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Table 1 The important characteristics of controlled trials of quetiapine in major depressive disorder

From: Quetiapine monotherapy in acute phase for major depressive disorder: a meta-analysis of randomized, placebo-controlled trials

Study (author, year) Number of patients Age of subjects (years) Study duration (weeks) Drug /Dose Diagnostic criteria Respond criteria Remission criteria Outcome measures
Cutler AJ 2009 461 18–65 8 Quetiapine XR/150 and 300 mg/day DSM IV ≥ 50% reduction in MADRS MADRS ≤ 8 MADRS, HAM-D, HAM-A, CGI-S, CGI-I, PSQI, SAS, BARS, CSFQ, 18-item TDSS scale
Weisler R 2009 700 18–65 8 Quetiapine XR/50, 150 and 300 mg/day DSM IV ≥ 50% reduction in MADRS MADRS ≤ 8 MADRS, HAM-D, HAM-A, CGI-S, CGI-I, PSQI, SAS, BARS, CSFQ, Q-LES-Q, 18-item TDSS scale
Bortnick B 2011 299 18–65 10 Quetiapine XR/150 to 300 mg/day DSM IV ≥ 50% reduction in MADRS MADRS ≤ 8 MADRS, HAM-D, HAM-A, CGI-S, CGI-I, PSQI, SAS, BARS, CSFQ, Q-LES-Q, 18-item TDSS scale
  1. MADRS = Montgomery-Åsberg Depression Rating Scale; HAM-D = Hamilton Rating Scale for Depression; HAM-A = Hamilton Rating Scale for Anxiety; CGI-S= Clinical Global Impression–Severity of Illness; CGI-I = Clinical Global Impression–Improvement scale; PSQI = Pittsburgh Sleep Quality Index; SAS = Simpson-Angus Scale, BARS = Barnes Akathisia Rating Scale; CSFQ = Changes in Sexual Functioning Questionnaire; Q-LES-Q = Quality of Life Enjoyment Satisfaction Questionnaire; TDSS scale = Treatment discontinuation.