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Table 8 Benzodiazepine-haloperidol mix versus haloperidol alone – 3 trials, 96 participants

From: TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243]

Main outcomes B-H mix Hal'dol RR (95% CI)
Not improved by 90 minutes 8/32 13/35 0.67 (0.3–1.4)
Needing another injection 27/32 31/35 0.95 (0.8–1.2)
Mental state: asleep – by 3 hours 20/32 11/35 2.0 (1.1–3.5)
Leaving the study early 0/49 0/47 -
Adverse effects: needing antiparkinsonian medication 3/32 9/35 0.36 (0.1–1.2)