Table 33 Strength of evidence of treatments for anxiety and related disorders in children and adolescents

OCD

Fluoxetine (Level 1) [1264–1269]

Antipsychotics

Clomipramine (Level 1) [1274–1276]

Adjunctive aripiprazole (Level 3) 1293

Citalopram (Level 2) [1264, 1270]

Other

Fluvoxamine (Level 2) 1271

Riluzole (Level 4) 1294

Paroxetine (Level 2) 1272

Sertraline (Level 2) 1273

Panic disorder

Anxiolytics

Clonazepam (Level 4) [1287, 1288]

Alprazolam (Level 4) 1289

SAD

Fluoxetine (Level 1) [1227, 1277]

Anxiolytics

Fluvoxamine (Level 2) 1278

Alprazolam (Level 2, -ve) 1290

Paroxetine (Level 2) 1279

Venlafaxine XR (Level 2) 1282

Escitalopram (Level 3) 1280

Sertraline (Level 3) 1281

Mirtazapine (Level 3) 1283

Separation anxiety disorder

Fluoxetine (Level 2) 1277

Anxiolytics

Fluvoxamine (Level 2) 1278

Clonazepam (Level 2, -ve) 1292

GAD

Fluoxetine (Level 2) 1277

Anxiolytics

Fluvoxamine (Level 2) 1278

Alprazolam (Level 2, -ve) 1290

Sertraline (Level 2) 1284

School-refusal

Citalopram (Level 4) 1285

Anxiolytics

Adjunctive imipramine (Level 2) 1259

Alprazolam (Level 2, -ve) 1291

PTSD

Sertraline (Level 2, -ve) 1286

Adjunctive sertraline (Level 2, -ve) [946]