Table 1 Power calculations for genetic study of 1,000 cases and 1,000 controls
| Â | Â | Â | Power (alpha = 0.05/12) | Power (alpha = 0.05/360) | ||
|---|---|---|---|---|---|---|
Risk allele freq. | GRR(het) | GRR(hom) | Lower bound (r2 = 0.8) | Upper bound (r2 = 1) | Lower bound (r2 = 0.8) | Upper bound (r2 = 1) |
1% of variance in liability | ||||||
0.010 | 2.65 | 4.86 | 0.87 | 0.95 | 0.58 | 0.75 |
0.025 | 1.95 | 3.25 | 0.87 | 0.94 | 0.57 | 0.74 |
0.050 | 1.65 | 2.49 | 0.86 | 0.94 | 0.55 | 0.72 |
0.100 | 1.45 | 2.02 | 0.84 | 0.93 | 0.53 | 0.70 |
0.250 | 1.31 | 1.67 | 0.83 | 0.92 | 0.50 | 0.67 |
0.500 | 1.27 | 1.59 | 0.81 | 0.91 | 0.47 | 0.65 |
0.750 | 1.34 | 1.75 | 0.79 | 0.89 | 0.45 | 0.62 |
0.900 | 1.56 | 2.33 | 0.76 | 0.87 | 0.40 | 0.57 |
2% of variance in liability | ||||||
0.010 | 3.59 | 6.55 | 1.00 | 1.00 | 0.96 | 0.99 |
0.025 | 2.48 | 4.54 | 1.00 | 1.00 | 0.97 | 0.99 |
0.050 | 1.99 | 3.37 | 1.00 | 1.00 | 0.97 | 0.99 |
0.100 | 1.69 | 2.61 | 1.00 | 1.00 | 0.96 | 0.99 |
0.250 | 1.47 | 2.05 | 0.99 | 1.00 | 0.95 | 0.99 |
0.500 | 1.42 | 1.94 | 0.99 | 1.00 | 0.93 | 0.98 |
0.750 | 1.53 | 2.25 | 0.99 | 1.00 | 0.91 | 0.97 |
0.900 | 1.96 | 3.50 | 0.98 | 1.00 | 0.87 | 0.96 |