Atypical brain structural connectivity and social cognition in childhood maltreatment and peer victimisation

Lim, Lena; Talozzi, Lia; Howells, Henrietta

doi:10.1186/s12888-024-05759-3

BMC Psychiatry

Table 3 Group differences in tract volume and fractional anisotropy of the Uncinate Fasciculus (UF), Anterior Thalamic Radiation (ATR) Inferior Longitudinal Fasciculus (ILF) and Inferior Fronto-Occipital Fasciculus (IFOF) tracts

From: Atypical brain structural connectivity and social cognition in childhood maltreatment and peer victimisation

Tract Measurement	Childhood Maltreatment group (n = 34)		Peer Victimisation group (n = 35)		Comparison group (n = 38)		Group Comparisons^a,b,c
	Childhood Maltreatment group (n = 34)		Peer Victimisation group (n = 35)		Comparison group (n = 38)		CM vs C			PV vs C			CM vs PV
	Mean	SD	Mean	SD	Mean	SD	F(1,67)	p		F(1,68)	p		F(1,64)	p
Right UF
Tract Volume (mm³)	3423	463	3937	651	3702	645	0.09	ns	–	0.001	ns	–	5.64	0.021	CM < PV
Fractional Anisotropy:
Tract-averaged	0.372	0.021	0.367	0.026	0.368	0.017	5.81	0.019	CM > C	7.48	0.008	PV < C	4.66	0.035	CM > PV
Segment 1	0.399	0.036	0.399	0.036	0.395	0.026	2.20	ns	–	4.82	0.032	PV > C	0.38	ns	–
Segment 2	0.415	0.032	0.403	0.036	0.407	0.026	5.10	0.027	CM > C	2.94	(0.09)	(PV < C)	5.31	0.024	CM > PV
Segment 3	0.301	0.030	0.299	0.026	0.300	0.020	0.085	ns	–	6.10	0.016	PV < C	0.74	ns	–
Left UF
Tract Volume (mm³)	2991	482	3256	555	3115	548	0.45	ns	–	0.18	ns	–	0.63	ns	–
Fractional Anisotropy:
Tract-averaged	0.379	0.028	0.375	0.032	0.380	0.023	0.48	ns	–	2.24	ns	–	0.99	ns	–
Segment 1	0.413	0.046	0.413	0.045	0.420	0.034	0.45	ns	–	0.23	ns	–	0.56	ns	–
Segment 2	0.406	0.032	0.396	0.038	0.402	0.028	2.24	ns	–	1.23	ns	–	2.75	ns	–
Segment 3	0.297	0.036	0.292	0.030	0.298	0.025	1.93	ns	–	0.42	ns	–	0.003	ns	–
Right ATR
Tract Volume (mm³)	5154	1096	5390	1048	5353	918	5.56	0.021	CM < C	0.018	ns	–	0.006	ns	–
Fractional Anisotropy:
Tract-averaged	0.369	0.022	0.357	0.020	0.362	0.018	0.78	ns	–	1.71	ns	–	1.60	ns	–
Segment 1	0.395	0.043	0.376	0.036	0.387	0.034	0.62	ns	–	0.24	ns	–	1.73	ns	–
Segment 2	0.471	0.034	0.445	0.036	0.454	0.026	0.19	ns	–	0.66	ns	–	5.09	0.027	CM > PV
Segment 3	0.356	0.038	0.353	0.027	0.349	0.031	2.91	(0.09)	(CM > C)	0.07	ns	–	0.006	ns	–
Segment 4	0.267	0.021	0.260	0.021	0.264	0.022	3.24	(0.07)	(CM > C)	0.003	ns	–	0.31	ns	–
Left ATR
Tract Volume (mm³)	5113	898	5348	752	5200	857	3.11	ns	–	0.26	ns	–	0.28	ns	–
Fractional Anisotropy:
Tract-averaged	0.377	0.022	0.365	0.023	0.369	0.020	0.60	ns	–	1.01	ns	–	3.65	(0.06)	(CM > PV)
Segment 1	0.388	0.046	0.370	0.031	0.381	0.042	0.95	ns	–	1.40	ns	–	5.71	0.020	CM > PV
Segment 2	0.466	0.044	0.446	0.044	0.463	0.030	0.02	ns	–	1.57	ns	–	4.01	0.050	CM > PV
Segment 3	0.372	0.041	0.373	0.040	0.365	0.041	2.90	(0.09)	(CM > C)	0.07	ns	–	0.03	ns	–
Segment 4	0.285	0.026	0.282	0.020	0.283	0.027	0.10	ns	–	0.30	ns	–	0.04	ns	–
Tract Volume (mm³)	6508	1629	6943	1568	7630	1859	0.12	ns		2.11	ns	–	0.002	ns	–
Fractional Anisotropy:
Tract-averaged	0.456	0.020	0.453	0.028	0.450	0.021	1.17	ns	–	5.28	0.025	PV > C	0.73	ns	–
Segment 1	0.355	0.029	0.337	0.025	0.343	0.028	0.02	ns	–	1.98	ns	–	5.07	0.028	CM > PV
Segment 2	0.390	0.024	0.382	0.033	0.387	0.022	0.68	ns	–	15.9	0.001	PV < C	2.06	ns	–
Segment 3	0.471	0.022	0.469	0.033	0.470	0.025	0.32	ns	–	9.09	0.004	PV < C	0.48	ns	–
Segment 4	0.519	0.029	0.512	0.033	0.514	0.027	0.61	ns	–	1.29	ns	–	1.43	ns	–
Segment 5	0.519	0.030	0.521	0.035	0.511	0.035	0.001	ns	–	1.04	ns	–	0.02	ns	–
Segment 6	0.458	0.054	0.433	0.054	0.453	0.059	0.004	ns	–	1.29	ns	–	2.10	ns	–
Tract Volume (mm³)	6435	1881	6666	1600	6883	1530	0.16	ns		1.07	ns	–	0.004	ns	–
Fractional Anisotropy:
Tract-averaged	0.468	0.024	0.461	0.029	0.461	0.020	0.19	ns	–	4.17	0.045	PV > C	1.32	ns	–
Segment 1	0.364	0.032	0.354	0.026	0.353	0.029	0.02	ns	–	0.10	ns	–	0.58	ns	–
Segment 2	0.392	0.031	0.385	0.032	0.393	0.024	0.07	ns	–	2.35	ns	–	1.12	ns	–
Segment 3	0.475	0.040	0.465	0.037	0.465	0.028	0.83	ns	–	1.02	ns	–	0.75	ns	–
Segment 4	0.522	0.040	0.508	0.039	0.515	0.025	0.06	ns	–	10.2	0.002	PV < C	3.06	(0.08)	(CM > PV)
Segment 5	0.538	0.034	0.540	0.034	0.535	0.031	0.001	ns	–	1.03	ns	–	0.72	ns	–
Segment 6	0.476	0.053	0.469	0.055	0.455	0.060	0.10	ns	–	0.003	ns	–	2.05	ns	–
Tract Volume (mm³)	7016	845	6869	980	7023	1236	2.72	ns		0.001	ns	–	0.03	ns	–
Fractional Anisotropy:
Tract-averaged	0.490	0.181	0.484	0.027	0.485	0.019	0.23	ns	–	6.87	0.011	PV < C	1.37	ns	–
Segment 1	0.443	0.026	0.438	0.032	0.441	0.026	1.75	ns	–	6.67	0.012	PV < C	1.15	ns	–
Segment 2	0.441	0.033	0.427	0.035	0.439	0.029	1.60	ns	–	4.34	0.041	PV < C	5.27	0.025	CM > PV
Segment 3	0.475	0.030	0.477	0.032	0.475	0.028	1.78	ns	–	3.04	(0.08)	(PV > C)	0.13	ns	–
Segment 4	0.543	0.026	0.535	0.035	0.533	0.033	0.008	ns	–	3.54	(0.06)	(PV > C)	0.76	ns	–
Segment 5	0.532	0.040	0.529	0.048	0.521	0.044	1.88	ns	–	0.22	ns	–	0.09	ns	–
Tract Volume (mm³)	6954	1340	6836	1324	6741	1137	1.18	ns		0.07	ns	–	0.36	ns	–
Fractional Anisotropy:
Tract-averaged	0.510	0.025	0.497	0.031	0.501	0.016	1.83	ns	–	6.92	0.011	PV < C	6.88	0.011	CM > PV
Segment 1	0.447	0.042	0.433	0.037	0.443	0.028	0.99	ns	–	1.90	ns	–	3.11	(0.08)	(CM > PV)
Segment 2	0.478	0.040	0.463	0.040	0.470	0.036	2.78	ns	–	0.87	ns	–	1.84	ns	–
Segment 3	0.500	0.035	0.500	0.038	0.494	0.029	1.23	ns	–	2.53	ns	–	0.26	ns	–
Segment 4	0.561	0.033	0.554	0.043	0.549	0.027	0.03	ns	–	2.36	ns	–	4.96	0.029	CM > PV
Segment 5	0.543	0.045	0.540	0.048	0.541	0.035	0.20	ns	–	5.67	0.020	PV < C	4.49	0.038	CM > PV

^aCM childhood maltreatment group, PV peer victimisation group, C = comparison group
^bThe values in parentheses are marginally statistically significant
^cGroup differences in tract volume and fractional anisotropy were conducted with number of recent stressful events, age onset and duration of early-life stress exposure as covariates

Back to article page

ISSN: 1471-244X

Contact us

Submission enquiries: bmcpsychiatry@biomedcentral.com
General enquiries: ORSupport@springernature.com