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Table 5 Absolute and categorical changes in weight, total cholesterol, triglycerides, LDL, HDL, and glucose

From: Efficacy and safety of olanzapine for treatment of patients with bipolar depression: Japanese subpopulation analysis of a randomized, double-blind, placebo-controlled study

  Placebo Olanzapine p Value
  n LS mean (SE) n LS mean (SE)  
Weight gain, kg 52 −0.36 (0.29) 104 +2.12 (0.21) <.001
   n/N (%)   n/N (%)  
Patients with significant weight gain (≥7% body weight)   1/52 (1.9)   21/104 (20.2) .001
  n LS mean (SE) n LS mean (SE)  
Baseline-to-endpoint change in fasting laboratory values      
 Cholesterol, mg/dL 52 −0.96 (3.37) 104 +10.06 (2.38) .008
 Triglycerides, mg/dL 52 −4.17 (12.31) 104 +30.67 (8.68) .02
 LDL, mg/dL 51 −1.06 (3.07) 103 +8.78 (2.16) .01
 HDL, mg/dL 52 +1.10 (1.27) 104 −2.99 (0.90) .01
 Glucose, mg/dL 51 −1.02 (1.11) 100 + 1.01 (0.79) .14
   n/N (%)   n/N (%)  
Patients with categorical shifts in fasting cholesterol values      
 Normal to borderline   2/17 (11.8)   13/39 (33.3) .11
 Normal to high   0/17 (0.0)   1/39 (2.6) 1.00
 Borderline to high   0/25 (0.0)   13/52 (25.0) .007
Patients with categorical shifts in fasting triglyceride values      
 Normal to borderline   3/37 (8.1)   5/82 (6.1) .70
 Normal to high   1/37 (2.7)   9/82 (11.0) .17
 Normal to extremely high   0/37 (0.0)   0/82 (0.0) --
 Borderline to high   1/9 (11.1)   3/12 (25.0) .60
 Borderline to extremely high   0/9 (0.0)   0/12 (0.0) --
Patients with categorical shifts in fasting LDL cholesterol values      
 Normal to borderline   4/9 (44.4)   11/26 (42.3) >.99
 Normal to high   0/9 (0.0)   0/26 (0.0) --
 Borderline to high   0/34 (0.0)   6/68 (8.8) .18
Patients with categorical shifts in fasting HDL cholesterol values      
 Normal to low   0/46 (0.0)   8/97 (8.2) .05
Patients with categorical shifts in fasting glucose values      
 Normal to impaired   5/32 (15.6)   9/72 (12.5) .76
 Impaired to high   0/18 (0.0)   2/28 (7.1) .51
 Normal/impaired to high   0/50 (0.0)   3/100 (3.0) .55
 Normal to high   0/32 (0.0)   1/72 (1.4) 1.00
  1. Abbreviations: HDL = high-density lipoprotein; LDL = low-density lipoprotein; LS mean = least squares mean; SE = standard error.
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