Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls

Table 3 Gene expression (mean ± SE) for genes differing between all patients with Depressive Disorders (DD) versus Controls (CON)

GENE	CON (n=19)	DD (n=23)	p value^A	p value^B	Cohen’s d^C
			Log transformed	Raw data
APP	5.65E-01 ± 3.12E-02	6.70E-01 ± 3.59E-02	0.043	0.029	0.661
IL-10	3.86E-03 ± 3.66E-04	5.27E-03 ± 5.33E-04	0.045	0.039	0.655
IL-6	2.02E-03 ± 2.79E-04	2.94E-03 ± 3.45E-04	0.028	0.045	0.719
OXTR	2.94E-03 ± 3.00E-04	4.75E-03 ± 6.95E-04	0.079	0.037	0.569
P2RX7	4.64E-02 ± 3.22E-03	5.84E-02 ± 4.89E-03	0.042	0.050	0.663
P2RY1	7.48E-02 ± 3.89E-03	9.45E-02 ± 5.82E-03	0.015	0.015	0.801
TRPV1	1.15E-02 ± 6.36E-04	1.35E-02 ± 5.07E-04	0.019	0.010	0.777

Raw data is displayed in the table. Expressed in scientific notation units where E+00 = x1, E-01 = x0.1, E-02 = x0.01, etc. Data were log transformed prior to analysis.
^ADifferences between DD vs. CON examined using log transformed data and Student’s t-test.
^BDifferences between DD vs. CON examined using non-transformed data and nonparametric Wilcoxon Rank Sum test.
All comparisons had 40 degrees of freedom and F values ranging from 4.29 – 6.42.
^CCohen d effect sizes were all moderate to large and are reported with DD as the reference group.

ISSN: 1471-244X