Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network

Guloksuz, Sinan; van Nierop, Martine; Bak, Maarten; de Graaf, Ron; ten Have, Margreet; van Dorsselaer, Saskia; Gunther, Nicole; Lieb, Roselind; van Winkel, Ruud; Wittchen, Hans-Ulrich; van Os, Jim

doi:10.1186/s12888-016-0935-1

BMC Psychiatry

Table 3 The association between symptom dimensions as a function of exposure to environmental risk factors in the EDSP sample

From: Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network

Dependent	Independent	B (dimension)	B (environment)	B (interaction)
Depression	Anxiety	0.79^***	NS	0.03^**
	Psychosis	0.94^***	NS	0.03^**
	OCD	0.7^***	−0.05^***	0.05^***
	Somatization	0.62^***	NS	0.03^*
	Phobia	0.93^***	NS	NS
	Hostility	0.55^***	NS	0.03^***
	Sensitivity	0.63^***	−0.05^***	0.05^***
Psychosis	Anxiety	0.62^***	NS	NS
	Depression	0.58^***	NS	NS
	OCD	0.52^***	NS	0.01^*
	Somatization	0.47^***	NS	NS
	Phobia	0.71^***	NS	NS
	Hostility	0.43^***	−0.02^*	0.02^**
	Sensitivity	0.52^***	−0.03^***	0.03^***
Anxiety	Depression	0.51^***	−0.04^***	0.02^**
	Psychosis	0.67^***	−0.03^**	0.02^*
	OCD	0.49^***	−0.05^***	0.03^***
	Somatization	0.59^***	NS	NS
	Phobia	0.73^***	−0.06^***	0.04^***
	Hostility	0.39^***	−0.04^***	0.03^***
	Sensitivity	0.41^***	−0.04^***	0.03^***
OCD	Anxiety	0.78^***	NS	NS
	Psychosis	0.88^***	NS	NS
	Depression	0.73^***	NS	NS
	Somatization	0.57^***	NS	NS
	Phobia	0.94^***	NS	NS
	Hostility	0.49^***	NS	0.02^*
	Sensitivity	0.54^***	−0.04^***	0.04^***
Somatization	Anxiety	0.51^***	NS	NS
	Psychosis	0.44^***	NS	NS
	OCD	0.32^***	−0.04^**	0.03^**
	Depression	0.35^***	NS	NS
	Phobia	0.47^***	NS	NS
	Hostility	0.28^***	NS	NS
	Sensitivity	0.26^***	NS	0.02^*
Phobia	Anxiety	0.48^***	−0.04^***	0.04^**
	Psychosis	0.51^***	NS	0.02^*
	OCD	0.40^***	−0.05^***	0.04^***
	Somatization	0.35^***	−0.04^**	0.03^***
	Depression	0.41^***	−0.02^**	0.02^**
	Hostility	0.29^***	NS	0.02^**
	Sensitivity	0.32^***	−0.04^***	0.04^***
Hostility	Anxiety	0.74^***	NS	NS
	Psychosis	0.89^***	NS	NS
	OCD	0.59^***	−0.04^*	0.02^*
	Somatization	0.61^***	NS	NS
	Phobia	0.81^***	NS	NS
	Depression	0.69^***	NS	NS
	Sensitivity	0.58^***	−0.03^*	0.02^*
Sensitivity	Anxiety	0.86^***	0.05^**	−0.04^***
	Psychosis	1.19^***	0.05^***	−0.05^***
	OCD	0.73^***	NS	NS
	Somatization	0.62^***	NS	NS
	Phobia	0.99^***	NS	NS
	Hostility	0.64^***	NS	NS
	Depression	0.88^***	0.04^***	−0.05^***

Dependent variables for each analysis were reported on the far left column, and next to those were independent variables. For each analysis examining connectivity between symptom dimensions as a function of exposure to environmental risk factors, unstandardized regression coefficients (B) for symptom dimension, environmental exposure, and interaction between environmental exposure and symptom dimension were provided, respectively. For example, the first row shows coefficients from the analysis investigating to what degree the exposure to environment moderated the impact of anxiety predicting depression
NS : non-significant, ^*** p < 0.001, ^** p < 0.01, ^* p < 0.05

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