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Table 30 Recommendations for pharmacotherapy for core symptoms of PTSD

From: Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders

First-line

Fluoxetine, paroxetine, sertraline, venlafaxine XR

Second-line

Fluvoxamine, mirtazapine, phenelzine

Third-line

Amitriptyline, aripiprazole, bupropion SR, buspirone, carbamazepine, desipramine, duloxetine, escitalopram, imipramine, lamotrigine, memantine, moclobemide, quetiapine, reboxetine, risperidone, tianeptine, topiramate, trazodone

Adjunctive therapy

Second-line: eszopiclone, olanzapine, risperidone

Third-line: aripiprazole, clonidine, gabapentin, levetiracetam, pregabalin, quetiapine, reboxetine, tiagabine

Not recommended: bupropion SR, guanfacine, topiramate, zolpidem

Not recommended

Alprazolam, citalopram, clonazepam, desipramine, divalproex, olanzapine, tiagabine

  1. SR = sustained release; XR = extended release.
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BMC Psychiatry

ISSN: 1471-244X

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