry 2012 12:192

    Content type: Research article

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  39. Suicide is the leading cause of death among Japanese adolescents, and they may commit suicide differently from adults. However, there are few studies in medical-based data concerning adolescent patients seriou...

    Authors: Yoshitaka Kawashima, Takao Ito, Ryuichiro Narishige, Takuya Saito and Yoshiro Okubo

    Citation: BMC Psychiatry 2012 12:191

    Content type: Research article

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  40. Symptoms of hyperactivity are believed to fade with age leaving ADHD adults mostly inattentive and impulsive. Our aim was to test this assertion using objective measures of hyperactivity, impulsivity and inatt...

    Authors: Martin H Teicher, Ann Polcari, Nikolaos Fourligas, Gordana Vitaliano and Carryl P Navalta

    Citation: BMC Psychiatry 2012 12:190

    Content type: Research article

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  41. Depression is one of the most common mental disorders with a high prevalence among the older adults. In recent years, after realizing some side effects of the antidepressants, non-pharmacological psychological...

    Authors: Ting-ji Chen, Hui-jie Li and Juan Li

    Citation: BMC Psychiatry 2012 12:189

    Content type: Study protocol

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  42. Parental history of mood or anxiety disorders is one of the strongest and most consistent risk factors for the development of these disorders in offspring. Gaps remain however in our knowledge of whether mater...

    Authors: Nancy CP Low, Erika Dugas, Evelyn Constantin, Igor Karp, Daniel Rodriguez and Jennifer O’Loughlin

    Citation: BMC Psychiatry 2012 12:188

    Content type: Research article

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  43. Given the high prevalence of depression in primary health care (PHC), the use of screening instruments has been recommended. Both brief and long depression screening instruments have been validated in low and ...

    Authors: Dickens Akena, John Joska, Ekwaro A Obuku, Taryn Amos, Seggane Musisi and Dan J Stein

    Citation: BMC Psychiatry 2012 12:187

    Content type: Research article

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  44. Suicidal patients admitted to a psychiatric hospital are considered to be at risk of suicidal behavior (SB) and suicide. The present study aimed to seek predictors of SB recurrence of the high-risk patients by...

    Authors: Naoki Hayashi, Miyabi Igarashi, Atsushi Imai, Yuka Yoshizawa, Kaori Utsumi, Yoichi Ishikawa, Taro Tokunaga, Kayo Ishimoto, Hirohiko Harima, Yoshitaka Tatebayashi, Naoki Kumagai, Makoto Nozu, Hidetoki Ishii and Yuji Okazaki

    Citation: BMC Psychiatry 2012 12:186

    Content type: Research article

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  45. Cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) is the first-line treatment for patients with obsessive-compulsive disorder (OCD). However, not all of them achieve remission on a...

    Authors: Elisabeth Hertenstein, Nina Rose, Ulrich Voderholzer, Thomas Heidenreich, Christoph Nissen, Nicola Thiel, Nirmal Herbst and Anne Katrin Külz

    Citation: BMC Psychiatry 2012 12:185

    Content type: Research article

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  46. Subthreshold depressive disorders (minor and subthrehold depression) have been defined in a wide range of forms, varying on the number of symptoms and duration required. Disability associated with these condit...

    Authors: Mar Rivas Rodríguez, Roberto Nuevo, Somnath Chatterji and José Luis Ayuso-Mateos

    Citation: BMC Psychiatry 2012 12:181

    Content type: Research article

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