Skip to main content

Table 4 Adjusted Cox proportionate hazards models (aripiprazole reference) for unmatched samples

From: One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics: a retrospective claims database analysis

Effect Ziprasidone
Hazard Ratio
(95% CI)
Olanzapine
Hazard Ratio
(95% CI)
Quetiapine
Hazard Ratio
(95% CI)
Risperidone
Hazard Ratio
(95% CI)
Age 0.988 (0.971-1.006) 0.992 (0.980-1.004) 0.991 (0.980-1.001) 0.994 (0.981-1.007)
Women vs. Men 1.137 (0.735-1.759) 1.013 (0.773-1.326) 1.193 (0.928-1.533) 0.909 (0.675-1.224)
Charlson Comorbidity Index 1.168 (1.027-1.328) 1.054 (0.912-1.218) 0.988 (0.855-1.142) 1.100 (0.968-1.249)
Prior Psychiatric Hospitalization 2.805 (1.902-4.136) 3.051 (2.333-3.990) 2.777 (2.213-3.485) 2.551 (1.923-3.385)
Prior Diabetes 0.901 (0.414-1.965) 1.056 (0.550-2.026) 1.170 (0.704-1.944) 1.294 (0.738-2.269)
Prior Hyperlipidemia 1.255 (0.685-2.299) 0.834 (0.539-1.289) 0.828 (0.572-1.199) 1.162 (0.764-1.769)
Prior Lipid Test 0.641 (0.357-1.149) 0.807 (0.546-1.192) 1.000 (0.722-1.386) 1.048 (0.696-1.579)
Prior Glucose Test 1.305 (0.858-1.983) 1.288 (0.963-1.722) 1.030 (0.801-1.325) 1.132 (0.819-1.563)
Pre-index mood stabilizer
   1 vs. none 1.624 (0.946-2.789) 0.735 (0.499-1.085) 0.849 (0.606-1.188) 1.310 (0.863-1.988)
   2 vs. none 1.241 (0.533-2.890) 0.387 (0.196-0.764) 0.646 (0.372-1.122) 1.737 (0.925-3.263)
   ≥3 vs. none 0.833 (0.162-4.287) 0.434 (0.134-1.408) 0.705 (0.225-2.207) 0.304 (0.038-2.416)
Post-index mood stabilizer
   Carbamazepine 2.792 (1.292-6.031) 2.741 (1.417-5.301) 1.745 (0.986-3.087) 1.482 (0.720-3.049)
   Lamotrigine 1.204 (0.671-2.161) 1.765 (1.056-2.952) 1.058 (0.719-1.555) 1.273 (0.810-2.002)
   Lithium 0.588 (0.298-1.159) 2.314 (1.509-3.551) 0.931 (0.626-1.385) 0.740 (0.452-1.210)
   Oxcarbazepine 1.342 (0.655-2.748) 1.876 (1.034-3.403) 0.870 (0.519-1.459) 1.016 (0.584-1.766)
   Topiramate 1.006 (0.493-2.051) 1.753 (0.994-3.091) 1.336 (0.844-2.117) 1.052 (0.596-1.855)
   Valproate 0.646 (0.341-1.224) 1.352 (0.889-2.056) 0.824 (0.561-1.211) 0.782 (0.504-1.214)
Year of Index Prescription 0.937 (0.732-1.199) 1.032 (0.868-1.228) 0.963 (0.837-1.109) 0.959 (0.803-1.146)
Comparator vs. Aripiprazole 2.047 (1.388-3.019) 1.549 (1.098-2.184) 1.551 (1.139-2.113) 1.567 (1.124-2.186)