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Table 1 Baseline Characteristics and Selected Univariate Predictors of Switching

From: Predictors of switching antipsychotic medications in the treatment of schizophrenia

Variable

All patients

(N = 648)

Switchers

(n = 191)

Completers

(n = 304)

p value

(switchers vs.

completers)1

p value

(univariate

survival

comparison)2

Age, mean (SD), y

42.9 (12.1)

42.8 (12.5)

43.7 (11.8)

0.404

0.724

Female, n (%)

239 (37%)

87 (46%)

106 (35%)

0.018

0.013

Caucasian, n (%)

352 (54%)

107 (56%)

170 (56%)

0.998

0.890

Currently employed,

n (%)

122 (19%)

36 (19%)

64 (21%)

0.568

0.903

Illness duration, mean (SD), y

20.6 (12.2)

20.6 (12.6)

21.3 (12.1)

0.577

0.981

Hospitalized, previous year, mo

mean (SD)

0.51 (1.53)

0.40 (1.25)

0.49 (1.54)

0.450

0.343

Switch in previous year, n (%)

85 (13%)

23 (13%)

44 (15%)

0.588

0.650

Any antipsychotic previous year, n (%)

579 (89%)

165 (86%)

284 (93%)

0.011

0.095

Substance abuse diagnosis, n (%)

289 (45%)

70 (37%)

135 (44%)

0.111

0.038

Schizoaffective diagnosis, n (%)

280 (43%)

80 (42%)

130 (43%)

0.852

0.795

Ever attempted suicide, n (%)

235 (38%)

78 (43%)

99 (34%)

0.064

0.084

Ever incarcerated,

n (%)

284 (46%)

71 (38%)

127 (43%)

0.295

0.075

PANSS total score, mean (SD)

86.8 (20.0)

84.5 (18.8)

87.4 (21.1)

0.120

0.102

PANSS Davis, positive symptoms, mean (SD)

22.3 (6.3)

21.9 (5.8)

22.1 (6.6)

0.796

0.545

PANSS Davis, negative symptoms, mean (SD)

21.3 (7.0)

20.4 (6.8)

21.9 (7.3)

0.026

0.043

PANSS Davis, impulsivity/hostility, mean (SD)

8.9 (3.6)

8.9 (3.9)

8.9 (3.6)

0.990

0.675

PANSS Davis, disorganized thought, mean (SD)

21.2 (6.0)

20.7 (5.6)

21.6 (6.3)

0.096

0.085

PANSS Davis, anxiety/depression, mean (SD)

13.0 (4.2)

12.7 (4.0)

13.0 (4.3)

0.411

0.445

SF-36 Physical component score, mean (SD)

-0.43 (1.04)

-0.43 (1.05)

-0.42 (1.01)

0.963

0.803

SF-36 Mental component score, mean (SD)

-1.08 (1.33)

-1.14 (1.33)

-0.82 (1.28)

0.009

0.106

Barnes Akathisia

0.24

0.20 (0.53)

0.25 (0.62)

0.356

0.273

item #1, objective, mean (SD)

(0.57)

    

Barnes Akathisia, total score, mean (SD)

0.99 (1.58)

0.96 (1.46)

0.95 (1.67)

0.954

0.813

GAF functioning, current score, mean (SD)

46.1 (12.9)

47.2 (13.4)

47.0 (13.2)

0.842

0.323

Antidepressant Drugs taken (%)

297 (46%)

85 (45%)

212 (46%)

0.667

0.340

Anti-Anxiety

Drugs taken (%)

187 (29%)

54 (28%)

133 (29%)

0.850

0.810

Antiparkinsonian

Drugs taken (%)

315 (49%)

93 (49%)

222 (49%)

1.000

0.453

Patient weight, mean (SD), kg

86.7 (20.7)

86.9 (21.2)

87.7 (20.4)

0.706

0.947

Body mass index, mean (SD)

29.7 (6.8)

30.4 (7.1)

29.8 (6.9)

0.426

0.229

Patient weight change from baseline to 2 weeks, mean (SD), kg

+0.8 (2.8)

+0.7 (3.2)

+0.8 (2.4)

0.706

0.646

Pre-existing depression, n (%)

96 (15%)

36 (19%)

39 (13%)

0.073

0.056

Pre-existing insomnia, n (%)

66 (10%)

26 (14%)

24 (8%)

0.047

0.030

PANSS Davis anxiety/depression, change from baseline to 2 weeks, mean (SD)

-1.42 (3.47)

-1.19 (3.74)

-1.88 (3.36)

0.041

0.093

Barnes Akathisia objective score, change from baseline to 2 weeks, mean (SD)

-0.04 (0.59)

+0.02 (0.62)

-0.05 (0.57)

0.193

0.058

  1. Abbreviations: PANSS, positive and negative syndrome scale; SD, standard deviation; SF-36, Medical Outcomes Study 36-item short form health survey; GAF, global assessment of functioning scale.
  2. 1Univariate descriptive statistic comparisons, using unpaired t-tests for numeric data (confirming with Wilcoxon rank-sum test, if non-normality was suspected) or chi-square tests (or Fisher's exact test, for small numbers) for categorical data.
  3. 2Univariate survival comparisons, using Cox proportional hazards models with only the one single variable.
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BMC Psychiatry

ISSN: 1471-244X

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