Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia

BMC Psychiatry

Table 6 Differences between atypicals and haloperidol with prophylactic anticholinergic agents on time to all-cause medication discontinuation

Antipsychotic	Statistical approach
	Survival analysis, log-rank test	Cox PH model	Propensity score bootstrap
CLZ, OLZ, RIS, QUE, ZIP (combined) vs. HAL+	**	**	**
Clozapine vs. HAL+	**	**	**
Olanzapine vs. HAL+	**	**	**
Risperidone vs. HAL+	**	**	**
Quetiapine vs. HAL+	**	NS	NS
Ziprasidone vs. HAL+	NS	NS	NS

Abbreviations: CLZ, clozapine; OLZ, olanzapine; RIS, risperidone; QUE, quetiapine; ZIP, ziprasidone; NS, not significant; HAL+ denotes the use of haloperidol with prophylactic anticholinergic agent.
*Significant at p < 0.05 level
**Significant at p ≤ 0.01 level
Prophylactic use of anticholinergics is defined as a prescription for haloperidol and an anticholinergic on the date haloperidol was initiated, or 1 day later.

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