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Table 4 Adjusted Cox proportionate hazards models (aripiprazole reference) for unmatched samples

From: One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics: a retrospective claims database analysis

Effect

Ziprasidone

Hazard Ratio

(95% CI)

Olanzapine

Hazard Ratio

(95% CI)

Quetiapine

Hazard Ratio

(95% CI)

Risperidone

Hazard Ratio

(95% CI)

Age

0.988 (0.971-1.006)

0.992 (0.980-1.004)

0.991 (0.980-1.001)

0.994 (0.981-1.007)

Women vs. Men

1.137 (0.735-1.759)

1.013 (0.773-1.326)

1.193 (0.928-1.533)

0.909 (0.675-1.224)

Charlson Comorbidity Index

1.168 (1.027-1.328)

1.054 (0.912-1.218)

0.988 (0.855-1.142)

1.100 (0.968-1.249)

Prior Psychiatric Hospitalization

2.805 (1.902-4.136)

3.051 (2.333-3.990)

2.777 (2.213-3.485)

2.551 (1.923-3.385)

Prior Diabetes

0.901 (0.414-1.965)

1.056 (0.550-2.026)

1.170 (0.704-1.944)

1.294 (0.738-2.269)

Prior Hyperlipidemia

1.255 (0.685-2.299)

0.834 (0.539-1.289)

0.828 (0.572-1.199)

1.162 (0.764-1.769)

Prior Lipid Test

0.641 (0.357-1.149)

0.807 (0.546-1.192)

1.000 (0.722-1.386)

1.048 (0.696-1.579)

Prior Glucose Test

1.305 (0.858-1.983)

1.288 (0.963-1.722)

1.030 (0.801-1.325)

1.132 (0.819-1.563)

Pre-index mood stabilizer

   1 vs. none

1.624 (0.946-2.789)

0.735 (0.499-1.085)

0.849 (0.606-1.188)

1.310 (0.863-1.988)

   2 vs. none

1.241 (0.533-2.890)

0.387 (0.196-0.764)

0.646 (0.372-1.122)

1.737 (0.925-3.263)

   ≥3 vs. none

0.833 (0.162-4.287)

0.434 (0.134-1.408)

0.705 (0.225-2.207)

0.304 (0.038-2.416)

Post-index mood stabilizer

   Carbamazepine

2.792 (1.292-6.031)

2.741 (1.417-5.301)

1.745 (0.986-3.087)

1.482 (0.720-3.049)

   Lamotrigine

1.204 (0.671-2.161)

1.765 (1.056-2.952)

1.058 (0.719-1.555)

1.273 (0.810-2.002)

   Lithium

0.588 (0.298-1.159)

2.314 (1.509-3.551)

0.931 (0.626-1.385)

0.740 (0.452-1.210)

   Oxcarbazepine

1.342 (0.655-2.748)

1.876 (1.034-3.403)

0.870 (0.519-1.459)

1.016 (0.584-1.766)

   Topiramate

1.006 (0.493-2.051)

1.753 (0.994-3.091)

1.336 (0.844-2.117)

1.052 (0.596-1.855)

   Valproate

0.646 (0.341-1.224)

1.352 (0.889-2.056)

0.824 (0.561-1.211)

0.782 (0.504-1.214)

Year of Index Prescription

0.937 (0.732-1.199)

1.032 (0.868-1.228)

0.963 (0.837-1.109)

0.959 (0.803-1.146)

Comparator vs. Aripiprazole

2.047 (1.388-3.019)

1.549 (1.098-2.184)

1.551 (1.139-2.113)

1.567 (1.124-2.186)