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Table 2 Clinical characteristics of the sample

From: Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment

  Switching Combination Augmentation Total
(N = 133) (N = 80) (N = 60) (N = 273)
Number of previous depressive episodes, mean (95%CI) 1.8 (1.5-2.1) 2.0 (1.5-2.4) 3.5 (2.5-4.4) 2.2 (1.9-2.5)
Previous hospitalization, n (%) 12 (9.0) 10 (12.5) 15 (25.0) 37 (13.6)
Previous suicide attempt, n (%) 20 (15.2) 17 (21.3) 16 (26.7) 53 (19.5)
Family history of psychiatric disorders, n (%) 56 (42.1) 44 (55.0) 30 (50.0) 130 (47.6)
Duration of AD treatment (weeks), mean (95%CI)* 12.7 (10.7-14.6) 10.6 (9.1-12.1) 12.2 (8.3-16) 12.0 (10.6-13.3)
Presence of psychotic symptoms, n (%) 3 (2.3) 5 (6.3) 11 (18.3) 19 (7.0)
MADRS total score, mean (95%CI) 31.5 (30.3-32.6) 32.5 (30.9-34.1) 32.8 (30.9-34.6) 32.1 (31.2-32.9)
MADRS Item 10 (suicidality) score, mean (95%CI) 2.0 (1.7-2.2) 2.3 (2.0-2.6) 2.5 (2.2-2.7) 2.2 (2.0-2.3)
HARS total score, mean (95%CI) 24.3 (23.1-25.6) 24.0 (22.3-25.6) 23.0 (21.5-24.5) 24.0 (23.1-24.7)
CGI-S score, mean (95%CI) 4.5 (4.3-4.6) 4.7 (4.5-4.8) 4.7 (4.5-4.9) 4.6 (4.5-4.6)
  1. *Antidepressant treatment for the current MDD episode at enrolment.
  2. MADRS, Montgomery-Asberg Depression Rating Scale; HARS, Hamilton Anxiety Rating Scale; CGI-S, Clinical Global Impression – Severity scale.