Figure 1

Projection of Z-scores (see method section for description of this measure) for patients with schizophrenia (upper two rows) and with affective or neurotic/reactive diagnoses (lower two rows) onto outer surface (left column) and inner view (second left column) of the brain hemispheres. The letters 'L' and 'R' behind the diagnostic groups indicate the left hemispheric and the right hemispheric views. Z-scores depict ASWA relative to the group of 116 healthy subjects with colors indicating the range of deviation from the healthy subject group; they vary between large deviation (red color = Z-scores > 0.4) to reverse deviation (lower ASWA relative to the healthy subject group; blue color = Z-scores > -0.4); small to negligible deviation from normal is depicted by green color. The segmented brain was calculated using the software package Caret (Van Essen DC, Drury HA, Dickson J, Harwell J, Hanlon D, Anderson CH (2001) An integrated software suite for surface-based analyses of cerebral cortex. J Am Med Inform Assoc, 8: 443–59), overlays of ASWA and the voxel based t-test results are based on AFNI/SUMA (Cox RW (1996) AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res, 29, 162–73).