Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network

BMC Psychiatry

Table 4 The association between symptom dimensions as a function of exposure to environmental risk factors in the NEMESIS-1 sample

Dependent	Independent	RD (dimension)	RD (environment)	RD (interaction)
Psychosis	Depression	0.04^***	0.01^***	0.04^***
	Anxiety	0.03^***	0.01^***	0.05^***
	Mania	0.12^***	0.01^***	0.07^**
	Dysthymia	0.05^**	0.02^***	0.04^**
Depression	Psychosis	0.23^***	0.05^***	NS
	Anxiety	0.21^***	0.04^***	0.05^***
	Mania	0.35^***	0.05^***	NS
	Dysthymia	0.55^***	0.05^***	NS
Anxiety	Psychosis	0.29^***	0.05^***	0.05^*
	Depression	0.29^***	0.04^***	NS
	Mania	0.41^***	0.05^***	NS
	Dysthymia	0.37^***	0.05^***	NS
Mania	Psychosis	0.12^***	0.02^***	0.08^***
	Anxiety	0.04^***	0.01^***	0.06^***
	Depression	0.05^***	0.01^***	0.03^***
	Dysthymia	0.06^***	0.02^***	NS
Dysthymia	Psychosis	0.10^***	0.02^***	NS
	Anxiety	0.10^***	0.01^***	0.03^***
	Mania	0.15^***	0.02^***	NS
	Depression	0.20^***	0.01^***	0.02^*

Dependent variables for each analysis were reported on the far left column, and next to those were independent variables. For each analysis examining connectivity between symptom dimensions as a function of exposure to environmental risk factors, risk differences (RD) for symptom dimension, environmental exposure, and interaction between environmental exposure and symptom dimension were provided, respectively. For example, the first row shows risk differences from the analysis investigating to what degree the exposure to environment moderated the impact of depression predicting psychosis
NS: non-significant, ^*** p < 0.001, ^** p < 0.01, ^* p < 0.05

ISSN: 1471-244X