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Table 2 Study characteristics

From: Comparative efficacy and acceptability of methylphenidate and atomoxetine in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis

Study Number of participants Blinding Design Follow-up Baseline severity ADHD-RS total score Mean daily dose-atomoxetine and frequency Mean daily dose-methylphenidate and frequency
Yildiz
2010
n = 25 Open label Parallel group 12 weeks Parents T-DSM-IV inattention scores
atomoxetine = 16.72
MPH = 17.72
1.28 mg/kg/day
Once a day
OROS-MPH = 1.07 mg/kg
(IR = equivalent 0.89 mg/kg)
Once a day
Newcorn 2008 n = 442 Double blind Parallel group 6 weeks Atomoxetine = 40.9(SD 8.8)
MPH = 40.0
(SD 8.8)
1.45 mg/kg
Twice a day
OROS-MPH =
1.16 mg/kg
(IR equivalent = 0.966 mg/kg
Once a day
Prasad 2007 n = 180 Open label Parallel group 10 weeks Atomoxetine = 45.5(SD 8.7)
MPH not stated
1.5 mg/kg
Once a daily
8 pts got twice daily
IR MPH = 0.8 mg/kg
OROS-MPH = 1.03 mg/kg
(IR equivalent = 0.858 mg/kg)
Wang
2007
n = 330 Double blind Parallel group 8 weeks Atomoxetine = 38.6 (SD 7.6)
MPH = 37.4
(SD 7.6)
Final range
0.8 mg/kg-1.8 mg/kg
Once a day
IR MPH = 17.8/mg/day
Twice a day
Kemner 2005 n = 1323 Open label Parallel group 3 weeks Atomoxetine = 38.6 (SD8.1)
MPH = 39.
1.08 mg/kg/Once a day OROS-MPH 1.01 mg/kg/day
(IR equivalent 0.841 mg/kg) Once a day
Sangal 2005 n = 85 Double blind Cross over 7 weeks Atomoxetine = 39.6
MPH not stated
1.56 mg/kg/day
Twice a day
IR MPH = 1.12 mg/kg
Three times a day
Kratochvil 2002 n = 228 Open label Parallel group 10 weeks Atomoxetine = 39.4
MPH = 37.6
0.48 mg/kg*
or
1.4 mg/kg/kg**
Twice daily
Final mean dose 0.85 mg/kg
Three times a day
Spencer 2002 HFBD n = 84 Double blind Parallel group 9 weeks Atomoxetine = 39.5 1.56 mg/kg
Twice a day
IR MPH = 1.12 mg/kg
Twice a day
Spencer 2002 HFBK n = 79 Double blind Parallel group 9 weeks Atomoxetine = 39.5 1.56 mg/kg
Twice a day
IR MPH = 1.12 mg/kg
Twice a day
  1. *atomoxetine slow metabolisers **atomoxetine rapid metabolisers
  2. 18 mg OROS MPH = 15 mg IR MPH