| Melancholic Status | Mean Change (SD) | p-valuea | p-valueb | |
---|---|---|---|---|---|
 |  | Duloxetine | Placebo |  |  |
HAMD 17 Total Score | |||||
All Studies | MEL (n = 1249) | -8.97 (7.36) | -6.57 (7.24) | <.001 | Â |
 | NON-MEL (n = 621) | -8.25 (6.55) | -6.20 (6.22) | <.001 | .651 |
Positive Studies | MEL (n = 984) | -9.83 (7.20) | -7.03 (7.06) | <.001 | Â |
 | NON-MEL (n = 474) | -9.15 (6.23) | -6.47 (6.27) | <.001 | .781 |
CGI-Severity | |||||
All Studies | MEL (n = 1251) | -1.52 (1.25) | -1.11 (1.21) | <.001 | Â |
 | NON-MEL (n = 621) | -1.47 (1.23) | -1.14 (1.19) | .001 | .511 |
Positive Studies | MEL (n = 986) | -1.62 (1.25) | -1.16 (1.20) | <.001 | Â |
 | NON-MEL (n = 474) | -1.54 (1.13) | -1.15 (1.17) | <.001 | .679 |
PGI-Improvement †| Mean (SD) | ||||
All Studies | MEL (n = 1249) | 2.67 (1.27) | 3.07 (1.27) | <.001 | Â |
 | NON-MEL (n = 621) | 2.71 (1.31) | 3.17 (1.27) | <.001 | .865 |
Positive Studies | MEL (n = 984) | 2.64 (1.26) | 3.09 (1.27) | <.001 | Â |
 | NON-MEL (n = 474) | 2.70 (1.28) | 3.18 (1.32) | <.001 | .912 |