Table 1 Numbers of patients treated with different drugs in trials of atypical antipsychotics in bipolar disorder
From: Atypical antipsychotics in bipolar disorder: systematic review of randomised trials
Index episode and duration | Drug | Number of Patients |
|---|---|---|
Depression | Â | Â |
8–12 weeks | olanzapine | 351 |
| Â | olanzapine/fluoxetine | 287 |
| Â | quetiapine | 661 |
| Â | risperidone + ms | 10 |
| Â | risperidone/paroxetine + ms | 10 |
| Â | paroxetine + ms | 10 |
| Â | lamotrigine | 205 |
| Â | placebo | 685 |
Mania/Mixed | Â | Â |
<6 weeks | olanzapine | 265 |
| Â | risperidone | 449 |
| Â | risperidone + ms | 127 |
| Â | quetiapine | 209 |
| Â | quetiapine + ms | 275 |
| Â | ziprasidone | 270 |
| Â | aripiprazole | 437 |
| Â | divalproex | 126 |
| Â | haloperidol | 428 |
| Â | haloperidol + ms | 53 |
| Â | lithium | 128 |
| Â | placebo | 1126 |
| Â | placebo + ms | 411 |
6–12 weeks | olanzapine | 291 |
| Â | olanzapine + ms | 229 |
| Â | quetiapine | 209 |
| Â | aripiprazole | 174 |
| Â | divalproex | 63 |
| Â | lithium | 98 |
| Â | haloperidol | 488 |
| Â | placebo | 196 |
| Â | placebo + ms | 115 |
>12 weeks | olanzapine | 567 |
| Â | olanzapine + ms | 51 |
| Â | aripipazole | 78 |
| Â | divalproex | 126 |
| Â | lithium | 214 |
| Â | placebo | 219 |
| Â | placebo + ms | 48 |