Neurobehavioral consequences of chronic intrauterine opioid exposure in infants and preschool children: a systematic review and meta-analysis

Table 3 Specific characteristics of selected studies comparing opioid exposed infants and children with non opioid exposed controls (n = 5)

Study	Age in months when tested	Gestational age in weeks	Mean birth weight in g	Mean head circumference (cms)	Mother’s age (median) in years	Mother’s methadone dose in mg
Infants
Hunt et al. [6]	19.9	37.7	2900in OE	33.6 in OE	n/a	n/a
			3300 in C	34.5 in C
Moe et al. [71]	12	n/a	3037 in OE	34 in OE	n/a	na
			3754 in C	35.8 in C
Hans et al. (2011)	12/24	n/a	2922 in OE	n/a	27.1 in OE	20 mg
			3236 in C		25.8 in C
Bunkowski et al. (1998)	12.4	37.4	2783 in OE	n/a	27 in OE	n/a
			3240 in C		30.2 in C
Pre-school children
Hunt et al. [6]	38.2	37.7	2900in OE	33.6 in OE	n/a	n/a
			3300 in C	34.5 in C
Moe et al. [71]	54	n/a	3037 in OE	34 in OE	n/a	n/a
			3754 in C	35.8 in C
Ornoy et al. [72]	60	36	2487 in OE	27.8 in OE	n/a	n/a
			3346 in C	39.8 in C

Mg, Milligrammes; g, Grammes; cms, Centimetres; n/a, Not available; OE, Opioid Exposed; C, Non-Opioid Exposed Controls.

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