Association of cognitive impairment with the interaction between chronic kidney disease and depression: findings from NHANES 2011–2014

Table 2 Analysis of the interactive effect of CKD and depression

CKD	Depression	CoI/Total (n)	Model 1			Model 2			Model 3
			OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
0	0	316/1,575	Ref			Ref			Ref
0 1 1	1 0 1	164/487 137/431 83/173	2.24 2.37 6.38	1.67–2.98 1.79–3.12 4.47–9.07	< 0.001 < 0.001 < 0.001	2.17 1.50 5.15	1.57–2.99 1.10–2.05 3.45–7.68	< 0.001 0.011 < 0.001	1.83 1.19 4.03	1.29–2.59 0.84–1.68 2.59–6.25	0.001 0.3 < 0.001
RERI (95% CI)			2.77 (0.60–4.94)			2.48 (0.49–4.47)			2.01 (0.31–3.71)
AP (95% CI)			0.43 (0.22–0.65)			0.48 (0.25–0.71)			0.50 (0.25–0.75)
S (95% CI)			2.06 (1.27–3.34)			2.48 (1.32–4.66)			2.97 (1.27–6.92)

Model 1: unadjusted model; Model 2: adjustment for age and race; Model 3: adjustment for age, race, education, annual family income, BMI, marital status, work activity, alcohol user, hypertension, diabetes, CVD. Abbreviations: RERI, relative excess risk due to interaction; AP, attributable proportion of interaction; S, synergy index; CKD, Chronic kidney disease; CVD, Cardiovascular disease; OR, odds ratio; CI, confidence interval; CoI, cognitive impairment

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