Advertisement
Table 2 Levels of [3 H]DAMGO (mean ± SEM) binding in subjects with schizophrenia, major depressive disorder, bipolar disorder or no history of psychiatric disorder who did or did not die as a result of suicide
| Group BA 24 | Sample size | [3 H]DAMGO binding (fmole/mg ETE) | Analysis parameters | P value |
|---|---|---|---|---|
| Suicide | 41 | 32.25 ± 1.76 | t = 2.7, df = 120 (non-suicide) | 0.008 |
| Non-suicide | 81 | 38.34 ± 1.34 | ||
| Diagnosis/suicide | BA 24 | |||
| Controls | 51 | 37.63 ± 1.83 | ||
| Suicides | 9 | 34.02 ± 3.80 | t = 0.88 (controls) | n.s |
| MDD | 5 | 27.95 ± 9.06 | t = 1.84 (controls) | n.s |
| MDD (suicide) | 15 | 35.69 ± 2.84 | t = 0.58 (controls) | n.s |
| BP | 8 | 50.51 ± 1.98 | t = 3.00 (controls) | n.s |
| BP (suicide) | 5 | 35.38 ± 3.07 | t = 0.43 (controls) | n.s |
| Schizophrenia | 26 | 37.80 ± 1.83 | t = 0.04 (controls) | n.s |
| Schizophrenia (suicide) | 12 | 25.31 ± 3.17 | t = 3.39 (controls) t = 3.21 (schizophrenia) | <0.05 |
| Schizophrenia/suicide | BA 9 | |||
| Controls | 20 | 31.65 ± 2.11 | ||
| Schizophrenia | 26 | 34.40 ± 1.32 | t = 1.15 (controls) | n.s |
| Schizophrenia (suicide) | 12 | 24.12 ± 2.27 | t = 2.57 (controls) t = 3.68 (schizophrenia) | <0.05 <0.05 |
| CPu | ||||
| Controls | 20 | 25.40 ± 2.16 | ||
| Schizophrenia | 24 | 23.72 ± 1.37 | t = 0.67 (controls) | n.s |
| Schizophrenia (suicide) | 11 | 16.29 ± 2.42 | t = 2.97 (controls) t = 2.50 (schizophrenia) | <0.05 <0.05 |
