Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms

BMC Psychiatry

Table 4 Significant partial correlations between regional GM and symptom severity measures in the autism group.

MEASURES	T	CLUSTER SIZE	MNI COORDINATES
ADI-R Repetitive and Stereotyped Behaviors
Left Caudate Nucleus	2.99	145	-15	22	10
Right Caudate Nucleus	3.88	541	17	-1	19
Left Inferior Frontal Gyrus, Pars Triangularis	3.49	589	-42	42	14
Left Precentral Gyrus	3.23	40	-37	1	40
Right Amygdala	3.04	334	32	4	-21
Left Superior Temporal Gyrus	-5.07	7835	-60	-37	17
Right Superior Temporal Gyrus	-7.44	9192	55	-40	14
Left Postcentral Gyrus	-4.12	1476	-54	-56	-26
Left Inferior Frontal Gyrus	-3.16	42	-37	48	-17
Right Inferior Frontal Gyrus	-3.85	734	53	36	-7
Left Cerebellar Lobule VI	-4.04	13101	-54	-56	-26
Right Cerebellar Crus I	-3.72	12453	40	-63	-23
ADI-R Social and Communication Total
Left Caudate Nucleus	3.88	613	-9	0	14
Right Caudate Nucleus	3.12	133	8	7	5
Left Post-central Gyrus	3.38	231	-52	-29	56
Left Superior Temporal Gyrus	2.79	186	57	-40	13
Right Superior Temporal Gyrus	3.07	466	-57	-36	19
Left Cerebellar Lobule VI*	3.33	13114	3	-60	-20
Right Cerebellar Lobule VI*	3.20	13114	8	-58	-21
Right Cerebellar Lobule VIII	3.15	249	19	-40	-55
Left Medial Frontal Gyrus	-3.29	518	-10	54	29
Left Inferior Frontal Gyrus, Pars Triangularis	-3.78	411	-40	44	14
Left Precentral Gyrus	-3.50	247	-37	1	38
Left Precuneus	-3.38	336	-24	-50	6
ADOS-G Severity Measure
Left Cerebellar Lobule VI	-4.07	16420	-25	-52	-33
Right Superior Temporal Gyrus	-3.08	315	62	-40	15

Notes: The sign of the t-statistic indicates whether the correlation coefficients are positive or negative partial correlations. Regions reported in table are significant after small volume correction, p < .05. Cluster size is the number of contiguous voxels in cluster at p < .01 uncorrected. ^† All labels are derived from AAL atlas (see text). * This contiguous cluster has two local maxima, one on each side of the cerebellum.

ISSN: 1471-244X