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Table 8 Benzodiazepine-haloperidol mix versus haloperidol alone – 3 trials, 96 participants

From: TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243]

Main outcomes

B-H mix

Hal'dol

RR (95% CI)

Not improved by 90 minutes

8/32

13/35

0.67 (0.3–1.4)

Needing another injection

27/32

31/35

0.95 (0.8–1.2)

Mental state: asleep – by 3 hours

20/32

11/35

2.0 (1.1–3.5)

Leaving the study early

0/49

0/47

-

Adverse effects: needing antiparkinsonian medication

3/32

9/35

0.36 (0.1–1.2)