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Table 1 Medication dose and reasons for discontinuation before and after switching

From: Clinical consequences of switching from olanzapine to risperidone and vice versa in outpatients with schizophrenia: 36-month results from the worldwide schizophrenia outpatients health outcomes (W-SOHO) study

  Before switching After switching
  OLZ-RIS (n=162) RIS-OLZ (n=136) OLZ-RIS (n=162) RIS-OLZ (n=136)
Dose (Mean ± SD) 10.1±5.3 4.7±3.0 4.6±3.2 10.9±5.9
Reason for discontinuation (%) a     
  Lack of efficacy 41.3 59.1 36.0 34.0
  Intolerability 29.7 31.8 15.7 20.0
  Lack of compliance 19.4 23.5 19.1 16.0
  Patient request 34.8 28.8 19.1 26.0
  1. aMore than one reason allowed.
  2. OLZ-RIS: Patients who switched from olanzapine to risperidone.
  3. RIS-OLZ: Patients who switched from risperidone to olanzapine.