Number of medication trials | Studies | Comparator | Outcomes/effect; study duration |
---|---|---|---|
≥2 medication trials | Fregni F, et al. (2006) [24] |  | Higher response rate to rTMS therapy in patients who had a lower number of refractory treatment trials. |
≤1 medication trial | Huang M-L, et al. (2012) [26]; | rTMS plus med vs. sham plus med | Significantly higher number of improvers at 4 weeks with rTMS plus med. |
Wang H-N, et al. (2017) [27]; | rTMS plus med vs. med | Significantly higher number in response and remission at 12 months with rTMS plus med. | |
Wang Y-M, et al. (2017) [28]; | rTMS plus med vs. sham plus med | Response and remission significantly higher in the rTMS + med | |
Yang H, et al. (2017) [29] | rTMS plus med vs. sham plus med | Response and remission significantly higher in the rTMS + med | |
≥2 medication trials vs. ≤1 medication trial | Brakemeier E-L, et al. (2007) [30]; | Use of rTMS with Low (1 trial) vs. high (≥2 trials) medication treatment resistance | Likelihood of response was higher in low treatment resistant patients |
O’Reardon JP, et al. (2009) [25]; | Use of rTMS with Low (1 trial) vs. high (≥2 trials) medication treatment resistance | Likelihood of response was 4X higher and statistically significantly different in low treatment resistant patients | |
Brakemeier E-L, et al. (2008) [31]; | Use of rTMS with Low (1 trial) vs. high (≥2 trials) medication treatment resistance | Use of rTMS in low treatment resistant patients had a statistically significant effect on improved outcomes | |
Cohen RB, et al. (2010) [32]; | Use of rTMS with Low (1 trial) vs. high (≥2 trials) medication treatment resistance | Use of rTMS in low treatment resistant patients had a statistically significant effect on improved outcomes | |
Carpenter LL, et al. (2012); [33] | Use of rTMS with Low (≤1 trial) vs. high (≥2 trials) medication treatment resistance | Use of rTMS in low treatment resistant patients had a modest effect on improving outcomes. |