Efficacy and safety of olanzapine for treatment of patients with bipolar depression: Japanese subpopulation analysis of a randomized, double-blind, placebo-controlled study

Table 2 Secondary efficacy measures

Baseline-to-endpoint change	Placebo	Olanzapine	p Value
	(n = 52)	(n = 104)
	LS Mean (SE)	LS Mean (SE)
CGI-BP
Depression	−0.89 (0.16)	−1.41 (0.11)	.008
Mania	0.03 (0.04)	0.01 (0.03)	.68
Bipolar	−0.83 (0.15)	−1.31 (0.11)	.01
HAMD-17 total	−7.88 (1.04)	−11.66 (0.74)	.004
YMRS total	0.34 (0.24)	−0.32 (0.17)	.03

Abbreviations: CGI-BP = Clinical Global Impressions-Bipolar Version Severity of Illness; HAMD-17 = Hamilton Depression Rating Scale-17 items; LS mean = least squares mean; SE = standard error; YMRS = Young Mania Rating Scale.

ISSN: 1471-244X