Table 2 Clinical characteristics of the sample
Switching | Combination | Augmentation | Total | |
|---|---|---|---|---|
(N = 133) | (N = 80) | (N = 60) | (N = 273) | |
Number of previous depressive episodes, mean (95%CI) | 1.8 (1.5-2.1) | 2.0 (1.5-2.4) | 3.5 (2.5-4.4) | 2.2 (1.9-2.5) |
Previous hospitalization, n (%) | 12 (9.0) | 10 (12.5) | 15 (25.0) | 37 (13.6) |
Previous suicide attempt, n (%) | 20 (15.2) | 17 (21.3) | 16 (26.7) | 53 (19.5) |
Family history of psychiatric disorders, n (%) | 56 (42.1) | 44 (55.0) | 30 (50.0) | 130 (47.6) |
Duration of AD treatment (weeks), mean (95%CI)* | 12.7 (10.7-14.6) | 10.6 (9.1-12.1) | 12.2 (8.3-16) | 12.0 (10.6-13.3) |
Presence of psychotic symptoms, n (%) | 3 (2.3) | 5 (6.3) | 11 (18.3) | 19 (7.0) |
MADRS total score, mean (95%CI) | 31.5 (30.3-32.6) | 32.5 (30.9-34.1) | 32.8 (30.9-34.6) | 32.1 (31.2-32.9) |
MADRS Item 10 (suicidality) score, mean (95%CI) | 2.0 (1.7-2.2) | 2.3 (2.0-2.6) | 2.5 (2.2-2.7) | 2.2 (2.0-2.3) |
HARS total score, mean (95%CI) | 24.3 (23.1-25.6) | 24.0 (22.3-25.6) | 23.0 (21.5-24.5) | 24.0 (23.1-24.7) |
CGI-S score, mean (95%CI) | 4.5 (4.3-4.6) | 4.7 (4.5-4.8) | 4.7 (4.5-4.9) | 4.6 (4.5-4.6) |