Predictive properties of the A-TAC inventory when screening for childhood-onset neurodevelopmental problems in a population-based sample

Table 1 Screen-positive cases according to A-TAC of screen-negative siblings and random, screen-negative controls compared with subsequent gold standard diagnoses at a clinical examination three years later

			Follow-up Clinical Diagnoses in CATSS-15/DOGSS
Baseline A-TAC in CATSS 9/12			NDP^A				No NDP^A	No NDP^ASpecified
			ASDs	AD/HD	LD	TD		Other	No
								K-SADS	K-SADS
								diagnoses^C	diagnoses
Screen-positive cases according to the CATSS-15/DOGSS inclusion criteria N = 247			N = 20	N = 72	N = 23	N = 47	N = 125	N = 42	N = 83
	198 out of whom were NDP^A screen-positive	of whom 27 were screen-positive for ASD	13	10	8	7	2	1	1
		of whom 95 were screen-positive for AD/HD	10	46	15	19	34	11	23
		of whom 74 were screen-positive for LD	5	23	12	8	38	12	26
		of whom 35 were screen-positive for TD	4	12	3	21	7	2	5
		of whom 38 were screen positive for DCD	3	3	6	4	26	5	21
	49 out of whom were screen-positive for other mental health problems only^B		1	9	1	8	35	18	17
Screen-negative siblings of cases N = 157			0	20	2	16	125	32	93
Screen-negative random controls N = 46			0	3	2	1	41	13	28
Missing data N = 2^D			0	1	0	0	0	0	0
N = 452			N = 20	N = 96	N = 27	N = 64	N = 291	N = 87	N = 204

Baseline: CATSS-9/12 study (N = screen-positive in A-TAC).
Follow-up: Diagnostic outcome in the clinical follow-up study, CATSS-15/DOGSS (N = clinical diagnosis).
No NDP specified: Children who received another diagnoses in K-SADS or no diagnosis at the clinical examination (italics indicate those screen-positive, but do not add up due to diagnostic overlap).
^A NDP defined as ASD and/or AD/HD and/or LD and/or TD and/or DCD (However, DCD had no corresponding diagnosis in the clinical examination), with a possible overlap of other mental health problems.
^B Other mental health problems defined as OCD and/or ODD and/or CD and/or ED, with no NDP overlap.
^C Other K-SADS diagnoses (i.e. “Other mental health problems” and/or depression, anxiety, stress disorder, mania, and/or psychosis with no NDP overlap).
^D Missing data: one sibling was not screened at 12, but diagnosed with AD/HD at follow-up. Another sibling could not participate in either baseline or follow-up, due to somatic problems (Sotos syndrome).

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