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Table 3 Reduction protocol for low-potency drugs

From: Study protocol: safety correction of high dose antipsychotic polypharmacy in Japan

Generic name Product name Maximum reduction rate(mg/week) Maximum reduction(mg)
Sulpiride Dogmatyl, others 50 100
Sultopride Barnetil 50 100
Pipamperone Propitan 50 100
Chlorpromazine Contomin, others 25 50
Levomepromazine Levotomin, others 25 50
Carpiprammine Defecton 25 50
Oxypertine Forit 20 40
Zotepine Lodopin, others 16.5 33
Quetiapine Seroquel 16.5 33
Clocapramine Clofekton 10 20
Mosapramine Cremin 8.25 16.5
Propericiazine Neuleptil 5 10
Prochlorperazine Novamin 3.75 7.5
Moperone Luvatren 3.125 6.25
  1. Maximum reduction rate represents the maximum acceptable reduction per week.
  2. Maximum reduction represents the maximum amount of reduction at a time. After maximum reduction, subsequent reduction is performed after a minimum 2-week observation period.
  3. (Cited and partially modified from Sukegawa [11]).