Figure 2
From: Evaluating dose response from flexible dose clinical trials
Unweighted analysis. A. Least-squares means in groups by modal dose received during the most recent visit interval; estimated from unweighted analysis of covariance for reduction in the Young Mania Rating Scale (YMRS) total score in patients with bipolar disorder. Olanzapine (Olz): negative dose effect (20 vs.5–10 mg) at Weeks 3–12, p < .01. B. Least-squares means in groups by modal dose received during the most recent visit interval; estimated from unweighted mixed-effects model, repeated measures (MMRM) analysis of reduction in the Young Mania Rating Scale (YMRS) total score in patients with bipolar disorder. Olanzapine (Olz): overall dose effect (20 vs. 5–10 mg) for Weeks 3–12 is negative, p < .001; individual dose contrasts significant (p < .05) at Weeks 3,7,8,10.