Figure 1

Genomic Organization of RORB with Association Results. The genomic location and organization of RORB are shown, with exons represented by vertical purple bars. All 43 analyzed RORB SNPs are shown and their positions are indicated. The four SNPs with significant associations to bipolar disorder in the case-control sample are highlighted in red. The haplotype block structure in the case-control sample as defined by the Confidence Intervals algorithm [38] in Haploview [34] is illustrated, with the linkage disequilibrium (LD) structure shown below. The two haplotype blocks with two-tailed permutation-based P-values < 0.001 are highlighted in red, and the block with P < 0.01 is highlighted in orange. Image created using LocusView http://www.broad.mit.edu/mpg/locusview/[51].