Figure 2

Oct-6 Immunoreactivity in the Cerebral Cortex. Oct-6 immunoreactivity in the cerebral cortex of a schizophrenic patient. Staining was observed in a layer-specific pattern restricted to layers II/III and V (B) seen at higher magnification in (A) & (C). Oct-6-positive cells had the morphological characteristics of pyramidal neurones. In general, POU3F1 immunoreactivity was dispersed throughout the cell (asterisks in A), though some did have the cytoplasmic/perinuclear localization noted in the hippocampus (arrowheads in A). Immunoreactivity was also observed in the apical dendrites (arrows). Cells in layer V (C) appeared considerably smaller than those in layer II/III (A). A similar cortical expression was observed in all groups. Scale bars: (B) = 200 μm (A & C) = 50 μm