Table 3 Meta-analysis of case–control studies on A218C/A779C TPH-1 gene variants in patients with suicidal behavior

All populations

Allelic

With heterogeneity

1.10 (0.98-1.22)

1.09 (1.04-1.16)

<0.001

0.85

0.96 (0.76-1.22)

1.09 (0.99-1.21)

<0.0001

0.46

Without heterogeneity

1.02 (0.94-1.11)

1.01 (0.95-1.08)

0.11

0.27

0.97 (0.85-1.11)

0.97 (0.85-1.11)

0.43

0.24

Additive

With heterogeneity

1.22 (0.98-1.52)

1.22 (1.09-1.37)

<0.00001

0.95

1.02 (0.67-1.54)

1.29 (1.04-1.59)

0.001

0.25

Without heterogeneity

1.06 (0.90-1.24)

1.04 (0.92-1.19)

0.15

0.50

0.92 (0.71-1.19)

0.92 (0.71-1.19)

0.42

0.11

Dominant

With heterogeneity

1.16 (0.96-1.41)

1.16 (1.07-1.27)

<0.0001

0.93

1.17 (0.75-1.83)

1.43 (1.21-1.69)

<0.0001

0.07

Without heterogeneity

1.04 (0.91-1.18)

1.02 (0.93-1.13)

0.07

0.65

1.00 (0.82-1.22)

1.00 (0.82-1.22)

0.47

0.73

Recessive

With heterogeneity

1.10 (0.94-1.28)

1.04 (0.95-1.15)

0.0005

0.15

Without heterogeneity

0.97 (0.87-1.08)

0.97 (0.87-1.08)

0.97

0.80

0.88 (0.72-1.08)

0.90 (0.76-1.06)

0.23

0.23

Caucasian population

Allelic

With heterogeneity

1.12 (0.971.29)

1.10 (1.04-1.17)

<0.0001

0.69

0.90(0.62-1.30)

1.11(0.98 1.25)

<0.0001

0.60

Without heterogeneity

1.01(0.91-1.13)

1.00 (0.93-1.08)

0.006

0.36

0.95(0.78-1.14)

0.95(0.78 1.14)

0.58

0.25

Additive

With heterogeneity

1.25 (0.95-1.64)

1.22 (1.07-1.39)

<0.0001

0.73

0.89(0.46-1.71)

1.36 (1.05 1.75)

<0.0001

0.80

Without heterogeneity

1.05(0.87-1.27)

1.03 (0.88-1.19)

0.18

0.22

0.80(0.55-1.16)

0.80(0.55-1.16)

0.69

0.94

Dominant

With heterogeneity

1.24(0.96-1.59)

1.20 (1.09-1.32)

<0.0001

0.68

1.17(0.75-1.83)

1.43(1.21-1.69)

<0.0001

0.40

Without heterogeneity

1.12(0.97-1.28)

1.10 (0.97-1.25)

0.35

0.06

1.09(0.83-1.44)

1.09(0.83 -1.44)

0.77

0.58

Recessive

With heterogeneity

1.02 (0.841.24)

0.97 (0.87-1.09)

<0.0001

0.34

0.81(0.67-0.98)

0.81(0.670.98)

<0.0001

0.30

Without heterogeneity

0.95 (0.84-1.06)

0.95 (0.84-1.06)

0.66

0.20

0.68(0.51-0.91)

68(0.51-0.91)

0.71

0.31

Asian population

Allelic

With heterogeneity

1.06(0.89-1.27)

1.06 (0.94-1.20)

0.04

0.72

1.05(0.88 1.27)

1.05(0.88-1.27)

0.93

0.84

Without heterogeneity

1.11(0.95-1.28)

1.10 (0.97 1.24)

0.21

0.30

Additive

With heterogeneity

Without heterogeneity

1.17(0.83-1.65)

1.18 (0.93 1.50)

0.06

0.69

1.15(0.79-1.68)

1.15(0.79-1.68)

0.83

0.76

Dominant

With heterogeneity

0.99(0.73-1.35)

0.99(0.73-1.35)

0.45

0.10

Without heterogeneity

1.01(0.82-1.25)

1.01(0.84-1.23)

0.31

0.27

0.92(0.67.1.28)

0.92(0.67-1.28)

0.88

1.000

Recessive

With heterogeneity

1.18(0.81-1.72)

1.19(0.97-1.45)

0.002

0.89

1.16(0.86-1.58)

1.16(0.86-1.58)

0.40

0.54

Without heterogeneity

0.94(0.74-1.18)

0.94 (0.74-1.18)

0.52

0.27