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Table 3 Affected areas and sides of studies included in the meta-analysis

From: Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder

Citation

Area

Effect

Aybek, et al. [52]

Midbrain including periaqueductal grey area (bi), premotor and supplementary areas (bi), dorsolateral prefrontal cortex (l), cingulate cortex (l) superior frontal gyrus (l)

increased BOLD response

Aybek, et al. [47]

Supplementary motor area (r), postcentral gyrus BA1 (r), postcentral gyrus BA4/3b (r), superior temporal gyrus (r), angular gyrus at temporoparietal junction (r), supramarginal gyrus at temporoparietal junction (r)

increased BOLD response

lingual gyrus (l), parahippocampal gyrus (l), hippocampus (l)

decreased BOLD response

Czarnecki, et al. [60]

cerebellar hemispheres (bi), superior orbital gyrus (l), inferior frontal gyrus (l), insula (l), precentral and postcentral gyri (l), supplementary motor area (r), cerebellar hemisphere and vermis (ipsi), supplementary motor area (r)

increased rCBF

medial prefrontal cortex (bi), anterior cingulate cortex (l), cerebellum (l), lingual gyrus (l)

reduced rCBF

de Lange, et al. [16]

dorsal intraparietal sulcus (r), dorsal precentral sulcus (bi), posterior end of the Sylvian fissure

increased BOLD response to task complexity

superior temporal cortex (l), parietal operculum, prefrontal cortex, superior temporal cortex (r), posterior end of the Sylvian fissure

increased BOLD response for the affected hand

de Lange, et al. [64]

dorsal parietal and premotor cortex

increased BOLD response to task complexity

frontal cortex, gyrus rectus, superior temporal cortex

increased BOLD response for the affected hand

Elzinga, et al. [46]

anterior prefrontal cortex (l), dorsolateral prefrontal cortex (l), parietal lobe (l)

increased BOLD response

Spence, et al. [20]

dorsolateral prefrontal cortex

reduced rCBF

Stone, et al. [74]

basal ganglia, insula, lingual gyri, interior frontal cortex, right middle frontal gyrus (r), orbitofrontal cortex

increased BOLD response

van Beilen, et al. [50]

cingulate cortex (l), vental premotor cortex (ipsi), supramarginal cortex (ipsi), superior temporal cortex (contra + ipsi), anterior cingulate cortex (contra + ipsi), triangular cortex inferior frontal (contra)

increased BOLD response

supramarginal gyrus (r), dlPFC (r), frontal pole (ipsi), ventral lateral prefrontal (ipsi), precuneus (contra), cerebellum (ipsi)

decreased BOLD response

Voon, et al. [43]

anterior cingulate gyrus (l), primary motor cortex (l), somatosensory cortex (l), secondary visual cortex (r), ventral premotor cortex (ipsi), supramarginal cortex (bi), anterior cingulate cortex (contra), triangular cortex (contra)

increased BOLD response

primary motor cortex (r), somatosensory cortex (r), dorsolateral prefrontal cortex (r), medial frontal pole (r), insular cortex (l), cerebellum (l), frontal pole (ipsi), ventral lateral prefrontal (ipsi), precuneus (contra), cerebellum (ipsi), supplementary motor cortex (contra), frontal pole (contra), ventrolateral prefrontal cortex (ipsi), orbitofrontal cortex (ipsi), supramarginal cortex (contra), precuneus (contra), superior parietal cortex (contra), frontal eye fields (contra)

decreased BOLD response

Voon, et al. [27]

amygdala

increased BOLD response

amygdala to supplementary motor area

more connectivitya

Vuilleumier, et al. [22]

Thalamus, caudate, putamen

decreased rCBF before treatment

  1. l left, r right, bi both sides, dlPFC dorsolateral prefrontal cortex, rCBF relative cerebral blood flow, BOLD blood oxygen level dependent. aconnectivity was measured as interregional correlation between conversion tremor and voluntary tremor within the same patients