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Table 1 Numbers of patients treated with different drugs in trials of atypical antipsychotics in bipolar disorder

From: Atypical antipsychotics in bipolar disorder: systematic review of randomised trials

Index episode and duration Drug Number of Patients
Depression   
8–12 weeks olanzapine 351
  olanzapine/fluoxetine 287
  quetiapine 661
  risperidone + ms 10
  risperidone/paroxetine + ms 10
  paroxetine + ms 10
  lamotrigine 205
  placebo 685
Mania/Mixed   
<6 weeks olanzapine 265
  risperidone 449
  risperidone + ms 127
  quetiapine 209
  quetiapine + ms 275
  ziprasidone 270
  aripiprazole 437
  divalproex 126
  haloperidol 428
  haloperidol + ms 53
  lithium 128
  placebo 1126
  placebo + ms 411
6–12 weeks olanzapine 291
  olanzapine + ms 229
  quetiapine 209
  aripiprazole 174
  divalproex 63
  lithium 98
  haloperidol 488
  placebo 196
  placebo + ms 115
>12 weeks olanzapine 567
  olanzapine + ms 51
  aripipazole 78
  divalproex 126
  lithium 214
  placebo 219
  placebo + ms 48
  1. ms: mood stabiliser (lithium, valproate, divalproex, carbamazepine)