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Table 1 Rates of reduction used in previous research

From: Study protocol: safety correction of high dose antipsychotic polypharmacy in Japan

Tanabe’s research [9]
Group Mean dose before reduction Reduction speed GAF SOI n
Successful 1,372 mg CP 40.4 mg CP/week 34.1 4.5 37
Unsuccessful 1,832 mg CP 95.4 mg CP/week 29.8 4.8 11
Murasugi’s research [10]
Group Mean dose before reduction Reduction speed GAF SOI n
Successful 1,581 mg CP 43.0 mg CP/week 35.2 4.8 5
Unsuccessful 2,389 mg CP 97.4 mg CP/week 44.0 4.5 5
Combination of both studies
Group Mean dose before reduction Reduction speed GAF SOI n
Successful 1,397 mg CP 40.7 mg/week 33.5 4.5 42
Unsuccessful 2, 006 mgCP 96.0 mg/week 34.2 4.7 16
  1. Abbreviations: GAF global assessment of functioning in DSM-4-TR; SOI severity of illness; n number of patients.