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Table 1 Patient demographic and clinical characteristics.

From: The co-administration of quetiapine or placebo to cognitive-behavior therapy in treatment refractory depression: A preliminary trial

 

Q+CBT

(N = 11)

P+CBT

(N = 11)

All patients

(N = 31)

Women

8 (73%)

8 (73%)

23 (74%)

Average age

41.6 ± 13

44.9 ± 10

43.7 ± 11

Average # of treatments*f

3 ± 1

3 ± 1

3 ± 1

Average onset of depression

21 ± 15 mo

24 ± 15 mo

22.7 ± 16 mo

Prior augmentation **

4 (36%)

4 (36%)

11 (35%)

Prior ECT***

1

1

2

Mean HADS at screen

30 ± 6.4

29.8 ± 6.7

28.4 ± 6.7

Mean HRSD at screen

23.4 ± 3

22.4 ± 4.7

23 ± 3.5

Mean MADRS at screen

30.5 ± 3

29.8 ± 5

30.7 ± 4

Mean CGI at screen

4.2 ± 0.4

4.2 ± 0.4

4.2 ± 0.4

  1. * Although patients had, on average, 3 adequate antidepressant trials (see f) many also received antidepressants at lower dosages than those described below.
  2. fTherapeutically recommended daily doses were; venlafaxine, 225 mg/350 mg (moderate, severe depression, respectively), citalopram 40 mg, sertraline 200 mg, mirtazapine 45 mg, nefazodone 600 mg, paroxetine 50 mg, amitriptyline 300 mg, phenelzine 90 mg [17, 18].
  3. ** With either lithium carbonate or an atypical antipsychotic.
  4. *** Electroconvulsive therapy.