Figure 1From: Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate The vigilance regulation model of mania: Unstable vigilance induces a pathogenic circle with vigilance stabilisation syndrome leading to full-blown mania. Figure taken from: Hegerl U., et al. Are psychostimulants a treatment option in mania? Pharmacopsychiatry 2009; 42:169-174. Reproduced with kind permission of Georg Thieme Verlag KG”.Back to article page