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Table 1 Medication dose and reasons for discontinuation before and after switching

From: Clinical consequences of switching from olanzapine to risperidone and vice versa in outpatients with schizophrenia: 36-month results from the worldwide schizophrenia outpatients health outcomes (W-SOHO) study

 

Before switching

After switching

 

OLZ-RIS (n=162)

RIS-OLZ (n=136)

OLZ-RIS (n=162)

RIS-OLZ (n=136)

Dose (Mean ± SD)

10.1±5.3

4.7±3.0

4.6±3.2

10.9±5.9

Reason for discontinuation (%) a

    

  Lack of efficacy

41.3

59.1

36.0

34.0

  Intolerability

29.7

31.8

15.7

20.0

  Lack of compliance

19.4

23.5

19.1

16.0

  Patient request

34.8

28.8

19.1

26.0

  1. aMore than one reason allowed.
  2. OLZ-RIS: Patients who switched from olanzapine to risperidone.
  3. RIS-OLZ: Patients who switched from risperidone to olanzapine.